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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

Gene

Gng13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-MMU-163359 Glucagon signaling in metabolic regulation
R-MMU-202040 G-protein activation
R-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-MMU-392170 ADP signalling through P2Y purinoceptor 12
R-MMU-392451 G beta:gamma signalling through PI3Kgamma
R-MMU-392851 Prostacyclin signalling through prostacyclin receptor
R-MMU-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-MMU-4086398 Ca2+ pathway
R-MMU-416476 G alpha (q) signalling events
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-418217 G beta:gamma signalling through PLC beta
R-MMU-418555 G alpha (s) signalling events
R-MMU-418592 ADP signalling through P2Y purinoceptor 1
R-MMU-418594 G alpha (i) signalling events
R-MMU-418597 G alpha (z) signalling events
R-MMU-420092 Glucagon-type ligand receptors
R-MMU-428930 Thromboxane signalling through TP receptor
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-MMU-500657 Presynaptic function of Kainate receptors
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
Gene namesi
Name:Gng13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1925616 Gng13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000126731 – 64Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13Add BLAST64
PropeptideiPRO_000001267465 – 67Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64Cysteine methyl esterBy similarity1
Lipidationi64S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ9JMF3
PaxDbiQ9JMF3
PeptideAtlasiQ9JMF3
PRIDEiQ9JMF3

PTM databases

iPTMnetiQ9JMF3
PhosphoSitePlusiQ9JMF3

Expressioni

Gene expression databases

BgeeiENSMUSG00000025739 Expressed in 125 organ(s), highest expression level in olfactory epithelium
GenevisibleiQ9JMF3 MM

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211062, 1 interactor
DIPiDIP-46321N
IntActiQ9JMF3, 2 interactors
STRINGi10090.ENSMUSP00000110760

Structurei

3D structure databases

ProteinModelPortaliQ9JMF3
SMRiQ9JMF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00530000064157
HOVERGENiHBG098057
InParanoidiQ9JMF3
KOiK04547
OMAiGQQENDP
OrthoDBiEOG091G17J0
PhylomeDBiQ9JMF3
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR039227 GNG13
PANTHERiPTHR15936 PTHR15936, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JMF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEWDVPQMK KEVESLKYQL AFKREMSSKT IPELLKWIED GIPKDPFLNP
60
DLMKNNPWVE KAKCTIL
Length:67
Mass (Da):7,979
Last modified:October 1, 2000 - v1
Checksum:i1FB8D74EB5CE50F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029485 mRNA Translation: AAK40268.1
AB030194 mRNA Translation: BAA92757.1
AK018778 mRNA Translation: BAB31403.1
BC048431 mRNA Translation: AAH48431.1
BC059712 mRNA Translation: AAH59712.1
CCDSiCCDS37503.1
RefSeqiNP_071867.1, NM_022422.5
XP_006524842.1, XM_006524779.3
UniGeneiMm.171123

Genome annotation databases

EnsembliENSMUST00000115108; ENSMUSP00000110760; ENSMUSG00000025739
ENSMUST00000172002; ENSMUSP00000131648; ENSMUSG00000025739
GeneIDi64337
KEGGimmu:64337
UCSCiuc008bbi.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029485 mRNA Translation: AAK40268.1
AB030194 mRNA Translation: BAA92757.1
AK018778 mRNA Translation: BAB31403.1
BC048431 mRNA Translation: AAH48431.1
BC059712 mRNA Translation: AAH59712.1
CCDSiCCDS37503.1
RefSeqiNP_071867.1, NM_022422.5
XP_006524842.1, XM_006524779.3
UniGeneiMm.171123

3D structure databases

ProteinModelPortaliQ9JMF3
SMRiQ9JMF3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211062, 1 interactor
DIPiDIP-46321N
IntActiQ9JMF3, 2 interactors
STRINGi10090.ENSMUSP00000110760

PTM databases

iPTMnetiQ9JMF3
PhosphoSitePlusiQ9JMF3

Proteomic databases

MaxQBiQ9JMF3
PaxDbiQ9JMF3
PeptideAtlasiQ9JMF3
PRIDEiQ9JMF3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115108; ENSMUSP00000110760; ENSMUSG00000025739
ENSMUST00000172002; ENSMUSP00000131648; ENSMUSG00000025739
GeneIDi64337
KEGGimmu:64337
UCSCiuc008bbi.2 mouse

Organism-specific databases

CTDi51764
MGIiMGI:1925616 Gng13

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00530000064157
HOVERGENiHBG098057
InParanoidiQ9JMF3
KOiK04547
OMAiGQQENDP
OrthoDBiEOG091G17J0
PhylomeDBiQ9JMF3
TreeFamiTF319909

Enzyme and pathway databases

ReactomeiR-MMU-163359 Glucagon signaling in metabolic regulation
R-MMU-202040 G-protein activation
R-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-MMU-392170 ADP signalling through P2Y purinoceptor 12
R-MMU-392451 G beta:gamma signalling through PI3Kgamma
R-MMU-392851 Prostacyclin signalling through prostacyclin receptor
R-MMU-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-MMU-4086398 Ca2+ pathway
R-MMU-416476 G alpha (q) signalling events
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-418217 G beta:gamma signalling through PLC beta
R-MMU-418555 G alpha (s) signalling events
R-MMU-418592 ADP signalling through P2Y purinoceptor 1
R-MMU-418594 G alpha (i) signalling events
R-MMU-418597 G alpha (z) signalling events
R-MMU-420092 Glucagon-type ligand receptors
R-MMU-428930 Thromboxane signalling through TP receptor
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-MMU-500657 Presynaptic function of Kainate receptors
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

PROiPR:Q9JMF3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025739 Expressed in 125 organ(s), highest expression level in olfactory epithelium
GenevisibleiQ9JMF3 MM

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR039227 GNG13
PANTHERiPTHR15936 PTHR15936, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGBG13_MOUSE
AccessioniPrimary (citable) accession number: Q9JMF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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