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Protein

Cytokine receptor-like factor 1

Gene

Crlf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development (By similarity). Plays an essential role in the initiation and/or maintenance of suckling in neonatal mice.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-6788467 IL-6-type cytokine receptor ligand interactions
R-MMU-9020956 Interleukin-27 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine receptor-like factor 1
Alternative name(s):
Cytokine receptor-like molecule 3
Short name:
CRLM-3
Cytokine-like factor 1
Short name:
CLF-1
Novel cytokine receptor 6
Short name:
NR6
Gene namesi
Name:Crlf1
Synonyms:Crlm3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1340030 Crlf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000001104034 – 425Cytokine receptor-like factor 1Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 156By similarity
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi187 ↔ 198By similarity
Modified residuei222Phosphoserine1 Publication1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi385N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9JM58
PaxDbiQ9JM58
PeptideAtlasiQ9JM58
PRIDEiQ9JM58

PTM databases

iPTMnetiQ9JM58
PhosphoSitePlusiQ9JM58

Expressioni

Tissue specificityi

Widely expressed in the embryo. Not detected in the brain of adult mice.1 Publication

Gene expression databases

BgeeiENSMUSG00000007888 Expressed in 177 organ(s), highest expression level in metanephric ureteric bud
CleanExiMM_CRLF1
ExpressionAtlasiQ9JM58 baseline and differential
GenevisibleiQ9JM58 MM

Interactioni

Subunit structurei

Forms covalently linked di- and tetramers. Forms a heteromeric complex with cardiotrophin-like cytokine (CLC); the CRLF1/CLC complex is a ligand for the ciliary neurotrophic factor receptor (CNTFR) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9JM58, 1 interactor
MINTiQ9JM58
STRINGi10090.ENSMUSP00000008032

Structurei

3D structure databases

ProteinModelPortaliQ9JM58
SMRiQ9JM58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 134Ig-like C2-typeAdd BLAST100
Domaini140 – 235Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini240 – 344Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST105

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi330 – 334WSXWS motif5

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IV7Y Eukaryota
ENOG410Z87J LUCA
GeneTreeiENSGT00530000063112
HOGENOMiHOG000111972
HOVERGENiHBG051119
InParanoidiQ9JM58
OMAiHKTRNQA
OrthoDBiEOG091G07OT
PhylomeDBiQ9JM58
TreeFamiTF106501

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR015152 Growth/epo_recpt_lig-bind
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF09067 EpoR_lig-bind, 1 hit
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9JM58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAGRPGPVA QSARRPPRPL SSLWSPLLLC VLGVPRGGSG AHTAVISPQD
60 70 80 90 100
PTLLIGSSLQ ATCSIHGDTP GATAEGLYWT LNGRRLPSEL SRLLNTSTLA
110 120 130 140 150
LALANLNGSR QQSGDNLVCH ARDGSILAGS CLYVGLPPEK PFNISCWSRN
160 170 180 190 200
MKDLTCRWTP GAHGETFLHT NYSLKYKLRW YGQDNTCEEY HTVGPHSCHI
210 220 230 240 250
PKDLALFTPY EIWVEATNRL GSARSDVLTL DVLDVVTTDP PPDVHVSRVG
260 270 280 290 300
GLEDQLSVRW VSPPALKDFL FQAKYQIRYR VEDSVDWKVV DDVSNQTSCR
310 320 330 340 350
LAGLKPGTVY FVQVRCNPFG IYGSKKAGIW SEWSHPTAAS TPRSERPGPG
360 370 380 390 400
GGVCEPRGGE PSSGPVRREL KQFLGWLKKH AYCSNLSFRL YDQWRAWMQK
410 420
SHKTRNQDEG ILPSGRRGAA RGPAG
Length:425
Mass (Da):46,662
Last modified:October 1, 2000 - v1
Checksum:i910535C629CA7056
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RP70F6RP70_MOUSE
Cytokine receptor-like factor 1
Crlf1
129Annotation score:
F6T1W4F6T1W4_MOUSE
Cytokine receptor-like factor 1
Crlf1
118Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040038 mRNA Translation: BAA92777.1
CCDSiCCDS22369.1
RefSeqiNP_061297.1, NM_018827.3
UniGeneiMm.335584

Genome annotation databases

EnsembliENSMUST00000008032; ENSMUSP00000008032; ENSMUSG00000007888
GeneIDi12931
KEGGimmu:12931
UCSCiuc009maj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040038 mRNA Translation: BAA92777.1
CCDSiCCDS22369.1
RefSeqiNP_061297.1, NM_018827.3
UniGeneiMm.335584

3D structure databases

ProteinModelPortaliQ9JM58
SMRiQ9JM58
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JM58, 1 interactor
MINTiQ9JM58
STRINGi10090.ENSMUSP00000008032

PTM databases

iPTMnetiQ9JM58
PhosphoSitePlusiQ9JM58

Proteomic databases

MaxQBiQ9JM58
PaxDbiQ9JM58
PeptideAtlasiQ9JM58
PRIDEiQ9JM58

Protocols and materials databases

DNASUi12931
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008032; ENSMUSP00000008032; ENSMUSG00000007888
GeneIDi12931
KEGGimmu:12931
UCSCiuc009maj.1 mouse

Organism-specific databases

CTDi9244
MGIiMGI:1340030 Crlf1

Phylogenomic databases

eggNOGiENOG410IV7Y Eukaryota
ENOG410Z87J LUCA
GeneTreeiENSGT00530000063112
HOGENOMiHOG000111972
HOVERGENiHBG051119
InParanoidiQ9JM58
OMAiHKTRNQA
OrthoDBiEOG091G07OT
PhylomeDBiQ9JM58
TreeFamiTF106501

Enzyme and pathway databases

ReactomeiR-MMU-6788467 IL-6-type cytokine receptor ligand interactions
R-MMU-9020956 Interleukin-27 signaling

Miscellaneous databases

PROiPR:Q9JM58
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007888 Expressed in 177 organ(s), highest expression level in metanephric ureteric bud
CleanExiMM_CRLF1
ExpressionAtlasiQ9JM58 baseline and differential
GenevisibleiQ9JM58 MM

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR015152 Growth/epo_recpt_lig-bind
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF09067 EpoR_lig-bind, 1 hit
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCRLF1_MOUSE
AccessioniPrimary (citable) accession number: Q9JM58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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