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Protein

Tropomodulin-4

Gene

Tmod4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).By similarity

GO - Molecular functioni

  • actin filament binding Source: InterPro
  • tropomyosin binding Source: MGI

GO - Biological processi

  • muscle contraction Source: GO_Central
  • myofibril assembly Source: GO_Central
  • pointed-end actin filament capping Source: InterPro

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomodulin-4
Alternative name(s):
Skeletal muscle tropomodulin
Short name:
Sk-Tmod
Gene namesi
Name:Tmod4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1355285 Tmod4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861371 – 345Tropomodulin-4Add BLAST345

Proteomic databases

MaxQBiQ9JLH8
PaxDbiQ9JLH8
PRIDEiQ9JLH8

PTM databases

PhosphoSitePlusiQ9JLH8

Expressioni

Gene expression databases

BgeeiENSMUSG00000005628 Expressed in 115 organ(s), highest expression level in muscle of leg
CleanExiMM_TMOD4
ExpressionAtlasiQ9JLH8 baseline and differential
GenevisibleiQ9JLH8 MM

Interactioni

Subunit structurei

Binds to the N-terminus of tropomyosin and to actin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005769

Structurei

3D structure databases

ProteinModelPortaliQ9JLH8
SMRiQ9JLH8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tropomodulin family.Curated

Phylogenomic databases

eggNOGiKOG3735 Eukaryota
ENOG410YAHM LUCA
GeneTreeiENSGT00760000119226
HOGENOMiHOG000261624
HOVERGENiHBG056172
InParanoidiQ9JLH8
KOiK10370
OMAiMKTNTYV
OrthoDBiEOG091G0C3H
PhylomeDBiQ9JLH8
TreeFamiTF315841

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR004934 TMOD
IPR030129 TMOD4
PANTHERiPTHR10901 PTHR10901, 1 hit
PTHR10901:SF9 PTHR10901:SF9, 1 hit
PfamiView protein in Pfam
PF03250 Tropomodulin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9JLH8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYQKELEK YRDIDEDEIL RTLSPEELEQ LDCELQEMDP ENMLLPAGLR
60 70 80 90 100
QRDQTKKSPT GPLDRDALLQ YLEQQALEVK ERDDLVPYTG EKKGKPFIQP
110 120 130 140 150
KREIPAQEQI TLEPELEEAL SHATDAEMCD IAAILGMYTL MSNKQYYDAI
160 170 180 190 200
CSGEICNTEG ISSVVQPDKY KPVPDEPPNP TNIEEMLKRV RSNDKELEEV
210 220 230 240 250
NLNNIQDIPI PVLSDLCEAM KTNTYVRSFS LVATKSGDPI ANAVADMLRE
260 270 280 290 300
NRSLQSLNIE SNFISSTGLM AVLKAVRENA TLTELRVDNQ RQWPGDAVEM
310 320 330 340
EMATVLEQCP SIVRFGYHFT QQGPRARAAH AMTRNNELRR QQKKR
Length:345
Mass (Da):39,261
Last modified:October 1, 2000 - v1
Checksum:i5C19ED96398F8A54
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z5Q9D3Z5Q9_MOUSE
Tropomodulin-4
Tmod4
184Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177174 mRNA Translation: AAF31673.1
BC068020 mRNA Translation: AAH68020.1
CCDSiCCDS17601.1
RefSeqiNP_057921.1, NM_016712.3
XP_017175125.1, XM_017319636.1
UniGeneiMm.71935

Genome annotation databases

EnsembliENSMUST00000005769; ENSMUSP00000005769; ENSMUSG00000005628
ENSMUST00000107227; ENSMUSP00000102846; ENSMUSG00000005628
GeneIDi50874
KEGGimmu:50874
UCSCiuc008qib.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177174 mRNA Translation: AAF31673.1
BC068020 mRNA Translation: AAH68020.1
CCDSiCCDS17601.1
RefSeqiNP_057921.1, NM_016712.3
XP_017175125.1, XM_017319636.1
UniGeneiMm.71935

3D structure databases

ProteinModelPortaliQ9JLH8
SMRiQ9JLH8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005769

PTM databases

PhosphoSitePlusiQ9JLH8

Proteomic databases

MaxQBiQ9JLH8
PaxDbiQ9JLH8
PRIDEiQ9JLH8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005769; ENSMUSP00000005769; ENSMUSG00000005628
ENSMUST00000107227; ENSMUSP00000102846; ENSMUSG00000005628
GeneIDi50874
KEGGimmu:50874
UCSCiuc008qib.1 mouse

Organism-specific databases

CTDi29765
MGIiMGI:1355285 Tmod4

Phylogenomic databases

eggNOGiKOG3735 Eukaryota
ENOG410YAHM LUCA
GeneTreeiENSGT00760000119226
HOGENOMiHOG000261624
HOVERGENiHBG056172
InParanoidiQ9JLH8
KOiK10370
OMAiMKTNTYV
OrthoDBiEOG091G0C3H
PhylomeDBiQ9JLH8
TreeFamiTF315841

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Miscellaneous databases

PROiPR:Q9JLH8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005628 Expressed in 115 organ(s), highest expression level in muscle of leg
CleanExiMM_TMOD4
ExpressionAtlasiQ9JLH8 baseline and differential
GenevisibleiQ9JLH8 MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR004934 TMOD
IPR030129 TMOD4
PANTHERiPTHR10901 PTHR10901, 1 hit
PTHR10901:SF9 PTHR10901:SF9, 1 hit
PfamiView protein in Pfam
PF03250 Tropomodulin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMOD4_MOUSE
AccessioniPrimary (citable) accession number: Q9JLH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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