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Protein

Thrombospondin type-1 domain-containing protein 1

Gene

Thsd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • hematopoietic progenitor cell differentiation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin type-1 domain-containing protein 1
Alternative name(s):
Transmembrane molecule with thrombospondin module
Gene namesi
Name:Thsd1
Synonyms:Tmtsp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1929096 Thsd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 412ExtracellularSequence analysisAdd BLAST388
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 851CytoplasmicSequence analysisAdd BLAST418

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000024958525 – 851Thrombospondin type-1 domain-containing protein 1Add BLAST827

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi351 ↔ 386PROSITE-ProRule annotation
Disulfide bondi355 ↔ 391PROSITE-ProRule annotation
Disulfide bondi366 ↔ 376PROSITE-ProRule annotation
Modified residuei462PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JM61
PRIDEiQ9JM61

PTM databases

iPTMnetiQ9JM61
PhosphoSitePlusiQ9JM61

Expressioni

Gene expression databases

CleanExiMM_THSD1

Interactioni

Protein-protein interaction databases

IntActiQ9JM61, 1 interactor
MINTiQ9JM61
STRINGi10090.ENSMUSP00000067701

Structurei

3D structure databases

ProteinModelPortaliQ9JM61
SMRiQ9JM61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini339 – 392TSP type-1PROSITE-ProRule annotationAdd BLAST54

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG2S Eukaryota
ENOG410Z44J LUCA
HOGENOMiHOG000230926
HOVERGENiHBG079998
InParanoidiQ9JM61
PhylomeDBiQ9JM61
TreeFamiTF333148

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR038877 THSD1
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PANTHERiPTHR16311 PTHR16311, 1 hit
PfamiView protein in Pfam
PF00090 TSP_1, 1 hit
SMARTiView protein in SMART
SM00209 TSP1, 1 hit
SUPFAMiSSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS50092 TSP1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9JM61-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPMLKDFSN LLLVVLCDYV LGEAEYLLLQ EPVHVALSDR TVSVGFHYLS
60 70 80 90 100
DVNGTLRNVS VMLWEANTNR TLTTKYLLTN QAQGTLQFEC FYFKEAGDYW
110 120 130 140 150
FVMIPEVTDN GTQVPLWEKS AFLKVEWPVF HIDLNRTAKA AEGTFQVGVF
160 170 180 190 200
TTQPLCLFPV DKPDMLVDVI FTDRLPEARA SLGQPLEIRA SKRTKLTQGQ
210 220 230 240 250
WVEFGCAPVG VEAYVTVMLR LLGQDSVIAS TGPIDLAQKF GYKLMMAPEV
260 270 280 290 300
TCESVLEVMV LPPPCVFVQG VLAVYKEAPK RPEERTFQVA ENRLPLGERR
310 320 330 340 350
TVFNCTLFDV GKNKYCFNFG IVKKGHFSAK ECMLIQRNIE TWGPWQPWSP
360 370 380 390 400
CSTTCGDAVR ERRRLCVTSF PSRPSCSGMS SETSPCSLEE CAVFRPPGPS
410 420 430 440 450
PVSPQDPVKS NNVVTVTGIS LCLFIIFATV LITLWRRFGR APKCSTPVRH
460 470 480 490 500
NSIHSPGFRK NSDEENICEL SEPRGSFSDA GDGPRGSPGD TGIPLTYRCS
510 520 530 540 550
ASAPPEDEAS GSESFQSNAQ KIIPPLFSYR LAQQQLKEMK KKGLTETTKV
560 570 580 590 600
YHVSQSPLTD TVVDATASPP LDLECPEEAA ASKFRIKSPF LDQPGAGTGE
610 620 630 640 650
RPPSRLDGIV PPPGCAVSPS QTLIQKSQIR STGGRDGSSE RCHSRSSLFR
660 670 680 690 700
RTASFHETKQ SRPFRERSLS ALTPRQVPAY SSRMRTWDQM EDRCRPPSRS
710 720 730 740 750
THLLPERPEH FQGAGRTSSP LGPLSKSYTV GHPRRKPDPG DRQAGLVAGA
760 770 780 790 800
EKMEPHRAHR GPSPSHRSAS RKQSSPIFLK DSYQKVSQLS PSHFRKDKCQ
810 820 830 840 850
SFPIHPEFAF YDNTSFRLTE AEQRMLDLPG YFGSNEEDET TSTLSVEKLV

I
Length:851
Mass (Da):94,696
Last modified:October 3, 2006 - v2
Checksum:i2D157E7253FE902D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0U4A0A0R4J0U4_MOUSE
Thrombospondin type-1 domain-contai...
Thsd1 mCG_6962
851Annotation score:
G3XA27G3XA27_MOUSE
Thrombospondin type-1 domain-contai...
Thsd1 mCG_6962
798Annotation score:
A0A1B0GT60A0A1B0GT60_MOUSE
Thrombospondin type-1 domain-contai...
Thsd1 mCG_6962
790Annotation score:

Sequence cautioni

The sequence BAC33850 differs from that shown. Reason: Frameshift at position 744.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti625Q → R in BAA92685 (Ref. 1) Curated1
Sequence conflicti625Q → R in AAI19604 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039946 mRNA Translation: BAA92685.1
AK049636 mRNA Translation: BAC33850.1 Frameshift.
BC119603 mRNA Translation: AAI19604.1
CCDSiCCDS22172.1
RefSeqiNP_062522.1, NM_019576.2
XP_006509236.1, XM_006509173.3
XP_006509237.1, XM_006509174.3
UniGeneiMm.32067

Genome annotation databases

GeneIDi56229
KEGGimmu:56229
UCSCiuc009lcv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039946 mRNA Translation: BAA92685.1
AK049636 mRNA Translation: BAC33850.1 Frameshift.
BC119603 mRNA Translation: AAI19604.1
CCDSiCCDS22172.1
RefSeqiNP_062522.1, NM_019576.2
XP_006509236.1, XM_006509173.3
XP_006509237.1, XM_006509174.3
UniGeneiMm.32067

3D structure databases

ProteinModelPortaliQ9JM61
SMRiQ9JM61
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JM61, 1 interactor
MINTiQ9JM61
STRINGi10090.ENSMUSP00000067701

PTM databases

iPTMnetiQ9JM61
PhosphoSitePlusiQ9JM61

Proteomic databases

PaxDbiQ9JM61
PRIDEiQ9JM61

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56229
KEGGimmu:56229
UCSCiuc009lcv.2 mouse

Organism-specific databases

CTDi55901
MGIiMGI:1929096 Thsd1

Phylogenomic databases

eggNOGiENOG410IG2S Eukaryota
ENOG410Z44J LUCA
HOGENOMiHOG000230926
HOVERGENiHBG079998
InParanoidiQ9JM61
PhylomeDBiQ9JM61
TreeFamiTF333148

Miscellaneous databases

PROiPR:Q9JM61
SOURCEiSearch...

Gene expression databases

CleanExiMM_THSD1

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR038877 THSD1
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PANTHERiPTHR16311 PTHR16311, 1 hit
PfamiView protein in Pfam
PF00090 TSP_1, 1 hit
SMARTiView protein in SMART
SM00209 TSP1, 1 hit
SUPFAMiSSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS50092 TSP1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTHSD1_MOUSE
AccessioniPrimary (citable) accession number: Q9JM61
Secondary accession number(s): Q8C7Q9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: June 20, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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