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UniProtKB - Q9JLR5 (TCF23_MOUSE)
Protein
Transcription factor 23
Gene
Tcf23
Organism
Mus musculus (Mouse)
Status
Functioni
Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. May be involved in the regulation or modulation of smooth muscle contraction of the uterus during pregnancy and particularly around the time of delivery. Seems to play a role in the inhibition of myogenesis.
1 PublicationGO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II-specific DNA-binding transcription factor binding Source: ARUK-UCL
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- transcription regulator inhibitor activity Source: ARUK-UCL
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- decidualization Source: MGI
- developmental process Source: GO_Central
- muscle organ development Source: UniProtKB-KW
- negative regulation of muscle cell differentiation Source: ARUK-UCL
- negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
- positive regulation of gene expression Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Myogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor 23Short name: TCF-23 Alternative name(s): Basic helix-loop-helix transcription factor OUT Ovary, uterus and testis protein |
Gene namesi | Name:Tcf23 Synonyms:Out |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1934960, Tcf23 |
VEuPathDBi | HostDB:ENSMUSG00000006642 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- euchromatin Source: ARUK-UCL
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315821 | 1 – 209 | Transcription factor 23Add BLAST | 209 |
Proteomic databases
PaxDbi | Q9JLR5 |
PRIDEi | Q9JLR5 |
ProteomicsDBi | 263148 |
PTM databases
iPTMneti | Q9JLR5 |
PhosphoSitePlusi | Q9JLR5 |
Expressioni
Tissue specificityi
Highly expressed in the uterus (predominantly in myometrium), ovary, and testis. Expression in the uterus is higher in the diestrus phase than in the estrus phase and reaches a maximum at 7.5 dpc. Expression declines towards the time of delivery and returns to the non-pregnant level 4 days after delivery. Low expression seen in lung, heart, intestine, and spleen.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000006642, Expressed in uterus and 134 other tissues |
Genevisiblei | Q9JLR5, MM |
Interactioni
Subunit structurei
Forms inactive heterodimeric complex with TCF3.
1 PublicationGO - Molecular functioni
- protein dimerization activity Source: InterPro
- RNA polymerase II-specific DNA-binding transcription factor binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 213716, 1 interactor |
STRINGi | 10090.ENSMUSP00000006818 |
Miscellaneous databases
RNActi | Q9JLR5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 75 – 127 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 54 – 85 | DisorderedSequence analysisAdd BLAST | 32 |
Domaini
Both the bHLH region and the C-terminal portion are essential for inhibitory function.
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000161395 |
HOGENOMi | CLU_101416_1_0_1 |
InParanoidi | Q9JLR5 |
OMAi | RTRQDLW |
OrthoDBi | 1462533at2759 |
PhylomeDBi | Q9JLR5 |
TreeFami | TF350742 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9JLR5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQEATEAPA MPGEGHGHNK AKARWLLGTD RKRSRINRTR QDLWEDTSWS
60 70 80 90 100
NHRLSRATSA PRGTRARGTA HGRSEASPEN AARERTRVKT LRQAFLALQA
110 120 130 140 150
ALPAVPPDTK LSKLDVLVLA TSYIAHLTRT LGHELPGPAW PPFVRGLRYL
160 170 180 190 200
HPLKKWPMRS RLYAGGLGCS DLDSTTAITT GQRCKDAELG SQDSVAAESL
LTSPAFGNK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB059397 Genomic DNA Translation: BAB69473.1 AF142405 mRNA Translation: AAF31168.1 AK030277 mRNA Translation: BAC26873.1 AK030297 mRNA Translation: BAC26885.1 BC119346 mRNA Translation: AAI19347.1 BC120609 mRNA Translation: AAI20610.1 |
CCDSi | CCDS19168.1 |
RefSeqi | NP_444315.1, NM_053085.2 |
Genome annotation databases
Ensembli | ENSMUST00000006818; ENSMUSP00000006818; ENSMUSG00000006642 |
GeneIDi | 69852 |
KEGGi | mmu:69852 |
UCSCi | uc008wws.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB059397 Genomic DNA Translation: BAB69473.1 AF142405 mRNA Translation: AAF31168.1 AK030277 mRNA Translation: BAC26873.1 AK030297 mRNA Translation: BAC26885.1 BC119346 mRNA Translation: AAI19347.1 BC120609 mRNA Translation: AAI20610.1 |
CCDSi | CCDS19168.1 |
RefSeqi | NP_444315.1, NM_053085.2 |
3D structure databases
AlphaFoldDBi | Q9JLR5 |
SMRi | Q9JLR5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 213716, 1 interactor |
STRINGi | 10090.ENSMUSP00000006818 |
PTM databases
iPTMneti | Q9JLR5 |
PhosphoSitePlusi | Q9JLR5 |
Proteomic databases
PaxDbi | Q9JLR5 |
PRIDEi | Q9JLR5 |
ProteomicsDBi | 263148 |
Protocols and materials databases
Antibodypediai | 47343, 27 antibodies from 12 providers |
DNASUi | 69852 |
Genome annotation databases
Ensembli | ENSMUST00000006818; ENSMUSP00000006818; ENSMUSG00000006642 |
GeneIDi | 69852 |
KEGGi | mmu:69852 |
UCSCi | uc008wws.1, mouse |
Organism-specific databases
CTDi | 150921 |
MGIi | MGI:1934960, Tcf23 |
VEuPathDBi | HostDB:ENSMUSG00000006642 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000161395 |
HOGENOMi | CLU_101416_1_0_1 |
InParanoidi | Q9JLR5 |
OMAi | RTRQDLW |
OrthoDBi | 1462533at2759 |
PhylomeDBi | Q9JLR5 |
TreeFami | TF350742 |
Miscellaneous databases
BioGRID-ORCSi | 69852, 5 hits in 72 CRISPR screens |
PROi | PR:Q9JLR5 |
RNActi | Q9JLR5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000006642, Expressed in uterus and 134 other tissues |
Genevisiblei | Q9JLR5, MM |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TCF23_MOUSE | |
Accessioni | Q9JLR5Primary (citable) accession number: Q9JLR5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot