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Protein

Hypermethylated in cancer 2 protein

Gene

Hic2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri446 – 468C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: GO_Central

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Hypermethylated in cancer 2 protein
Short name:
Hic-2
Gene namesi
Name:Hic2
Synonyms:Kiaa1020
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1929869 Hic2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000469461 – 619Hypermethylated in cancer 2 proteinAdd BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei166PhosphoserineBy similarity1
Modified residuei169PhosphoserineBy similarity1
Modified residuei197PhosphoserineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei416PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JLZ6
PaxDbiQ9JLZ6
PeptideAtlasiQ9JLZ6
PRIDEiQ9JLZ6

PTM databases

iPTMnetiQ9JLZ6
PhosphoSitePlusiQ9JLZ6
SwissPalmiQ9JLZ6

Expressioni

Gene expression databases

BgeeiENSMUSG00000050240 Expressed in 192 organ(s), highest expression level in ear vesicle
CleanExiMM_HIC2
GenevisibleiQ9JLZ6 MM

Interactioni

Subunit structurei

Self-associates. Interacts with HIC1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208374, 1 interactor
IntActiQ9JLZ6, 1 interactor
MINTiQ9JLZ6
STRINGi10090.ENSMUSP00000087656

Structurei

3D structure databases

ProteinModelPortaliQ9JLZ6
SMRiQ9JLZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 109BTBPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni247 – 249Binding to CtBPBy similarity3

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri446 – 468C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150995
HOGENOMiHOG000026793
HOVERGENiHBG079492
InParanoidiQ9JLZ6
OMAiEGAEDNH
OrthoDBiEOG091G054Q
TreeFamiTF333488

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9JLZ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVSGPLALRW CPWAGHRDMG PDMELPSHSK QLLLQLNQQR AKGFLCDVII
60 70 80 90 100
MVENSIFRAH KNVLAASSIY FKSLVLHDNL INLDTDMVSS TVFQQILDFI
110 120 130 140 150
YTGKLLPSDQ PSEPNFSTLL TAASYLQLPE LAALCRRKLK RAGKPFGPGR
160 170 180 190 200
VGTAGIGRPT RSQRLSTASV IQARFPGLVD VRKGHPAPQE LPQAKGSDDE
210 220 230 240 250
LFLGTSTQES THGLGLGGPA GGEMGLGGCS TSTNGSSGGC EQELGLDLSK
260 270 280 290 300
KSPPLPPTTP GPHLTPEDPA QLSDSQRESP APTSTSALPV GNSASFVELG
310 320 330 340 350
ATPEEPMDVE GAEENHLSLL EGQGGQPRKS LRHSARKKDW NKKEPVAGSP
360 370 380 390 400
FDRRETGSKG SCPGEEGEGT GDRVPNGVLA SSAGGGGPSA SYGEQSFPCK
410 420 430 440 450
EEEENGKDGS EDSGQSGSEG GSGHTGAHYV YRQEGYETVS YGDNVYVCIP
460 470 480 490 500
CAKGFPSSEQ LNAHVETHTE EELFIKEEGA YETGSGGAEE EAEDLSTPSA
510 520 530 540 550
AYTADSRPFK CSVCEKTYKD PATLRQHEKT HWLTRPFPCN ICGKMFTQRG
560 570 580 590 600
TMTRHMRSHL GLKPFACDEC GMRFTRQYRL TEHMRVHSGE KPYECQLCGG
610
KFTQQRNLIS HLRMHTSPS
Length:619
Mass (Da):66,766
Last modified:June 28, 2011 - v4
Checksum:iAA7E58CC3BA8AB39
GO
Isoform 2 (identifier: Q9JLZ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     544-619: KMFTQRGTMT...SHLRMHTSPS → SEPTPSCPLQSSGMSGNLQQSQR

Note: No experimental confirmation available.
Show »
Length:566
Mass (Da):60,187
Checksum:i7E7110E46948CAF7
GO

Sequence cautioni

The sequence BAC98076 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI30631 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti354 – 355RE → AA in AAF28801 (Ref. 5) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010499544 – 619KMFTQ…HTSPS → SEPTPSCPLQSSGMSGNLQQ SQR in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ868292 mRNA Translation: CAI30631.1 Sequence problems.
AK084975 mRNA Translation: BAC39326.1
AK145386 mRNA Translation: BAE26404.1
AK156332 mRNA Translation: BAE33679.1
AK157276 mRNA Translation: BAE34025.1
AK129266 mRNA Translation: BAC98076.1 Different initiation.
BC065124 mRNA Translation: AAH65124.1
AF117382 mRNA Translation: AAF28801.1
CCDSiCCDS27999.1 [Q9JLZ6-1]
RefSeqiNP_849253.2, NM_178922.3 [Q9JLZ6-1]
UniGeneiMm.261602
Mm.470636

Genome annotation databases

EnsembliENSMUST00000090190; ENSMUSP00000087656; ENSMUSG00000050240 [Q9JLZ6-1]
ENSMUST00000232082; ENSMUSP00000156293; ENSMUSG00000050240 [Q9JLZ6-2]
GeneIDi58180
KEGGimmu:58180
UCSCiuc007yko.1 mouse [Q9JLZ6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ868292 mRNA Translation: CAI30631.1 Sequence problems.
AK084975 mRNA Translation: BAC39326.1
AK145386 mRNA Translation: BAE26404.1
AK156332 mRNA Translation: BAE33679.1
AK157276 mRNA Translation: BAE34025.1
AK129266 mRNA Translation: BAC98076.1 Different initiation.
BC065124 mRNA Translation: AAH65124.1
AF117382 mRNA Translation: AAF28801.1
CCDSiCCDS27999.1 [Q9JLZ6-1]
RefSeqiNP_849253.2, NM_178922.3 [Q9JLZ6-1]
UniGeneiMm.261602
Mm.470636

3D structure databases

ProteinModelPortaliQ9JLZ6
SMRiQ9JLZ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208374, 1 interactor
IntActiQ9JLZ6, 1 interactor
MINTiQ9JLZ6
STRINGi10090.ENSMUSP00000087656

PTM databases

iPTMnetiQ9JLZ6
PhosphoSitePlusiQ9JLZ6
SwissPalmiQ9JLZ6

Proteomic databases

EPDiQ9JLZ6
PaxDbiQ9JLZ6
PeptideAtlasiQ9JLZ6
PRIDEiQ9JLZ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090190; ENSMUSP00000087656; ENSMUSG00000050240 [Q9JLZ6-1]
ENSMUST00000232082; ENSMUSP00000156293; ENSMUSG00000050240 [Q9JLZ6-2]
GeneIDi58180
KEGGimmu:58180
UCSCiuc007yko.1 mouse [Q9JLZ6-1]

Organism-specific databases

CTDi23119
MGIiMGI:1929869 Hic2
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150995
HOGENOMiHOG000026793
HOVERGENiHBG079492
InParanoidiQ9JLZ6
OMAiEGAEDNH
OrthoDBiEOG091G054Q
TreeFamiTF333488

Miscellaneous databases

ChiTaRSiHic2 mouse
PROiPR:Q9JLZ6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050240 Expressed in 192 organ(s), highest expression level in ear vesicle
CleanExiMM_HIC2
GenevisibleiQ9JLZ6 MM

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHIC2_MOUSE
AccessioniPrimary (citable) accession number: Q9JLZ6
Secondary accession number(s): Q3U030
, Q3ULP4, Q5K036, Q8BSZ9, Q8C3T5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: June 28, 2011
Last modified: November 7, 2018
This is version 158 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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