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UniProtKB - Q9JMG7 (HDGR3_MOUSE)
Protein
Hepatoma-derived growth factor-related protein 3
Gene
Hdgfl3
Organism
Mus musculus (Mouse)
Status
Functioni
Enhances DNA synthesis and may play a role in cell proliferation.
By similarityGO - Molecular functioni
- chromatin binding Source: UniProtKB
- double-stranded DNA binding Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- microtubule binding Source: UniProtKB
- transcription coregulator activity Source: GO_Central
- tubulin binding Source: UniProtKB
GO - Biological processi
- microtubule polymerization Source: UniProtKB
- negative regulation of microtubule depolymerization Source: UniProtKB
- neuron projection development Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Growth factor |
Names & Taxonomyi
Protein namesi | Recommended name: Hepatoma-derived growth factor-related protein 3Short name: HRP-3 |
Gene namesi | Name:Hdgfl3 Synonyms:Hdgfrp3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1352760, Hdgfl3 |
VEuPathDBi | HostDB:ENSMUSG00000025104 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191704 | 1 – 202 | Hepatoma-derived growth factor-related protein 3Add BLAST | 202 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 110 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 121 | PhosphoserineCombined sources | 1 | |
Modified residuei | 122 | PhosphoserineCombined sources | 1 | |
Modified residuei | 161 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9JMG7 |
jPOSTi | Q9JMG7 |
MaxQBi | Q9JMG7 |
PaxDbi | Q9JMG7 |
PeptideAtlasi | Q9JMG7 |
PRIDEi | Q9JMG7 |
ProteomicsDBi | 269650 [Q9JMG7-1] 269651 [Q9JMG7-2] |
PTM databases
iPTMneti | Q9JMG7 |
PhosphoSitePlusi | Q9JMG7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000025104, Expressed in rostral migratory stream and 279 other tissues |
Genevisiblei | Q9JMG7, MM |
Interactioni
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- microtubule binding Source: UniProtKB
- tubulin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 205940, 6 interactors |
IntActi | Q9JMG7, 1 interactor |
MINTi | Q9JMG7 |
STRINGi | 10090.ENSMUSP00000102926 |
Miscellaneous databases
RNActi | Q9JMG7, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q9JMG7 |
BMRBi | Q9JMG7 |
SMRi | Q9JMG7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9JMG7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 68 | PWWPPROSITE-ProRule annotationAdd BLAST | 58 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 90 – 202 | DisorderedSequence analysisAdd BLAST | 113 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 135 – 147 | Nuclear localization signalSequence analysisAdd BLAST | 13 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 94 – 117 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 121 – 138 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 139 – 154 | Basic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 157 – 180 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 181 – 202 | Polar residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the HDGF family.Curated
Phylogenomic databases
eggNOGi | KOG1904, Eukaryota |
GeneTreei | ENSGT00940000153942 |
HOGENOMi | CLU_090867_1_0_1 |
InParanoidi | Q9JMG7 |
OMAi | CIRNPFA |
OrthoDBi | 530959at2759 |
PhylomeDBi | Q9JMG7 |
TreeFami | TF105385 |
Family and domain databases
CDDi | cd05834, HDGF_related, 1 hit |
IDEALi | IID50182 |
InterProi | View protein in InterPro IPR035496, HDGF-rel_PWWP IPR000313, PWWP_dom |
Pfami | View protein in Pfam PF00855, PWWP, 1 hit |
SMARTi | View protein in SMART SM00293, PWWP, 1 hit |
PROSITEi | View protein in PROSITE PS50812, PWWP, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9JMG7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MARPRPREYK AGDLVFAKMK GYPHWPARID ELPEGAVKPP ANKYPIFFFG
60 70 80 90 100
THETAFLGPK DLFPYKEYKD KFGKSNKRKG FNEGLWEIEN NPGVKFTGYQ
110 120 130 140 150
TIQQQSSSET EGEGGNTADA SSEEEGDRVE DGKGKRKNEK GGSKRKKSYT
160 170 180 190 200
SKKSSKQSRK SPGDEDDKDC KEEENKSSSE GGDAGNDTRN TTADLQKAGE
GT
Sequence cautioni
The sequence BAC32413 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 198 – 199 | AG → TS in BAA90478 (PubMed:10581169).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014188 | 202 | T → VRMC in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB029493 mRNA Translation: BAA90478.1 AK019487 mRNA Translation: BAB31754.1 AK044858 mRNA Translation: BAC32123.1 AK045542 mRNA Translation: BAC32413.1 Frameshift. AK051401 mRNA Translation: BAC34628.1 AK162418 mRNA Translation: BAE36904.1 BC055734 mRNA Translation: AAH55734.1 |
CCDSi | CCDS40011.1 [Q9JMG7-1] |
RefSeqi | NP_038914.2, NM_013886.4 [Q9JMG7-1] |
Genome annotation databases
Ensembli | ENSMUST00000026094; ENSMUSP00000026094; ENSMUSG00000025104 [Q9JMG7-2] ENSMUST00000107305; ENSMUSP00000102926; ENSMUSG00000025104 [Q9JMG7-1] |
GeneIDi | 29877 |
KEGGi | mmu:29877 |
UCSCi | uc009icr.1, mouse [Q9JMG7-1] uc009ics.1, mouse [Q9JMG7-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB029493 mRNA Translation: BAA90478.1 AK019487 mRNA Translation: BAB31754.1 AK044858 mRNA Translation: BAC32123.1 AK045542 mRNA Translation: BAC32413.1 Frameshift. AK051401 mRNA Translation: BAC34628.1 AK162418 mRNA Translation: BAE36904.1 BC055734 mRNA Translation: AAH55734.1 |
CCDSi | CCDS40011.1 [Q9JMG7-1] |
RefSeqi | NP_038914.2, NM_013886.4 [Q9JMG7-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1N27 | NMR | - | A | 8-90 | [»] | |
AlphaFoldDBi | Q9JMG7 | |||||
BMRBi | Q9JMG7 | |||||
SMRi | Q9JMG7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 205940, 6 interactors |
IntActi | Q9JMG7, 1 interactor |
MINTi | Q9JMG7 |
STRINGi | 10090.ENSMUSP00000102926 |
PTM databases
iPTMneti | Q9JMG7 |
PhosphoSitePlusi | Q9JMG7 |
Proteomic databases
EPDi | Q9JMG7 |
jPOSTi | Q9JMG7 |
MaxQBi | Q9JMG7 |
PaxDbi | Q9JMG7 |
PeptideAtlasi | Q9JMG7 |
PRIDEi | Q9JMG7 |
ProteomicsDBi | 269650 [Q9JMG7-1] 269651 [Q9JMG7-2] |
Protocols and materials databases
Antibodypediai | 28189, 191 antibodies from 29 providers |
DNASUi | 29877 |
Genome annotation databases
Ensembli | ENSMUST00000026094; ENSMUSP00000026094; ENSMUSG00000025104 [Q9JMG7-2] ENSMUST00000107305; ENSMUSP00000102926; ENSMUSG00000025104 [Q9JMG7-1] |
GeneIDi | 29877 |
KEGGi | mmu:29877 |
UCSCi | uc009icr.1, mouse [Q9JMG7-1] uc009ics.1, mouse [Q9JMG7-2] |
Organism-specific databases
CTDi | 50810 |
MGIi | MGI:1352760, Hdgfl3 |
VEuPathDBi | HostDB:ENSMUSG00000025104 |
Phylogenomic databases
eggNOGi | KOG1904, Eukaryota |
GeneTreei | ENSGT00940000153942 |
HOGENOMi | CLU_090867_1_0_1 |
InParanoidi | Q9JMG7 |
OMAi | CIRNPFA |
OrthoDBi | 530959at2759 |
PhylomeDBi | Q9JMG7 |
TreeFami | TF105385 |
Miscellaneous databases
BioGRID-ORCSi | 29877, 1 hit in 75 CRISPR screens |
ChiTaRSi | Hdgfl3, mouse |
EvolutionaryTracei | Q9JMG7 |
PROi | PR:Q9JMG7 |
RNActi | Q9JMG7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025104, Expressed in rostral migratory stream and 279 other tissues |
Genevisiblei | Q9JMG7, MM |
Family and domain databases
CDDi | cd05834, HDGF_related, 1 hit |
IDEALi | IID50182 |
InterProi | View protein in InterPro IPR035496, HDGF-rel_PWWP IPR000313, PWWP_dom |
Pfami | View protein in Pfam PF00855, PWWP, 1 hit |
SMARTi | View protein in SMART SM00293, PWWP, 1 hit |
PROSITEi | View protein in PROSITE PS50812, PWWP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HDGR3_MOUSE | |
Accessioni | Q9JMG7Primary (citable) accession number: Q9JMG7 Secondary accession number(s): Q3TRX2 Q9D2M7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2005 |
Last sequence update: | June 21, 2005 | |
Last modified: | May 25, 2022 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families