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Protein

Scm-like with four MBT domains protein 1

Gene

Sfmbt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Scm-like with four MBT domains protein 1
Gene namesi
Name:Sfmbt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1859609 Sfmbt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000719671 – 863Scm-like with four MBT domains protein 1Add BLAST863

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei764PhosphoserineCombined sources1
Modified residuei772PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JMD1
PaxDbiQ9JMD1
PRIDEiQ9JMD1

PTM databases

iPTMnetiQ9JMD1
PhosphoSitePlusiQ9JMD1

Expressioni

Tissue specificityi

Highly expressed in the testis, low expression is detected in brain, kidney, heart and lung. Highly expressed in germ cells, where it associates with the synaptic regions of meiotic chromosomes in pachytene stage spermatocytes.2 Publications

Developmental stagei

Highly expressed in undifferentiated myoblasts and expression is reduced during the course of differentiation.1 Publication

Gene expression databases

BgeeiENSMUSG00000006527 Expressed in 245 organ(s), highest expression level in secondary oocyte
CleanExiMM_SFMBT1
GenevisibleiQ9JMD1 MM

Interactioni

Subunit structurei

Interacts with MYOD1 (By similarity). Component of the SLC (SFMBT1-LSD1-CoREST) corepressor complex, which also contains KDM1A/LSD1 and RCOR1/CoREST. Interacts with KDM1A/LSD1 and RCOR1/CoREST (By similarity). Interacts with MYOD1.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056744

Structurei

3D structure databases

ProteinModelPortaliQ9JMD1
SMRiQ9JMD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 120MBT 1Add BLAST101
Repeati128 – 232MBT 2Add BLAST105
Repeati242 – 346MBT 3Add BLAST105
Repeati354 – 451MBT 4Add BLAST98
Domaini793 – 861SAMAdd BLAST69

Domaini

The MBT repeats mediate binding to histones tails; however, in contrast to other MBT repeats, does not bind specific histone lysine modifications. The MBT repeats lack the conserved Asp and aromatic cage at conserved positions (By similarity).By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3766 Eukaryota
ENOG410Y4AQ LUCA
GeneTreeiENSGT00760000119024
HOGENOMiHOG000004859
HOVERGENiHBG085238
InParanoidiQ9JMD1
OMAiPEKQIPS
OrthoDBiEOG091G02E7
PhylomeDBiQ9JMD1
TreeFamiTF316498

Family and domain databases

CDDicd09581 SAM_Scm-like-4MBT1_2, 1 hit
Gene3Di1.20.1380.20, 1 hit
InterProiView protein in InterPro
IPR004092 Mbt
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR037604 Scm-like-4MBT1/2_SAM
IPR021987 SLED
IPR038348 SLED_sf
PfamiView protein in Pfam
PF02820 MBT, 4 hits
PF00536 SAM_1, 1 hit
PF12140 SLED, 1 hit
SMARTiView protein in SMART
SM00561 MBT, 4 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51079 MBT, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9JMD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGEQQLDAD LGSGVEVEEF SWEDYLEETG STTVPYASFK HVDIRLQNGF
60 70 80 90 100
APGMKLEVAL KNDPETYWVA TIITACEQLL LLRYEGYGED RKADFWCDIR
110 120 130 140 150
KAGLYPIGWC QQNKKTLEAP EGIRDKVSDW NAFLQQTLIG ACGPPVSLLE
160 170 180 190 200
GLRNGRNPLD LIAPGSKLEC QDFRDSLSTW LVTVVENIGG RLKLRYEGLE
210 220 230 240 250
SRDGFEHWLY YLDPFLHHIG WAAQQGCDLQ PPLAIKHLKS EADWQEILAK
260 270 280 290 300
VKEEEPLPSY LFKDKQVIGT HEFSINMKLE AVDPWSPFGI SPATIAKVFD
310 320 330 340 350
DKYFLVEMDD LRPEDHTRRS FVCHANSPGI FPVQWSLKNG LHINPPPGFR
360 370 380 390 400
SQDFDWADYL KQCGAEAAPQ KCFPQSISEH QFKENMKLEA VNPLFPEEVC
410 420 430 440 450
IATVTAVRGS YLWLQLEGSK KPVPEFIVSA ESMNIFPLGW CETNGHPLST
460 470 480 490 500
PRRARGHKLR KIAVVQPEKQ ILSSRTVHEG LKNQLNSTHS VMINGKYCCP
510 520 530 540 550
KIYFNHRCFS GPYLNKGRIA ELPQCVGPGN CVLVLREVLT LLINAAYKPS
560 570 580 590 600
RVLRELQLDK DSVWHGCGEV LKAKYKGKSY RATVEIVRTA DRVTEFCRQT
610 620 630 640 650
CIKLECCPNL FGPRMVLDTC SENCSVLTKT KYTHYYGKKK NKRIGRPPGG
660 670 680 690 700
HSNLSCALKK SSKRRKRRKN IFVHKKKRSS ASVDNTPVGS PQGSGGEDEE
710 720 730 740 750
DADDGDEDSL TEGSTSEQQE ELQEESEVSE KKSSSSSPTQ SETPTPLPPD
760 770 780 790 800
TQTNKRDAQT SSVSDDENKP PSPKEIRIEV DERLHLDSNP LKWSVADVVR
810 820 830 840 850
FIRSTDCAPL ARIFLDQEID GQALLLLTLP TVQECMDLKL GPAIKLCHHI
860
ERIKFAFYEQ FAN
Length:863
Mass (Da):97,338
Last modified:October 1, 2000 - v1
Checksum:iDB1CADA81B42566D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BRX3A0A2I3BRX3_MOUSE
Scm-like with four MBT domains prot...
Sfmbt1
636Annotation score:
A0A2I3BPX6A0A2I3BPX6_MOUSE
Scm-like with four MBT domains prot...
Sfmbt1
820Annotation score:

Sequence cautioni

The sequence AAH36972 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH66188 differs from that shown. Reason: Erroneous termination at position 466. Translated as Gln.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032165 mRNA Translation: BAA96305.1
BC036972 mRNA Translation: AAH36972.1 Sequence problems.
BC066188 mRNA Translation: AAH66188.1 Sequence problems.
CCDSiCCDS26897.1
RefSeqiNP_001160003.1, NM_001166531.1
NP_001160004.1, NM_001166532.1
NP_062333.1, NM_019460.2
XP_006519350.1, XM_006519287.3
XP_006519351.1, XM_006519288.3
XP_006519352.1, XM_006519289.3
XP_011243422.1, XM_011245120.2
XP_011243423.1, XM_011245121.2
UniGeneiMm.294662

Genome annotation databases

EnsembliENSMUST00000054230; ENSMUSP00000056744; ENSMUSG00000006527
ENSMUST00000112184; ENSMUSP00000107802; ENSMUSG00000006527
ENSMUST00000228006; ENSMUSP00000153861; ENSMUSG00000006527
GeneIDi54650
KEGGimmu:54650
UCSCiuc007svp.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032165 mRNA Translation: BAA96305.1
BC036972 mRNA Translation: AAH36972.1 Sequence problems.
BC066188 mRNA Translation: AAH66188.1 Sequence problems.
CCDSiCCDS26897.1
RefSeqiNP_001160003.1, NM_001166531.1
NP_001160004.1, NM_001166532.1
NP_062333.1, NM_019460.2
XP_006519350.1, XM_006519287.3
XP_006519351.1, XM_006519288.3
XP_006519352.1, XM_006519289.3
XP_011243422.1, XM_011245120.2
XP_011243423.1, XM_011245121.2
UniGeneiMm.294662

3D structure databases

ProteinModelPortaliQ9JMD1
SMRiQ9JMD1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056744

PTM databases

iPTMnetiQ9JMD1
PhosphoSitePlusiQ9JMD1

Proteomic databases

MaxQBiQ9JMD1
PaxDbiQ9JMD1
PRIDEiQ9JMD1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054230; ENSMUSP00000056744; ENSMUSG00000006527
ENSMUST00000112184; ENSMUSP00000107802; ENSMUSG00000006527
ENSMUST00000228006; ENSMUSP00000153861; ENSMUSG00000006527
GeneIDi54650
KEGGimmu:54650
UCSCiuc007svp.2 mouse

Organism-specific databases

CTDi51460
MGIiMGI:1859609 Sfmbt1

Phylogenomic databases

eggNOGiKOG3766 Eukaryota
ENOG410Y4AQ LUCA
GeneTreeiENSGT00760000119024
HOGENOMiHOG000004859
HOVERGENiHBG085238
InParanoidiQ9JMD1
OMAiPEKQIPS
OrthoDBiEOG091G02E7
PhylomeDBiQ9JMD1
TreeFamiTF316498

Miscellaneous databases

PROiPR:Q9JMD1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006527 Expressed in 245 organ(s), highest expression level in secondary oocyte
CleanExiMM_SFMBT1
GenevisibleiQ9JMD1 MM

Family and domain databases

CDDicd09581 SAM_Scm-like-4MBT1_2, 1 hit
Gene3Di1.20.1380.20, 1 hit
InterProiView protein in InterPro
IPR004092 Mbt
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR037604 Scm-like-4MBT1/2_SAM
IPR021987 SLED
IPR038348 SLED_sf
PfamiView protein in Pfam
PF02820 MBT, 4 hits
PF00536 SAM_1, 1 hit
PF12140 SLED, 1 hit
SMARTiView protein in SMART
SM00561 MBT, 4 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51079 MBT, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSMBT1_MOUSE
AccessioniPrimary (citable) accession number: Q9JMD1
Secondary accession number(s): Q6NZD3, Q8CFS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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