UniProtKB - Q9JLF1 (GBRT_MOUSE)
Protein
Gamma-aminobutyric acid receptor subunit theta
Gene
Gabrq
Organism
Mus musculus (Mouse)
Status
Functioni
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
GO - Molecular functioni
- chloride channel activity Source: UniProtKB-KW
- extracellular ligand-gated ion channel activity Source: InterPro
- GABA-A receptor activity Source: MGI
- neurotransmitter receptor activity Source: GO_Central
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- chloride transmembrane transport Source: GO_Central
- chloride transport Source: MGI
- gamma-aminobutyric acid signaling pathway Source: MGI
- ion transmembrane transport Source: GO_Central
- nervous system process Source: GO_Central
- regulation of membrane potential Source: GO_Central
- signal transduction Source: GO_Central
Keywordsi
Molecular function | Chloride channel, Ion channel |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Enzyme and pathway databases
Reactomei | R-MMU-977443, GABA receptor activation |
Names & Taxonomyi
Protein namesi | Recommended name: Gamma-aminobutyric acid receptor subunit thetaAlternative name(s): GABA(A) receptor subunit theta |
Gene namesi | Name:Gabrq |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1888498, Gabrq |
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: MGI
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- chloride channel complex Source: UniProtKB-KW
- GABA-A receptor complex Source: GO_Central
- neuron projection Source: GO_Central
- receptor complex Source: MGI
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 267 | ExtracellularSequence analysisAdd BLAST | 246 | |
Transmembranei | 268 – 288 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 326 – 346 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 618 – 638 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000000496 | 22 – 638 | Gamma-aminobutyric acid receptor subunit thetaAdd BLAST | 617 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 127 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 183 ↔ 197 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9JLF1 |
PRIDEi | Q9JLF1 |
PTM databases
GlyGeni | Q9JLF1, 1 site |
PhosphoSitePlusi | Q9JLF1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000031344, Expressed in secondary oocyte and 45 other tissues |
ExpressionAtlasi | Q9JLF1, baseline and differential |
Genevisiblei | Q9JLF1, MM |
Interactioni
Subunit structurei
Generally pentameric. This subunit coassembles with alpha-2, beta-1 and gamma-1.
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000033711 |
Miscellaneous databases
RNActi | Q9JLF1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRQ sub-subfamily. [View classification]Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3643, Eukaryota |
GeneTreei | ENSGT00940000162167 |
InParanoidi | Q9JLF1 |
OrthoDBi | 480926at2759 |
PhylomeDBi | Q9JLF1 |
TreeFami | TF315453 |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR008101, GABAAt_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00253, GABAARECEPTR PR01725, GABAARTHETA PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9JLF1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGIRGMLRAA ALLLLIRTWL AESNGPSPTP KFHFELSSST PEVILDLFNC
60 70 80 90 100
KNCANEAVVQ KILDRVLSTY DVRLRPNFGG APVPVSVSIY VSSIEQISEI
110 120 130 140 150
NMDYTITMFL HQTWKDTRLA YYETNLNLTL DYRMHEKLWV PDCYFVNSKD
160 170 180 190 200
AFVHDVTVEN RVFQLHPDGT VRYGIRLTTT AACSLDLQKF PMDKQSCKLE
210 220 230 240 250
VESYGYTVED IVLSWEDDNA IHITDGLHIP QYTYLGRTIT SKEVYFYTGS
260 270 280 290 300
YMRLIVKFQV QREVRSYLVQ VYWPTVLTTI LSWISFWMNY DSSAARVTIG
310 320 330 340 350
LTSILVLTTI DSHMRDKLPH ISCIKAIDIY ILVCLFFVFL SLLEYVYINY
360 370 380 390 400
LFFSQVPRRN HRRCRKPRRV VARYRYQEVV VANVQDGLIN VEDRVEDRAG
410 420 430 440 450
PLPDSPMQAH LASQESLGSL VFTSEQAQLA TSESLSLLSS ASSQTQLATG
460 470 480 490 500
ESLSDLPSTS EQTVPECTIH FHGFLTNDSI IPIKIHSRSD ACDDEDSEES
510 520 530 540 550
LSSEESHGHG SSHTGRLKLQ ISQRCVQEAS WDLDKIEILQ DDISITSSWL
560 570 580 590 600
GLDEQCKGDA DSIWSLTDEE LMACDQEKDS SSESEENCSP SPGCSFNEGF
610 620 630
SFQLFKPNRV PKVDRWSRFL FPLSFGLFNV VYWLYHVY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB1AUQ5 | B1AUQ5_MOUSE | Gamma-aminobutyric acid receptor su... | Gabrq | 525 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF189260 mRNA Translation: AAF70381.1 |
CCDSi | CCDS30188.1 |
RefSeqi | NP_065234.1, NM_020488.2 XP_006528236.1, XM_006528173.1 |
Genome annotation databases
Ensembli | ENSMUST00000033711; ENSMUSP00000033711; ENSMUSG00000031344 |
GeneIDi | 57249 |
KEGGi | mmu:57249 |
UCSCi | uc009tkq.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF189260 mRNA Translation: AAF70381.1 |
CCDSi | CCDS30188.1 |
RefSeqi | NP_065234.1, NM_020488.2 XP_006528236.1, XM_006528173.1 |
3D structure databases
SMRi | Q9JLF1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000033711 |
Chemistry databases
ChEMBLi | CHEMBL2094133 |
DrugCentrali | Q9JLF1 |
PTM databases
GlyGeni | Q9JLF1, 1 site |
PhosphoSitePlusi | Q9JLF1 |
Proteomic databases
PaxDbi | Q9JLF1 |
PRIDEi | Q9JLF1 |
Protocols and materials databases
Antibodypediai | 73628, 103 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000033711; ENSMUSP00000033711; ENSMUSG00000031344 |
GeneIDi | 57249 |
KEGGi | mmu:57249 |
UCSCi | uc009tkq.2, mouse |
Organism-specific databases
CTDi | 55879 |
MGIi | MGI:1888498, Gabrq |
Phylogenomic databases
eggNOGi | KOG3643, Eukaryota |
GeneTreei | ENSGT00940000162167 |
InParanoidi | Q9JLF1 |
OrthoDBi | 480926at2759 |
PhylomeDBi | Q9JLF1 |
TreeFami | TF315453 |
Enzyme and pathway databases
Reactomei | R-MMU-977443, GABA receptor activation |
Miscellaneous databases
BioGRID-ORCSi | 57249, 2 hits in 17 CRISPR screens |
PROi | PR:Q9JLF1 |
RNActi | Q9JLF1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031344, Expressed in secondary oocyte and 45 other tissues |
ExpressionAtlasi | Q9JLF1, baseline and differential |
Genevisiblei | Q9JLF1, MM |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR008101, GABAAt_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00253, GABAARECEPTR PR01725, GABAARTHETA PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GBRT_MOUSE | |
Accessioni | Q9JLF1Primary (citable) accession number: Q9JLF1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 4, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families