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Protein

Polycystic kidney disease 2-like 2 protein

Gene

Pkd2l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a subunit of a cation channel and play a role in fertilization.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Polycystic kidney disease 2-like 2 protein
Alternative name(s):
Polycystin-2L2
Polycystin-L2
Gene namesi
Name:Pkd2l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1858231 Pkd2l2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31CytoplasmicSequence analysisAdd BLAST31
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 277ExtracellularSequence analysisAdd BLAST225
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 314CytoplasmicSequence analysisAdd BLAST16
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Topological domaini336 – 360ExtracellularSequence analysisAdd BLAST25
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Topological domaini382 – 406CytoplasmicSequence analysisAdd BLAST25
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 468ExtracellularSequence analysisAdd BLAST41
Transmembranei469 – 489HelicalSequence analysisAdd BLAST21
Topological domaini490 – 621CytoplasmicSequence analysisAdd BLAST132

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001643621 – 621Polycystic kidney disease 2-like 2 proteinAdd BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JLG4
PRIDEiQ9JLG4

PTM databases

PhosphoSitePlusiQ9JLG4

Expressioni

Tissue specificityi

Expressed only in testis and heart.

Gene expression databases

BgeeiENSMUSG00000014503 Expressed in 75 organ(s), highest expression level in primary oocyte
CleanExiMM_PKD2L2
GenevisibleiQ9JLG4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000014647

Structurei

3D structure databases

ProteinModelPortaliQ9JLG4
SMRiQ9JLG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili521 – 551Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the polycystin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3599 Eukaryota
ENOG410XTGE LUCA
GeneTreeiENSGT00700000104221
HOGENOMiHOG000230858
HOVERGENiHBG014945
InParanoidiQ9JLG4
KOiK04991
OMAiEFKSAYF
OrthoDBiEOG091G034F
TreeFamiTF316484

Family and domain databases

InterProiView protein in InterPro
IPR013122 PKD1_2_channel
IPR003915 PKD_2
PfamiView protein in Pfam
PF08016 PKD_channel, 1 hit
PRINTSiPR01433 POLYCYSTIN2

Sequencei

Sequence statusi: Complete.

Q9JLG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEATWWYRG GTSKHDLHYR REAEVNTTLE ELLLYFIFLI NLCILTFGMV
60 70 80 90 100
NPHMYYLNKV MSSLFVDTSL PDDERSSFRS IRSITEFWKF MEGPLIDGLY
110 120 130 140 150
WDSWYGNKQL YSVKNSSRIY YENVLLGIPR VRQLRVRNNT CKVYPAFQSL
160 170 180 190 200
VSDCYSKYTV ENEDFSDFGL KRNPEWTHTP SSRTAPWHWG FVGVYRDGGY
210 220 230 240 250
IVTLSKSKSE TKAKFVDLRL NNWISRGTRA VFIDFSLYNA NVNLFCIIRL
260 270 280 290 300
LAEFPATGGL LTSWQFYSVK LLRYVSYYDY FIASCEVIFC IFLFVFIIQE
310 320 330 340 350
LRKVNEFKSA YFRSVWNWLE MLLLLLCFLA VSFYAYCNMQ SFLLLGQLLK
360 370 380 390 400
NTDSYPDFYF LAYWHIYYNN VIAITIFFAW IKIFKFISFN ETMSQLSSTL
410 420 430 440 450
SRCMKDIVGF AIMFFIIFSA YAQLGFLVFG SQVDDFSTFQ NSIFAQFRIV
460 470 480 490 500
LGDFNFAGIQ QANWILGPIY FITFIFFVFF VLLNMFLAII NDTYSEVKAD
510 520 530 540 550
YSIGRRPDFE LGKIIQKSCF NVLEKLRLKK AQAKEEKKMQ TTDLAQRARR
560 570 580 590 600
DGFDESEIQE AEQMKRWKER LEKKYYSTEI QDDYQPVTQQ EFRELFLYAV
610 620
ELEKELHYVS LKLNQLMRKL H
Length:621
Mass (Da):73,683
Last modified:July 27, 2011 - v2
Checksum:iC542425A2C8A7480
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107N → T in AAF65621 (PubMed:10756092).Curated1
Sequence conflicti551D → E in AAF65621 (PubMed:10756092).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182033 mRNA Translation: AAF65621.1
BC138717 mRNA Translation: AAI38718.1
CCDSiCCDS29127.1
RefSeqiNP_001156476.1, NM_001163004.1
NP_058623.2, NM_016927.3
XP_017173434.1, XM_017317945.1
UniGeneiMm.445792

Genome annotation databases

EnsembliENSMUST00000014647; ENSMUSP00000014647; ENSMUSG00000014503
ENSMUST00000166156; ENSMUSP00000127257; ENSMUSG00000014503
GeneIDi53871
KEGGimmu:53871
UCSCiuc008ekm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPK2L2_MOUSE
AccessioniPrimary (citable) accession number: Q9JLG4
Secondary accession number(s): B2RS50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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