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Protein

Tumor necrosis factor receptor superfamily member 19

Gene

Tnfrsf19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Can mediate activation of c-Jun and NF-kappa-B. May promote caspase-independent cell death (By similarity). Isoform 2 and isoform 3 may act as decoy receptors.By similarity

GO - Biological processi

  • hair follicle development Source: MGI
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  • positive regulation of JNK cascade Source: GO_Central

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 19
Alternative name(s):
TRADE
Toxicity and JNK inducer
Gene namesi
Name:Tnfrsf19
Synonyms:Taj, Troy
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1352474 Tnfrsf19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 170ExtracellularSequence analysisAdd BLAST141
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 416CytoplasmicSequence analysisAdd BLAST225

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000003459830 – 416Tumor necrosis factor receptor superfamily member 19Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 46PROSITE-ProRule annotation
Disulfide bondi49 ↔ 62PROSITE-ProRule annotation
Disulfide bondi52 ↔ 72PROSITE-ProRule annotation
Disulfide bondi75 ↔ 89PROSITE-ProRule annotation
Disulfide bondi92 ↔ 106PROSITE-ProRule annotation
Disulfide bondi95 ↔ 114PROSITE-ProRule annotation
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi117 ↔ 135PROSITE-ProRule annotation
Disulfide bondi138 ↔ 149PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JLL3
PRIDEiQ9JLL3

PTM databases

PhosphoSitePlusiQ9JLL3

Expressioni

Tissue specificityi

Highly expressed in adult brain, and in embryos from day 11-17, but not earlier. Detected in embryonic brain and epithelium, and at lower levels in adult heart, lung and liver. In neonatal mice, mainly in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. Isoform 3 was found in embryonic day 17.5 skin but not in brain and liver.

Gene expression databases

BgeeiENSMUSG00000060548
GenevisibleiQ9JLL3 MM

Interactioni

Subunit structurei

Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.By similarity

Protein-protein interaction databases

BioGridi205900, 1 interactor
CORUMiQ9JLL3
STRINGi10090.ENSMUSP00000106865

Structurei

3D structure databases

ProteinModelPortaliQ9JLL3
SMRiQ9JLL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati33 – 72TNFR-Cys 1Add BLAST40
Repeati74 – 114TNFR-Cys 2Add BLAST41
Repeati116 – 149TNFR-Cys 3; truncatedAdd BLAST34

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFRK Eukaryota
ENOG410ZU96 LUCA
GeneTreeiENSGT00730000110978
HOVERGENiHBG069143
InParanoidiQ9JLL3
KOiK05155
OMAiAWPLMQN
OrthoDBiEOG091G0ADI
TreeFamiTF331385

Family and domain databases

CDDicd13418 TNFRSF19, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022342 TNFR_19
IPR034047 TNFRSF19_N
PANTHERiPTHR12120:SF1 PTHR12120:SF1, 1 hit
PfamiView protein in Pfam
PF00020 TNFR_c6, 1 hit
PRINTSiPR01969 TNFACTORR19
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JLL3-1) [UniParc]FASTAAdd to basket
Also known as: TAJ-alphaL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALKVLPLHR TVLFAAILFL LHLACKVSCE TGDCRQQEFK DRSGNCVLCK
60 70 80 90 100
QCGPGMELSK ECGFGYGEDA QCVPCRPHRF KEDWGFQKCK PCADCALVNR
110 120 130 140 150
FQRANCSHTS DAVCGDCLPG FYRKTKLVGF QDMECVPCGD PPPPYEPHCT
160 170 180 190 200
SKVNLVKISS TVSSPRDTAL AAVICSALAT VLLALLILCV IYCKRQFMEK
210 220 230 240 250
KPSWSLRSQD IQYNGSELSC FDQPRLRHCA HRACCQYHRD SAPMYGPVHL
260 270 280 290 300
IPSLCCEEAR SSARAVLGCG LRSPTTLQER NPASVGDTMP AFFGSVSRSI
310 320 330 340 350
CAEFSDAWPL MQNPLGGDSS LCDSYPELTG EDTNSLNPEN ESAASLDSSG
360 370 380 390 400
GQDLAGTAAL ESSGNVSEST DSPRHGDTGT VWEQTLAQDA QRTPSQGGWE
410
DRENLNLAMP TAFQDA
Length:416
Mass (Da):45,265
Last modified:July 27, 2011 - v2
Checksum:i9BDC7C7A2D6A9C47
GO
Isoform 2 (identifier: Q9JLL3-2) [UniParc]FASTAAdd to basket
Also known as: TAJ-beta1

The sequence of this isoform differs from the canonical sequence as follows:
     150-150: T → E
     151-416: Missing.

Show »
Length:150
Mass (Da):16,728
Checksum:i4A1B2E93AEF7FF43
GO
Isoform 3 (identifier: Q9JLL3-3) [UniParc]FASTAAdd to basket
Also known as: TAJ-alphaS, dTROY

The sequence of this isoform differs from the canonical sequence as follows:
     204-214: WSLRSQDIQYN → CKLPSLCLTVK
     215-416: Missing.

Show »
Length:214
Mass (Da):23,564
Checksum:iECC63981C37482B8
GO
Isoform 4 (identifier: Q9JLL3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-348: NESAASLDS → MLCFRFRDL
     349-416: Missing.

Show »
Length:348
Mass (Da):38,471
Checksum:i08A8273AA5280FFD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31T → A in AAF19795 (PubMed:10585776).Curated1
Sequence conflicti208S → P in AAF19795 (PubMed:10585776).Curated1
Sequence conflicti287D → N in AAF19795 (PubMed:10585776).Curated1
Sequence conflicti287D → N in AAF71825 (PubMed:10809768).Curated1
Sequence conflicti343A → T in AAF71825 (PubMed:10809768).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006513150T → E in isoform 2. 1 Publication1
Alternative sequenceiVSP_006514151 – 416Missing in isoform 2. 1 PublicationAdd BLAST266
Alternative sequenceiVSP_006515204 – 214WSLRSQDIQYN → CKLPSLCLTVK in isoform 3. 3 PublicationsAdd BLAST11
Alternative sequenceiVSP_006516215 – 416Missing in isoform 3. 3 PublicationsAdd BLAST202
Alternative sequenceiVSP_006517340 – 348NESAASLDS → MLCFRFRDL in isoform 4. 1 Publication9
Alternative sequenceiVSP_006518349 – 416Missing in isoform 4. 1 PublicationAdd BLAST68

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173166 mRNA Translation: AAF19795.1
AF167552 mRNA Translation: AAF71825.1
AF167554 mRNA Translation: AAF71827.1
AF167553 mRNA Translation: AAF71826.1
AB040432 mRNA Translation: BAB03267.1
AB040433 mRNA Translation: BAB03268.1
AF247000 mRNA Translation: AAK28397.1
AK028146 mRNA Translation: BAC25774.1
BC030062 mRNA Translation: AAH30062.1
CCDSiCCDS36941.1 [Q9JLL3-1]
RefSeqiNP_001157627.1, NM_001164155.1 [Q9JLL3-1]
NP_038897.4, NM_013869.5 [Q9JLL3-1]
UniGeneiMm.281356

Genome annotation databases

EnsembliENSMUST00000111234; ENSMUSP00000106865; ENSMUSG00000060548 [Q9JLL3-1]
ENSMUST00000111236; ENSMUSP00000106867; ENSMUSG00000060548 [Q9JLL3-1]
ENSMUST00000224371; ENSMUSP00000153577; ENSMUSG00000060548 [Q9JLL3-3]
ENSMUST00000225730; ENSMUSP00000152920; ENSMUSG00000060548 [Q9JLL3-3]
GeneIDi29820
KEGGimmu:29820
UCSCiuc007ufi.2 mouse [Q9JLL3-1]
uc007ufl.2 mouse [Q9JLL3-3]
uc007ufn.2 mouse [Q9JLL3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTNR19_MOUSE
AccessioniPrimary (citable) accession number: Q9JLL3
Secondary accession number(s): Q80T13
, Q812G3, Q9JHF1, Q9JJH6, Q9JLL2, Q9QXW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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