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Protein

DnaJ homolog subfamily A member 4

Gene

Dnaja4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi135Zinc 1By similarity1
Metal bindingi138Zinc 1By similarity1
Metal bindingi151Zinc 2By similarity1
Metal bindingi154Zinc 2By similarity1
Metal bindingi178Zinc 2By similarity1
Metal bindingi181Zinc 2By similarity1
Metal bindingi194Zinc 1By similarity1
Metal bindingi197Zinc 1By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri122 – 206CR-typeAdd BLAST85

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily A member 4
Alternative name(s):
MmDjA4
Gene namesi
Name:Dnaja4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1927638 Dnaja4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710151 – 394DnaJ homolog subfamily A member 4Add BLAST394
PropeptideiPRO_0000396761395 – 397Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineBy similarity1
Modified residuei394Cysteine methyl esterBy similarity1
Lipidationi394S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ9JMC3
MaxQBiQ9JMC3
PaxDbiQ9JMC3
PeptideAtlasiQ9JMC3
PRIDEiQ9JMC3

2D gel databases

REPRODUCTION-2DPAGEiQ9JMC3

PTM databases

iPTMnetiQ9JMC3
PhosphoSitePlusiQ9JMC3

Expressioni

Tissue specificityi

Specifically expressed in testis and heart.

Gene expression databases

BgeeiENSMUSG00000032285 Expressed in 238 organ(s), highest expression level in blood
CleanExiMM_DNAJA4
ExpressionAtlasiQ9JMC3 baseline and differential
GenevisibleiQ9JMC3 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208406, 1 interactor
IntActiQ9JMC3, 2 interactors
MINTiQ9JMC3
STRINGi10090.ENSMUSP00000070413

Structurei

3D structure databases

ProteinModelPortaliQ9JMC3
SMRiQ9JMC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 70JAdd BLAST67
Repeati135 – 142CXXCXGXG motif8
Repeati151 – 158CXXCXGXG motif8
Repeati178 – 185CXXCXGXG motif8
Repeati194 – 201CXXCXGXG motif8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 96Gly-richAdd BLAST22

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri122 – 206CR-typeAdd BLAST85

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0712 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00860000133716
HOGENOMiHOG000226718
HOVERGENiHBG066727
InParanoidiQ9JMC3
KOiK09505
OMAiWLPEHLM
OrthoDBiEOG091G0CAC
PhylomeDBiQ9JMC3
TreeFamiTF105141

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd10719 DnaJ_zf, 1 hit
Gene3Di1.10.287.110, 1 hit
HAMAPiMF_01152 DnaJ, 1 hit
InterProiView protein in InterPro
IPR012724 DnaJ
IPR002939 DnaJ_C
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR008971 HSP40/DnaJ_pept-bd
IPR001305 HSP_DnaJ_Cys-rich_dom
IPR036410 HSP_DnaJ_Cys-rich_dom_sf
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF01556 DnaJ_C, 1 hit
PF00684 DnaJ_CXXCXGXG, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF49493 SSF49493, 2 hits
SSF57938 SSF57938, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
PS51188 ZF_CR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9JMC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKETQYYDI LGVKPSASPE EIKKAYRKLA LKYHPDKNPD EGEKFKLISQ
60 70 80 90 100
AYEVLSDPKK RDIYDQGGEQ AIKEGGSGSP SFSSPMDIFD MFFGGGGRMT
110 120 130 140 150
RERRGKNVVH QLSVTLEDLY NGITKKLALQ KNVICEKCEG IGGKKGSVEK
160 170 180 190 200
CPLCKGRGMQ VHIQQIGPGM VQQIQTVCIE CKGQGERINP KDRCENCSGA
210 220 230 240 250
KVTREKKIIE VHVEKGMKDG QKILFHGEGD QEPELDPGDV IIVLDQKDHS
260 270 280 290 300
VFQRRGQDLI MKMKIQLSEA LCGFKKTIKT LDDRVLVISS KSGEVIKHGD
310 320 330 340 350
LKCIRNEGMP IYKAPLEKGV MIIQFLVVFP EKQWLSQEKL PQLEALLPPR
360 370 380 390
QKVRITDDMD QVELKEFNPN EQSWRQHREA YEEDDEEPRA GVQCQTA
Length:397
Mass (Da):44,902
Last modified:October 1, 2000 - v1
Checksum:iEF47E79FADDD9055
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z1U5D3Z1U5_MOUSE
DnaJ homolog subfamily A member 4
Dnaja4
207Annotation score:

Sequence cautioni

The sequence BAB30367 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032401 mRNA Translation: BAA92775.1
AK003903 mRNA Translation: BAB23067.1
AK016666 mRNA Translation: BAB30367.2 Different initiation.
AK046476 mRNA Translation: BAC32747.1
AK076175 mRNA Translation: BAC36232.1
AK141909 mRNA Translation: BAE24880.1
BC147484 mRNA Translation: AAI47485.1
BC147486 mRNA Translation: AAI47487.1
CCDSiCCDS23193.1
RefSeqiNP_067397.1, NM_021422.4
UniGeneiMm.489676

Genome annotation databases

EnsembliENSMUST00000070070; ENSMUSP00000070413; ENSMUSG00000032285
ENSMUST00000120452; ENSMUSP00000112520; ENSMUSG00000032285
GeneIDi58233
KEGGimmu:58233
UCSCiuc009prk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032401 mRNA Translation: BAA92775.1
AK003903 mRNA Translation: BAB23067.1
AK016666 mRNA Translation: BAB30367.2 Different initiation.
AK046476 mRNA Translation: BAC32747.1
AK076175 mRNA Translation: BAC36232.1
AK141909 mRNA Translation: BAE24880.1
BC147484 mRNA Translation: AAI47485.1
BC147486 mRNA Translation: AAI47487.1
CCDSiCCDS23193.1
RefSeqiNP_067397.1, NM_021422.4
UniGeneiMm.489676

3D structure databases

ProteinModelPortaliQ9JMC3
SMRiQ9JMC3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208406, 1 interactor
IntActiQ9JMC3, 2 interactors
MINTiQ9JMC3
STRINGi10090.ENSMUSP00000070413

PTM databases

iPTMnetiQ9JMC3
PhosphoSitePlusiQ9JMC3

2D gel databases

REPRODUCTION-2DPAGEiQ9JMC3

Proteomic databases

EPDiQ9JMC3
MaxQBiQ9JMC3
PaxDbiQ9JMC3
PeptideAtlasiQ9JMC3
PRIDEiQ9JMC3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070070; ENSMUSP00000070413; ENSMUSG00000032285
ENSMUST00000120452; ENSMUSP00000112520; ENSMUSG00000032285
GeneIDi58233
KEGGimmu:58233
UCSCiuc009prk.2 mouse

Organism-specific databases

CTDi55466
MGIiMGI:1927638 Dnaja4

Phylogenomic databases

eggNOGiKOG0712 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00860000133716
HOGENOMiHOG000226718
HOVERGENiHBG066727
InParanoidiQ9JMC3
KOiK09505
OMAiWLPEHLM
OrthoDBiEOG091G0CAC
PhylomeDBiQ9JMC3
TreeFamiTF105141

Enzyme and pathway databases

ReactomeiR-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)

Miscellaneous databases

ChiTaRSiDnaja4 mouse
PROiPR:Q9JMC3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032285 Expressed in 238 organ(s), highest expression level in blood
CleanExiMM_DNAJA4
ExpressionAtlasiQ9JMC3 baseline and differential
GenevisibleiQ9JMC3 MM

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd10719 DnaJ_zf, 1 hit
Gene3Di1.10.287.110, 1 hit
HAMAPiMF_01152 DnaJ, 1 hit
InterProiView protein in InterPro
IPR012724 DnaJ
IPR002939 DnaJ_C
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR008971 HSP40/DnaJ_pept-bd
IPR001305 HSP_DnaJ_Cys-rich_dom
IPR036410 HSP_DnaJ_Cys-rich_dom_sf
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF01556 DnaJ_C, 1 hit
PF00684 DnaJ_CXXCXGXG, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF49493 SSF49493, 2 hits
SSF57938 SSF57938, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
PS51188 ZF_CR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDNJA4_MOUSE
AccessioniPrimary (citable) accession number: Q9JMC3
Secondary accession number(s): B2RW09
, Q543S9, Q9CTD6, Q9CUD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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