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Protein

Erythroid membrane-associated protein

Gene

Ermap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible role as a cell-adhesion or receptor molecule of erythroid cells.

GO - Molecular functioni

  • signaling receptor binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Erythroid membrane-associated protein
Gene namesi
Name:Ermap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1349816 Ermap

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 246ExtracellularSequence analysisAdd BLAST217
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 566CytoplasmicSequence analysisAdd BLAST299

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000022608930 – 566Erythroid membrane-associated proteinAdd BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 123PROSITE-ProRule annotation
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei509PhosphoserineCombined sources1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JLN5
PRIDEiQ9JLN5

PTM databases

iPTMnetiQ9JLN5
PhosphoSitePlusiQ9JLN5

Expressioni

Tissue specificityi

Expressed in spleen and bone marrow.1 Publication

Developmental stagei

First detected at E.11. Expressed in fetal liver at E12.5 and E13.5.1 Publication

Gene expression databases

CleanExiMM_ERMAP

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000123426

Structurei

3D structure databases

ProteinModelPortaliQ9JLN5
SMRiQ9JLN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 139Ig-like V-typeAdd BLAST110
Domaini311 – 509B30.2/SPRYPROSITE-ProRule annotationAdd BLAST199

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
HOGENOMiHOG000197761
HOVERGENiHBG050747
InParanoidiQ9JLN5
KOiK06712

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR006574 PRY
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF07686 V-set, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50835 IG_LIKE, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JLN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERPSPCGSW LVGCLFTIAV FQPPVQVLGD AGKVYIAPLR DTANLPCPLF
60 70 80 90 100
LWPNMVLSEM RWYRPGHLPR TQAVHVFRDG QDRDEDLMPE YKGRTALVRD
110 120 130 140 150
AHKESYILQI SNVRLEDRGL YQCQVWVGNS SREDNVTLQV AVLGSDPYIH
160 170 180 190 200
VKGYDAGWIE LLCQSVGWFP KPWTEWRDTT GRALLSLSEV HSLDENGLFR
210 220 230 240 250
TAVSSRIRDN ALGNVSCTIH NEALGQEKTT AMIIGAPERG SLSSPAVALS
260 270 280 290 300
VVLPVLGLLI LLGIWLICKQ KKSKEKLLYE QAMEVENLLE DHAKEKGRLH
310 320 330 340 350
KALKKLRSEL KLKRAAANAG WRRARLHFVA VTLDPDTAHP KLILSEDRRC
360 370 380 390 400
VRLGDRKRPV PDNPERFDFV VSVLGSEYFT TGCHYWEVYV GEKTKWILGV
410 420 430 440 450
CSESVSRKGK VTASPANGHW LVRQSRGNEY EALTSPQTSF RLKESPKCVG
460 470 480 490 500
IFLDYEAGII SFYNVTDKSH IFTFTHSFSS PLRPFFEPCL HDEGKNTAPL
510 520 530 540 550
IICTELQKSE ESIVPKQEGK DRANGDVSLK MNPSLLSPQG SELFLLNDTW
560
PSNLGPALKG LKVPSL
Length:566
Mass (Da):63,512
Last modified:March 7, 2006 - v2
Checksum:i0017069E16D5D112
GO
Isoform 2 (identifier: Q9JLN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-147: VWVGNSSREDNVTLQVAVLGSDP → EFPYTGAQNLHRTKKPLLPLMTN
     148-566: Missing.

Note: No experimental confirmation available.
Show »
Length:147
Mass (Da):16,910
Checksum:iD94BAFF1D0ED3D94
GO
Isoform 3 (identifier: Q9JLN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-143: Missing.

Note: No experimental confirmation available.
Show »
Length:564
Mass (Da):63,300
Checksum:i5A46DF790035C6C3
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A7P7A2A7P7_MOUSE
Erythroblast membrane-associated pr...
Ermap mCG_6289
592Annotation score:
E9QKE5E9QKE5_MOUSE
Erythroid membrane-associated prote...
Ermap
334Annotation score:
A2A7P5A2A7P5_MOUSE
Erythroid membrane-associated prote...
Ermap
185Annotation score:
A2A7P8A2A7P8_MOUSE
Erythroid membrane-associated prote...
Ermap
188Annotation score:
D6RFS7D6RFS7_MOUSE
Erythroid membrane-associated prote...
Ermap
43Annotation score:
A2A7P6A2A7P6_MOUSE
Erythroid membrane-associated prote...
Ermap
107Annotation score:
D6RCV8D6RCV8_MOUSE
Erythroid membrane-associated prote...
Ermap
72Annotation score:

Sequence cautioni

The sequence AAF31162 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH63257 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE23390 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91Y → S in AAF31162 (PubMed:10721728).Curated1
Sequence conflicti180T → A in AAF31162 (PubMed:10721728).Curated1
Sequence conflicti221N → I in AAF31162 (PubMed:10721728).Curated1
Sequence conflicti287N → S in AAF31162 (PubMed:10721728).Curated1
Sequence conflicti374L → P in AAF31162 (PubMed:10721728).Curated1
Sequence conflicti462F → L in BAC25788 (PubMed:16141072).Curated1
Sequence conflicti541S → C in AAF31162 (PubMed:10721728).Curated1
Sequence conflicti554L → F in AAF31162 (PubMed:10721728).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017425125 – 147VWVGN…LGSDP → EFPYTGAQNLHRTKKPLLPL MTN in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_017426142 – 143Missing in isoform 3. 1 Publication2
Alternative sequenceiVSP_017427148 – 566Missing in isoform 2. 1 PublicationAdd BLAST419

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153906 mRNA Translation: AAF31162.1 Different initiation.
AK028170 mRNA Translation: BAC25788.1
AK137510 mRNA Translation: BAE23390.1 Different initiation.
BC063257 mRNA Translation: AAH63257.1 Different initiation.
RefSeqiNP_038876.2, NM_013848.2
UniGeneiMm.290753

Genome annotation databases

GeneIDi27028
KEGGimmu:27028
UCSCiuc008ulh.2 mouse [Q9JLN5-2]
uc012dke.1 mouse [Q9JLN5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153906 mRNA Translation: AAF31162.1 Different initiation.
AK028170 mRNA Translation: BAC25788.1
AK137510 mRNA Translation: BAE23390.1 Different initiation.
BC063257 mRNA Translation: AAH63257.1 Different initiation.
RefSeqiNP_038876.2, NM_013848.2
UniGeneiMm.290753

3D structure databases

ProteinModelPortaliQ9JLN5
SMRiQ9JLN5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000123426

PTM databases

iPTMnetiQ9JLN5
PhosphoSitePlusiQ9JLN5

Proteomic databases

PaxDbiQ9JLN5
PRIDEiQ9JLN5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi27028
KEGGimmu:27028
UCSCiuc008ulh.2 mouse [Q9JLN5-2]
uc012dke.1 mouse [Q9JLN5-3]

Organism-specific databases

CTDi114625
MGIiMGI:1349816 Ermap

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
HOGENOMiHOG000197761
HOVERGENiHBG050747
InParanoidiQ9JLN5
KOiK06712

Miscellaneous databases

PROiPR:Q9JLN5
SOURCEiSearch...

Gene expression databases

CleanExiMM_ERMAP

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR006574 PRY
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF07686 V-set, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERMAP_MOUSE
AccessioniPrimary (citable) accession number: Q9JLN5
Secondary accession number(s): Q3UV82, Q6P4T5, Q8CEH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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