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UniProtKB - Q9JMH9 (MY18A_MOUSE)

Entry version 173 (23 Feb 2022)
Sequence version 2 (06 Feb 2007)
Previous versions | rss
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Protein

Unconventional myosin-XVIIIa

Gene

Myo18a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035).

Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (By similarity).

May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (PubMed:10733906).

Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346).

Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:21123169).

Strongly enhances natural killer cell cytotoxicity (By similarity).

By similarity4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi498 – 505ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein, Myosin
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Unconventional myosin-XVIIIa
Alternative name(s):
Molecule associated with JAK3 N-terminus
Short name:
MAJN
Myosin containing a PDZ domain
Surfactant protein receptor SP-R2101 Publication
Short name:
SP-R2101 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myo18a
Synonyms:Myspdz1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2667185, Myo18a

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000000631

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi503 – 504GK → SA: Loss of function. 1 Publication2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001234771 – 2050Unconventional myosin-XVIIIaAdd BLAST2050

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei35PhosphoserineBy similarity1
Modified residuei52PhosphoserineBy similarity1
Modified residuei72PhosphoserineCombined sources1
Modified residuei74PhosphoserineBy similarity1
Modified residuei79PhosphothreonineBy similarity1
Modified residuei83PhosphoserineCombined sources1
Modified residuei98PhosphoserineBy similarity1
Modified residuei99PhosphothreonineBy similarity1
Modified residuei102PhosphoserineCombined sources1
Modified residuei103PhosphoserineCombined sources1
Modified residuei140PhosphoserineBy similarity1
Modified residuei145PhosphoserineBy similarity1
Modified residuei157PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei164PhosphoserineCombined sources1
Modified residuei234PhosphoserineBy similarity1
Modified residuei983PhosphoserineCombined sources1
Modified residuei1063PhosphoserineBy similarity1
Modified residuei1064PhosphoserineBy similarity1
Modified residuei1066PhosphoserineBy similarity1
Modified residuei1636PhosphoserineBy similarity1
Modified residuei1938PhosphoserineBy similarity1
Modified residuei1966PhosphoserineCombined sources1
Modified residuei1970PhosphoserineBy similarity1
Modified residuei1994PhosphoserineCombined sources1
Modified residuei1998PhosphoserineBy similarity1
Modified residuei2002PhosphoserineBy similarity1
Modified residuei2003PhosphoserineBy similarity1
Modified residuei2016PhosphoserineCombined sources1
Modified residuei2032PhosphoserineCombined sources1
Modified residuei2037PhosphoserineCombined sources1
Modified residuei2039PhosphoserineCombined sources1
Modified residuei2041PhosphothreonineCombined sources1
Isoform 6 (identifier: Q9JMH9-6)
Modified residuei340PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine upon CSF1R activation. Isoform 6 is phosphorylated on Ser-340.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9JMH9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9JMH9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9JMH9

PeptideAtlas

More...PeptideAtlasi		Q9JMH9

PRoteomics IDEntifications database

More...PRIDEi		Q9JMH9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		252618 [Q9JMH9-3]
252619 [Q9JMH9-1]
252620 [Q9JMH9-2]
252621 [Q9JMH9-4]
252622 [Q9JMH9-5]
252623 [Q9JMH9-6]
252624 [Q9JMH9-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9JMH9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9JMH9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1; Expressed ubiquitously. Isoform 2: Specifically expressed in most hematopoietic cells. Isoform 3: Predominantly expressed in alveolar macrophages (PubMed:25965346).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000000631, Expressed in hindlimb stylopod muscle and 308 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9JMH9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9JMH9, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Forms a tripartite complex with CDC42BPA/CDC42BPB and LURAP1 with the latter acting as an adapter connecting CDC42BPA/CDC42BPB and MYO18A (By similarity). Binds F-actin; regulated by ADP and GOLPH3 (PubMed:15582604).

Interacts with GOLPH3; the interaction is direct and may link Golgi membranes to the actin cytoskeleton (By similarity).

Interacts with JAK3 (PubMed:10733938).

Interacts with MSR1 and CD14 (By similarity).

By similarity2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		237427, 14 interactors

Protein interaction database and analysis system

More...IntActi		Q9JMH9, 4 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000130696

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9JMH9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9JMH9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini220 – 311PDZPROSITE-ProRule annotationAdd BLAST92
Domaini349 – 401Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST53
Domaini405 – 1181Myosin motorPROSITE-ProRule annotationAdd BLAST777
Domaini1184 – 1213IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 398Mediates nucleotide-independent binding to F-actin and interaction with GOLPH3By similarityAdd BLAST398
Regioni1 – 34DisorderedSequence analysisAdd BLAST34
Regioni140 – 167DisorderedSequence analysisAdd BLAST28
Regioni1051 – 1071DisorderedSequence analysisAdd BLAST21
Regioni1448 – 1477DisorderedSequence analysisAdd BLAST30
Regioni1848 – 1897DisorderedSequence analysisAdd BLAST50
Regioni1955 – 2050DisorderedSequence analysisAdd BLAST96

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1242 – 1967Sequence analysisAdd BLAST726

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi114 – 118Interaction with actinBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi140 – 164Polar residuesSequence analysisAdd BLAST25
Compositional biasi1955 – 1981Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi1995 – 2009Polar residuesSequence analysisAdd BLAST15
Compositional biasi2012 – 2027Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi2030 – 2050Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The myosin motor domain binds ADP and ATP but has no intrinsic ATPase activity. Mediates ADP-dependent binding to actin (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0161, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155768

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9JMH9

Identification of Orthologs from Complete Genome Data

More...OMAi		EAWHETE

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9JMH9

Family and domain databases

Conserved Domains Database

More...CDDi		cd01386, MYSc_Myo18, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 1 hit
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR031244, MYO18A
IPR001609, Myosin_head_motor_dom
IPR004009, Myosin_N
IPR002928, Myosin_tail
IPR036064, MYSc_Myo18
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR036034, PDZ_sf

The PANTHER Classification System

More...PANTHERi		PTHR45615:SF13, PTHR45615:SF13, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00063, Myosin_head, 2 hits
PF01576, Myosin_tail_1, 1 hit
PF00595, PDZ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00015, IQ, 1 hit
SM00242, MYSc, 1 hit
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50156, SSF50156, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50096, IQ, 1 hit
PS51456, MYOSIN_MOTOR, 1 hit
PS50106, PDZ, 1 hit
PS51844, SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q9JMH9-3) [UniParc]FASTAAdd to basket
Also known as: SP-R210L1 Publication

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS MRRGFFNLNR 
        60         70         80         90        100
SSKRESKTRL EISNPIPIKV ASGSDLHLTD IDSDSNRGSI ILDSGHLSTA 
       110        120        130        140        150
SSSDDLKGEE GSFRGSVLQR AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA 
       160        170        180        190        200
SETSTPSEHS AAPSPQVEVR TLEGQLMQHP GLGIPRPGPR SRVPELVTKR 
       210        220        230        240        250
FPADLRLPAL VPPPPPALRE LELQRRPTGD FGFSLRRTTM LDRAPEGQAY 
       260        270        280        290        300
RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GQNVENKSRD EIVEMIRQSG 
       310        320        330        340        350
DSVRLKVQPI PELSELSRSW LRTGEGHRRE PADAKTEEQI AAEEAWYETE 
       360        370        380        390        400
KVWLVHRDGF SLASQLKSEE LSLPEGKARV KLDHDGAILD VDEDDIEKAN 
       410        420        430        440        450
APSCDRLEDL ASLVYLNESS VLHTLRQRYG ASLLHTYAGP SLLVLSTRGA 
       460        470        480        490        500
PAVYSEKVMH MFKGCRREDM APHIYAVAQT AYRAMLMSRQ DQSIVLLGSS 
       510        520        530        540        550
GSGKTTSFQH LVQYLATIAG TSGTKVFSVE KWQALSTLLE AFGNSPTIMN 
       560        570        580        590        600
GSATRFSQIL SLDFDQAGQV ASASIQTMLL EKLRVARRPA SEATFNVFYY 
       610        620        630        640        650
LLACGDATLR TELHLNHLAE NNVFGIVPLS KPEEKQKAAQ QFSKLQAAMK 
       660        670        680        690        700
VLAISPEEQK TCWLILASIY HLGAAGATKE AAEAGRKQFA RHEWAQKAAY 
       710        720        730        740        750
LLGCSLEELS SAIFKHQLKG GTLQRSTSFR QGPEESGLGE GTKLSALECL 
       760        770        780        790        800
EGMASGLYSE LFTLLISLVN RALKSSQHSL CSMMIVDTPG FQNPEWGGSA 
       810        820        830        840        850
RGASFEELCH NYAQDRLQRL FHERTFLQEL ERYKEDNIEL AFDDLEPVAD 
       860        870        880        890        900
DSVAAVDQAS HLVRSLAHAD EARGLLWLLE EEALVPGATE DALLDRLFSY 
       910        920        930        940        950
YGPQEGDKKG QSPLLRSSKP RHFLLGHSHG TNWVEYNVAG WLNYTKQNPA 
       960        970        980        990       1000
TQNAPRLLQD SQKKIISNLF LGRAGSATVL SGSIAGLEGG SQLALRRATS 
      1010       1020       1030       1040       1050
MRKTFTTGMA AVKKKSLCIQ IKLQVDALID TIKRSKMHFV HCFLPVAEGW 
      1060       1070       1080       1090       1100
PGEPRSASSR RVSSSSELDL PPGDPCEAGL LQLDVSLLRA QLRGSRLLDA 
      1110       1120       1130       1140       1150
MRMYRQGYPD HMVFSEFRRR FDVLAPHLTK KHGRNYIVVD EKRAVEELLE 
      1160       1170       1180       1190       1200
SLDLEKSSCC LGLSRVFFRA GTLARLEEQR DEQTSRHLTL FQAACRGYLA 
      1210       1220       1230       1240       1250
RQHFKKRKIQ DLAIRCVQKN IKKNKGVKDW PWWKLFTTVR PLIQVQLSEE 
      1260       1270       1280       1290       1300
QIRNKDEEIQ QLRSKLEKVE KERNELRLSS DRLETRISEL TSELTDERNT 
      1310       1320       1330       1340       1350
GESASQLLDA ETAERLRTEK EMKELQTQYD ALKKQMEVME MEVMEARLIR 
      1360       1370       1380       1390       1400
AAEINGEVDD DDAGGEWRLK YERAVREVDF TKKRLQQELE DKMEVEQQSR 
      1410       1420       1430       1440       1450
RQLERRLGDL QADSDESQRA LQQLKKKCQR LTAELQDTKL HLEGQQVRNH 
      1460       1470       1480       1490       1500
ELEKKQRRFD SELSQAHEET QREKLQREKL QREKDMLLAE AFSLKQQMEE 
      1510       1520       1530       1540       1550
KDLDIAGFTQ KVVSLEAELQ DISSQESKDE ASLAKVKKQL RDLEAKVKDQ 
      1560       1570       1580       1590       1600
EEELDEQAGS IQMLEQAKLR LEMEMERMRQ THSKEMESRD EEVEEARQSC 
      1610       1620       1630       1640       1650
QKKLKQMEVQ LEEEYEDKQK ALREKRELES KLSTLSDQVN QRDFESEKRL 
      1660       1670       1680       1690       1700
RKDLKRTKAL LADAQIMLDH LKNNAPSKRE IAQLKNQLEE SEFTCAAAVK 
      1710       1720       1730       1740       1750
ARKAMEVEME DLHLQIDDIA KAKTALEEQL SRLQREKNEI QNRLEEDQED 
      1760       1770       1780       1790       1800
MNELMKKHKA AVAQASRDMA QMNDLQAQIE ESNKEKQELQ EKLQALQSQV 
      1810       1820       1830       1840       1850
EFLEQSMVDK SLVSRQEAKI RELETRLEFE KTQVKRLENL ASRLKETMEK 
      1860       1870       1880       1890       1900
LTEERDQRAA AENREKEQNK RLQRQLRDTK EEMSELARKE AEASRKKHEL 
      1910       1920       1930       1940       1950
EMDLESLEAA NQSLQADLKL AFKRIGDLQA AIEDEMESDE NEDLINSLQD 
      1960       1970       1980       1990       2000
MVTKYQKKKN KLEGDSDVDS ELEDRVDGVK SWLSKNKGPS KAPSDDGSLK 
      2010       2020       2030       2040       2050
SSSPTSHWKP LAPDPSDDEH DPVDSISRPR FSHSYLSDSD TEAKLTETSA
Length:2,050
Mass (Da):232,755
Last modified:February 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D82B901F03D73B4
GO
Isoform 1 (identifier: Q9JMH9-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1948-1962: Missing.

Show »
Length:2,035
Mass (Da):230,908
Checksum:iC5CE4BB053475119
GO
Isoform 2 (identifier: Q9JMH9-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-331: Missing.
     332-333: AD → ML

Show »
Length:1,719
Mass (Da):195,894
Checksum:iF533D2057E1E555A
GO
Isoform 4 (identifier: Q9JMH9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1567-1603: Missing.
     1948-1962: Missing.

Show »
Length:1,998
Mass (Da):226,357
Checksum:i78A7FB6FF72A32D1
GO
Isoform 5 (identifier: Q9JMH9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-331: Missing.
     332-333: AD → ML
     1948-1962: Missing.

Show »
Length:1,704
Mass (Da):194,047
Checksum:i494995EAC30B1C00
GO
Isoform 6 (identifier: Q9JMH9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     333-333: D → DLDPEAASPAYSQ

Show »
Length:2,062
Mass (Da):233,985
Checksum:i823FB756634D16B9
GO
Isoform 7 (identifier: Q9JMH9-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-331: Missing.
     332-333: AD → MLLDPEAASPAYSQ
     1948-1962: Missing.

Show »
Length:1,716
Mass (Da):195,277
Checksum:i893846897B291215
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QAX2E9QAX2_MOUSE
Unconventional myosin-XVIIIa
Myo18a
2,083Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q405E9Q405_MOUSE
Unconventional myosin-XVIIIa
Myo18a
1,700Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B2RRE2B2RRE2_MOUSE
Myo18a protein
Myo18a
2,047Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1C7ZN10A0A1C7ZN10_MOUSE
Unconventional myosin-XVIIIa
Myo18a
1,722Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QA74E9QA74_MOUSE
Unconventional myosin-XVIIIa
Myo18a
1,642Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K3W4L0K3W4L0_MOUSE
Unconventional myosin-XVIIIa
Myo18a
2,036Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6ZGN3F6ZGN3_MOUSE
Unconventional myosin-XVIIIa
Myo18a
501Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PUR2E9PUR2_MOUSE
Unconventional myosin-XVIIIa
Myo18a
307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q0K8E9Q0K8_MOUSE
Unconventional myosin-XVIIIa
Myo18a
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti399A → T in BAE28009 (PubMed:16141072).Curated1
Sequence conflicti466R → Q in BAE42402 (PubMed:16141072).Curated1
Sequence conflicti680 – 683Missing in BAE42402 (PubMed:16141072).Curated4
Sequence conflicti680E → EPLEEQD in BAE28009 (PubMed:16141072).Curated1
Sequence conflicti798G → D in BAE42402 (PubMed:16141072).Curated1
Sequence conflicti1362D → N in BAE42402 (PubMed:16141072).Curated1
Sequence conflicti1655K → R in BAE28009 (PubMed:16141072).Curated1
Sequence conflicti1978G → R in AAV80766 (PubMed:16087679).Curated1
Sequence conflicti1990S → P in AAV80765 (PubMed:16087679).Curated1
Sequence conflicti2027S → F in AAV80767 (PubMed:16087679).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0078731 – 331Missing in isoform 2, isoform 5 and isoform 7. 1 PublicationAdd BLAST331
Alternative sequenceiVSP_007874332 – 333AD → ML in isoform 2 and isoform 5. 1 Publication2
Alternative sequenceiVSP_023059332 – 333AD → MLLDPEAASPAYSQ in isoform 7. Curated2
Alternative sequenceiVSP_023060333D → DLDPEAASPAYSQ in isoform 6. Curated1
Alternative sequenceiVSP_0230611567 – 1603Missing in isoform 4. CuratedAdd BLAST37
Alternative sequenceiVSP_0230621948 – 1962Missing in isoform 1, isoform 4, isoform 5 and isoform 7. 4 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB026497 mRNA Translation: BAA93660.1
AK137574 mRNA Translation: BAE23413.1
AK147584 mRNA Translation: BAE28009.1
AK171342 mRNA Translation: BAE42402.1
AL591065 Genomic DNA No translation available.
BC046638 mRNA Translation: AAH46638.1
AY692137 mRNA Translation: AAV80765.1
AY692138 mRNA Translation: AAV80766.1
AY692139 mRNA Translation: AAV80767.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS25085.1 [Q9JMH9-1]

NCBI Reference Sequences

More...RefSeqi		NP_001278141.1, NM_001291212.1
NP_001278142.1, NM_001291213.1
NP_001278143.1, NM_001291214.1
NP_001278144.1, NM_001291215.1
NP_035716.1, NM_011586.3 [Q9JMH9-1]
XP_006533667.1, XM_006533604.3 [Q9JMH9-3]
XP_006533669.1, XM_006533606.2 [Q9JMH9-1]
XP_006533677.2, XM_006533614.3 [Q9JMH9-2]
XP_017170115.1, XM_017314626.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000092884; ENSMUSP00000090560; ENSMUSG00000000631 [Q9JMH9-5]
ENSMUST00000092887; ENSMUSP00000090563; ENSMUSG00000000631 [Q9JMH9-1]
ENSMUST00000102488; ENSMUSP00000099546; ENSMUSG00000000631 [Q9JMH9-1]
ENSMUST00000108375; ENSMUSP00000104012; ENSMUSG00000000631 [Q9JMH9-3]
ENSMUST00000108376; ENSMUSP00000104013; ENSMUSG00000000631 [Q9JMH9-4]
ENSMUST00000130305; ENSMUSP00000119574; ENSMUSG00000000631 [Q9JMH9-7]
ENSMUST00000130627; ENSMUSP00000119839; ENSMUSG00000000631 [Q9JMH9-6]
ENSMUST00000164334; ENSMUSP00000131771; ENSMUSG00000000631 [Q9JMH9-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		360013

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:360013

UCSC genome browser

More...UCSCi		uc007khg.2, mouse [Q9JMH9-1]
uc007khh.2, mouse [Q9JMH9-5]
uc007khi.2, mouse [Q9JMH9-7]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026497 mRNA Translation: BAA93660.1
AK137574 mRNA Translation: BAE23413.1
AK147584 mRNA Translation: BAE28009.1
AK171342 mRNA Translation: BAE42402.1
AL591065 Genomic DNA No translation available.
BC046638 mRNA Translation: AAH46638.1
AY692137 mRNA Translation: AAV80765.1
AY692138 mRNA Translation: AAV80766.1
AY692139 mRNA Translation: AAV80767.1
CCDSiCCDS25085.1 [Q9JMH9-1]
RefSeqiNP_001278141.1, NM_001291212.1
NP_001278142.1, NM_001291213.1
NP_001278143.1, NM_001291214.1
NP_001278144.1, NM_001291215.1
NP_035716.1, NM_011586.3 [Q9JMH9-1]
XP_006533667.1, XM_006533604.3 [Q9JMH9-3]
XP_006533669.1, XM_006533606.2 [Q9JMH9-1]
XP_006533677.2, XM_006533614.3 [Q9JMH9-2]
XP_017170115.1, XM_017314626.1

3D structure databases

SMRiQ9JMH9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi237427, 14 interactors
IntActiQ9JMH9, 4 interactors
STRINGi10090.ENSMUSP00000130696

PTM databases

iPTMnetiQ9JMH9
PhosphoSitePlusiQ9JMH9

Proteomic databases

jPOSTiQ9JMH9
MaxQBiQ9JMH9
PaxDbiQ9JMH9
PeptideAtlasiQ9JMH9
PRIDEiQ9JMH9
ProteomicsDBi252618 [Q9JMH9-3]
252619 [Q9JMH9-1]
252620 [Q9JMH9-2]
252621 [Q9JMH9-4]
252622 [Q9JMH9-5]
252623 [Q9JMH9-6]
252624 [Q9JMH9-7]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7183, 78 antibodies from 23 providers

The DNASU plasmid repository

More...DNASUi		360013

Genome annotation databases

EnsembliENSMUST00000092884; ENSMUSP00000090560; ENSMUSG00000000631 [Q9JMH9-5]
ENSMUST00000092887; ENSMUSP00000090563; ENSMUSG00000000631 [Q9JMH9-1]
ENSMUST00000102488; ENSMUSP00000099546; ENSMUSG00000000631 [Q9JMH9-1]
ENSMUST00000108375; ENSMUSP00000104012; ENSMUSG00000000631 [Q9JMH9-3]
ENSMUST00000108376; ENSMUSP00000104013; ENSMUSG00000000631 [Q9JMH9-4]
ENSMUST00000130305; ENSMUSP00000119574; ENSMUSG00000000631 [Q9JMH9-7]
ENSMUST00000130627; ENSMUSP00000119839; ENSMUSG00000000631 [Q9JMH9-6]
ENSMUST00000164334; ENSMUSP00000131771; ENSMUSG00000000631 [Q9JMH9-2]
GeneIDi360013
KEGGimmu:360013
UCSCiuc007khg.2, mouse [Q9JMH9-1]
uc007khh.2, mouse [Q9JMH9-5]
uc007khi.2, mouse [Q9JMH9-7]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		399687
MGIiMGI:2667185, Myo18a
VEuPathDBiHostDB:ENSMUSG00000000631

Phylogenomic databases

eggNOGiKOG0161, Eukaryota
GeneTreeiENSGT00940000155768
InParanoidiQ9JMH9
OMAiEAWHETE
PhylomeDBiQ9JMH9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		360013, 0 hits in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Myo18a, mouse

Protein Ontology

More...PROi		PR:Q9JMH9
RNActiQ9JMH9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000000631, Expressed in hindlimb stylopod muscle and 308 other tissues
ExpressionAtlasiQ9JMH9, baseline and differential
GenevisibleiQ9JMH9, MM

Family and domain databases

CDDicd01386, MYSc_Myo18, 1 hit
Gene3Di2.30.42.10, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR031244, MYO18A
IPR001609, Myosin_head_motor_dom
IPR004009, Myosin_N
IPR002928, Myosin_tail
IPR036064, MYSc_Myo18
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR036034, PDZ_sf
PANTHERiPTHR45615:SF13, PTHR45615:SF13, 1 hit
PfamiView protein in Pfam
PF00063, Myosin_head, 2 hits
PF01576, Myosin_tail_1, 1 hit
PF00595, PDZ, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM00015, IQ, 1 hit
SM00242, MYSc, 1 hit
SM00228, PDZ, 1 hit
SUPFAMiSSF50156, SSF50156, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096, IQ, 1 hit
PS51456, MYOSIN_MOTOR, 1 hit
PS50106, PDZ, 1 hit
PS51844, SH3_LIKE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMY18A_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JMH9
Secondary accession number(s): Q3TBB2
, Q3UH48, Q3UV60, Q5QD54, Q5QD55, Q5QD56, Q5SYN8, Q5SYN9, Q5SYP0, Q5SYP1, Q811D7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: February 6, 2007
Last modified: February 23, 2022
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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