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Protein

WD repeat-containing protein WRAP73

Gene

Wrap73

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein WRAP73
Alternative name(s):
WD repeat-containing protein 8
WD repeat-containing protein antisense to TP73 gene
Gene namesi
Name:Wrap73
Synonyms:Dd57, Wdr8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1891749 Wrap73

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513571 – 462WD repeat-containing protein WRAP73Add BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei281PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JM98
PaxDbiQ9JM98
PRIDEiQ9JM98

PTM databases

PhosphoSitePlusiQ9JM98

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000029029 Expressed in 260 organ(s), highest expression level in pancreas
CleanExiMM_WDR8
ExpressionAtlasiQ9JM98 baseline and differential
GenevisibleiQ9JM98 MM

Interactioni

Subunit structurei

Interacts with SSX2IP (PubMed:26675238).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SSX2IPQ9Y2D83EBI-11694665,EBI-2212028From Homo sapiens.

Protein-protein interaction databases

IntActiQ9JM98, 2 interactors
STRINGi10090.ENSMUSP00000030895

Structurei

3D structure databases

ProteinModelPortaliQ9JM98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati46 – 86WD 1Add BLAST41
Repeati89 – 129WD 2Add BLAST41
Repeati176 – 210WD 3Add BLAST35
Repeati221 – 260WD 4Add BLAST40
Repeati328 – 369WD 5Add BLAST42
Repeati371 – 410WD 6Add BLAST40

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG4497 Eukaryota
ENOG410Y2P7 LUCA
GeneTreeiENSGT00390000003623
HOGENOMiHOG000243586
HOVERGENiHBG022803
InParanoidiQ9JM98
OMAiYSAYEWS
OrthoDBiEOG091G0OTT
TreeFamiTF329103

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR011044 Quino_amine_DH_bsu
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50969 SSF50969, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9JM98-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNFSESFKLS GLLCRFSPDG KYLASCVQYR LVIRDVTTLQ ILQLYTCLDQ
60 70 80 90 100
IQHIEWSADS LFILCAMYRR GLVQVWSLEQ PEWHCKIDEG SAGLVASCWS
110 120 130 140 150
PDGRHILNTT EFHLRITVWS LCTKSVSYIK YPKACQQGLT FTRDGRYLAL
160 170 180 190 200
AERRDCRDYV SIFVCSDWQL LRHFDTDTQD LTGIEWAPNG CVLAAWDTCL
210 220 230 240 250
EYKVLLYSLD GRLLSAYCAY EWSLGIKSVA WSPSSQFLAI GSYDGKVRLL
260 270 280 290 300
NHVTWKMITE FGHPATINNP KTVVYKEAEK SPLLGLGHLS FPPPRAMAGA
310 320 330 340 350
LSTSESKYEI ASGPVSLQTL KPVADRANPR MGVGMLAFSS DSYFLASRND
360 370 380 390 400
NVPNAVWIWD IQKLKLFVVL EHMSPVRSFQ WDPQQPRLAI CTGGSKVYLW
410 420 430 440 450
SPAGCVSVQV PGEGDFPVLG LCWHLSGDSL ALLSKDHFCL CFLETKERVG
460
TAYEQRDGMP RT
Length:462
Mass (Da):52,053
Last modified:May 31, 2011 - v2
Checksum:i6A32524BB1945845
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6VR19F6VR19_MOUSE
WD repeat-containing protein WRAP73
Wrap73 Wdr8
133Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti417P → A in BAA92311 (PubMed:11401440).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034911 mRNA Translation: BAA92311.1
AK051688 mRNA Translation: BAC34722.1
AK156969 mRNA Translation: BAE33920.1
AK160331 mRNA Translation: BAE35741.1
AL806525 Genomic DNA Translation: CAM18777.1
CH466594 Genomic DNA Translation: EDL14958.1
CCDSiCCDS19010.1
RefSeqiNP_067474.2, NM_021499.2
UniGeneiMm.46508

Genome annotation databases

EnsembliENSMUST00000030895; ENSMUSP00000030895; ENSMUSG00000029029
GeneIDi59002
KEGGimmu:59002
UCSCiuc008wbi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034911 mRNA Translation: BAA92311.1
AK051688 mRNA Translation: BAC34722.1
AK156969 mRNA Translation: BAE33920.1
AK160331 mRNA Translation: BAE35741.1
AL806525 Genomic DNA Translation: CAM18777.1
CH466594 Genomic DNA Translation: EDL14958.1
CCDSiCCDS19010.1
RefSeqiNP_067474.2, NM_021499.2
UniGeneiMm.46508

3D structure databases

ProteinModelPortaliQ9JM98
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JM98, 2 interactors
STRINGi10090.ENSMUSP00000030895

PTM databases

PhosphoSitePlusiQ9JM98

Proteomic databases

MaxQBiQ9JM98
PaxDbiQ9JM98
PRIDEiQ9JM98

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030895; ENSMUSP00000030895; ENSMUSG00000029029
GeneIDi59002
KEGGimmu:59002
UCSCiuc008wbi.1 mouse

Organism-specific databases

CTDi49856
MGIiMGI:1891749 Wrap73

Phylogenomic databases

eggNOGiKOG4497 Eukaryota
ENOG410Y2P7 LUCA
GeneTreeiENSGT00390000003623
HOGENOMiHOG000243586
HOVERGENiHBG022803
InParanoidiQ9JM98
OMAiYSAYEWS
OrthoDBiEOG091G0OTT
TreeFamiTF329103

Miscellaneous databases

PROiPR:Q9JM98
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029029 Expressed in 260 organ(s), highest expression level in pancreas
CleanExiMM_WDR8
ExpressionAtlasiQ9JM98 baseline and differential
GenevisibleiQ9JM98 MM

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR011044 Quino_amine_DH_bsu
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50969 SSF50969, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWRP73_MOUSE
AccessioniPrimary (citable) accession number: Q9JM98
Secondary accession number(s): Q8BQ21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 31, 2011
Last modified: November 7, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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