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Protein

Signal-transducing adaptor protein 1

Gene

Stap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as an adapter molecule downstream of KIT in the proliferation or differentiation of hematopoietic stem cells.1 Publication

GO - Molecular functioni

  • macrophage colony-stimulating factor receptor binding Source: BHF-UCL
  • phosphotyrosine residue binding Source: MGI
  • protein kinase binding Source: MGI
  • receptor tyrosine kinase binding Source: BHF-UCL
  • SH3/SH2 adaptor activity Source: MGI
  • transmembrane receptor protein tyrosine kinase adaptor activity Source: BHF-UCL

GO - Biological processi

  • cellular response to lipopolysaccharide Source: BHF-UCL
  • myeloid cell differentiation Source: MGI
  • negative regulation of macrophage chemotaxis Source: BHF-UCL
  • negative regulation of macrophage colony-stimulating factor signaling pathway Source: BHF-UCL
  • negative regulation of microglial cell migration Source: BHF-UCL
  • negative regulation of phosphorylation Source: BHF-UCL
  • negative regulation of ruffle assembly Source: BHF-UCL
  • positive regulation of actin cytoskeleton reorganization Source: BHF-UCL
  • positive regulation of B cell receptor signaling pathway Source: MGI
  • positive regulation of gene expression Source: BHF-UCL
  • positive regulation of microglial cell activation Source: BHF-UCL
  • positive regulation of microglial cell mediated cytotoxicity Source: BHF-UCL
  • positive regulation of non-membrane spanning protein tyrosine kinase activity Source: MGI
  • positive regulation of phagocytosis, engulfment Source: BHF-UCL
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: BHF-UCL

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-transducing adaptor protein 1
Short name:
STAP-1
Alternative name(s):
Stem cell adaptor protein 1
Gene namesi
Name:Stap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1926193 Stap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722381 – 297Signal-transducing adaptor protein 1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei170PhosphotyrosineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine by TEC. Phosphorylated on tyrosine by KIT.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JM90
PaxDbiQ9JM90
PeptideAtlasiQ9JM90
PRIDEiQ9JM90

PTM databases

iPTMnetiQ9JM90
PhosphoSitePlusiQ9JM90
SwissPalmiQ9JM90

Expressioni

Tissue specificityi

Expression restricted to the bone marrow.1 Publication

Gene expression databases

BgeeiENSMUSG00000029254
CleanExiMM_STAP1
ExpressionAtlasiQ9JM90 baseline and differential
GenevisibleiQ9JM90 MM

Interactioni

Subunit structurei

Interacts with URI1; the interaction is phosphorylation-dependent occurs in a growth-dependent manner (By similarity). Interacts with KIT and CSF1R.By similarity1 Publication

GO - Molecular functioni

  • macrophage colony-stimulating factor receptor binding Source: BHF-UCL
  • phosphotyrosine residue binding Source: MGI
  • protein kinase binding Source: MGI
  • receptor tyrosine kinase binding Source: BHF-UCL
  • SH3/SH2 adaptor activity Source: MGI
  • transmembrane receptor protein tyrosine kinase adaptor activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi208177, 4 interactors
STRINGi10090.ENSMUSP00000031171

Structurei

3D structure databases

ProteinModelPortaliQ9JM90
SMRiQ9JM90
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 121PHPROSITE-ProRule annotationAdd BLAST97
Domaini179 – 273SH2PROSITE-ProRule annotationAdd BLAST95

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IGPX Eukaryota
ENOG4111PK4 LUCA
GeneTreeiENSGT00530000063841
HOGENOMiHOG000234375
HOVERGENiHBG062262
InParanoidiQ9JM90
OMAiYWTELRG
OrthoDBiEOG091G0929
PhylomeDBiQ9JM90
TreeFamiTF332087

Family and domain databases

CDDicd10403 SH2_STAP1, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR039111 STAP1/STAP2
IPR035877 STAP1_SH2
PANTHERiPTHR16186 PTHR16186, 1 hit
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50001 SH2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JM90-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAKKPPKPA PRRIFQERLK ITALPLYFEG FLLVKRSDHQ EYKHYWTELR
60 70 80 90 100
GTTLFFYTDK KSTIYVGKLD IIDLVCLTGQ HSTEKNCAKF TLVLPKEEVH
110 120 130 140 150
VKTENTESGE EWRGFILTVT ELTVPQHVSL LPGQVIRLHE VLEREKKRRI
160 170 180 190 200
ETDQLPLMPP EKEKEPVQDY ADVLNPLPEC FYAVSRKEAT AMLEKNPSWG
210 220 230 240 250
NMILRPGSDS KNYSITIRQE IEMPRIKHFK VTRTGNNYTI ELEKPVTLPN
260 270 280 290
LFSVIDYFVK ETRGNLRPFI HSADDNFGQD PNIEDRSEKF KKNPHNA
Length:297
Mass (Da):34,628
Last modified:October 1, 2000 - v1
Checksum:i8033C606990AAA75
GO
Isoform 2 (identifier: Q9JM90-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-127: LTVPQH → VIRFPL
     128-297: Missing.

Note: No experimental confirmation available.
Show »
Length:127
Mass (Da):14,921
Checksum:iAFAAE1584FA79F68
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013399122 – 127LTVPQH → VIRFPL in isoform 2. 1 Publication6
Alternative sequenceiVSP_013400128 – 297Missing in isoform 2. 1 PublicationAdd BLAST170

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036058 mRNA Translation: BAA92531.1
AK041474 mRNA Translation: BAC30953.1
AK162655 mRNA Translation: BAE37007.1
BC057898 mRNA Translation: AAH57898.1
BC145828 mRNA Translation: AAI45829.1
BC145830 mRNA Translation: AAI45831.1
CCDSiCCDS19377.1 [Q9JM90-1]
RefSeqiNP_001297568.1, NM_001310639.1
NP_064376.1, NM_019992.4 [Q9JM90-1]
XP_006535224.1, XM_006535161.3 [Q9JM90-2]
UniGeneiMm.131237

Genome annotation databases

EnsembliENSMUST00000198435; ENSMUSP00000143251; ENSMUSG00000029254 [Q9JM90-1]
GeneIDi56792
KEGGimmu:56792
UCSCiuc008xxf.1 mouse [Q9JM90-2]
uc008xxg.1 mouse [Q9JM90-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTAP1_MOUSE
AccessioniPrimary (citable) accession number: Q9JM90
Secondary accession number(s): A6H6C6, Q3TRM1, Q6PES6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 1, 2000
Last modified: July 18, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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