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Entry version 112 (02 Jun 2021)
Sequence version 1 (01 Oct 2000)
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Protein

Iron-regulated protein FrpC

Gene

frpC

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May participate in the pathogenesis of meningococcal disease.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionToxin
Biological processVirulence
LigandCalcium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
NMEN122586:G1G1B-1367-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Iron-regulated protein FrpC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:frpC
Ordered Locus Names:NMB1415
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeisseria meningitidis serogroup B (strain MC58)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri122586 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000425 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell outer membrane, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001962441 – 1829Iron-regulated protein FrpCAdd BLAST1829

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JYV5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Small Angle Scattering Biological Data Bank

More...
SASBDBi
Q9JYV5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JYV5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati869 – 886Hemolysin-type calcium-binding 1Add BLAST18
Repeati887 – 904Hemolysin-type calcium-binding 2Add BLAST18
Repeati1015 – 1032Hemolysin-type calcium-binding 3Add BLAST18
Repeati1033 – 1050Hemolysin-type calcium-binding 4Add BLAST18
Repeati1051 – 1068Hemolysin-type calcium-binding 5Add BLAST18
Repeati1069 – 1086Hemolysin-type calcium-binding 6Add BLAST18
Repeati1087 – 1104Hemolysin-type calcium-binding 7Add BLAST18
Repeati1215 – 1232Hemolysin-type calcium-binding 8Add BLAST18
Repeati1233 – 1250Hemolysin-type calcium-binding 9Add BLAST18
Repeati1251 – 1268Hemolysin-type calcium-binding 10Add BLAST18
Repeati1269 – 1286Hemolysin-type calcium-binding 11Add BLAST18
Repeati1287 – 1304Hemolysin-type calcium-binding 12Add BLAST18
Repeati1415 – 1432Hemolysin-type calcium-binding 13Add BLAST18
Repeati1433 – 1450Hemolysin-type calcium-binding 14Add BLAST18
Repeati1451 – 1468Hemolysin-type calcium-binding 15Add BLAST18
Repeati1469 – 1486Hemolysin-type calcium-binding 16Add BLAST18
Repeati1487 – 1504Hemolysin-type calcium-binding 17Add BLAST18
Repeati1615 – 1632Hemolysin-type calcium-binding 18Add BLAST18
Repeati1633 – 1650Hemolysin-type calcium-binding 19Add BLAST18
Repeati1651 – 1668Hemolysin-type calcium-binding 20Add BLAST18
Repeati1669 – 1686Hemolysin-type calcium-binding 21Add BLAST18
Repeati1687 – 1704Hemolysin-type calcium-binding 22Add BLAST18

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1671 – 1690DisorderedSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Gly-rich region is probably involved in binding calcium, which is required for target cell-binding or cytolytic activity.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001954_0_1_4

Identification of Orthologs from Complete Genome Data

More...
OMAi
HEYYQFE

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.150.10.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010566, Haemolys_ca-bd
IPR018511, Hemolysin-typ_Ca-bd_CS
IPR001343, Hemolysn_Ca-bd
IPR003995, RTX_toxin_determinant-A
IPR011049, Serralysin-like_metalloprot_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06594, HCBP_related, 4 hits
PF00353, HemolysinCabind, 9 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01488, RTXTOXINA

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51120, SSF51120, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00330, HEMOLYSIN_CALCIUM, 17 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9JYV5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNEGEVVLTP EQIQTLRGYA SRGDTYGGWR YLANLGDRYA DDAAAIVGKD
60 70 80 90 100
ANLNGLNLWM KKGVENLWDD TVGKKTRLEK FDRVALQHFR QYARLINQNN
110 120 130 140 150
GRLPNTSEIE RSYYKAVTDN GVSSSAAIDL VINRSLPDMA DGYWALGLGI
160 170 180 190 200
EAERIHNEQA VNNPNGSERD NRKQLISALD KGFDGSFKEK HFTFLQSVMM
210 220 230 240 250
DVTKLGVEYT IDGWQKIGGW GNGIINDLYK SVVKREWTGI FEIVNNNIKQ
260 270 280 290 300
GNEAFKNEIN SLVHDMKAAG KEFGDDLNTQ WNNLTQAAEI IYNDIVDNTS
310 320 330 340 350
QGIEKGVKAI KELSEKMKNA ASDLADGSAE KAKQVVEDLA QAAKEAYENA
360 370 380 390 400
KSTAEKAAQA AREFFKGLPS FKDLAEKFRD LFPNPEGWID DGHQCLAPWV
410 420 430 440 450
KETKKRNGKY HVYDPLALDL DGDGIETVAT KGFAGSLFDH TNNGIRTATG
460 470 480 490 500
WVSADDGLLV RDLNGNGIID NGAELFGDNT KLADGSFAKH GYAALAELDS
510 520 530 540 550
NGDNIINAAD AAFQTLRVWQ DLNQDGISQA NELRTLEELG IQSLDLAYKD
560 570 580 590 600
VNKNLGNGNT LAQQGSYTKT DGTTAKMGDL LLAADNLHSR FKDKVELTAE
610 620 630 640 650
QAKAANLAGI GRLRDLREAA ALSGDLANML KAYSAAETKE AQLALLDNLI
660 670 680 690 700
HKWAETDSNW GKKSPMRLST DWTQTANEGI ALTPSQVAQL KKNALVSLSD
710 720 730 740 750
KAKAAIDAAR DRIAVLDAYT GQDSNTLYYM SEEDALNIVK VTNDTYDHLA
760 770 780 790 800
KNIYQNLLFQ TRLQPYLNQI SFKMENDTFT LDFSGLVQAF NHVKETNPQK
810 820 830 840 850
AFVDLAEMLA YGELRSWYEG RRLMTDYVEE AKKAGKFEDY QKVLGQETVA
860 870 880 890 900
LLAKTSGTQA DDILQNVGFG HNKNVSLYGN DGNDTLIGGA GNDYLEGGSG
910 920 930 940 950
SDTYVFGEGF GQDTVYNYDY ATGRKDIIRF TDGITADMLT FTREGNHLLI
960 970 980 990 1000
KAKDGSGQVT VQSYFQNDGS GAYRIDEIHF DNGKVLDVAT VKELVQQSTD
1010 1020 1030 1040 1050
GSDRLYAYQS GNTLNGGLGD DYLYGADGDD LLNGDAGNDS IYSGNGNDTL
1060 1070 1080 1090 1100
DGGEGNDALY GYNGNDALNG GEGNDHLNGE DGNDTLIGGA GNDYLEGGSG
1110 1120 1130 1140 1150
SDTYVFGKGF GQDTVYNYDY ATGRKDIIRF TDGITADMLT FTREGNHLLI
1160 1170 1180 1190 1200
KAKDGSGQVT VQYYFQNDGS GAYRIDEIHF DNGKVLDVAT VKELVQQSTD
1210 1220 1230 1240 1250
GSDRLYAYQS GNTLNGGLGD DYLYGADGDD LLNGDAGNDS IYSGNGNDTL
1260 1270 1280 1290 1300
DGGEGNDALY GYNGNDALNG GEGNDHLNGE DGNDTLIGGA GNDYLEGGSG
1310 1320 1330 1340 1350
SDTYVFGKGF GQDAVYNYDY ATGRKDIIRF TDGITADMLT FTREGNHLLI
1360 1370 1380 1390 1400
KAKDGSGQVT VQSYFQNDGS GAYRIDEIHF DNGKVLDVAT VKELVQQSTD
1410 1420 1430 1440 1450
GSDRLYAYQS GNTLNGGLGD DYLYGADGDD LLNGDAGNDS IYSGNGNDTL
1460 1470 1480 1490 1500
NGGEGNDALY GYNGNDALNG GEGNDHLNGE DGNDTLIGGA GNDYLEGGSG
1510 1520 1530 1540 1550
SDTYVFGKGF GQDAVYNYDY ATGRKDIIRF TDGITADMLT FTREGNHLLI
1560 1570 1580 1590 1600
KAKDGSGQVT VQSYFQNDGS GAYRIDEIHF DNGKVLDVAT VKELVQQSTD
1610 1620 1630 1640 1650
GSDRLYAYQS GSTLNGGLGD DYLYGADGDD LLNGDAGNDS IYSGNGNDTL
1660 1670 1680 1690 1700
DGGEGNDALY GYNGNDALNG GEGNDHLNGE DGNDTLIGGA GNDYLEGGSG
1710 1720 1730 1740 1750
SDTYVFGEGF GQDTVYNYHV DKNSDTMHFK GFKAADVHFI RSGSDLVLSA
1760 1770 1780 1790 1800
SEQDNVRISG FFYGENHRVD TFVFDDAAIS NPDFAKYINA GNNLVQSMSV
1810 1820
FGSNTAATGG NVDANIQSVQ QPLLVTPSA
Length:1,829
Mass (Da):197,446
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F63506E1F6D9B40
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE002098 Genomic DNA Translation: AAF41776.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E81086

NCBI Reference Sequences

More...
RefSeqi
NP_274427.1, NC_003112.2
WP_010980934.1, NC_003112.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAF41776; AAF41776; NMB1415

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nme:NMB1415

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|122586.8.peg.1767

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002098 Genomic DNA Translation: AAF41776.1
PIRiE81086
RefSeqiNP_274427.1, NC_003112.2
WP_010980934.1, NC_003112.2

3D structure databases

SASBDBiQ9JYV5
SMRiQ9JYV5
ModBaseiSearch...

Proteomic databases

PaxDbiQ9JYV5

Genome annotation databases

EnsemblBacteriaiAAF41776; AAF41776; NMB1415
KEGGinme:NMB1415
PATRICifig|122586.8.peg.1767

Phylogenomic databases

HOGENOMiCLU_001954_0_1_4
OMAiHEYYQFE

Enzyme and pathway databases

BioCyciNMEN122586:G1G1B-1367-MONOMER

Family and domain databases

Gene3Di2.150.10.10, 9 hits
InterProiView protein in InterPro
IPR010566, Haemolys_ca-bd
IPR018511, Hemolysin-typ_Ca-bd_CS
IPR001343, Hemolysn_Ca-bd
IPR003995, RTX_toxin_determinant-A
IPR011049, Serralysin-like_metalloprot_C
PfamiView protein in Pfam
PF06594, HCBP_related, 4 hits
PF00353, HemolysinCabind, 9 hits
PRINTSiPR01488, RTXTOXINA
SUPFAMiSSF51120, SSF51120, 5 hits
PROSITEiView protein in PROSITE
PS00330, HEMOLYSIN_CALCIUM, 17 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFRPC_NEIMB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JYV5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: June 2, 2021
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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