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Protein

Suppressor of cytokine signaling 6

Gene

Socs6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity).By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • 1-phosphatidylinositol-3-kinase regulator activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 6
Short name:
SOCS-6
Alternative name(s):
Cytokine-inducible SH2 protein 4
Short name:
CIS-4
Suppressor of cytokine signaling 4
Short name:
SOCS-4
Gene namesi
Name:Socs6
Synonyms:Cis4, Cish4, Socs4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1924885 Socs6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001812521 – 533Suppressor of cytokine signaling 6Add BLAST533

Proteomic databases

MaxQBiQ9JLY0
PaxDbiQ9JLY0
PeptideAtlasiQ9JLY0
PRIDEiQ9JLY0

PTM databases

iPTMnetiQ9JLY0
PhosphoSitePlusiQ9JLY0

Expressioni

Gene expression databases

BgeeiENSMUSG00000056153 Expressed in 270 organ(s), highest expression level in pineal body
CleanExiMM_SOCS4
MM_SOCS6
ExpressionAtlasiQ9JLY0 baseline and differential
GenevisibleiQ9JLY0 MM

Interactioni

Subunit structurei

Interacts with KIT (phosphorylated) (By similarity). Interacts with RBCK1. Interacts with phosphorylated IRS4. Interacts with PIM3.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RBCK1Q9BYM85EBI-8500205,EBI-2340624From Homo sapiens.

Protein-protein interaction databases

BioGridi207682, 8 interactors
IntActiQ9JLY0, 3 interactors
MINTiQ9JLY0
STRINGi10090.ENSMUSP00000064929

Structurei

3D structure databases

ProteinModelPortaliQ9JLY0
SMRiQ9JLY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini382 – 489SH2PROSITE-ProRule annotationAdd BLAST108
Domaini484 – 533SOCS boxPROSITE-ProRule annotationAdd BLAST50

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000027792
HOVERGENiHBG057479
InParanoidiQ9JLY0
KOiK04699
OMAiTMPLDEG
OrthoDBiEOG091G0EP6
TreeFamiTF321368

Family and domain databases

CDDicd10387 SH2_SOCS6, 1 hit
cd03740 SOCS_SOCS6, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR028421 SOCS6
IPR035865 SOCS6_SH2
IPR037345 SOCS6_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44562 PTHR44562, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9JLY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKISLKTFR KSFNLSKSKD ETEFMVVQPQ SLAGDFVKDD SLFGSCYGKD
60 70 80 90 100
MASCDIGSED EKGKNRSKSE SLMGTLKRRL SAKQKTKGKG GTASTDEDTF
110 120 130 140 150
SSASAPGGLK DVRAPRPIRS TSLRSHHYSP TPWPLRPTSS EETCIKMEMR
160 170 180 190 200
VKALVHAASP GPVNGVRKDL RELQPRELRD LQPEPRPESR CSPSSPGDLS
210 220 230 240 250
LHLEEHVPVV IGLMSQDYLQ YTVPLDDGMC PLEGPRSCCL DTSSPMEVSA
260 270 280 290 300
VPLPGASGAF SEDDSHVDQD LVVGPEILVD SSVNNLLIGT TGVMLQSPRG
310 320 330 340 350
GHDDAPPLSP LLPPMQNNPI QRNFSGLSGP DLHMAESVRC HLNFDPNSAP
360 370 380 390 400
GVARVYDSVQ SSGPMVVTSL TEELKKLAKQ GWYWGPITRW EAEGKLANVP
410 420 430 440 450
DGSFLVRDSS DDRYLLSLSF RSHGKTLHTR IEHSNGRFSF YEQPDVEGHT
460 470 480 490 500
SIVDLIEHSI RDSENGAFCY SRSRLPGSAT YPVRLTNPVS RFMQVRSLQY
510 520 530
LCRFVIRQYT RIDLIQKLPL PNKMKDYLQE KHY
Length:533
Mass (Da):59,077
Last modified:July 27, 2011 - v2
Checksum:iF779C6519DB0A17B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z776D3Z776_MOUSE
Suppressor of cytokine-signaling 6
Socs6
180Annotation score:
A0A1C7ZMY9A0A1C7ZMY9_MOUSE
Suppressor of cytokine-signaling 6
Socs6
8Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10R → T in AAF28872 (Ref. 1) Curated1
Sequence conflicti92T → S in AAF28872 (Ref. 1) Curated1
Sequence conflicti149 – 152MRVK → IASE in AAF28872 (Ref. 1) Curated4
Sequence conflicti308L → I in BAB31956 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121907 mRNA Translation: AAF28872.1
AK019993 mRNA Translation: BAB31956.1
AK028665 mRNA Translation: BAC26055.1
AK028701 mRNA Translation: BAC26074.1
AK031164 mRNA Translation: BAC27287.1
AK044946 mRNA Translation: BAC32154.1
AK142069 mRNA Translation: BAE24930.1
AK156591 mRNA Translation: BAE33770.1
CH466632 Genomic DNA Translation: EDL00645.1
CH466632 Genomic DNA Translation: EDL00646.1
BC017597 mRNA Translation: AAH17597.1
BC094443 mRNA Translation: AAH94443.1
CCDSiCCDS29389.1
RefSeqiNP_061291.2, NM_018821.4
XP_006526576.1, XM_006526513.2
XP_011245391.1, XM_011247089.1
XP_011245392.1, XM_011247090.2
UniGeneiMm.476577
Mm.91920

Genome annotation databases

EnsembliENSMUST00000070116; ENSMUSP00000064929; ENSMUSG00000056153
ENSMUST00000123826; ENSMUSP00000114993; ENSMUSG00000056153
ENSMUST00000125362; ENSMUSP00000118764; ENSMUSG00000056153
GeneIDi54607
KEGGimmu:54607
UCSCiuc008fvf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121907 mRNA Translation: AAF28872.1
AK019993 mRNA Translation: BAB31956.1
AK028665 mRNA Translation: BAC26055.1
AK028701 mRNA Translation: BAC26074.1
AK031164 mRNA Translation: BAC27287.1
AK044946 mRNA Translation: BAC32154.1
AK142069 mRNA Translation: BAE24930.1
AK156591 mRNA Translation: BAE33770.1
CH466632 Genomic DNA Translation: EDL00645.1
CH466632 Genomic DNA Translation: EDL00646.1
BC017597 mRNA Translation: AAH17597.1
BC094443 mRNA Translation: AAH94443.1
CCDSiCCDS29389.1
RefSeqiNP_061291.2, NM_018821.4
XP_006526576.1, XM_006526513.2
XP_011245391.1, XM_011247089.1
XP_011245392.1, XM_011247090.2
UniGeneiMm.476577
Mm.91920

3D structure databases

ProteinModelPortaliQ9JLY0
SMRiQ9JLY0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207682, 8 interactors
IntActiQ9JLY0, 3 interactors
MINTiQ9JLY0
STRINGi10090.ENSMUSP00000064929

PTM databases

iPTMnetiQ9JLY0
PhosphoSitePlusiQ9JLY0

Proteomic databases

MaxQBiQ9JLY0
PaxDbiQ9JLY0
PeptideAtlasiQ9JLY0
PRIDEiQ9JLY0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070116; ENSMUSP00000064929; ENSMUSG00000056153
ENSMUST00000123826; ENSMUSP00000114993; ENSMUSG00000056153
ENSMUST00000125362; ENSMUSP00000118764; ENSMUSG00000056153
GeneIDi54607
KEGGimmu:54607
UCSCiuc008fvf.1 mouse

Organism-specific databases

CTDi9306
MGIiMGI:1924885 Socs6

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000027792
HOVERGENiHBG057479
InParanoidiQ9JLY0
KOiK04699
OMAiTMPLDEG
OrthoDBiEOG091G0EP6
TreeFamiTF321368

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8951664 Neddylation

Miscellaneous databases

PROiPR:Q9JLY0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056153 Expressed in 270 organ(s), highest expression level in pineal body
CleanExiMM_SOCS4
MM_SOCS6
ExpressionAtlasiQ9JLY0 baseline and differential
GenevisibleiQ9JLY0 MM

Family and domain databases

CDDicd10387 SH2_SOCS6, 1 hit
cd03740 SOCS_SOCS6, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR028421 SOCS6
IPR035865 SOCS6_SH2
IPR037345 SOCS6_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44562 PTHR44562, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOCS6_MOUSE
AccessioniPrimary (citable) accession number: Q9JLY0
Secondary accession number(s): Q8VEN5, Q9D2A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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