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UniProtKB - Q9JMH6 (TRXR1_MOUSE)

Entry version 175 (13 Feb 2019)
Sequence version 3 (26 Feb 2008)
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Protein

Thioredoxin reductase 1, cytoplasmic

Gene

Txnrd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

The active site is a redox-active disulfide bond. The selenocysteine residue is also essential for catalytic activity (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei586Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi156 – 173FADBy similarityAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.8.1.9 3474

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-3299685 Detoxification of Reactive Oxygen Species
R-MMU-499943 Interconversion of nucleotide di- and triphosphates
R-MMU-5263617 Metabolism of ingested MeSeO2H into MeSeH
R-MMU-5628897 TP53 Regulates Metabolic Genes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thioredoxin reductase 1, cytoplasmic (EC:1.8.1.9)
Short name:
TR
Alternative name(s):
Thioredoxin reductase TR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Txnrd1
Synonyms:Trxr1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1354175 Txnrd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000679821 – 613Thioredoxin reductase 1, cytoplasmicAdd BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi173 ↔ 178Redox-activeBy similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei182N6-succinyllysineCombined sources1
Modified residuei245PhosphotyrosineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki611 ↔ 612Cysteinyl-selenocysteine (Cys-Sec)By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9JMH6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9JMH6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9JMH6

PeptideAtlas

More...PeptideAtlasi		Q9JMH6

PRoteomics IDEntifications database

More...PRIDEi		Q9JMH6

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		Q9JMH6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9JMH6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9JMH6

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9JMH6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000020250 Expressed in 303 organ(s), highest expression level in cochlea

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9JMH6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9JMH6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9JMH6, 3 interactors

Molecular INTeraction database

More...MINTi		Q9JMH6

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000020484

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q9JMH6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9JMH6

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi26 – 90Pro-richAdd BLAST65

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0405 Eukaryota
COG1249 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160180

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000276712

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG004959

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9JMH6

KEGG Orthology (KO)

More...KOi		K22182

Identification of Orthologs from Complete Genome Data

More...OMAi		EEVKHNW

Database of Orthologous Groups

More...OrthoDBi		581771at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9JMH6

TreeFam database of animal gene trees

More...TreeFami		TF314782

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.390.30, 1 hit
3.50.50.60, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
IPR006338 Thioredoxin/glutathione_Rdtase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000350 Mercury_reductase_MerA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01438 TGR, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JMH6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVDDCWLYF PASRGRTFVQ TVWVAPTCPN CCWFPGFLPP VPRPPHVPRV 
        60         70         80         90        100
LLRGPRGAVL PASRPSKTLP SSSQTPCPTD PCICPPPSTP DSRQEKNTQS 
       110        120        130        140        150
ELPNKKGQLQ KLPTMNGSKD PPGSYDFDLI IIGGGSGGLA AAKEAAKFDK 
       160        170        180        190        200
KVLVLDFVTP TPLGTRWGLG GTCVNVGCIP KKLMHQAALL GQALKDSRNY 
       210        220        230        240        250
GWKVEDTVKH DWEKMTESVQ SHIGSLNWGY RVALREKKVV YENAYGRFIG 
       260        270        280        290        300
PHRIVATNNK GKEKIYSAER FLIATGERPR YLGIPGDKEY CISSDDLFSL 
       310        320        330        340        350
PYCPGKTLVV GASYVALECA GFLAGIGLDV TVMVRSILLR GFDQDMANKI 
       360        370        380        390        400
GEHMEEHGIK FIRQFVPTKI EQIEAGTPGR LRVTAQSTNS EETIEGEFNT 
       410        420        430        440        450
VLLAVGRDSC TRTIGLETVG VKINEKTGKI PVTDEEQTNV PYIYAIGDIL 
       460        470        480        490        500
EGKLELTPVA IQAGRLLAQR LYGGSNVKCD YDNVPTTVFT PLEYGCCGLS 
       510        520        530        540        550
EEKAVEKFGE ENIEVYHSFF WPLEWTVPSR DNNKCYAKII CNLKDDERVV 
       560        570        580        590        600
GFHVLGPNAG EVTQGFAAAL KCGLTKQQLD STIGIHPVCA EIFTTLSVTK 
       610 
RSGGDILQSG CUG
Length:613
Mass (Da):67,084
Last modified:February 26, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9FD2E2E8C55118C
GO
Isoform 2 (identifier: Q9JMH6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.

Show »
Length:499
Mass (Da):54,544
Checksum:iFEBB478D8B22429E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P6U1A0A1W2P6U1_MOUSE
Thioredoxin reductase 1, cytoplasmi...
Txnrd1
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH37643 differs from that shown. Reason: Erroneous termination at position 612. Translated as Sec.Curated
The sequence BAE26918 differs from that shown. Reason: Erroneous termination at position 612. Translated as Sec.Curated
The sequence BAE40292 differs from that shown. Reason: Erroneous termination at position 612. Translated as Sec.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti238K → E in BAE28994 (PubMed:16141072).Curated1
Sequence conflicti372Q → R in BAE26918 (PubMed:16141072).Curated1
Sequence conflicti607L → V in BAE26918 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0315661 – 114Missing in isoform 2. 3 PublicationsAdd BLAST114

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the occurrence of non-standard amino acids selenocysteine (Sec) or pyrrolysine (Pyl) in the protein sequence.<p><a href='/help/non_std' target='_top'>More...</a></p>Non-standard residuei612SelenocysteineBy similarity1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB027565 mRNA Translation: BAA86985.2
AF333036 mRNA Translation: AAK01140.1
AK011902 mRNA Translation: BAB27905.1
AK146125 mRNA Translation: BAE26918.1 Sequence problems.
AK149625 mRNA Translation: BAE28994.1
AK168356 mRNA Translation: BAE40292.1 Sequence problems.
BC037643 mRNA Translation: AAH37643.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS24072.1 [Q9JMH6-2]

NCBI Reference Sequences

More...RefSeqi		NP_001035978.1, NM_001042513.1 [Q9JMH6-2]
NP_001035979.1, NM_001042514.1 [Q9JMH6-2]
NP_001035988.1, NM_001042523.1 [Q9JMH6-1]
NP_056577.2, NM_015762.2 [Q9JMH6-2]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Mm.210155
Mm.471159

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000020484; ENSMUSP00000020484; ENSMUSG00000020250 [Q9JMH6-2]
ENSMUST00000219368; ENSMUSP00000151629; ENSMUSG00000020250 [Q9JMH6-1]
ENSMUST00000219442; ENSMUSP00000152046; ENSMUSG00000020250 [Q9JMH6-2]
ENSMUST00000219962; ENSMUSP00000151825; ENSMUSG00000020250 [Q9JMH6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		50493

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:50493

UCSC genome browser

More...UCSCi		uc007gjy.1 mouse [Q9JMH6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Selenocysteine

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027565 mRNA Translation: BAA86985.2
AF333036 mRNA Translation: AAK01140.1
AK011902 mRNA Translation: BAB27905.1
AK146125 mRNA Translation: BAE26918.1 Sequence problems.
AK149625 mRNA Translation: BAE28994.1
AK168356 mRNA Translation: BAE40292.1 Sequence problems.
BC037643 mRNA Translation: AAH37643.1 Sequence problems.
CCDSiCCDS24072.1 [Q9JMH6-2]
RefSeqiNP_001035978.1, NM_001042513.1 [Q9JMH6-2]
NP_001035979.1, NM_001042514.1 [Q9JMH6-2]
NP_001035988.1, NM_001042523.1 [Q9JMH6-1]
NP_056577.2, NM_015762.2 [Q9JMH6-2]
UniGeneiMm.210155
Mm.471159

3D structure databases

ProteinModelPortaliQ9JMH6
SMRiQ9JMH6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JMH6, 3 interactors
MINTiQ9JMH6
STRINGi10090.ENSMUSP00000020484

PTM databases

iPTMnetiQ9JMH6
PhosphoSitePlusiQ9JMH6
SwissPalmiQ9JMH6

2D gel databases

REPRODUCTION-2DPAGEiQ9JMH6

Proteomic databases

EPDiQ9JMH6
jPOSTiQ9JMH6
PaxDbiQ9JMH6
PeptideAtlasiQ9JMH6
PRIDEiQ9JMH6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020484; ENSMUSP00000020484; ENSMUSG00000020250 [Q9JMH6-2]
ENSMUST00000219368; ENSMUSP00000151629; ENSMUSG00000020250 [Q9JMH6-1]
ENSMUST00000219442; ENSMUSP00000152046; ENSMUSG00000020250 [Q9JMH6-2]
ENSMUST00000219962; ENSMUSP00000151825; ENSMUSG00000020250 [Q9JMH6-2]
GeneIDi50493
KEGGimmu:50493
UCSCiuc007gjy.1 mouse [Q9JMH6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7296
MGIiMGI:1354175 Txnrd1

Phylogenomic databases

eggNOGiKOG0405 Eukaryota
COG1249 LUCA
GeneTreeiENSGT00940000160180
HOGENOMiHOG000276712
HOVERGENiHBG004959
InParanoidiQ9JMH6
KOiK22182
OMAiEEVKHNW
OrthoDBi581771at2759
PhylomeDBiQ9JMH6
TreeFamiTF314782

Enzyme and pathway databases

BRENDAi1.8.1.9 3474
ReactomeiR-MMU-3299685 Detoxification of Reactive Oxygen Species
R-MMU-499943 Interconversion of nucleotide di- and triphosphates
R-MMU-5263617 Metabolism of ingested MeSeO2H into MeSeH
R-MMU-5628897 TP53 Regulates Metabolic Genes

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Txnrd1 mouse

Protein Ontology

More...PROi		PR:Q9JMH6

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000020250 Expressed in 303 organ(s), highest expression level in cochlea
ExpressionAtlasiQ9JMH6 baseline and differential
GenevisibleiQ9JMH6 MM

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
IPR006338 Thioredoxin/glutathione_Rdtase
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01438 TGR, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRXR1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JMH6
Secondary accession number(s): Q3UEB7
, Q3UK84, Q8CI31, Q99P49, Q9CSV5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: February 26, 2008
Last modified: February 13, 2019
This is version 175 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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