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Entry version 124 (13 Feb 2019)
Sequence version 2 (06 Dec 2005)
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Protein

Proteoglycan 4

Gene

Prg4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.1 Publication

Miscellaneous

Different forms varying in molecular weight have been observed. Such forms are possibly due to different levels of glycosylation and protein cleavage.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proteoglycan 4
Alternative name(s):
Lubricin
Megakaryocyte-stimulating factor
Superficial zone proteoglycan
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Prg4
Synonyms:Msf, Szp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1891344 Prg4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable and fertile. In the newborn period, their joints appear normal. The aged mice exhibit abnormal protein deposits on the cartilage surface and disappearance of underlying superficial zone chondrocytes. In addition to cartilage surface changes and subsequent cartilage deterioration, intimal cells in the synovium surrounding the joint space become hyperplastic, which further contribute to joint failure.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi795C → A: Not cleaved by subtilisin-like proprotein convertase. Not cleaved by subtilisin-like proprotein convertase; when associated with A-1053. 1 Publication1
Mutagenesisi851 – 853CNC → ANA: Cleaved by subtilisin-like proprotein convertase. 1 Publication3
Mutagenesisi851C → A: Cleaved by subtilisin-like proprotein convertase. 1
Mutagenesisi930C → A: Cleaved by subtilisin-like proprotein convertase. 1 Publication1
Mutagenesisi949 – 955RRRRFER → ARARFEA: Not cleaved by subtilisin-like proprotein convertase 4. 1 Publication7
Mutagenesisi949 – 951RRR → ARA: Cleaved by subtilisin-like proprotein convertase 4. 1 Publication3
Mutagenesisi955R → A: Not cleaved by subtilisin-like proprotein convertase 4. 1
Mutagenesisi1053C → A: Not cleaved by subtilisin-like proprotein convertase 4. Not cleaved by subtilisin-like proprotein convertase; when associated with A-795. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004323425 – 1054Proteoglycan 4Add BLAST1030
ChainiPRO_0000043235956 – 1054Proteoglycan 4 C-terminal partAdd BLAST99

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 46AlternatePROSITE-ProRule annotation
Disulfide bondi30 ↔ 34PROSITE-ProRule annotation
Disulfide bondi34 ↔ 64AlternatePROSITE-ProRule annotation
Disulfide bondi44 ↔ 57AlternatePROSITE-ProRule annotation
Disulfide bondi44 ↔ 46PROSITE-ProRule annotation
Disulfide bondi50 ↔ 56PROSITE-ProRule annotation
Disulfide bondi57 ↔ 64PROSITE-ProRule annotation
Disulfide bondi70 ↔ 86AlternatePROSITE-ProRule annotation
Disulfide bondi70 ↔ 74PROSITE-ProRule annotation
Disulfide bondi74 ↔ 104AlternatePROSITE-ProRule annotation
Disulfide bondi84 ↔ 97AlternatePROSITE-ProRule annotation
Disulfide bondi84 ↔ 86PROSITE-ProRule annotation
Disulfide bondi90 ↔ 96PROSITE-ProRule annotation
Disulfide bondi97 ↔ 104PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135O-linked (GalNAc...) serineBy similarity1
Glycosylationi237O-linked (GalNAc...) threonineBy similarity1
Glycosylationi250O-linked (GalNAc...) threonineBy similarity1
Glycosylationi301O-linked (GalNAc...) threonineBy similarity1
Glycosylationi302O-linked (GalNAc...) serineBy similarity1
Glycosylationi306O-linked (GalNAc...) threonineBy similarity1
Glycosylationi313O-linked (GalNAc...) serineBy similarity1
Glycosylationi327O-linked (GalNAc...) serineBy similarity1
Glycosylationi330O-linked (GalNAc...) threonineBy similarity1
Glycosylationi338O-linked (GalNAc...) threonineBy similarity1
Glycosylationi354O-linked (GalNAc...) threonineBy similarity1
Glycosylationi362O-linked (GalNAc...) threonineBy similarity1
Glycosylationi369O-linked (GalNAc...) threonineBy similarity1
Glycosylationi377O-linked (GalNAc...) threonineBy similarity1
Glycosylationi378O-linked (GalNAc...) threonineBy similarity1
Glycosylationi385O-linked (GalNAc...) threonineBy similarity1
Glycosylationi386O-linked (GalNAc...) threonineBy similarity1
Glycosylationi393O-linked (GalNAc...) threonineBy similarity1
Glycosylationi394O-linked (GalNAc...) threonineBy similarity1
Glycosylationi416O-linked (GalNAc...) threonineBy similarity1
Glycosylationi417O-linked (GalNAc...) threonineBy similarity1
Glycosylationi424O-linked (GalNAc...) threonineBy similarity1
Glycosylationi432O-linked (GalNAc...) threonineBy similarity1
Glycosylationi433O-linked (GalNAc...) threonineBy similarity1
Glycosylationi440O-linked (GalNAc...) threonineBy similarity1
Glycosylationi441O-linked (GalNAc...) threonineBy similarity1
Glycosylationi448O-linked (GalNAc...) threonineBy similarity1
Glycosylationi472O-linked (GalNAc...) threonineBy similarity1
Glycosylationi480O-linked (GalNAc...) threonineBy similarity1
Glycosylationi481O-linked (GalNAc...) threonineBy similarity1
Glycosylationi488O-linked (GalNAc...) threonineBy similarity1
Glycosylationi489O-linked (GalNAc...) threonineBy similarity1
Glycosylationi496O-linked (GalNAc...) threonineBy similarity1
Glycosylationi497O-linked (GalNAc...) threonineBy similarity1
Glycosylationi504O-linked (GalNAc...) threonineBy similarity1
Glycosylationi505O-linked (GalNAc...) threonineBy similarity1
Glycosylationi512O-linked (GalNAc...) threonineBy similarity1
Glycosylationi520O-linked (GalNAc...) threonineBy similarity1
Glycosylationi521O-linked (GalNAc...) threonineBy similarity1
Glycosylationi528O-linked (GalNAc...) threonineBy similarity1
Glycosylationi529O-linked (GalNAc...) threonineBy similarity1
Glycosylationi553O-linked (GalNAc...) threonineBy similarity1
Glycosylationi560O-linked (GalNAc...) threonineBy similarity1
Glycosylationi561O-linked (GalNAc...) threonineBy similarity1
Glycosylationi568O-linked (GalNAc...) threonineBy similarity1
Glycosylationi569O-linked (GalNAc...) threonineBy similarity1
Glycosylationi576O-linked (GalNAc...) threonineBy similarity1
Glycosylationi577O-linked (GalNAc...) threonineBy similarity1
Glycosylationi592O-linked (GalNAc...) threonineBy similarity1
Glycosylationi600O-linked (GalNAc...) threonineBy similarity1
Glycosylationi601O-linked (GalNAc...) threonineBy similarity1
Glycosylationi622O-linked (GalNAc...) threonineBy similarity1
Glycosylationi624O-linked (GalNAc...) threonineBy similarity1
Glycosylationi628O-linked (GalNAc...) threonineBy similarity1
Glycosylationi629O-linked (GalNAc...) threonineBy similarity1
Glycosylationi692O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi795 ↔ 1053PROSITE-ProRule annotation1 Publication
Glycosylationi808N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi810O-linked (GalNAc...) threonineBy similarity1
Glycosylationi938N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity
O-glycosylated; contains glycosaminoglycan chondroitin sulfate and keratan sulfate. O-glycosylated with sialylated oligosaccharides which are predominantly represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated O-glycans.By similarity
The disulfide bond between Cys-795 and Cys-1053 is essential for protein cleavage.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei955 – 956Cleavage; by subtilisin-like proprotein convertase 42

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9JM99

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JM99

PeptideAtlas

More...
PeptideAtlasi
Q9JM99

PRoteomics IDEntifications database

More...
PRIDEi
Q9JM99

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JM99

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JM99

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in cartilage, bone and liver and weakly expressed in heart, brain and muscle. Expressed in the surface chondrocytes and in synovial intimal cells. Isoform B is expressed in bone, small intestine, muscle, testis, heart, liver and lung. Isoform C and isoform D are widely expressed.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected at the forming joint surface from 15.5 dpc, after cavitation has begun. At later stages of morphogenesis, strong expression is observed in cartilage surface cells (superficial zone chondocytes) and in the newly forming synovium.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked.1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000125677

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JM99

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 69SMB 1PROSITE-ProRule annotationAdd BLAST44
Domaini66 – 108SMB 2PROSITE-ProRule annotationAdd BLAST43
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati317 – 3241; approximate8
Repeati325 – 3322; approximate8
Repeati333 – 3403; approximate8
Repeati349 – 3564; approximate8
Repeati357 – 36458
Repeati365 – 3716; approximate7
Repeati372 – 37978
Repeati380 – 38788
Repeati388 – 39598
Repeati396 – 403108
Repeati404 – 411118
Repeati412 – 41812; approximate7
Repeati419 – 426138
Repeati427 – 434148
Repeati435 – 442158
Repeati443 – 45016; approximate8
Repeati451 – 458178
Repeati459 – 466188
Repeati467 – 474198
Repeati475 – 482208
Repeati483 – 490218
Repeati491 – 498228
Repeati499 – 506238
Repeati507 – 514248
Repeati515 – 522258
Repeati523 – 530268
Repeati531 – 538278
Repeati539 – 546288
Repeati547 – 554298
Repeati555 – 562308
Repeati563 – 570318
Repeati571 – 578328
Repeati579 – 586338
Repeati587 – 594348
Repeati595 – 602358
Repeati603 – 610368
Repeati611 – 618378
Repeati797 – 840Hemopexin 1Add BLAST44
Repeati841 – 888Hemopexin 2Add BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni317 – 61837 X 8 AA repeats of K-X-P-X-P-T-T-XAdd BLAST302

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi157 – 184Ser-richAdd BLAST28
Compositional biasi350 – 606Glu-richAdd BLAST257
Compositional biasi659 – 699Lys-richAdd BLAST41

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1565 Eukaryota
ENOG410XQ5D LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115691

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG101613

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JM99

Database of Orthologous Groups

More...
OrthoDBi
419397at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00094 HX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.110.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR036024 Somatomedin_B-like_dom_sf
IPR020436 Somatomedin_B_chordata
IPR001212 Somatomedin_B_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00045 Hemopexin, 1 hit
PF01033 Somatomedin_B, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00022 SOMATOMEDINB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00120 HX, 2 hits
SM00201 SO, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50923 SSF50923, 1 hit
SSF90188 SSF90188, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 2 hits
PS00524 SMB_1, 2 hits
PS50958 SMB_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q9JM99-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGWKILPVCL SLLLPVVLIQ QVSSQDLSSC AGRCGEGYSR DATCNCDYNC
60 70 80 90 100
QHYMECCPDF KRVCSPELSC KGRCFESFAR GRECDCDSQC KQYGKCCADY
110 120 130 140 150
DSFCEEVHNS TSPSSKTAPT PAGASDTIKS TTKRSPKSPT TRTIKVVESE
160 170 180 190 200
ELTEEHSDSE NQESSSSSSS SSSTIRKIKS SKNSANRELQ KNPNVKDNKK
210 220 230 240 250
NTPKKKPNPE PPAVDEAGSG LDNGEFKLTP PPPDPPTTPH SKVATSPKTT
260 270 280 290 300
AAKPVTPKPS LAPNSETSKE ASLASNKETT VETKETTATN KQSSASKKKT
310 320 330 340 350
TSVKETRSAE KTSDKDVEPT STTPKNSAPT TTKKPVTTTK ESKFLPLPQE
360 370 380 390 400
PEPTTAKEPP PTTKKPEPTT RKEPEPTTPK EPEPTTPKEP EPTTPKEPEP
410 420 430 440 450
TTPKEPPPTT KKPEPTTPKE PGPTTPKEPE PTTTKEPEPT TTKEPESTTR
460 470 480 490 500
KEPEPTTPKE PEPTTPKEPE PTTLKEPEPT TPKEPEPTTP KEPEPTTPKE
510 520 530 540 550
PEPTTPKEPE PTTPKEPEPT TPKEPEPTTP KEPEPTTPKE PEPTTPKKPE
560 570 580 590 600
PTTPKEPVPT TPKEPEPTTP KEPEPTTPKE PEPTTRKEPE PTTPKEPEPT
610 620 630 640 650
TPKEPEPTTP KKPEPTTTSP KTTTLKATTL APKVTAPAEE IQNKPEETTP
660 670 680 690 700
ASEDSDDSKT TLKPQKPTKA PKPTKKPTKA PKKPTSTKKP KTPKTRKPKT
710 720 730 740 750
TPSPLKTTSA TPELNTTPLE VMLPTTTIPK QTPNPETAEV NPDHEDADGG
760 770 780 790 800
EGEKPLIPGP PVLFPTAIPG TDLLAGRLNQ GININPMLSD ETNLCNGKPV
810 820 830 840 850
DGLTTLRNGT LVAFRGHYFW MLNPFRPPSP PRRITEVWGI PSPIDTVFTR
860 870 880 890 900
CNCEGKTFFF KDSQYWRFTN DVVDPGYPKQ IVKGFGGLTG KIVAALSIAK
910 920 930 940 950
YKDRPESVYF FKRGGNIQQY TYKQEPMKKC TGRRPAINYS VYGEAAQVRR
960 970 980 990 1000
RRFERAVGPF QTHTFRIHYS VPMRVSYQDK GFLHNEVKVS TMWRGFPNVV
1010 1020 1030 1040 1050
TSAITLPNIR KPDGYDYYAF SKDQYYNIDV PTRTARAITT RSGQTLSKIW

YNCP
Length:1,054
Mass (Da):115,996
Last modified:December 6, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13312FB7070DF2A4
GO
Isoform B (identifier: Q9JM99-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.

Show »
Length:1,013
Mass (Da):111,425
Checksum:i49334633D98BD1E4
GO
Isoform C (identifier: Q9JM99-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-194: Missing.

Show »
Length:966
Mass (Da):106,637
Checksum:i123569A1FABFC5BD
GO
Isoform D (identifier: Q9JM99-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.
     107-194: Missing.

Show »
Length:925
Mass (Da):102,066
Checksum:i1CD5556F5467CD48
GO
Isoform E (identifier: Q9JM99-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-194: Missing.
     224-766: Missing.

Note: No experimental confirmation available.
Show »
Length:423
Mass (Da):47,989
Checksum:iEBC6B86287506E4C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CZ58E0CZ58_MOUSE
Proteoglycan 4
Prg4
1,221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QQ17E9QQ17_MOUSE
Proteoglycan 4
Prg4
1,012Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QQ18E9QQ18_MOUSE
Proteoglycan 4
Prg4
965Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J207A0A0R4J207_MOUSE
Proteoglycan 4
Prg4
423Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CXA1E0CXA1_MOUSE
Proteoglycan 4
Prg4
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CY90E0CY90_MOUSE
Proteoglycan 4
Prg4
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti65 – 66SP → TT in BAE28900 (PubMed:16141072).Curated2
Sequence conflicti703S → A in BAA92310 (PubMed:11124536).Curated1
Sequence conflicti780Q → R in BAA92310 (PubMed:11124536).Curated1
Sequence conflicti788L → P in BAA92310 (PubMed:11124536).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01647126 – 66Missing in isoform B and isoform D. CuratedAdd BLAST41
Alternative sequenceiVSP_016472107 – 194Missing in isoform C, isoform D and isoform E. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_016473224 – 766Missing in isoform E. 1 PublicationAdd BLAST543

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB034730 mRNA Translation: BAA92310.1
AK132597 mRNA Translation: BAE21253.1
AK149469 mRNA Translation: BAE28900.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48391.1 [Q9JM99-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001103616.1, NM_001110146.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.174256
Mm.329131

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
96875

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:96875

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034730 mRNA Translation: BAA92310.1
AK132597 mRNA Translation: BAE21253.1
AK149469 mRNA Translation: BAE28900.1
CCDSiCCDS48391.1 [Q9JM99-5]
RefSeqiNP_001103616.1, NM_001110146.1
UniGeneiMm.174256
Mm.329131

3D structure databases

SMRiQ9JM99
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125677

PTM databases

iPTMnetiQ9JM99
PhosphoSitePlusiQ9JM99

Proteomic databases

jPOSTiQ9JM99
PaxDbiQ9JM99
PeptideAtlasiQ9JM99
PRIDEiQ9JM99

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi96875
KEGGimmu:96875

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10216
MGIiMGI:1891344 Prg4

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
HOGENOMiHOG000115691
HOVERGENiHBG101613
InParanoidiQ9JM99
OrthoDBi419397at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9JM99

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd00094 HX, 1 hit
Gene3Di2.110.10.10, 1 hit
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR036024 Somatomedin_B-like_dom_sf
IPR020436 Somatomedin_B_chordata
IPR001212 Somatomedin_B_dom
PfamiView protein in Pfam
PF00045 Hemopexin, 1 hit
PF01033 Somatomedin_B, 2 hits
PRINTSiPR00022 SOMATOMEDINB
SMARTiView protein in SMART
SM00120 HX, 2 hits
SM00201 SO, 2 hits
SUPFAMiSSF50923 SSF50923, 1 hit
SSF90188 SSF90188, 2 hits
PROSITEiView protein in PROSITE
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 2 hits
PS00524 SMB_1, 2 hits
PS50958 SMB_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRG4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JM99
Secondary accession number(s): Q3UEL1, Q3V198
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: February 13, 2019
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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