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Protein

Transcription factor 23

Gene

Tcf23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. May be involved in the regulation or modulation of smooth muscle contraction of the uterus during pregnancy and particularly around the time of delivery. Seems to play a role in the inhibition of myogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 23
Short name:
TCF-23
Alternative name(s):
Basic helix-loop-helix transcription factor OUT
Ovary, uterus and testis protein
Gene namesi
Name:Tcf23
Synonyms:Out
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1934960 Tcf23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003158211 – 209Transcription factor 23Add BLAST209

Proteomic databases

PaxDbiQ9JLR5
PRIDEiQ9JLR5

PTM databases

iPTMnetiQ9JLR5
PhosphoSitePlusiQ9JLR5

Expressioni

Tissue specificityi

Highly expressed in the uterus (predominantly in myometrium), ovary, and testis. Expression in the uterus is higher in the diestrus phase than in the estrus phase and reaches a maximum at 7.5 dpc. Expression declines towards the time of delivery and returns to the non-pregnant level 4 days after delivery. Low expression seen in lung, heart, intestine, and spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000006642 Expressed in 111 organ(s), highest expression level in uterus
CleanExiMM_TCF23
GenevisibleiQ9JLR5 MM

Interactioni

Subunit structurei

Forms inactive heterodimeric complex with TCF3.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006818

Structurei

3D structure databases

ProteinModelPortaliQ9JLR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 127bHLHPROSITE-ProRule annotationAdd BLAST53

Domaini

Both the bHLH region and the C-terminal portion are essential for inhibitory function.

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00710000106684
HOGENOMiHOG000154520
HOVERGENiHBG096612
InParanoidiQ9JLR5
OMAiRTRQDLW
OrthoDBiEOG091G0MGD
PhylomeDBiQ9JLR5
TreeFamiTF350742

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JLR5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQEATEAPA MPGEGHGHNK AKARWLLGTD RKRSRINRTR QDLWEDTSWS
60 70 80 90 100
NHRLSRATSA PRGTRARGTA HGRSEASPEN AARERTRVKT LRQAFLALQA
110 120 130 140 150
ALPAVPPDTK LSKLDVLVLA TSYIAHLTRT LGHELPGPAW PPFVRGLRYL
160 170 180 190 200
HPLKKWPMRS RLYAGGLGCS DLDSTTAITT GQRCKDAELG SQDSVAAESL

LTSPAFGNK
Length:209
Mass (Da):22,895
Last modified:October 1, 2000 - v1
Checksum:i611E3878DE92446A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB059397 Genomic DNA Translation: BAB69473.1
AF142405 mRNA Translation: AAF31168.1
AK030277 mRNA Translation: BAC26873.1
AK030297 mRNA Translation: BAC26885.1
BC119346 mRNA Translation: AAI19347.1
BC120609 mRNA Translation: AAI20610.1
CCDSiCCDS19168.1
RefSeqiNP_444315.1, NM_053085.2
UniGeneiMm.57874

Genome annotation databases

EnsembliENSMUST00000006818; ENSMUSP00000006818; ENSMUSG00000006642
GeneIDi69852
KEGGimmu:69852
UCSCiuc008wws.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB059397 Genomic DNA Translation: BAB69473.1
AF142405 mRNA Translation: AAF31168.1
AK030277 mRNA Translation: BAC26873.1
AK030297 mRNA Translation: BAC26885.1
BC119346 mRNA Translation: AAI19347.1
BC120609 mRNA Translation: AAI20610.1
CCDSiCCDS19168.1
RefSeqiNP_444315.1, NM_053085.2
UniGeneiMm.57874

3D structure databases

ProteinModelPortaliQ9JLR5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006818

PTM databases

iPTMnetiQ9JLR5
PhosphoSitePlusiQ9JLR5

Proteomic databases

PaxDbiQ9JLR5
PRIDEiQ9JLR5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006818; ENSMUSP00000006818; ENSMUSG00000006642
GeneIDi69852
KEGGimmu:69852
UCSCiuc008wws.1 mouse

Organism-specific databases

CTDi150921
MGIiMGI:1934960 Tcf23

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00710000106684
HOGENOMiHOG000154520
HOVERGENiHBG096612
InParanoidiQ9JLR5
OMAiRTRQDLW
OrthoDBiEOG091G0MGD
PhylomeDBiQ9JLR5
TreeFamiTF350742

Miscellaneous databases

PROiPR:Q9JLR5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006642 Expressed in 111 organ(s), highest expression level in uterus
CleanExiMM_TCF23
GenevisibleiQ9JLR5 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCF23_MOUSE
AccessioniPrimary (citable) accession number: Q9JLR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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