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Protein

Actin-related protein 2/3 complex subunit 3

Gene

Arpc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 3
Alternative name(s):
Arp2/3 complex 21 kDa subunit
Short name:
p21-ARC
Gene namesi
Name:Arpc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1928375 Arpc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001240432 – 178Actin-related protein 2/3 complex subunit 3Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei47PhosphotyrosineCombined sources1
Modified residuei56N6-acetyllysineBy similarity1
Modified residuei61N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9JM76
MaxQBiQ9JM76
PaxDbiQ9JM76
PeptideAtlasiQ9JM76
PRIDEiQ9JM76
TopDownProteomicsiQ9JM76

PTM databases

iPTMnetiQ9JM76
PhosphoSitePlusiQ9JM76
SwissPalmiQ9JM76

Expressioni

Gene expression databases

BgeeiENSMUSG00000029465 Expressed in 292 organ(s), highest expression level in thymus
CleanExiMM_ARPC3
ExpressionAtlasiQ9JM76 baseline and differential
GenevisibleiQ9JM76 MM

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207939, 2 interactors
IntActiQ9JM76, 5 interactors
MINTiQ9JM76
STRINGi10090.ENSMUSP00000099584

Structurei

3D structure databases

ProteinModelPortaliQ9JM76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC3 family.Curated

Phylogenomic databases

eggNOGiKOG3155 Eukaryota
ENOG4111FTG LUCA
GeneTreeiENSGT00390000018018
HOGENOMiHOG000161465
HOVERGENiHBG050581
InParanoidiQ9JM76
KOiK05756
OMAiPSKWWMS
OrthoDBiEOG091G0OUM
PhylomeDBiQ9JM76
TreeFamiTF314598

Family and domain databases

Gene3Di1.10.1760.10, 1 hit
InterProiView protein in InterPro
IPR007204 ARPC3
IPR036753 ARPC3_sf
PANTHERiPTHR12391 PTHR12391, 1 hit
PfamiView protein in Pfam
PF04062 P21-Arc, 1 hit
PIRSFiPIRSF016315 ARP2/3_P21-Arc, 1 hit
SUPFAMiSSF69060 SSF69060, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9JM76-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAYHSSLMD PDTKLIGNMA LLPLRSQFKG PAPRETKDTD IVDEAIYYFK
60 70 80 90 100
ANVFFKNYEI KNEADRTLIY ITLYISECLK KLQKCNSKSQ GEKEMYTLGI
110 120 130 140 150
TNFPIPGEPG FPLNAIYAKP ASKQEDEMMR AYLQQLRQET GLRLCEKVFD
160 170
PQSDKPSKWW TCFVKRQFMN KSLSGPGQ
Length:178
Mass (Da):20,525
Last modified:January 23, 2007 - v3
Checksum:i6B4F467F89BF4BAC
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z2F7D3Z2F7_MOUSE
Actin-related protein 2/3 complex s...
Arpc3
161Annotation score:
H7BWZ3H7BWZ3_MOUSE
Actin-related protein 2/3 complex s...
Arpc3
170Annotation score:
D3Z2F8D3Z2F8_MOUSE
Actin-related protein 2/3 complex s...
Arpc3
163Annotation score:
A0A0G2JFK7A0A0G2JFK7_MOUSE
Actin-related protein 2/3 complex s...
Arpc3
142Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038243 mRNA Translation: BAA90788.1
AK003485 mRNA Translation: BAB22813.1
AK005437 mRNA Translation: BAB24031.1
AK171651 mRNA Translation: BAE42588.1
BC013618 mRNA Translation: AAH13618.1
BC054440 mRNA Translation: AAH54440.1
CCDSiCCDS19648.1
RefSeqiNP_062798.1, NM_019824.4
UniGeneiMm.275942

Genome annotation databases

EnsembliENSMUST00000102525; ENSMUSP00000099584; ENSMUSG00000029465
GeneIDi56378
KEGGimmu:56378
UCSCiuc008zlf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038243 mRNA Translation: BAA90788.1
AK003485 mRNA Translation: BAB22813.1
AK005437 mRNA Translation: BAB24031.1
AK171651 mRNA Translation: BAE42588.1
BC013618 mRNA Translation: AAH13618.1
BC054440 mRNA Translation: AAH54440.1
CCDSiCCDS19648.1
RefSeqiNP_062798.1, NM_019824.4
UniGeneiMm.275942

3D structure databases

ProteinModelPortaliQ9JM76
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207939, 2 interactors
IntActiQ9JM76, 5 interactors
MINTiQ9JM76
STRINGi10090.ENSMUSP00000099584

PTM databases

iPTMnetiQ9JM76
PhosphoSitePlusiQ9JM76
SwissPalmiQ9JM76

Proteomic databases

EPDiQ9JM76
MaxQBiQ9JM76
PaxDbiQ9JM76
PeptideAtlasiQ9JM76
PRIDEiQ9JM76
TopDownProteomicsiQ9JM76

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102525; ENSMUSP00000099584; ENSMUSG00000029465
GeneIDi56378
KEGGimmu:56378
UCSCiuc008zlf.1 mouse

Organism-specific databases

CTDi10094
MGIiMGI:1928375 Arpc3

Phylogenomic databases

eggNOGiKOG3155 Eukaryota
ENOG4111FTG LUCA
GeneTreeiENSGT00390000018018
HOGENOMiHOG000161465
HOVERGENiHBG050581
InParanoidiQ9JM76
KOiK05756
OMAiPSKWWMS
OrthoDBiEOG091G0OUM
PhylomeDBiQ9JM76
TreeFamiTF314598

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

PROiPR:Q9JM76
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029465 Expressed in 292 organ(s), highest expression level in thymus
CleanExiMM_ARPC3
ExpressionAtlasiQ9JM76 baseline and differential
GenevisibleiQ9JM76 MM

Family and domain databases

Gene3Di1.10.1760.10, 1 hit
InterProiView protein in InterPro
IPR007204 ARPC3
IPR036753 ARPC3_sf
PANTHERiPTHR12391 PTHR12391, 1 hit
PfamiView protein in Pfam
PF04062 P21-Arc, 1 hit
PIRSFiPIRSF016315 ARP2/3_P21-Arc, 1 hit
SUPFAMiSSF69060 SSF69060, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARPC3_MOUSE
AccessioniPrimary (citable) accession number: Q9JM76
Secondary accession number(s): Q3TAT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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