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UniProtKB - Q9JMA7 (CP341_MOUSE)
Functioni
Catalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]EC:1.14.14.1
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 443 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity Source: MGI
- aromatase activity Source: UniProtKB-EC
- caffeine oxidase activity Source: MGI
- demethylase activity Source: MGI
- enzyme binding Source: MGI
- estrogen 16-alpha-hydroxylase activity Source: MGI
- estrogen 2-hydroxylase activity Source: MGI
- heme binding Source: InterPro
- iron ion binding Source: MGI
- monooxygenase activity Source: MGI
- oxidoreductase activity Source: MGI
- retinoic acid 4-hydroxylase activity Source: MGI
- steroid binding Source: MGI
- steroid hydroxylase activity Source: MGI
- testosterone 6-beta-hydroxylase activity Source: MGI
- vitamin D 24-hydroxylase activity Source: MGI
- vitamin D3 25-hydroxylase activity Source: MGI
GO - Biological processi
- oxidative demethylation Source: GO_Central
- regulation of gene expression Source: MGI
- response to bacterium Source: MGI
- steroid metabolic process Source: GO_Central
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
Reactomei | R-MMU-211981, Xenobiotics R-MMU-5423646, Aflatoxin activation and detoxification |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Cyp3a41a Synonyms:Cyp3a41 AND Name:Cyp3a41b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1858451, Cyp3a41a MGI:3714859, Cyp3a41b |
VEuPathDBi | HostDB:ENSMUSG00000075551 HostDB:ENSMUSG00000075552 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Peripheral membrane protein Curated
- Microsome membrane Curated; Peripheral membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: MGI
Other locations
- cytoplasm Source: MGI
- intracellular membrane-bounded organelle Source: MGI
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051813 | 1 – 504 | Cytochrome P450 3A41Add BLAST | 504 |
Proteomic databases
jPOSTi | Q9JMA7 |
MaxQBi | Q9JMA7 |
PaxDbi | Q9JMA7 |
PeptideAtlasi | Q9JMA7 |
PRIDEi | Q9JMA7 |
ProteomicsDBi | 283618 |
PTM databases
iPTMneti | Q9JMA7 |
PhosphoSitePlusi | Q9JMA7 |
SwissPalmi | Q9JMA7 |
Expressioni
Tissue specificityi
Expressed in liver. Also expressed in the kidneys of female mice, with traces in the stomach, ovary, and heart of female mice and in the testis of male mice.
Developmental stagei
Detected immediately after birth in the livers of animals of both sexes, but increases with age in females, whereas it is gradually reduced in males, resulting in predominantly female-specific expression in livers.
Gene expression databases
Bgeei | ENSMUSG00000075551, Expressed in liver and 12 other tissues |
Genevisiblei | Q9JMA7, MM |
Interactioni
GO - Molecular functioni
- enzyme binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000075234 |
Miscellaneous databases
RNActi | Q9JMA7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
GeneTreei | ENSGT00950000182958 |
HOGENOMi | CLU_001570_5_2_1 |
InParanoidi | Q9JMA7 |
OMAi | WRKDYGP |
OrthoDBi | 467733at2759 |
PhylomeDBi | Q9JMA7 |
TreeFami | TF105087 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR008072, Cyt_P450_E_CYP3A IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01689, EP450IICYP3A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9JMA7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLFSALSLD TWVLLAIILV LLYRYGTRTH GLFKKQGIPG PKPLPFLGTV
60 70 80 90 100
LNYYKGLWKF DMECYEKYGK TWGLFDGQMP LFVITDPEMI KNVLVKECFS
110 120 130 140 150
VFTNRREFGP VGIMSKAISI SKDEEWKRYR ALLSPTFTSG KLKEMFPVIE
160 170 180 190 200
QYGDILVKYL MQEAEKGKPV TMKDVLGAYS IDVITSTSFG VNVDSLNNPE
210 220 230 240 250
DPFVEKAKGI LRVDFFDPLV FSVVLFPFLT PVYEMLNICM FPKDSIEFFK
260 270 280 290 300
KFVNRMKESR LDSKQKHRVD FLQLMMNAHN NSKDKDSHKA LSDMEITAQS
310 320 330 340 350
IVFIFAGYET TSSTLSFTLY CLATHPDIQK KLQEEIDETL PNKAPPTYDT
360 370 380 390 400
VMEMEYLDMV LNETLRLYPI GNRLERFCKK DVELNGVYIP KGSTVMIPSY
410 420 430 440 450
ALHHDPQHWP EPEEFQPERF SKENKGSIDP YLYMPFGIGP RNCIGMRFAF
460 470 480 490 500
MTMKLALTKV MQNFSFQPCQ ETQIPLKLSR QGLLQPEKPI VLKVVPRDVV
ITGA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 42 | K → T in BAA95951 (PubMed:10775455).Curated | 1 | |
Sequence conflicti | 42 | K → T in AAI38084 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 42 | K → T in AAI38085 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033414 mRNA Translation: BAA95951.1 AC124483 Genomic DNA No translation available. AC166648 Genomic DNA No translation available. BC138083 mRNA Translation: AAI38084.1 BC138084 mRNA Translation: AAI38085.1 |
CCDSi | CCDS39389.1 |
RefSeqi | NP_001098629.1, NM_001105159.1 NP_059092.2, NM_017396.3 |
Genome annotation databases
Ensembli | ENSMUST00000075837; ENSMUSP00000075234; ENSMUSG00000075552 ENSMUST00000094111; ENSMUSP00000091659; ENSMUSG00000075551 |
GeneIDi | 100041375 53973 |
KEGGi | mmu:100041375 mmu:53973 |
UCSCi | uc012egw.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033414 mRNA Translation: BAA95951.1 AC124483 Genomic DNA No translation available. AC166648 Genomic DNA No translation available. BC138083 mRNA Translation: AAI38084.1 BC138084 mRNA Translation: AAI38085.1 |
CCDSi | CCDS39389.1 |
RefSeqi | NP_001098629.1, NM_001105159.1 NP_059092.2, NM_017396.3 |
3D structure databases
SMRi | Q9JMA7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000075234 |
Chemistry databases
ChEMBLi | CHEMBL3637781 |
PTM databases
iPTMneti | Q9JMA7 |
PhosphoSitePlusi | Q9JMA7 |
SwissPalmi | Q9JMA7 |
Proteomic databases
jPOSTi | Q9JMA7 |
MaxQBi | Q9JMA7 |
PaxDbi | Q9JMA7 |
PeptideAtlasi | Q9JMA7 |
PRIDEi | Q9JMA7 |
ProteomicsDBi | 283618 |
Protocols and materials databases
DNASUi | 53973 |
Genome annotation databases
Ensembli | ENSMUST00000075837; ENSMUSP00000075234; ENSMUSG00000075552 ENSMUST00000094111; ENSMUSP00000091659; ENSMUSG00000075551 |
GeneIDi | 100041375 53973 |
KEGGi | mmu:100041375 mmu:53973 |
UCSCi | uc012egw.1, mouse |
Organism-specific databases
CTDi | 100041375 53973 |
MGIi | MGI:1858451, Cyp3a41a MGI:3714859, Cyp3a41b |
VEuPathDBi | HostDB:ENSMUSG00000075551 HostDB:ENSMUSG00000075552 |
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
GeneTreei | ENSGT00950000182958 |
HOGENOMi | CLU_001570_5_2_1 |
InParanoidi | Q9JMA7 |
OMAi | WRKDYGP |
OrthoDBi | 467733at2759 |
PhylomeDBi | Q9JMA7 |
TreeFami | TF105087 |
Enzyme and pathway databases
Reactomei | R-MMU-211981, Xenobiotics R-MMU-5423646, Aflatoxin activation and detoxification |
Miscellaneous databases
BioGRID-ORCSi | 100041375, 3 hits in 30 CRISPR screens 53973, 3 hits in 29 CRISPR screens |
ChiTaRSi | Cyp3a41b, mouse |
PROi | PR:Q9JMA7 |
RNActi | Q9JMA7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000075551, Expressed in liver and 12 other tissues |
Genevisiblei | Q9JMA7, MM |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR008072, Cyt_P450_E_CYP3A IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01689, EP450IICYP3A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP341_MOUSE | |
Accessioni | Q9JMA7Primary (citable) accession number: Q9JMA7 Secondary accession number(s): B2RQU5, E9QJT9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 19, 2002 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families