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Entry version 108 (02 Jun 2021)
Sequence version 2 (28 Feb 2018)
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Protein

CDK5 regulatory subunit-associated protein 2

Gene

Cdk5rap2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity).

Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Required for the recruitment of AKAP9 to centrosomes (By similarity).

Plays a role in neurogenesis. Contrary to higher mammalian orthologs, including human, chimpanzee, bovine and dog, does not interact with EB1/MAPRE1, therefore its function in the regulation of microtubule dynamics is unclear (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CDK5 regulatory subunit-associated protein 2
Alternative name(s):
CDK5 activator-binding protein C48
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
708451, Cdk5rap2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000898381 – 1903CDK5 regulatory subunit-associated protein 2Add BLAST1903

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei485PhosphoserineCombined sources1
Modified residuei544PhosphoserineBy similarity1
Modified residuei1193PhosphothreonineCombined sources1
Modified residuei1241PhosphoserineCombined sources1
Modified residuei1243PhosphoserineBy similarity1
Modified residuei1495PhosphoserineCombined sources1
Modified residuei1673PhosphoserineCombined sources1
Modified residuei1676PhosphoserineCombined sources1
Modified residuei1903PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in vitro by CDK5.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JLH5

PeptideAtlas

More...
PeptideAtlasi
Q9JLH5

PRoteomics IDEntifications database

More...
PRIDEi
Q9JLH5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JLH5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JLH5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDK5R1 (p35 form) (PubMed:10721722). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. May form a complex with CDK5R1 and CDK5.

Interacts (via C-terminus) with PCNT; the interaction is leading to centrosomal localization of CDK5RAP2 and PCNT (By similarity).

Interacts with AKAP9; the interaction is leading to Golgi localization of CDK5RAP2 and AKAP9.

Interacts with TUBG1; the interaction is leading to the centrosomal localization of CDK5RAP2 and TUBG1.

Interacts with TUBGCP3.

Interacts with CALM1.

Interacts with CDC20.

Interacts with CEP68; degradation of CEP68 in early mitosis leads to removal of CDK5RAP2 from the centrosome which promotes centriole disengagement and subsequent centriole separation.

Interacts with NCKAP5L.

Interacts with LGALS3BP; this interaction may connect the pericentrosomal complex to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (By similarity). Contrary to human, chimpanzee, bovine and dog orthologous proteins, does not interact with EB1/MAPRE1, possibly due to a divergence at the level of the critical residue 939, which is a proline in MAPRE1-binding orthologs and a leucine in mouse and rat (Probable).

By similarity1 Publication1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9JLH5, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000007710

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JLH5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni244 – 282DisorderedSequence analysisAdd BLAST39
Regioni1022 – 1044DisorderedSequence analysisAdd BLAST23
Regioni1349 – 1387DisorderedSequence analysisAdd BLAST39
Regioni1736 – 1903Required for centrosomal attachment, Golgi localization and CALM1 interactionBy similarityAdd BLAST168
Regioni1736 – 1778Interaction with CDK5R11 PublicationAdd BLAST43
Regioni1871 – 1880Required for centrosomal attachment, Golgi localization and CALM1 interactionBy similarity10
Regioni1883 – 1903DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi263 – 282Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1027 – 1044Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1364 – 1387Basic and acidic residuesSequence analysisAdd BLAST24

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTI7, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JLH5

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9JLH5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012943, Cnn_1N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07989, Cnn_1N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9JLH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMDSGMEEDV TLPGTLSGCS GLHPVLPSDL DVISDTTGLG NGVLPIMSEE
60 70 80 90 100
KVSPTRARNM KDFENQITEL KKENFNLKLR IYFLEERIQQ EFAGPTEHIY
110 120 130 140 150
KKNIELKVEV ESLKRELQER DQLLVKASKA VESLAEGGGS EIQRVKEDAR
160 170 180 190 200
KKVQQVEELL TKRIHLLEED VKAAQAELEK AFAGTETEKA LRLSLESKLS
210 220 230 240 250
AMKKMQEGDL EMTLALEEKD RLIEELKLSL KSKEALIQCL KEEKSQMASP
260 270 280 290 300
DENVSSGELR GLSATLREEK ERDAEERQKE RNHFEERIQA LQEDLREKER
310 320 330 340 350
EIATEKKNSL KRDKAIQGLT MALKSKEKEV EELNSIIKEL TADSTQSREA
360 370 380 390 400
PLKTQVSEFE VRESENCEAA LAEKEALLAK LHSENVTKNT ENHRLLRNVK
410 420 430 440 450
KVTQELNDLK KEKLRLERDL EEAHREGNRG ARTIHDLRNE VEKLRKEVCE
460 470 480 490 500
REKAVEKHYK SLPGESSSKF HSQEQVVKGL TESASQEDLL LQKSNEKDLE
510 520 530 540 550
AIQQNCYLMT AEELKFGSDG LITEKCSQQS PDSKLIFSKE KQQSEYEGLT
560 570 580 590 600
GDLKTEQNVY AHLAKNLQDT DSKLQAELKR VLALRKQLEQ DVLAYRNLQT
610 620 630 640 650
ALQEQLSEIR KREEEPFSFY SDQTSYLSIC LEEHSQFQLE HFSQEEIKKK
660 670 680 690 700
VIDLIQLVKD LHADNQHLKK TIFDISCMGV QGNDRLESTK QAELMASKAD
710 720 730 740 750
EDTLKFKADD ENHFQSDQHL EQSREIMEDY AEGGGKDGYV RHMDSNILDH
760 770 780 790 800
DGAHTPDTSE DHSLEDELLS LLATFFSKKA TPSLESRPDL LKALGALLLE
810 820 830 840 850
RICLAEQGSP GDHSDSKAEK ALEQVAVRLR DELGHSCLAN SFSKSHSELK
860 870 880 890 900
SPRGTWLVKT GDEAKVELKS VSVQTMTIED STRGFKPERK REAWAGKPEE
910 920 930 940 950
AVFSTELESE ALGEMPGLQA THLSFPSAID KDDQKTGLLI QLKTPELLEN
960 970 980 990 1000
LYNLPASQEV VAQLQGQVLE LQKELKEYKI RNKQLLDKLI LAEAMMEGMA
1010 1020 1030 1040 1050
VPNSTPVNVP AAQAVVRTAF QGKPGEQEGH ETTHSAGRDK EVDSDQYTSF
1060 1070 1080 1090 1100
EIDSEICPPD DLALLPACKE NLEDFLGPPS IATYLDSKSQ LSVKVSVVGT
1110 1120 1130 1140 1150
DQSENINLPD DTEALKQKIH DLQTELEGYR NIIVQLQKHS QCSEAIITVL
1160 1170 1180 1190 1200
CGTEGAQDGL NKPKGHIDEE EMTFSSLHQV RYVKHMKILR PLTPEIIDGK
1210 1220 1230 1240 1250
MLESLKQQLV EQEQELQKEQ DLNLELFGEI HNLQNKFRDL SPSRYDSLVQ
1260 1270 1280 1290 1300
SQARELSLQR QQIKDSHDIC VVCHQHMSTM IKAFEELLQA SDVDSCVAEG
1310 1320 1330 1340 1350
FREQLTQCAG LLEQLEKLFL HGKSARVEPH TQTELLRRLR TEEDNLPYQH
1360 1370 1380 1390 1400
LLPESPEPSA SHALSDDEMS EKSFLSREPK PDSETEKYPT IASRFPQDLL
1410 1420 1430 1440 1450
MEHIQEIRTL RKHLEESIKT NEKLRKQLER QGCETDQGST NVSAYSSELH
1460 1470 1480 1490 1500
NSLTSEIQFL RKQNEALSTM LEKGSKEKQK ENEKLRESLA RKTESLEHLQ
1510 1520 1530 1540 1550
LEYASVREEN ERLRRDISEK ERQNQQLTQE VCSSLQELSR VQEEAKSRQQ
1560 1570 1580 1590 1600
LLLQKDELLQ SLQMELKVYE KLAEEHQKLQ QESRGEACGG GQKGQDPFSN
1610 1620 1630 1640 1650
LHGLLKEIQV LRDQAERSIQ TNNTLKSKLE KQLSQGSKQA QEGALTLAVQ
1660 1670 1680 1690 1700
ALSVTEWSLQ LDKHDVNKCP EASDNSFDLF ESTQAMAPKS ASETPVLSGT
1710 1720 1730 1740 1750
DVDSLSCDST SSATSPSCMP CLVAGRHLWA SKSGHHMLCL IEDYDALYKQ
1760 1770 1780 1790 1800
ISWGQTLLAK MDIQTQEALS PTSQKLGPKA SFSVPLSKFL SSMNTAKLIL
1810 1820 1830 1840 1850
EKASRLLKLF WRVSVPTNGQ CSLHCDQIGE MKAEITKLHK KLFEQEKKLQ
1860 1870 1880 1890 1900
NTAKLLQQSK HQEKIIFDQL VITHQVLRKA RGNLELRPRA AHPGTSSPSR

PGS
Length:1,903
Mass (Da):215,482
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i770918B8FFD50B84
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K6K7A0A0G2K6K7_RAT
CDK5 regulatory subunit-associated ...
Cdk5rap2
1,901Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1M4B7F1M4B7_RAT
CDK5 regulatory subunit-associated ...
Cdk5rap2
1,820Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JX524852 mRNA Translation: AFV70628.1
AF177478 mRNA Translation: AAF60224.1

Genome annotation databases

UCSC genome browser

More...
UCSCi
RGD:708451, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX524852 mRNA Translation: AFV70628.1
AF177478 mRNA Translation: AAF60224.1

3D structure databases

SMRiQ9JLH5
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9JLH5, 2 interactors
STRINGi10116.ENSRNOP00000007710

PTM databases

iPTMnetiQ9JLH5
PhosphoSitePlusiQ9JLH5

Proteomic databases

PaxDbiQ9JLH5
PeptideAtlasiQ9JLH5
PRIDEiQ9JLH5

Genome annotation databases

UCSCiRGD:708451, rat

Organism-specific databases

RGDi708451, Cdk5rap2

Phylogenomic databases

eggNOGiENOG502QTI7, Eukaryota
InParanoidiQ9JLH5
PhylomeDBiQ9JLH5

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9JLH5

Family and domain databases

InterProiView protein in InterPro
IPR012943, Cnn_1N
PfamiView protein in Pfam
PF07989, Cnn_1N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCK5P2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JLH5
Secondary accession number(s): K7QQW0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: February 28, 2018
Last modified: June 2, 2021
This is version 108 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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