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Protein

Prostaglandin E synthase

Gene

Ptges

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).By similarity

Catalytic activityi

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.

Cofactori

glutathioneBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei118GlutathioneBy similarity1
Binding sitei127GlutathioneBy similarity1
Binding sitei131GlutathioneBy similarity1
Binding sitei135GlutathioneBy similarity1

GO - Molecular functioni

  • glutathione binding Source: UniProtKB
  • prostaglandin-D synthase activity Source: MGI
  • prostaglandin-E synthase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

Enzyme and pathway databases

BRENDAi5.3.99.3 3474
ReactomeiR-MMU-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E synthase (EC:5.3.99.3)
Short name:
mPGES-1
Alternative name(s):
Microsomal prostaglandin E synthase 1
Gene namesi
Name:Ptges
Synonyms:Pges
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1927593 Ptges

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13LumenalBy similarityAdd BLAST13
Transmembranei14 – 42HelicalBy similarityAdd BLAST29
Topological domaini43 – 61CytoplasmicBy similarityAdd BLAST19
Transmembranei62 – 91HelicalBy similarityAdd BLAST30
Topological domaini92 – 96LumenalBy similarity5
Transmembranei97 – 120HelicalBy similarityAdd BLAST24
Topological domaini121 – 124CytoplasmicBy similarity4
Transmembranei125 – 153HelicalBy similarityAdd BLAST29

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2046261

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002177471 – 153Prostaglandin E synthaseAdd BLAST153

Proteomic databases

MaxQBiQ9JM51
PaxDbiQ9JM51
PRIDEiQ9JM51

PTM databases

iPTMnetiQ9JM51
PhosphoSitePlusiQ9JM51

Expressioni

Gene expression databases

BgeeiENSMUSG00000050737 Expressed in 147 organ(s), highest expression level in decidua
CleanExiMM_PTGES
GenevisibleiQ9JM51 MM

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi211054, 1 interactor
STRINGi10090.ENSMUSP00000099916

Structurei

3D structure databases

ProteinModelPortaliQ9JM51
SMRiQ9JM51
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 39Glutathione bindingBy similarityAdd BLAST11
Regioni71 – 78Glutathione bindingBy similarity8
Regioni111 – 114Glutathione bindingBy similarity4

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY81 Eukaryota
ENOG4111VJG LUCA
GeneTreeiENSGT00390000011980
HOGENOMiHOG000231759
HOVERGENiHBG052470
InParanoidiQ9JM51
KOiK15729
OMAiCFSMALQ
OrthoDBiEOG091G14I4
PhylomeDBiQ9JM51
TreeFamiTF105327

Family and domain databases

Gene3Di1.20.120.550, 1 hit
InterProiView protein in InterPro
IPR023352 MAPEG-like_dom_sf
IPR001129 Membr-assoc_MAPEG
PfamiView protein in Pfam
PF01124 MAPEG, 1 hit
SUPFAMiSSF161084 SSF161084, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JM51-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSPGLVMES GQVLPAFLLC STLLVIKMYA VAVITGQMRL RKKAFANPED
60 70 80 90 100
ALKRGGLQYY RSDPDVERCL RAHRNDMETI YPFLFLGFVY SFLGPNPLIA
110 120 130 140 150
WIHFLVVLTG RVVHTVAYLG KLNPRLRSGA YVLAQFSCFS MALQILWEVA

HHL
Length:153
Mass (Da):17,286
Last modified:October 1, 2000 - v1
Checksum:i08A1AF2D288D53F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041997 mRNA Translation: BAA96083.1
AB035323 mRNA Translation: BAB71813.1
AK010757 mRNA Translation: BAB27163.1
AK033752 mRNA Translation: BAC28463.1
AK172621 mRNA Translation: BAE43099.1
BC024960 mRNA Translation: AAH24960.1
CCDSiCCDS15889.1
RefSeqiNP_071860.1, NM_022415.3
UniGeneiMm.28768

Genome annotation databases

EnsembliENSMUST00000102852; ENSMUSP00000099916; ENSMUSG00000050737
GeneIDi64292
KEGGimmu:64292
UCSCiuc008jcz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041997 mRNA Translation: BAA96083.1
AB035323 mRNA Translation: BAB71813.1
AK010757 mRNA Translation: BAB27163.1
AK033752 mRNA Translation: BAC28463.1
AK172621 mRNA Translation: BAE43099.1
BC024960 mRNA Translation: AAH24960.1
CCDSiCCDS15889.1
RefSeqiNP_071860.1, NM_022415.3
UniGeneiMm.28768

3D structure databases

ProteinModelPortaliQ9JM51
SMRiQ9JM51
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211054, 1 interactor
STRINGi10090.ENSMUSP00000099916

Chemistry databases

ChEMBLiCHEMBL2046261

PTM databases

iPTMnetiQ9JM51
PhosphoSitePlusiQ9JM51

Proteomic databases

MaxQBiQ9JM51
PaxDbiQ9JM51
PRIDEiQ9JM51

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102852; ENSMUSP00000099916; ENSMUSG00000050737
GeneIDi64292
KEGGimmu:64292
UCSCiuc008jcz.1 mouse

Organism-specific databases

CTDi9536
MGIiMGI:1927593 Ptges

Phylogenomic databases

eggNOGiENOG410IY81 Eukaryota
ENOG4111VJG LUCA
GeneTreeiENSGT00390000011980
HOGENOMiHOG000231759
HOVERGENiHBG052470
InParanoidiQ9JM51
KOiK15729
OMAiCFSMALQ
OrthoDBiEOG091G14I4
PhylomeDBiQ9JM51
TreeFamiTF105327

Enzyme and pathway databases

BRENDAi5.3.99.3 3474
ReactomeiR-MMU-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Miscellaneous databases

ChiTaRSiPtges3 mouse
PROiPR:Q9JM51
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050737 Expressed in 147 organ(s), highest expression level in decidua
CleanExiMM_PTGES
GenevisibleiQ9JM51 MM

Family and domain databases

Gene3Di1.20.120.550, 1 hit
InterProiView protein in InterPro
IPR023352 MAPEG-like_dom_sf
IPR001129 Membr-assoc_MAPEG
PfamiView protein in Pfam
PF01124 MAPEG, 1 hit
SUPFAMiSSF161084 SSF161084, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTGES_MOUSE
AccessioniPrimary (citable) accession number: Q9JM51
Secondary accession number(s): Q3T9C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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