Tcf23

Functionⁱ

Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. May be involved in the regulation or modulation of smooth muscle contraction of the uterus during pregnancy and particularly around the time of delivery. Seems to play a role in the inhibition of myogenesis.1 Publication

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
decidualization
Source: MGI
Inferred from sequence orthologyⁱ
- 24571987
muscle organ development Source: UniProtKB-KW
positive regulation of gene expression
Source: MGI
Inferred from sequence orthologyⁱ
- 24571987

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Differentiation, Myogenesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor 23 Short name: TCF-23 Alternative name(s): Basic helix-loop-helix transcription factor OUT Ovary, uterus and testis protein
Gene namesⁱ	Name:Tcf23 Synonyms:Out
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:1934960 Tcf23

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000315821	1 – 209	Transcription factor 23Add BLAST		209

Proteomic databases

PaxDbⁱ	Q9JLR5
PRIDEⁱ	Q9JLR5

PTM databases

iPTMnetⁱ	Q9JLR5
PhosphoSitePlusⁱ	Q9JLR5

Expressionⁱ

Tissue specificityⁱ

Highly expressed in the uterus (predominantly in myometrium), ovary, and testis. Expression in the uterus is higher in the diestrus phase than in the estrus phase and reaches a maximum at 7.5 dpc. Expression declines towards the time of delivery and returns to the non-pregnant level 4 days after delivery. Low expression seen in lung, heart, intestine, and spleen.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000006642 Expressed in 111 organ(s), highest expression level in uterus
CleanExⁱ	MM_TCF23
Genevisibleⁱ	Q9JLR5 MM

Interactionⁱ

Subunit structureⁱ

Forms inactive heterodimeric complex with TCF3.1 Publication

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000006818

STRINGⁱ

10090.ENSMUSP00000006818

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9JLR5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	75 – 127	bHLHPROSITE-ProRule annotationAdd BLAST		53

Domainⁱ

Both the bHLH region and the C-terminal portion are essential for inhibitory function.

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00710000106684
HOGENOMⁱ	HOG000154520
HOVERGENⁱ	HBG096612
InParanoidⁱ	Q9JLR5
OMAⁱ	RTRQDLW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MGD
PhylomeDBⁱ	Q9JLR5
TreeFamⁱ	TF350742

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9JLR5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSQEATEAPA MPGEGHGHNK AKARWLLGTD RKRSRINRTR QDLWEDTSWS 
        60         70         80         90        100
NHRLSRATSA PRGTRARGTA HGRSEASPEN AARERTRVKT LRQAFLALQA 
       110        120        130        140        150
ALPAVPPDTK LSKLDVLVLA TSYIAHLTRT LGHELPGPAW PPFVRGLRYL 
       160        170        180        190        200
HPLKKWPMRS RLYAGGLGCS DLDSTTAITT GQRCKDAELG SQDSVAAESL 

LTSPAFGNK

Length:209

Mass (Da):22,895

Last modified:October 1, 2000 - v1

Checksum:ⁱ611E3878DE92446A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB059397 Genomic DNA Translation: BAB69473.1 AF142405 mRNA Translation: AAF31168.1 AK030277 mRNA Translation: BAC26873.1 AK030297 mRNA Translation: BAC26885.1 BC119346 mRNA Translation: AAI19347.1 BC120609 mRNA Translation: AAI20610.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19168.1
NCBI Reference Sequences More...RefSeqⁱ	NP_444315.1, NM_053085.2
UniGeneⁱ	Mm.57874

Genome annotation databases

Ensemblⁱ	ENSMUST00000006818; ENSMUSP00000006818; ENSMUSG00000006642
GeneIDⁱ	69852
KEGGⁱ	mmu:69852
UCSC genome browser More...UCSCⁱ	uc008wws.1 mouse

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9JLR5	transcription factor 23		MESAU		208	UniRef50_Q9JLR5
transcription factor 23		TARSY		217
transcription factor 23		Enhydra lutris kenyoni		216
transcription factor 23		ERIEU		208
Transcription factor 23		CAMFR		198
+16

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB059397 Genomic DNA Translation: BAB69473.1 AF142405 mRNA Translation: AAF31168.1 AK030277 mRNA Translation: BAC26873.1 AK030297 mRNA Translation: BAC26885.1 BC119346 mRNA Translation: AAI19347.1 BC120609 mRNA Translation: AAI20610.1
CCDSⁱ	CCDS19168.1
RefSeqⁱ	NP_444315.1, NM_053085.2
UniGeneⁱ	Mm.57874

3D structure databases

ProteinModelPortalⁱ	Q9JLR5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000006818

STRINGⁱ

10090.ENSMUSP00000006818

PTM databases

iPTMnetⁱ	Q9JLR5
PhosphoSitePlusⁱ	Q9JLR5

Proteomic databases

PaxDbⁱ	Q9JLR5
PRIDEⁱ	Q9JLR5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000006818; ENSMUSP00000006818; ENSMUSG00000006642
GeneIDⁱ	69852
KEGGⁱ	mmu:69852
UCSCⁱ	uc008wws.1 mouse

Organism-specific databases

CTDⁱ	150921
MGIⁱ	MGI:1934960 Tcf23

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
GeneTreeⁱ	ENSGT00710000106684
HOGENOMⁱ	HOG000154520
HOVERGENⁱ	HBG096612
InParanoidⁱ	Q9JLR5
OMAⁱ	RTRQDLW
OrthoDBⁱ	EOG091G0MGD
PhylomeDBⁱ	Q9JLR5
TreeFamⁱ	TF350742

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9JLR5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000006642 Expressed in 111 organ(s), highest expression level in uterus
CleanExⁱ	MM_TCF23
Genevisibleⁱ	Q9JLR5 MM

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TCF23_MOUSE
Accessionⁱ	Q9JLR5Primary (citable) accession number: Q9JLR5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	October 1, 2000
	Last modified:	September 12, 2018
	This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q9JLR5 (TCF23_MOUSE)

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Transcription factor 23

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ