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Protein

Phorbol-12-myristate-13-acetate-induced protein 1

Gene

Pmaip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1 (By similarity). Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1.By similarity5 Publications

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-111448 Activation of NOXA and translocation to mitochondria
R-MMU-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

Names & Taxonomyi

Protein namesi
Recommended name:
Phorbol-12-myristate-13-acetate-induced protein 1
Alternative name(s):
Protein Noxa
Gene namesi
Name:Pmaip1
Synonyms:Noxa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1930146 Pmaip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi27L → A: Loss of pro-apoptotic activity and of targeting to mitochondria; when associated with A-78. 1 Publication1
Mutagenesisi78L → A: Loss of pro-apoptotic activity and of targeting to mitochondria; when associated with A-27. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003332301 – 103Phorbol-12-myristate-13-acetate-induced protein 1Add BLAST103

Proteomic databases

PaxDbiQ9JM54
PRIDEiQ9JM54

PTM databases

iPTMnetiQ9JM54
PhosphoSitePlusiQ9JM54

Expressioni

Tissue specificityi

Detected in thymocytes after irradiation with X-rays. Not detectable in untreated thymocytes (at protein level). Detected in embryonic neural precursor cells of the telencephalon Constitutively expressed at low levels in adult brain, testis, thymus, spleen, lung and kidney.1 Publication

Inductioni

Up-regulated after exposure to ionizing radiation and other genotoxic agents. Up-regulation is mediated by p53.1 Publication

Gene expression databases

BgeeiENSMUSG00000024521 Expressed in 170 organ(s), highest expression level in forelimb bud
GenevisibleiQ9JM54 MM

Interactioni

Subunit structurei

Interacts with MCL1, BCL2A1 and BAX.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi208439, 2 interactors
ComplexPortaliCPX-305 MCL1:PMAIP1 complex
DIPiDIP-45232N
ELMiQ9JM54
IntActiQ9JM54, 4 interactors
MINTiQ9JM54
STRINGi10090.ENSMUSP00000025399

Structurei

Secondary structure

1103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9JM54
SMRiQ9JM54
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9JM54

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni90 – 99Required for mitochondrial locationBy similarity10

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi27 – 35BH3 19
Motifi78 – 86BH3 29

Domaini

The BH3 motif is essential for pro-apoptotic activity.

Sequence similaritiesi

Belongs to the PMAIP1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J6XT Eukaryota
ENOG4111AWA LUCA
GeneTreeiENSGT00530000065105
HOGENOMiHOG000034021
HOVERGENiHBG095669
InParanoidiQ9JM54
KOiK10131
OMAiADLKDEC
OrthoDBiEOG091G1040
TreeFamiTF339379

Family and domain databases

InterProiView protein in InterPro
IPR024140 Noxa
PANTHERiPTHR14299 PTHR14299, 1 hit
PfamiView protein in Pfam
PF15150 PMAIP1, 2 hits

Sequencei

Sequence statusi: Complete.

Q9JM54-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGRKARRNA PVNPTRAELP PEFAAQLRKI GDKVYCTWSA PDITVVLAQM
60 70 80 90 100
PGKSQKSRMR SPSPTRVPAD LKDECAQLRR IGDKVNLRQK LLNLISKLFN

LVT
Length:103
Mass (Da):11,566
Last modified:October 1, 2000 - v1
Checksum:i9B9A5B04D5535E30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041230 mRNA Translation: BAA95781.1
AK043856 mRNA Translation: BAC31682.1
AK088556 mRNA Translation: BAC40421.1
AK143990 mRNA Translation: BAE25650.1
AK169914 mRNA Translation: BAE41454.1
BC050821 mRNA Translation: AAH50821.1
CCDSiCCDS29315.1
RefSeqiNP_067426.1, NM_021451.2
UniGeneiMm.271878

Genome annotation databases

EnsembliENSMUST00000025399; ENSMUSP00000025399; ENSMUSG00000024521
GeneIDi58801
KEGGimmu:58801
UCSCiuc008fft.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041230 mRNA Translation: BAA95781.1
AK043856 mRNA Translation: BAC31682.1
AK088556 mRNA Translation: BAC40421.1
AK143990 mRNA Translation: BAE25650.1
AK169914 mRNA Translation: BAE41454.1
BC050821 mRNA Translation: AAH50821.1
CCDSiCCDS29315.1
RefSeqiNP_067426.1, NM_021451.2
UniGeneiMm.271878

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JM6NMR-A68-93[»]
2NLAX-ray2.80B68-93[»]
2RODNMR-B17-42[»]
ProteinModelPortaliQ9JM54
SMRiQ9JM54
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208439, 2 interactors
ComplexPortaliCPX-305 MCL1:PMAIP1 complex
DIPiDIP-45232N
ELMiQ9JM54
IntActiQ9JM54, 4 interactors
MINTiQ9JM54
STRINGi10090.ENSMUSP00000025399

PTM databases

iPTMnetiQ9JM54
PhosphoSitePlusiQ9JM54

Proteomic databases

PaxDbiQ9JM54
PRIDEiQ9JM54

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025399; ENSMUSP00000025399; ENSMUSG00000024521
GeneIDi58801
KEGGimmu:58801
UCSCiuc008fft.1 mouse

Organism-specific databases

CTDi5366
MGIiMGI:1930146 Pmaip1

Phylogenomic databases

eggNOGiENOG410J6XT Eukaryota
ENOG4111AWA LUCA
GeneTreeiENSGT00530000065105
HOGENOMiHOG000034021
HOVERGENiHBG095669
InParanoidiQ9JM54
KOiK10131
OMAiADLKDEC
OrthoDBiEOG091G1040
TreeFamiTF339379

Enzyme and pathway databases

ReactomeiR-MMU-111448 Activation of NOXA and translocation to mitochondria
R-MMU-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

Miscellaneous databases

ChiTaRSiPmaip1 mouse
EvolutionaryTraceiQ9JM54
PROiPR:Q9JM54
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024521 Expressed in 170 organ(s), highest expression level in forelimb bud
GenevisibleiQ9JM54 MM

Family and domain databases

InterProiView protein in InterPro
IPR024140 Noxa
PANTHERiPTHR14299 PTHR14299, 1 hit
PfamiView protein in Pfam
PF15150 PMAIP1, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiAPR_MOUSE
AccessioniPrimary (citable) accession number: Q9JM54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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