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Protein

Protein Tob2

Gene

Tob2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.By similarity

GO - Molecular functioni

  • transcription corepressor activity Source: GO_Central
  • vitamin D receptor binding Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Tob2
Alternative name(s):
Transducer of erbB-2 2
Gene namesi
Name:Tob2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1888525 Tob2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438161 – 345Protein Tob2Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei255PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JM55
MaxQBiQ9JM55
PaxDbiQ9JM55
PRIDEiQ9JM55

PTM databases

iPTMnetiQ9JM55
PhosphoSitePlusiQ9JM55

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000048546 Expressed in 272 organ(s), highest expression level in retina
CleanExiMM_TOB2
ExpressionAtlasiQ9JM55 baseline and differential
GenevisibleiQ9JM55 MM

Interactioni

Subunit structurei

Associates with CAF1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208229, 2 interactors
IntActiQ9JM55, 1 interactor
MINTiQ9JM55
STRINGi10090.ENSMUSP00000061390

Structurei

3D structure databases

ProteinModelPortaliQ9JM55
SMRiQ9JM55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
GeneTreeiENSGT00550000074461
HOVERGENiHBG006617
InParanoidiQ9JM55
KOiK14443
OMAiGHWYPEA
OrthoDBiEOG091G0LEQ
PhylomeDBiQ9JM55
TreeFamiTF105274

Family and domain databases

Gene3Di1.20.120.1120, 1 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR009818 Ataxin-2_C
IPR036054 BTG-like_sf
IPR015676 Tob1/2
IPR015678 Tob2
PANTHERiPTHR17537 PTHR17537, 1 hit
PTHR17537:SF3 PTHR17537:SF3, 1 hit
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PF07145 PAM2, 2 hits
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9JM55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLEIKVALN FIISYLYNKL PRRRADLFGE ELERLLRKKY EGHWYPEKPL
60 70 80 90 100
KGSGFRCVHI GEVVDPVVEL AAKRSGLAVE DVRANVPEEL SVWIDPFEVS
110 120 130 140 150
YQIGEKGVVK VLYLGDSEAS GTPELDKEIK SSFNPDAQVF VPIGSQDSSL
160 170 180 190 200
SSSPSPSFGQ SPSPTFIPRS AQPITFTTAS FAATKFGSTK MKKGGGASGG
210 220 230 240 250
VSVGGSGAGG QQPPPQQPRM ARSPTKNLLK HKSLSLSMHS LNLIPANPAP
260 270 280 290 300
QSQLSPNAKE FVYNGGGSPS LFFDGVEGPS TSTTAPFGSG GASTCNSSSF
310 320 330 340
DVSQVFGGGA NSLFLEKSPF VEGLSYNLNT MQYPNQPFQP VVLAN
Length:345
Mass (Da):36,798
Last modified:October 1, 2000 - v1
Checksum:i6DC28348E68AC976
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8W6W6A0A2R8W6W6_MOUSE
Protein Tob2
Tob2
44Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041225 Genomic DNA Translation: BAA94606.1
BC011163 mRNA Translation: AAH11163.1
CCDSiCCDS27673.1
RefSeqiNP_065253.1, NM_020507.3
UniGeneiMm.323595

Genome annotation databases

EnsembliENSMUST00000050467; ENSMUSP00000061390; ENSMUSG00000048546
GeneIDi57259
KEGGimmu:57259
UCSCiuc007wxm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041225 Genomic DNA Translation: BAA94606.1
BC011163 mRNA Translation: AAH11163.1
CCDSiCCDS27673.1
RefSeqiNP_065253.1, NM_020507.3
UniGeneiMm.323595

3D structure databases

ProteinModelPortaliQ9JM55
SMRiQ9JM55
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208229, 2 interactors
IntActiQ9JM55, 1 interactor
MINTiQ9JM55
STRINGi10090.ENSMUSP00000061390

PTM databases

iPTMnetiQ9JM55
PhosphoSitePlusiQ9JM55

Proteomic databases

EPDiQ9JM55
MaxQBiQ9JM55
PaxDbiQ9JM55
PRIDEiQ9JM55

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050467; ENSMUSP00000061390; ENSMUSG00000048546
GeneIDi57259
KEGGimmu:57259
UCSCiuc007wxm.1 mouse

Organism-specific databases

CTDi10766
MGIiMGI:1888525 Tob2

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
GeneTreeiENSGT00550000074461
HOVERGENiHBG006617
InParanoidiQ9JM55
KOiK14443
OMAiGHWYPEA
OrthoDBiEOG091G0LEQ
PhylomeDBiQ9JM55
TreeFamiTF105274

Miscellaneous databases

PROiPR:Q9JM55
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048546 Expressed in 272 organ(s), highest expression level in retina
CleanExiMM_TOB2
ExpressionAtlasiQ9JM55 baseline and differential
GenevisibleiQ9JM55 MM

Family and domain databases

Gene3Di1.20.120.1120, 1 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR009818 Ataxin-2_C
IPR036054 BTG-like_sf
IPR015676 Tob1/2
IPR015678 Tob2
PANTHERiPTHR17537 PTHR17537, 1 hit
PTHR17537:SF3 PTHR17537:SF3, 1 hit
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PF07145 PAM2, 2 hits
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOB2_MOUSE
AccessioniPrimary (citable) accession number: Q9JM55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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