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Protein

Cysteine-rich motor neuron 1 protein

Gene

Crim1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich motor neuron 1 protein
Short name:
CRIM-1
Gene namesi
Name:Crim1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1354756 Crim1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 940ExtracellularSequence analysisAdd BLAST906
Transmembranei941 – 961HelicalSequence analysisAdd BLAST21
Topological domaini962 – 1037CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000002100235 – 1037Cysteine-rich motor neuron 1 proteinAdd BLAST1003

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1036PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9JLL0
PaxDbiQ9JLL0
PeptideAtlasiQ9JLL0
PRIDEiQ9JLL0

PTM databases

iPTMnetiQ9JLL0
PhosphoSitePlusiQ9JLL0

Expressioni

Tissue specificityi

Expressed during embryonic development in brain, kidney, spinal chord, testis, lens, vibrissae, pinna, tooth primordia and in specific regions of the CNS. Expressed in adult lens. Displays male-specific expression in the fetal gonads with the strongest expression in the Sertoli cells of developing testis.3 Publications

Developmental stagei

Detected in embryo at 11.5 dpc to 17.7 dpc with a maximum between 12.5 and 13.5 dpc.2 Publications

Gene expression databases

BgeeiENSMUSG00000024074 Expressed in 313 organ(s), highest expression level in pigmented layer of retina
GenevisibleiQ9JLL0 MM

Interactioni

Subunit structurei

Interacts with BMP4 and BMP7.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108117

Structurei

3D structure databases

ProteinModelPortaliQ9JLL0
SMRiQ9JLL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 112IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST78
Domaini334 – 391VWFC 1PROSITE-ProRule annotationAdd BLAST58
Domaini401 – 457VWFC 2PROSITE-ProRule annotationAdd BLAST57
Domaini469 – 498Antistasin-like 1PROSITE-ProRule annotationAdd BLAST30
Domaini505 – 532Antistasin-like 2PROSITE-ProRule annotationAdd BLAST28
Domaini539 – 564Antistasin-like 3PROSITE-ProRule annotationAdd BLAST26
Domaini567 – 592Antistasin-like 4PROSITE-ProRule annotationAdd BLAST26
Domaini606 – 663VWFC 3PROSITE-ProRule annotationAdd BLAST58
Domaini677 – 735VWFC 4PROSITE-ProRule annotationAdd BLAST59
Domaini751 – 809VWFC 5PROSITE-ProRule annotationAdd BLAST59
Domaini817 – 874VWFC 6PROSITE-ProRule annotationAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi314 – 316Cell attachment siteSequence analysis3

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR8F Eukaryota
ENOG410Z6K0 LUCA
GeneTreeiENSGT00840000129763
HOGENOMiHOG000063671
HOVERGENiHBG081345
InParanoidiQ9JLL0
OMAiCSTVECP
OrthoDBiEOG091G01IV
PhylomeDBiQ9JLL0
TreeFamiTF106451

Family and domain databases

InterProiView protein in InterPro
IPR004094 Antistasin-like
IPR009030 Growth_fac_rcpt_cys_sf
IPR011061 Hirudin/antistatin
IPR000867 IGFBP-like
IPR001007 VWF_dom
PfamiView protein in Pfam
PF02822 Antistasin, 4 hits
PF00219 IGFBP, 1 hit
PF00093 VWC, 6 hits
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00214 VWC, 6 hits
SM00215 VWC_out, 4 hits
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57262 SSF57262, 3 hits
PROSITEiView protein in PROSITE
PS51252 ANTISTASIN, 4 hits
PS51323 IGFBP_N_2, 1 hit
PS01208 VWFC_1, 6 hits
PS50184 VWFC_2, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLL0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYLVAGGRGL AGCGHLSVSL LGLLLLLARS GTRALVCLPC DESKCEEPRS
60 70 80 90 100
CPGSIVQGVC GCCYMCARQR NESCGGAYGL HGACDRGLRC VIRPPLNGDS
110 120 130 140 150
ITEYEVGVCE DEDWDDDQLI GFEPCNENLI SGCNIINGKC ECGTIRTCNN
160 170 180 190 200
PFEFPRKDMC LSALKRIEEE KPDCSKARCE VRFSPRCPED SILIEGYAPP
210 220 230 240 250
GECCPLPSRC VCDPAGCLRK VCQPGYLNIL VSKASGKPGE CCDLYECKPV
260 270 280 290 300
FSVDCSTVEC PPVQQAVCPL DSYETQVRLT ADGCCTLPAR CECLSGLCGF
310 320 330 340 350
PVCEVGSTPR IVSRGDGTPG KCCDVFECVN ETKPACVFNS VEYYDGDMFR
360 370 380 390 400
MDNCRFCRCQ GGVSICFTAQ CGELNCERYY VPEGECCPVC EDPIYPLNNP
410 420 430 440 450
AGCYANGQIR AHGDRWREDD CTFCQCINGE PHCVATACGQ SCMHPVKVPG
460 470 480 490 500
ECCPVCEEPT YITIDPPACG ELSNCSLKEK DCVYGFKLDH NGCRTCQCKI
510 520 530 540 550
REELCLGLKR ACTLDCPFGF LTDVHNCELC QCRPRPKKCR PTMCDKFCPL
560 570 580 590 600
GFLKNKHGCD ICRCKKCPEL PCSKICPLGF QQDSHGCLIC KCREVPPSAG
610 620 630 640 650
PPVLSGTCLS MDGHHHKNEE SWHDGCRECY CHNGKEMCAL ITCPVPACGN
660 670 680 690 700
PTIRSGQCCP SCTDDFVVQK PELSTPSICH APGGEYFVEG ETWNIDSCTQ
710 720 730 740 750
CTCHSGRVLC ETEVCPPLLC QNPSRTQDSC CPQCTDDPPQ PSTSHNESVP
760 770 780 790 800
SYCRNDEGDI FLAAESWKPD ACTSCVCVDS AISCYSESCP SVACERPVLR
810 820 830 840 850
KGQCCPYCLE DTIPKKVVCH FSGKTYADEE RWDIDSCTHC YCLQGQTLCS
860 870 880 890 900
TVSCPPLPCA EPIKVEGSCC PMCPEMYVPE PTNVPIEKKN HRGEIDLEVP
910 920 930 940 950
MWPTPSENDI IHLPRDMGHL QVDYRDNNRL HPGEDSSLDS IVSVVVPIII
960 970 980 990 1000
CLSIIIAFLL INQKKQWVPL LCWYRTPTKP SSLNNQLVSV DCKKGTRVQV
1010 1020 1030
DGPQRMLRIA EPDARFSGFY SMQKQNHLQA DNFYQTV
Length:1,037
Mass (Da):114,066
Last modified:December 12, 2006 - v2
Checksum:iC41948C0A2B66EA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100348 mRNA Translation: AAI00349.1
AF168680 mRNA Translation: AAF34410.1
CCDSiCCDS28976.1
RefSeqiNP_056615.1, NM_015800.3
UniGeneiMm.311912

Genome annotation databases

EnsembliENSMUST00000112498; ENSMUSP00000108117; ENSMUSG00000024074
GeneIDi50766
KEGGimmu:50766
UCSCiuc008dou.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100348 mRNA Translation: AAI00349.1
AF168680 mRNA Translation: AAF34410.1
CCDSiCCDS28976.1
RefSeqiNP_056615.1, NM_015800.3
UniGeneiMm.311912

3D structure databases

ProteinModelPortaliQ9JLL0
SMRiQ9JLL0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108117

PTM databases

iPTMnetiQ9JLL0
PhosphoSitePlusiQ9JLL0

Proteomic databases

MaxQBiQ9JLL0
PaxDbiQ9JLL0
PeptideAtlasiQ9JLL0
PRIDEiQ9JLL0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112498; ENSMUSP00000108117; ENSMUSG00000024074
GeneIDi50766
KEGGimmu:50766
UCSCiuc008dou.2 mouse

Organism-specific databases

CTDi51232
MGIiMGI:1354756 Crim1

Phylogenomic databases

eggNOGiENOG410IR8F Eukaryota
ENOG410Z6K0 LUCA
GeneTreeiENSGT00840000129763
HOGENOMiHOG000063671
HOVERGENiHBG081345
InParanoidiQ9JLL0
OMAiCSTVECP
OrthoDBiEOG091G01IV
PhylomeDBiQ9JLL0
TreeFamiTF106451

Miscellaneous databases

ChiTaRSiCrim1 mouse
PROiPR:Q9JLL0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024074 Expressed in 313 organ(s), highest expression level in pigmented layer of retina
GenevisibleiQ9JLL0 MM

Family and domain databases

InterProiView protein in InterPro
IPR004094 Antistasin-like
IPR009030 Growth_fac_rcpt_cys_sf
IPR011061 Hirudin/antistatin
IPR000867 IGFBP-like
IPR001007 VWF_dom
PfamiView protein in Pfam
PF02822 Antistasin, 4 hits
PF00219 IGFBP, 1 hit
PF00093 VWC, 6 hits
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00214 VWC, 6 hits
SM00215 VWC_out, 4 hits
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57262 SSF57262, 3 hits
PROSITEiView protein in PROSITE
PS51252 ANTISTASIN, 4 hits
PS51323 IGFBP_N_2, 1 hit
PS01208 VWFC_1, 6 hits
PS50184 VWFC_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCRIM1_MOUSE
AccessioniPrimary (citable) accession number: Q9JLL0
Secondary accession number(s): Q497W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 12, 2006
Last modified: November 7, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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