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Entry version 130 (16 Oct 2019)
Sequence version 2 (09 Jan 2007)
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Protein

Sacsin

Gene

Sacs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sacsin
Alternative name(s):
DnaJ homolog subfamily C member 29
Short name:
DNAJC29
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sacs
Synonyms:Kiaa0730
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1354724 Sacs

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000975641 – 4582SacsinAdd BLAST4582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei945N6-acetyllysineBy similarity1
Modified residuei1781PhosphoserineBy similarity1
Modified residuei2513PhosphoserineCombined sources1
Modified residuei2518PhosphothreonineCombined sources1
Modified residuei3437PhosphoserineBy similarity1
Modified residuei4263PhosphothreonineCombined sources1
Modified residuei4266PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JLC8

PeptideAtlas

More...
PeptideAtlasi
Q9JLC8

PRoteomics IDEntifications database

More...
PRIDEi
Q9JLC8

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2689

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JLC8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JLC8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9JLC8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain (at protein level).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
206063, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9JLC8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000086816

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JLC8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 84Ubiquitin-likeAdd BLAST78
Domaini4309 – 4396JPROSITE-ProRule annotationAdd BLAST88
Domaini4454 – 4570HEPNPROSITE-ProRule annotationAdd BLAST117

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ubiquitin-like domain mediates interaction with the proteasome.By similarity
The J domain is functional and is able to stimulate E.coli dnaK ATPase activity.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IDYY Eukaryota
ENOG410XV7A LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154245

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JLC8

KEGG Orthology (KO)

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KOi
K17592

Database of Orthologous Groups

More...
OrthoDBi
1277at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9JLC8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.110, 1 hit
3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001623 DnaJ_domain
IPR036890 HATPase_C_sf
IPR007842 HEPN_dom
IPR036869 J_dom_sf
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05168 HEPN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00748 HEPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46565 SSF46565, 1 hit
SSF54236 SSF54236, 1 hit
SSF55874 SSF55874, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50076 DNAJ_2, 1 hit
PS50910 HEPN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JLC8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METKFQRWVR VTVLRGCVGC RTVAVPATAT GRDLKERIFA ETSFPVAEQR
60 70 80 90 100
LWRGDREVPD WIKIGDLTSK TCHLFVNLQS KGLKGGGRFG QTTPPLVDFL
110 120 130 140 150
KDILRRYPEG GQILKELIQN AEDAGATEVK FLYDETQYGT ETLWSKDMAQ
160 170 180 190 200
YQGSALYVYN NAVFTPEDWH GIQEIARSRK KDDPLKVGRF GIGFNSVYHI
210 220 230 240 250
TDVPCIFSGD QIGMLDPHQT LFGPHESGQC WNLKDDIKEI NELPDQFAPF
260 270 280 290 300
IGVFGSTKET FTNGSFPGTF FRFPLRLQPS QLSSNLYTKQ KVLELFDSFR
310 320 330 340 350
ADADTVLLFL KSVQAVSLHV READGTEKLV FRVTASENKA LKHERPNSIK
360 370 380 390 400
ILGTAISNYC KKIPSNSVTC VTYHINIVLE DESTKDAQKT SWLVCNSVGG
410 420 430 440 450
RGISSKLDSL ADELKFVPII GLAMPLSGKD EENGAISDFS GKAFCFLPLP
460 470 480 490 500
PGEESRTGLP VHISGFFGLT DNRRSIKWRE LDQWRDPAAL WNEYLIVNVV
510 520 530 540 550
PKTYATLILD SIKRLETEKS SDFPLSVDTI YKLWPEASKV KAHWHPVLGP
560 570 580 590 600
LFSELFQHAV IYSIGGEWVK LEQVHFSELD GSLESTRSVL NYLQSSGKQI
610 620 630 640 650
AKVPGNLAAA VQLSAASATS SASPVRKVTP AWVRQVLRKC AHLGSAEEKL
660 670 680 690 700
HLLEFVLSDQ AYSELLGLEL LPLQSGAFVP FSSSVSDQDV VYITSEEFPR
710 720 730 740 750
SLFPGLEARL ILENLKPHLL AALKEAAQTR GRPCTQLQLL NPERFARLIK
760 770 780 790 800
EVMNTFWPGR ELVVQWYPFS EDKRHPSLSW LKMVWKNLYI HFSEDLTLFD
810 820 830 840 850
EMPLIPRTLL NEDQTCVELI RLRIPSVVIL DDETEAQLPE FLADIVQKLG
860 870 880 890 900
GIVLKRLDTS IQHPLVKKYI HSPLPSAILQ IMEKIPLQKL CNQIASLLPT
910 920 930 940 950
HKDALRKFLA SLTDTSEKEK RIIQELTIFK RINHSSDQGI SSYTKLKGCK
960 970 980 990 1000
VLDHTAKLPT DLRLSVSVID SSDEATIRLA NMLKIEKLKT TSCLKFVLKD
1010 1020 1030 1040 1050
IGNAFYTQEE VTQLMLWILE NLSSLKNENS NVLDWLMPLK FIHMSQGHVV
1060 1070 1080 1090 1100
AAGDLFDPDI EVLRDLFYNE EEACFPPTIF TSPDILHSLR QIGLKNESSL
1110 1120 1130 1140 1150
KEKDVVQVAR KIEALQVSSC QNQDVLMKKA KTLLLVLNKN QTLLQSSEGK
1160 1170 1180 1190 1200
MALKKIKWVP ACKERPPNYP GSLVWKGDLC NLCAPPDMCD AAHAVLVGSS
1210 1220 1230 1240 1250
LPLVESVHVN LEQALSIFTK PTINAVLKHF KTVVDWYTSK TFSDEDYYQF
1260 1270 1280 1290 1300
QHILLEIYGF MHDHLSEGKD SFKALKFPWV WTGKNFCPLA QAVIKPTHDL
1310 1320 1330 1340 1350
DLQPYLYNVP KTMAKFHQLF KACGSIEELT SDHISMVIQK VYLKSDQELS
1360 1370 1380 1390 1400
EEESKQNLHL MLNIMRWLYS NQIPASPNTP VPIYHSRNPS KLVMKPIHEC
1410 1420 1430 1440 1450
CYCDIKVDDL NDLLEDSVEP IILVHEDIPM KTAEWLKVPC LSTRLINPEN
1460 1470 1480 1490 1500
MGFEQSGQRE PLTVRIKNIL EEYPSVSDIF KELLQNADDA NATECSFMID
1510 1520 1530 1540 1550
MRRNMDIREN LLDPGMAACH GPALWSFNNS EFSDSDFLNI TRLGESLKRG
1560 1570 1580 1590 1600
EVDKVGKFGL GFNSVYHITD IPIIMSREFM IMFDPNINHI SKHIKDRSNP
1610 1620 1630 1640 1650
GIKINWSKQQ KRLRKFPNQF KPFIDVFGCQ LPLAVEAPYS YNGTLFRLSF
1660 1670 1680 1690 1700
RTQQEAKVSE VSSTCYNTAD IYSLVDEFSL CGHRLIIFTQ SVNSMYLKYL
1710 1720 1730 1740 1750
KIEETNPSLA QDTIIIKKKV CPSKALNAPV LSVLKEAAKL MKTCSSSNKK
1760 1770 1780 1790 1800
LPTDVPKSSC ILQITVEEFH HVFRRIADLQ SPLFRGPDDD PATLFEMAKS
1810 1820 1830 1840 1850
GQSKKPSDEL PQKTVDCTTW LICTCMDTGE ALKFSLNESG RRLGLVPCGA
1860 1870 1880 1890 1900
VGVLLHETQE QKWTVKPHIG EVFCYLPLRI KTGLPIHING CFAVTSNRKE
1910 1920 1930 1940 1950
IWKTDTKGRW NTTFMRHVIV KAYLQALSVL RDLAIGGELT DYTYYAVWPD
1960 1970 1980 1990 2000
PDLVHDDFSV ICKGFYEDIA HGKGKELTRV FSDGSMWVSM KNVRFLDDSI
2010 2020 2030 2040 2050
LQRKDVGSAA FKIFLKYLKK TGSKNLCAVE LPSSVKAGFE EAGCKQILLE
2060 2070 2080 2090 2100
NTFSEKQFFS EVFFPNIQEI EAELRDPLMN FVLNEKLDEF SGILRVTPCV
2110 2120 2130 2140 2150
PCSLEGHPLV LPSRLIHPEG RVAKLFDTKD GRFPYGSTQD YLNPIILIKL
2160 2170 2180 2190 2200
VQLGMAKDDI LWDDMLERAE SVAEINKSDH AAACLRSSIL LSLIDEKLKI
2210 2220 2230 2240 2250
KDPRAKDFAA KYQTIPFLPF LTKPAGFSLE WKGNSFKPET MFAATDIYTA
2260 2270 2280 2290 2300
EYQDIVCLLQ PILNENSHSF RGCGSVSLAV KEFLGLLKKP TVDLVINQLK
2310 2320 2330 2340 2350
QVAKSVDDGI TLYQENITNA CYKYLHEAVL QNEMAKATII EKLKPFCFIL
2360 2370 2380 2390 2400
VENVYVESEK VSFHLNFEAA PYLYQLPNKY KNNFRELFES VGVRQSFTVE
2410 2420 2430 2440 2450
DFALVLESID QERGKKQITE ENFQLCRRII SEGIWSLIRE KRQEFCEKNY
2460 2470 2480 2490 2500
GKILLPDTNL LLLPAKSLCY NDCPWIKVKD STVKYCHADI PREVAVKLGA
2510 2520 2530 2540 2550
IPKRHKALER YASNICFTAL GTEFGQKEKL TSRIKSILNA YPSEKEMLKE
2560 2570 2580 2590 2600
LLQNADDAKA TEICFVFDPR QHPVDRIFDD KWAPLQGPAL CVYNNQPFTE
2610 2620 2630 2640 2650
DDVRGIQNLG KGTKEGNPCK TGHYGIGFNS VYHITDCPSF ISGNDILGIF
2660 2670 2680 2690 2700
DPHARYAPGA TSVSPGRMFR DLDADFRTQF SDVLDLYLGN HFKLDNCTMF
2710 2720 2730 2740 2750
RFPLRNAEMA QVSEISSVPS SDRMVQNLLD KLRSDGAELL MFLNHMEKIS
2760 2770 2780 2790 2800
ICEIDKATGG LNVLYSVKGK ITDGDRLKRK QFHASVIDSV TKKRQLKDIP
2810 2820 2830 2840 2850
VQQITYTMDT EDSEGNLTTW LICNRSGFSS MEKVSKSVIS AHKNQDITLF
2860 2870 2880 2890 2900
PRGGVAACIT HNYKKPHRAF CFLPLSLETG LPFHVNGHFA LDSARRNLWR
2910 2920 2930 2940 2950
DDNGVGVRSD WNNSLMTALI APAYVELLIQ LKKRYFPGSD PTLSVLQNTP
2960 2970 2980 2990 3000
IHVVKDTLKK FLSFFPVNRL DLQPDLYCLV KALYSCIHED MKRLLPVVRA
3010 3020 3030 3040 3050
PNIDGSDLHS AVIITWINMS TSNKTRPFFD NLLQDELQHL KNADYNITTR
3060 3070 3080 3090 3100
KTVAENVYRL KHLLLEIGFN LVYNCDETAN LYHCLVDADI PVSYVTPADV
3110 3120 3130 3140 3150
RSFLMTFSSP DTNCHIGKLP CRLQQTNLKL FHSLKLLVDY CFKDAEESEF
3160 3170 3180 3190 3200
EVEGLPLLIT LDSVLQIFDG KRPKFLTTYH ELIPSRKDLF MNTLYLKYSS
3210 3220 3230 3240 3250
VLLNCKVAKV FDISSFADLL SSVLPREYKT KNCAKWKDNF ASESWLKNAW
3260 3270 3280 3290 3300
HFISESVSVT DDQEEPKPAF DVIVDILKDW ALLPGTKFTV STSQLVVPEG
3310 3320 3330 3340 3350
DVLIPLSLMH IAVFPNAQSD KVFHALMKAG CIQLALNKIC SKDSALVPLL
3360 3370 3380 3390 3400
SCHTANIDSP ASILKAVHYM VQTSTFRTEK LMENDFEALL MYFNCNLSHL
3410 3420 3430 3440 3450
MSQDDIKILK SLPCYKSISG RYMSIAKFGT CYVLTKSIPS AEVEKWTQSS
3460 3470 3480 3490 3500
SSAFLEEKVH LKELYEVLGC VPVDDLEVYL KHLLPKIENL SYDAKLEHLI
3510 3520 3530 3540 3550
YLKNRLASIE EPSEIKEQLF EKLESLLIIH DANNRLKQAK HFYDRTVRVF
3560 3570 3580 3590 3600
EVMLPEKLFI PKEFFKKLEQ VIKPKNQAAF MTSWVEFLRN IGLKYALSQQ
3610 3620 3630 3640 3650
QLLQFAKEIS VRANTENWSK ETLQSTVDIL LHHIFQERMD LLSGNFLKEL
3660 3670 3680 3690 3700
SLIPFLCPER APAEYIRFHP QYQEVNGTLP LIKFNGAQVN PKFKQCDVLQ
3710 3720 3730 3740 3750
LLWTSCPILP EKATPLSIKE QEGSDLAPQE QLEQVLNMLN VNLDPPLDKV
3760 3770 3780 3790 3800
INNCRNICNI TTLDEEMVKT RAKVLRSIYE FLSAEKREFR FQLRGVAFVM
3810 3820 3830 3840 3850
VEDGWKLLKP EEVVINLEYE ADFKPYLYKL PLELGTFHQL FKHLGTEDII
3860 3870 3880 3890 3900
STKQYVEVLS RIFKSSEGKQ LDPNEMRTVK RVVSGLFKSL QNDSVKVRSD
3910 3920 3930 3940 3950
LENARDLALY LPSQDGKLVK SSILVFDDAP HYKSRIQGNI GVQMLVDLSQ
3960 3970 3980 3990 4000
CYLGKDHGFH TKLIMLFPQK LRPRLLSSIL EEQLDEETPK VCQFGALCSL
4010 4020 4030 4040 4050
QGRLQLLLSS EQFITGLIRI MKHENDNAFL ANEEKAIRLC KALREGLKVS
4060 4070 4080 4090 4100
CFEKLQTTLR VKGFNPIPHS RSETFAFLKR FGNAVILLYI QHSDSKDINF
4110 4120 4130 4140 4150
LLALAMTLKS ATDNLISDTS YLIAMLGCND IYRISEKLDS LGVKYDSSEP
4160 4170 4180 4190 4200
SKLELPMPGT PIPAEIHYTL LMDPMNVFYP GEYVGYLVDA EGGDIYGSYQ
4210 4220 4230 4240 4250
PTYTYAIIVQ EVEREDADNT SFLGKIYQID IGYSEYKIVS SLDLYKFSRP
4260 4270 4280 4290 4300
DESSQNRDSA PTTPTSPTEF LTPGLRSIPP LFSGKESHKS PSTKHHSPRK
4310 4320 4330 4340 4350
LKVNALPEIL KEVTSVVEQA WKLPESERKK IIRRLYLKWH PDKNPENHDI
4360 4370 4380 4390 4400
ANEVFKHLQN EINRLEKQAF LDQNADRASR RTFSTSASRF QSDKYSFQRF
4410 4420 4430 4440 4450
YTSWNQEATS HKSERQQQSK EKCPPSAGQT YSQRFFVPPT FKSVGNPVEA
4460 4470 4480 4490 4500
RRWLRQARAN FSAARNDLHK NANEWVCFKC YLSTKLALIA ADYAVRGKSD
4510 4520 4530 4540 4550
KDVKPTALAQ KIEEYSQQLE GLTNDVHTLE AYGVDSLKTR YPDLLPFPQI
4560 4570 4580
PNDRFTSEVA MRVMECTACI IIKLENFIQQ KV
Length:4,582
Mass (Da):520,685
Last modified:January 9, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2409B6DA64905B48
GO
Isoform 2 (identifier: Q9JLC8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-752: Missing.

Note: No experimental confirmation available.
Show »
Length:3,830
Mass (Da):436,755
Checksum:iB3F9DA5A3B0C3EF1
GO
Isoform 3 (identifier: Q9JLC8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: METKFQ → MGD

Note: No experimental confirmation available.
Show »
Length:4,579
Mass (Da):520,223
Checksum:i3FA662CF0D954276
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QNY8E9QNY8_MOUSE
Sacsin
Sacs
4,582Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J125A0A0R4J125_MOUSE
Sacsin
Sacs
768Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z3H1D3Z3H1_MOUSE
Sacsin
Sacs
745Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B2RRL5B2RRL5_MOUSE
Sacs protein
Sacs
744Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BR28A0A2I3BR28_MOUSE
Sacsin
Sacs
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8VKQ1A0A2R8VKQ1_MOUSE
Sacsin
Sacs
14Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC32757 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4 – 6KFQ → EET in BAE36019 (PubMed:16141072).Curated3
Sequence conflicti58V → I in BAC35006 (PubMed:16141072).Curated1
Sequence conflicti58V → I in BAE36019 (PubMed:16141072).Curated1
Sequence conflicti224P → H in BAC32757 (PubMed:16141072).Curated1
Sequence conflicti731 – 744GRPCT…LNPER → AQQLLWGYSGRITD in BAC32757 (PubMed:16141072).CuratedAdd BLAST14
Sequence conflicti732 – 768RPCTQ…VQWYP → YVKHDLLTTLERISLAYSGN KNSDSPSRRSPSAVTCK in BAE36019 (PubMed:16141072).CuratedAdd BLAST37

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0223261 – 752Missing in isoform 2. 1 PublicationAdd BLAST752
Alternative sequenceiVSP_0223271 – 6METKFQ → MGD in isoform 3. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF193557 Genomic DNA Translation: AAF31263.1
AC124555 Genomic DNA No translation available.
AC138718 Genomic DNA No translation available.
AK173011 mRNA Translation: BAD32289.1
AK038655 mRNA Translation: BAC30083.1
AK046501 mRNA Translation: BAC32757.1 Different initiation.
AK052467 mRNA Translation: BAC35006.1
AK160797 mRNA Translation: BAE36019.1

NCBI Reference Sequences

More...
RefSeqi
NP_766397.2, NM_172809.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
50720

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:50720

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193557 Genomic DNA Translation: AAF31263.1
AC124555 Genomic DNA No translation available.
AC138718 Genomic DNA No translation available.
AK173011 mRNA Translation: BAD32289.1
AK038655 mRNA Translation: BAC30083.1
AK046501 mRNA Translation: BAC32757.1 Different initiation.
AK052467 mRNA Translation: BAC35006.1
AK160797 mRNA Translation: BAE36019.1
RefSeqiNP_766397.2, NM_172809.3

3D structure databases

SMRiQ9JLC8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi206063, 2 interactors
IntActiQ9JLC8, 1 interactor
STRINGi10090.ENSMUSP00000086816

PTM databases

GlyConnecti2689
iPTMnetiQ9JLC8
PhosphoSitePlusiQ9JLC8
SwissPalmiQ9JLC8

Proteomic databases

PaxDbiQ9JLC8
PeptideAtlasiQ9JLC8
PRIDEiQ9JLC8

Genome annotation databases

GeneIDi50720
KEGGimmu:50720

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26278
MGIiMGI:1354724 Sacs

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IDYY Eukaryota
ENOG410XV7A LUCA
HOGENOMiHOG000154245
InParanoidiQ9JLC8
KOiK17592
OrthoDBi1277at2759
PhylomeDBiQ9JLC8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sacs mouse

Protein Ontology

More...
PROi
PR:Q9JLC8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di1.10.287.110, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036890 HATPase_C_sf
IPR007842 HEPN_dom
IPR036869 J_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF05168 HEPN, 1 hit
SMARTiView protein in SMART
SM00748 HEPN, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF54236 SSF54236, 1 hit
SSF55874 SSF55874, 3 hits
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit
PS50910 HEPN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSACS_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JLC8
Secondary accession number(s): Q3TUF2
, Q6A007, Q8BQT3, Q8C764, Q8CAJ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 9, 2007
Last modified: October 16, 2019
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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