Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP-dependent (S)-NAD(P)H-hydrate dehydratase

Gene

nnrD1

more
Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.UniRule annotation

Catalytic activityi

ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide = AMP + phosphate + NADH.UniRule annotation
ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide phosphate = AMP + phosphate + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei111NAD(P)HX; via amide nitrogenUniRule annotation1
Binding sitei232NAD(P)HXUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 206ADPUniRule annotation5
Nucleotide bindingi222 – 231ADPUniRule annotation10

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-dependent (S)-NAD(P)H-hydrate dehydrataseUniRule annotation (EC:4.2.1.136UniRule annotation)
Alternative name(s):
ADP-dependent NAD(P)HX dehydrataseUniRule annotation
Gene namesi
Name:nnrD1UniRule annotation
Ordered Locus Names:NMB1159
AND
Name:nnrD2UniRule annotation
Ordered Locus Names:NMB1197
OrganismiNeisseria meningitidis serogroup B (strain MC58)
Taxonomic identifieri122586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004161471 – 296ADP-dependent (S)-NAD(P)H-hydrate dehydrataseAdd BLAST296

Proteomic databases

PaxDbiQ9JRZ9

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi122586.NMB1197

Structurei

3D structure databases

ProteinModelPortaliQ9JRZ9
SMRiQ9JRZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 292YjeF C-terminalUniRule annotationAdd BLAST275

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni165 – 171NAD(P)HXUniRule annotation7

Sequence similaritiesi

Belongs to the NnrD/CARKD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DR1 Bacteria
COG0063 LUCA
HOGENOMiHOG000024581
KOiK17758
OMAiLGMLCCH
OrthoDBiPOG091H01XZ

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS51383 YJEF_C_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JRZ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPVFHLSGE SRRQMLQTAL RFPHVFKARA EDSHKGTFGT LAVVGGSAGM
60 70 80 90 100
SGAPVLAASA AMYLGCGKVW AGFNQDTLPF AVIAGFPEIM LDTADSLAKR
110 120 130 140 150
QDINAWVVGC GLGTGRAAVG TLAGILTEHT DKPVVLDADA LNILSTDAET
160 170 180 190 200
RNLARGCKNL ILTPHPAEAA RLLGTTVAQV QADRTAAVRK IGAIFGATVV
210 220 230 240 250
LKGHKTLVAS PDTEIYVNES GNAGLATAGS GDVLGGIIGS LLAQGVPVFE
260 270 280 290
AACAGAWLHG AAADVIKESA GIAAGLLAGE IAPAARWLRN RITKSM
Length:296
Mass (Da):30,347
Last modified:October 1, 2000 - v1
Checksum:i8A1AEE023D12DA3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002098 Genomic DNA Translation: AAF41545.1
AE002098 Genomic DNA Translation: AAF41580.1
PIRiG81111
RefSeqiNP_274187.1, NC_003112.2
NP_274223.1, NC_003112.2
WP_002225209.1, NC_003112.2

Genome annotation databases

EnsemblBacteriaiAAF41545; AAF41545; NMB1159
AAF41580; AAF41580; NMB1197
GeneIDi903580
903617
KEGGinme:NMB1159
nme:NMB1197
PATRICifig|122586.8.peg.1464

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002098 Genomic DNA Translation: AAF41545.1
AE002098 Genomic DNA Translation: AAF41580.1
PIRiG81111
RefSeqiNP_274187.1, NC_003112.2
NP_274223.1, NC_003112.2
WP_002225209.1, NC_003112.2

3D structure databases

ProteinModelPortaliQ9JRZ9
SMRiQ9JRZ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi122586.NMB1197

Proteomic databases

PaxDbiQ9JRZ9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF41545; AAF41545; NMB1159
AAF41580; AAF41580; NMB1197
GeneIDi903580
903617
KEGGinme:NMB1159
nme:NMB1197
PATRICifig|122586.8.peg.1464

Phylogenomic databases

eggNOGiENOG4105DR1 Bacteria
COG0063 LUCA
HOGENOMiHOG000024581
KOiK17758
OMAiLGMLCCH
OrthoDBiPOG091H01XZ

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS51383 YJEF_C_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNNRD_NEIMB
AccessioniPrimary (citable) accession number: Q9JRZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again