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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayi
UPA00219

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:NMA2062
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000626 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001091901 – 355UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseAdd BLAST355

Proteomic databases

PRIDEiQ9JSZ7

Structurei

3D structure databases

ProteinModelPortaliQ9JSZ7
SMRiQ9JSZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218321
KOiK02563
OMAiHQTKNAM

Family and domain databases

CDDicd03785 GT1_MurG, 1 hit
HAMAPiMF_00033 MurG, 1 hit
InterProiView protein in InterPro
IPR006009 GlcNAc_MurG
IPR007235 Glyco_trans_28_C
IPR004276 GlycoTrans_28_N
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF03033 Glyco_transf_28, 1 hit
TIGRFAMsiTIGR01133 murG, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JSZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGKTFMLMA GGTGGHIFPA LAVADSLRAR GHHVIWLGSK DSMEERIVPQ
60 70 80 90 100
YDILLETLAI KGVRGNGIKR KLMLPFTLYQ TVREAQQIIR KHRVECVIGF
110 120 130 140 150
GGFVTFPGGL AAKLLGVPIV IHEQNAVAGL SNRHLSRWAK RVLYAFPKAF
160 170 180 190 200
SHEGGLVGNP VRADISNLPV PAERFQGREG RLKILVVGGS LGADVLNKTV
210 220 230 240 250
PQALALLPDN ARPQMYHQSG RGKLGSLQAD YDALGVQAEC VEFITDMVSA
260 270 280 290 300
YRDADLVICR AGALTIAELT AAGLGALLVP YPHAVDDHQT ANARFMVQAE
310 320 330 340 350
AGLLLPQTQL TAEKLAEILG GLNREKCLKW AENARTLALP HSADDVAEAA

IACAA
Length:355
Mass (Da):38,056
Last modified:October 1, 2000 - v1
Checksum:iDD93836BB897C401
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA Translation: CAM09165.1
PIRiB81777
RefSeqiWP_002245894.1, NC_003116.1

Genome annotation databases

EnsemblBacteriaiCAM09165; CAM09165; NMA2062
KEGGinma:NMA2062

Similar proteinsi

Entry informationi

Entry nameiMURG_NEIMA
AccessioniPrimary (citable) accession number: Q9JSZ7
Secondary accession number(s): A1ITP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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