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Protein

BUB3-interacting and GLEBS motif-containing protein ZNF207

Gene

Znf207

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 34C2H2-type 1Add BLAST24
Zinc fingeri35 – 58C2H2-type 2Add BLAST24

GO - Molecular functioni

  • heparin binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • microtubule binding Source: UniProtKB
  • nucleic acid binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
BUB3-interacting and GLEBS motif-containing protein ZNF207By similarity
Short name:
BuGZBy similarity
Alternative name(s):
49 kDa zinc finger protein
Zinc finger protein 207By similarity
Gene namesi
Name:Znf207By similarity
Synonyms:BugzBy similarity, Zep1 Publication, Zfp207Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1340045 Zfp207

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi390 – 391EE → AA: Abolishes interaction and stabilization of BUB3. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004287331 – 495BUB3-interacting and GLEBS motif-containing protein ZNF207Add BLAST495

Proteomic databases

PaxDbiQ9JMD0
PeptideAtlasiQ9JMD0
PRIDEiQ9JMD0

PTM databases

iPTMnetiQ9JMD0
PhosphoSitePlusiQ9JMD0

Expressioni

Tissue specificityi

In day-13 embryo, strongly expressed in the nervous system (brain, spinal cord and dorsal root ganglia), with strong to weak expression in other regions. Continues to be strongly expressed in the neonatal brain while expression is weak in the brain and spinal cord of adult.1 Publication

Gene expression databases

BgeeiENSMUSG00000017421 Expressed in 312 organ(s), highest expression level in mandibular prominence
ExpressionAtlasiQ9JMD0 baseline and differential
GenevisibleiQ9JMD0 MM

Interactioni

Subunit structurei

Interacts (via GLEBS region) with BUB3.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9JMD0, 2 interactors
MINTiQ9JMD0
STRINGi10090.ENSMUSP00000054168

Structurei

3D structure databases

ProteinModelPortaliQ9JMD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 92Microtubule-binding regionBy similarityAdd BLAST92
Regioni376 – 408GLEBSBy similarityAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 7Poly-Lys4
Compositional biasi129 – 487Pro-richAdd BLAST359
Compositional biasi326 – 377Thr-richAdd BLAST52

Domaini

Mainly composed of disordered low-complexity regions outside of the C2H2-type zinc fingers. Coacervation depends on hydrophobic and aromatic Phe and Tyr in the disordered low-complexity region, that may promote coacervation by forming intermolecular hydrophobic interactions.1 Publication
The GLEBS region mediates interaction with BUB3.By similarity
The microtubule-binding region is required for efficient loading of BUB3 onto kinetochores and proper mitosis.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 34C2H2-type 1Add BLAST24
Zinc fingeri35 – 58C2H2-type 2Add BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2893 Eukaryota
ENOG410ZJGQ LUCA
GeneTreeiENSGT00730000111057
HOGENOMiHOG000013124
HOVERGENiHBG054182
InParanoidiQ9JMD0
OMAiMMHGMPP
OrthoDBiEOG091G0N0A
PhylomeDBiQ9JMD0
TreeFamiTF313844

Family and domain databases

InterProiView protein in InterPro
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JMD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRKKKKQLK PWCWYCNRDF DDEKILIQHQ KAKHFKCHIC HKKLYTGPGL
60 70 80 90 100
AIHCMQVHKE TIDAVPNAIP GRTDIELEIY GMEGIPEKDM DERRRLLEQK
110 120 130 140 150
TQESQKKKQQ DDSDEYDDDE SAASTSFQPQ PVQPQQGYIP PMAQPGLPPV
160 170 180 190 200
PGAPGMPPGI PPLMPGVPPL MPGMPPVMPG MPPGLHHQRK YTQSFCGENI
210 220 230 240 250
MMPMGGMMPP GPGIPPLMPG MPPGMPPPVP RPGIPPMTQA QAVSAPGILN
260 270 280 290 300
RPPAPTAAVP APQPPVTKPL FPSAGQMGTP VTSSSTASSN SESLSASSKA
310 320 330 340 350
LFPSTAQAQA AVQGPVGTDF KPLNSTPAAT TTEPPKPTFP AYTQSTASTT
360 370 380 390 400
STTNSTAAKP AASITSKPAT LTTTSATSKL IHPDEDISLE ERRAQLPKYQ
410 420 430 440 450
RNLPRPGQTP IGNPPVGPIG GMMPPQPGLP QQQAMRPPMP PHGQYGGHHQ
460 470 480 490
GMPGYLPGAM PPYGQGPPMV PPYQGGPPRP PMGMRPPVMS QGGRY
Length:495
Mass (Da):52,793
Last modified:October 1, 2000 - v1
Checksum:i71EB32147BB6A5AD
GO
Isoform 2 (identifier: Q9JMD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-200: Missing.

Show »
Length:479
Mass (Da):50,850
Checksum:i5C1F3F5AEF7C9BB6
GO
Isoform 3 (identifier: Q9JMD0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-306: Missing.

Show »
Length:464
Mass (Da):49,792
Checksum:iE1486181B179DEE4
GO
Isoform 4 (identifier: Q9JMD0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-222: Missing.
     276-306: Missing.

Show »
Length:460
Mass (Da):49,409
Checksum:i03A7D7302B45D6E7
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AQG7B1AQG7_MOUSE
Zinc finger protein 207
Zfp207
227Annotation score:
Q8CCB2Q8CCB2_MOUSE
Zinc finger protein 207
Zfp207
329Annotation score:
M0QWF0M0QWF0_MOUSE
Zinc finger protein 207
Zfp207
342Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054255185 – 200Missing in isoform 2. CuratedAdd BLAST16
Alternative sequenceiVSP_054256219 – 222Missing in isoform 4. 1 Publication4
Alternative sequenceiVSP_054257276 – 306Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013357 mRNA Translation: BAA37094.1
AB032196 mRNA Translation: BAA92375.1
AK087885 mRNA Translation: BAC40034.1
AK146787 mRNA Translation: BAE27431.1
AK159683 mRNA Translation: BAE35286.1
AL591146 Genomic DNA No translation available.
CH466556 Genomic DNA Translation: EDL15636.1
CH466556 Genomic DNA Translation: EDL15638.1
BC003715 mRNA Translation: AAH03715.1
CCDSiCCDS48863.1 [Q9JMD0-1]
CCDS48864.1 [Q9JMD0-3]
CCDS48865.1 [Q9JMD0-2]
PIRiJE0367
RefSeqiNP_001123641.1, NM_001130169.1 [Q9JMD0-1]
NP_001123642.1, NM_001130170.1 [Q9JMD0-2]
NP_001123643.1, NM_001130171.1 [Q9JMD0-3]
NP_035881.1, NM_011751.3 [Q9JMD0-4]
XP_006533252.1, XM_006533189.2 [Q9JMD0-1]
UniGeneiMm.401332
Mm.440925
Mm.456081
Mm.468199

Genome annotation databases

EnsembliENSMUST00000017567; ENSMUSP00000017567; ENSMUSG00000017421 [Q9JMD0-3]
ENSMUST00000053740; ENSMUSP00000054168; ENSMUSG00000017421 [Q9JMD0-1]
ENSMUST00000165565; ENSMUSP00000132968; ENSMUSG00000017421 [Q9JMD0-2]
ENSMUST00000178665; ENSMUSP00000136727; ENSMUSG00000017421 [Q9JMD0-3]
ENSMUST00000188489; ENSMUSP00000139653; ENSMUSG00000017421 [Q9JMD0-3]
GeneIDi22680
KEGGimmu:22680
UCSCiuc007kly.2 mouse [Q9JMD0-4]
uc007klz.2 mouse [Q9JMD0-1]
uc007kma.2 mouse [Q9JMD0-3]
uc007kmb.2 mouse [Q9JMD0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013357 mRNA Translation: BAA37094.1
AB032196 mRNA Translation: BAA92375.1
AK087885 mRNA Translation: BAC40034.1
AK146787 mRNA Translation: BAE27431.1
AK159683 mRNA Translation: BAE35286.1
AL591146 Genomic DNA No translation available.
CH466556 Genomic DNA Translation: EDL15636.1
CH466556 Genomic DNA Translation: EDL15638.1
BC003715 mRNA Translation: AAH03715.1
CCDSiCCDS48863.1 [Q9JMD0-1]
CCDS48864.1 [Q9JMD0-3]
CCDS48865.1 [Q9JMD0-2]
PIRiJE0367
RefSeqiNP_001123641.1, NM_001130169.1 [Q9JMD0-1]
NP_001123642.1, NM_001130170.1 [Q9JMD0-2]
NP_001123643.1, NM_001130171.1 [Q9JMD0-3]
NP_035881.1, NM_011751.3 [Q9JMD0-4]
XP_006533252.1, XM_006533189.2 [Q9JMD0-1]
UniGeneiMm.401332
Mm.440925
Mm.456081
Mm.468199

3D structure databases

ProteinModelPortaliQ9JMD0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JMD0, 2 interactors
MINTiQ9JMD0
STRINGi10090.ENSMUSP00000054168

PTM databases

iPTMnetiQ9JMD0
PhosphoSitePlusiQ9JMD0

Proteomic databases

PaxDbiQ9JMD0
PeptideAtlasiQ9JMD0
PRIDEiQ9JMD0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017567; ENSMUSP00000017567; ENSMUSG00000017421 [Q9JMD0-3]
ENSMUST00000053740; ENSMUSP00000054168; ENSMUSG00000017421 [Q9JMD0-1]
ENSMUST00000165565; ENSMUSP00000132968; ENSMUSG00000017421 [Q9JMD0-2]
ENSMUST00000178665; ENSMUSP00000136727; ENSMUSG00000017421 [Q9JMD0-3]
ENSMUST00000188489; ENSMUSP00000139653; ENSMUSG00000017421 [Q9JMD0-3]
GeneIDi22680
KEGGimmu:22680
UCSCiuc007kly.2 mouse [Q9JMD0-4]
uc007klz.2 mouse [Q9JMD0-1]
uc007kma.2 mouse [Q9JMD0-3]
uc007kmb.2 mouse [Q9JMD0-2]

Organism-specific databases

CTDi22680
MGIiMGI:1340045 Zfp207

Phylogenomic databases

eggNOGiKOG2893 Eukaryota
ENOG410ZJGQ LUCA
GeneTreeiENSGT00730000111057
HOGENOMiHOG000013124
HOVERGENiHBG054182
InParanoidiQ9JMD0
OMAiMMHGMPP
OrthoDBiEOG091G0N0A
PhylomeDBiQ9JMD0
TreeFamiTF313844

Miscellaneous databases

ChiTaRSiZfp207 mouse
PROiPR:Q9JMD0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017421 Expressed in 312 organ(s), highest expression level in mandibular prominence
ExpressionAtlasiQ9JMD0 baseline and differential
GenevisibleiQ9JMD0 MM

Family and domain databases

InterProiView protein in InterPro
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN207_MOUSE
AccessioniPrimary (citable) accession number: Q9JMD0
Secondary accession number(s): E9PW12, Q99LA2, Q9Z326
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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