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Protein

Short transient receptor potential channel 3

Gene

Trpc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3 (By similarity). May also be activated by internal calcium store depletion.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 3
Short name:
TrpC3
Alternative name(s):
Trp-related protein 3
Gene namesi
Name:Trpc3
Synonyms:Trrp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61973 Trpc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 369CytoplasmicSequence analysisAdd BLAST369
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 418ExtracellularSequence analysisAdd BLAST28
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21
Topological domaini440 – 451CytoplasmicSequence analysisAdd BLAST12
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Topological domaini473 – 523ExtracellularSequence analysisAdd BLAST51
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 567CytoplasmicSequence analysisAdd BLAST23
Transmembranei568 – 588HelicalSequence analysisAdd BLAST21
Topological domaini589 – 637ExtracellularSequence analysisAdd BLAST49
Transmembranei638 – 658HelicalSequence analysisAdd BLAST21
Topological domaini659 – 836CytoplasmicSequence analysisAdd BLAST178

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153121 – 836Short transient receptor potential channel 3Add BLAST836

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi404N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JMI9
PRIDEiQ9JMI9

PTM databases

iPTMnetiQ9JMI9
PhosphoSitePlusiQ9JMI9

Interactioni

Subunit structurei

Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in maintaining Ca2+ homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation (By similarity).By similarity

Protein-protein interaction databases

CORUMiQ9JMI9
DIPiDIP-59688N
IntActiQ9JMI9, 1 interactor
STRINGi10116.ENSRNOP00000046270

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 55ANK 1Add BLAST30
Repeati61 – 90ANK 2Add BLAST30
Repeati92 – 118ANK 3Add BLAST27
Repeati147 – 176ANK 4Add BLAST30

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
HOGENOMiHOG000020590
HOVERGENiHBG068337
InParanoidiQ9JMI9
PhylomeDBiQ9JMI9

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR013555 TRP_dom
IPR005459 TRPC3_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF8 PTHR10117:SF8, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01644 TRPCHANNEL3
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JMI9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRDKGRRQAV RGPAFMFGAR GPSLTAEEER FLDAAEYGNI PVVRKMLEES
60 70 80 90 100
RTLNVNCVDY MGQNALQLAV GNEHLEVTEL LLKKENLARI GDALLLAISK
110 120 130 140 150
GYVRIVEAIL GHPGFAASRR LTLSPCEQEL RDDDFYAYDE DGTRFSPDIT
160 170 180 190 200
PIILAAHCHK YEVVHLLLLK GARIERPHDY FCRCADCAEK QRLDAFSHSR
210 220 230 240 250
SRINAYKGLA SPAYLSLSSE DPVLTALELS NELAKLANIE KEFKNDYRKL
260 270 280 290 300
SMQCKDFVVG VLDLCRDSEE VEAILNGDLE SVEPLERHGH KASLSRVKLA
310 320 330 340 350
IKYEVKKFVA HPNCQQQLLT IWYENLSGLR EQTIAIKCLV VLVVALGLPF
360 370 380 390 400
LAIGYWIAPC SRLGKILRSP FMKFVAHAAS FIIFLGLLVF NASDRFEGIT
410 420 430 440 450
TLPNITVIDY PKQIFRVKTT QFTWTEMLIM VWVLGMMWSE CKELWLEGPR
460 470 480 490 500
EYIVQLWNVL DFGMLSIFIA AFTARFLAFL QATKAQQYVD SHVQESDLSE
510 520 530 540 550
VTLPPEVQYF TYARDKWLPS DPQIISEGLY AIAVVLSFSR IAYILPANES
560 570 580 590 600
FGPLQISLGR TVKDIFKFMV LFIMVFLAFM IGMFILYSYY LGAKVNPAFT
610 620 630 640 650
TVEESFKTLF WSIFGLSEVT SVVLKYDHKF IENIGYVLYG IYNVTMVVVL
660 670 680 690 700
LNMLIAMINS SYQEIEDDSD VEWKFARSKL WLSYFDDGKT LPPPFSLVPS
710 720 730 740 750
PKSFVYFIMR ITNFSKCRRR RLQKDLELGM GNSKSRLNLF TQSNSRVFES
760 770 780 790 800
HSFNSILNQP TRYQQIMKRL IKRYVLKAQV DKENDEVNEG ELKEIKQDIS
810 820 830
SLRYELLEDK SQATEELAIL IHKLSEKLNP SALRCE
Length:836
Mass (Da):95,682
Last modified:May 26, 2009 - v3
Checksum:iE405FBFC9285613F
GO
Isoform 2 (identifier: Q9JMI9-2)
Also known as: Trp3SV
Sequence is not available
Note: No experimental confirmation available.
Length:
Mass (Da):

Sequence cautioni

The sequence BAA93434 differs from that shown. Chimeric cDNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti335A → S in BAA93434 (PubMed:10984475).Curated1
Sequence conflicti361S → T in BAA93434 (PubMed:10984475).Curated1
Sequence conflicti394D → H in BAA93434 (PubMed:10984475).Curated1
Sequence conflicti486Q → H in BAA93434 (PubMed:10984475).Curated1
Sequence conflicti506E → K in BAA93434 (PubMed:10984475).Curated1
Sequence conflicti563K → E in BAA93434 (PubMed:10984475).Curated1
Sequence conflicti567K → Q in BAA93434 (PubMed:10984475).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03013307 Genomic DNA No translation available.
AABR03015957 Genomic DNA No translation available.
AB022331 mRNA Translation: BAA93434.1 Sequence problems.
UniGeneiRn.45385

Genome annotation databases

UCSCiRGD:61973 rat [Q9JMI9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTRPC3_RAT
AccessioniPrimary (citable) accession number: Q9JMI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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