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Entry version 146 (16 Oct 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Squamous cell carcinoma antigen recognized by T-cells 3

Gene

Sart3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites. May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly. May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (By similarity). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (PubMed:21447833).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Squamous cell carcinoma antigen recognized by T-cells 3Curated
Short name:
SART-31 Publication
Short name:
mSART-31 Publication
Alternative name(s):
Tumor-rejection antigen SART31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sart3Imported
Synonyms:Kiaa0156Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1858230 Sart3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Knockout of Sart3 is embryonic lethal.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002233142 – 962Squamous cell carcinoma antigen recognized by T-cells 3Add BLAST961

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei10PhosphoserineBy similarity1
Modified residuei216PhosphoserineBy similarity1
Modified residuei651PhosphoserineBy similarity1
Modified residuei795PhosphoserineBy similarity1
Modified residuei852PhosphoserineBy similarity1
Modified residuei906Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9JLI8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9JLI8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JLI8

PeptideAtlas

More...
PeptideAtlasi
Q9JLI8

PRoteomics IDEntifications database

More...
PRIDEi
Q9JLI8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JLI8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JLI8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9JLI8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed, with low level of expression in liver, heart and skeletal (PubMed:10761712). Also detected in hematopoietic cells (at protein level) (PubMed:21447833).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed from early prenatal stages, as early as 7 dpc and increased thereafter.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in proliferating hematopoietic cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000018974 Expressed in 258 organ(s), highest expression level in primary oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9JLI8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs.

Interacts with AGO1 and AGO2.

Interacts with PRPF3 and USP4; the interaction with PRPF3 is direct and recruits USP4 to its substrate PRPF3.

Interacts with USP15; the interaction is direct.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
207514, 19 interactors

Protein interaction database and analysis system

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IntActi
Q9JLI8, 21 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000019118

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9JLI8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati127 – 159HAT 1Sequence analysisAdd BLAST33
Repeati165 – 196HAT 2Sequence analysisAdd BLAST32
Repeati202 – 238HAT 3Sequence analysisAdd BLAST37
Repeati243 – 276HAT 4Sequence analysisAdd BLAST34
Repeati325 – 357HAT 5Sequence analysisAdd BLAST33
Repeati360 – 392HAT 6Sequence analysisAdd BLAST33
Repeati395 – 431HAT 7Sequence analysisAdd BLAST37
Repeati441 – 474HAT 8Sequence analysisAdd BLAST34
Repeati488 – 521HAT 9Sequence analysisAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini704 – 782RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini801 – 878RRM 2PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 352Mediates interaction with PRPF3By similarityAdd BLAST351
Regioni488 – 521Required for interaction with USP4By similarityAdd BLAST34
Regioni538 – 952Necessary and sufficient for U6 snRNA bindingBy similarityAdd BLAST415
Regioni601 – 670Required for nuclear localizationBy similarityAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili559 – 618Sequence analysisAdd BLAST60

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0128 Eukaryota
ENOG410XP88 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00900000141107

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000063708

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JLI8

KEGG Orthology (KO)

More...
KOi
K22611

Identification of Orthologs from Complete Genome Data

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OMAi
RRFCYVS

Database of Orthologous Groups

More...
OrthoDBi
867827at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9JLI8

TreeFam database of animal gene trees

More...
TreeFami
TF317554

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12391 RRM1_SART3, 1 hit
cd12392 RRM2_SART3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits
3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003107 HAT
IPR008669 LSM_interact
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034217 SART3_RRM1
IPR034218 SART3_RRM2
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05391 Lsm_interact, 1 hit
PF00076 RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00386 HAT, 7 hits
SM00360 RRM, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48452 SSF48452, 1 hit
SSF54928 SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9JLI8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATTAASSAS EPEVEPQAGP EAEGEEDEAK PAGVQRKVLS GAVAAEAAEA
60 70 80 90 100
KGPGWDLQRE GASGSDGDEE DAMASSAESS AGEDEWEYDE EEEKNQLEIE
110 120 130 140 150
RLEEQLSING YDYNCHVELI RLLRLEGELS RVRAARQKMS ELFPLTEELW
160 170 180 190 200
LEWLHDEISM AMDGLDREHV YELFERAVKD YICPNIWLEY GQYSVGGIGQ
210 220 230 240 250
KGGLEKVRSV FERALSSVGL HMTKGLAIWE AYREFESAIV EAARLEKVHS
260 270 280 290 300
LFRRQLAIPL YEMEATFAEY EEWSEEPMPE SVLQSYQKAL GQLEKYKPYE
310 320 330 340 350
EALLQAEAPR LAEYQAYIDF EMKIGDPARI QLIFERALVE NCLVPDLWIR
360 370 380 390 400
YSQYLDRQLK VKDLVLSVHS RAVRNCPWTV ALWSRYLLAM ERHGLDHQTI
410 420 430 440 450
SATFENALSA GFIQATDYVE IWQVYLDYLR RRVDFRQDSS KELEELRSMF
460 470 480 490 500
TRALEYLQQE VEERFSESGD PSCLIMQSWA RVEARLCNNM QKARELWDSI
510 520 530 540 550
MTRGNAKYAN MWLEYYNLER AHGDTQHCRK ALHRAVQCTS DYPEHVCEVL
560 570 580 590 600
LTMERTEGTL EDWDLAIQKT ETRLARVNEQ RMKAAEKEAA LVQQEEEKAE
610 620 630 640 650
QRKKVRAEKK ALKKKKKTRG ADKRREDEDE ENEWGEEEEE QPSKRRRTEN
660 670 680 690 700
SLASGEASAM KEETELSGKC LTIDVGPPSK QKEKAASLKR DMPKVAHDSS
710 720 730 740 750
KDSVTVFVSN LPYSIEEPEV KLRPLFEVCG EVVQIRPIFS NRGDFRGYCY
760 770 780 790 800
VEFGEEKSAQ QALELDRKIV EGRPMFVSPC VDKSKNPDFK VFRYSTTLEK
810 820 830 840 850
HKLFISGLPF SCTKEELEDI CKAHGTVKDL RLVTNRAGKP KGLAYVEYEN
860 870 880 890 900
ESQASQAVMK MDGMTIRENV IKVAISNPPQ RKVPEKPEVR TAPGAPMLPR
910 920 930 940 950
QMYGARGKGR TQLSLLPRAL QRQGAAPQAE NGPAPGPAVA PSVATEAPKM
960
SNADFAKLLL RK
Length:962
Mass (Da):109,619
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23BC235125E7A09C
GO
Isoform 2 (identifier: Q9JLI8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-401: DRQLKVKDLV...RHGLDHQTIS → PCCAELPMDS...RSECRLHPGH
     402-962: Missing.

Note: No experimental confirmation available.
Show »
Length:401
Mass (Da):45,291
Checksum:iAE0B8FA9BE117FFE
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH36350 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti160M → V in BAC39661 (PubMed:16141072).Curated1
Sequence conflicti792 – 814FRYST…FSCTK → CFLKKGVFRVGCPIGSAQ in BAC97877 (PubMed:14621295).CuratedAdd BLAST23

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017252356 – 401DRQLK…HQTIS → PCCAELPMDSCPVESVPSGH GATWTGPSNDFCDLRERSEC RLHPGH in isoform 2. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_017253402 – 962Missing in isoform 2. 1 PublicationAdd BLAST561

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF172722 mRNA Translation: AAF65228.1
AK053828 mRNA Translation: BAC35544.1
AK129067 Transcribed RNA Translation: BAC97877.2
AK086398 mRNA Translation: BAC39661.1
BC036350 mRNA Translation: AAH36350.1 Different initiation.
BC057156 mRNA Translation: AAH57156.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS19552.1 [Q9JLI8-1]

NCBI Reference Sequences

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RefSeqi
NP_058622.1, NM_016926.1 [Q9JLI8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000019118; ENSMUSP00000019118; ENSMUSG00000018974 [Q9JLI8-1]
ENSMUST00000197041; ENSMUSP00000143778; ENSMUSG00000018974 [Q9JLI8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
53890

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:53890

UCSC genome browser

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UCSCi
uc008yym.1 mouse [Q9JLI8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172722 mRNA Translation: AAF65228.1
AK053828 mRNA Translation: BAC35544.1
AK129067 Transcribed RNA Translation: BAC97877.2
AK086398 mRNA Translation: BAC39661.1
BC036350 mRNA Translation: AAH36350.1 Different initiation.
BC057156 mRNA Translation: AAH57156.1
CCDSiCCDS19552.1 [Q9JLI8-1]
RefSeqiNP_058622.1, NM_016926.1 [Q9JLI8-1]

3D structure databases

SMRiQ9JLI8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi207514, 19 interactors
IntActiQ9JLI8, 21 interactors
STRINGi10090.ENSMUSP00000019118

PTM databases

iPTMnetiQ9JLI8
PhosphoSitePlusiQ9JLI8
SwissPalmiQ9JLI8

Proteomic databases

EPDiQ9JLI8
jPOSTiQ9JLI8
PaxDbiQ9JLI8
PeptideAtlasiQ9JLI8
PRIDEiQ9JLI8

Genome annotation databases

EnsembliENSMUST00000019118; ENSMUSP00000019118; ENSMUSG00000018974 [Q9JLI8-1]
ENSMUST00000197041; ENSMUSP00000143778; ENSMUSG00000018974 [Q9JLI8-2]
GeneIDi53890
KEGGimmu:53890
UCSCiuc008yym.1 mouse [Q9JLI8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9733
MGIiMGI:1858230 Sart3

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0128 Eukaryota
ENOG410XP88 LUCA
GeneTreeiENSGT00900000141107
HOGENOMiHOG000063708
InParanoidiQ9JLI8
KOiK22611
OMAiRRFCYVS
OrthoDBi867827at2759
PhylomeDBiQ9JLI8
TreeFamiTF317554

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Sart3 mouse

Protein Ontology

More...
PROi
PR:Q9JLI8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000018974 Expressed in 258 organ(s), highest expression level in primary oocyte
GenevisibleiQ9JLI8 MM

Family and domain databases

CDDicd12391 RRM1_SART3, 1 hit
cd12392 RRM2_SART3, 1 hit
Gene3Di1.25.40.10, 2 hits
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR003107 HAT
IPR008669 LSM_interact
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034217 SART3_RRM1
IPR034218 SART3_RRM2
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF05391 Lsm_interact, 1 hit
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00386 HAT, 7 hits
SM00360 RRM, 2 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSART3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JLI8
Secondary accession number(s): Q6ZQI2
, Q8BPK9, Q8C3B7, Q8CFU9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2000
Last modified: October 16, 2019
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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