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Entry version 155 (12 Aug 2020)
Sequence version 3 (27 Jul 2011)
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Protein

Cubilin

Gene

Cubn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi980Calcium 1By similarity1
Metal bindingi988Calcium 1By similarity1
Metal bindingi1027Calcium 1By similarity1
Metal bindingi1030Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi1096Calcium 2By similarity1
Metal bindingi1105Calcium 2By similarity1
Metal bindingi1146Calcium 2By similarity1
Metal bindingi1213Calcium 3By similarity1
Metal bindingi1221Calcium 3By similarity1
Metal bindingi1262Calcium 3By similarity1
Metal bindingi1264Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi1265Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi1328Calcium 4By similarity1
Metal bindingi1336Calcium 4By similarity1
Metal bindingi1373Calcium 4By similarity1
Metal bindingi1375Calcium 4; via carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCholesterol metabolism, Lipid metabolism, Protein transport, Steroid metabolism, Sterol metabolism, Transport
LigandCalcium, Cobalamin, Cobalt, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cubilin
Alternative name(s):
Intrinsic factor-cobalamin receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cubn
Synonyms:Ifcr
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1931256, Cubn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Coated pit, Endosome, Lysosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000004607421 – 32Removed in mature formBy similarityAdd BLAST12
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004607533 – 3623CubilinAdd BLAST3591

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi133 ↔ 144By similarity
Disulfide bondi138 ↔ 153By similarity
Disulfide bondi155 ↔ 164By similarity
Disulfide bondi171 ↔ 187By similarity
Disulfide bondi181 ↔ 196By similarity
Disulfide bondi198 ↔ 207By similarity
Disulfide bondi264 ↔ 277By similarity
Disulfide bondi271 ↔ 286By similarity
Disulfide bondi289 ↔ 300By similarity
Disulfide bondi350 ↔ 363By similarity
Disulfide bondi357 ↔ 376By similarity
Disulfide bondi399 ↔ 409By similarity
Disulfide bondi404 ↔ 418By similarity
Disulfide bondi420 ↔ 429By similarity
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi436 ↔ 447By similarity
Disulfide bondi441 ↔ 456By similarity
Disulfide bondi458 ↔ 467By similarity
Disulfide bondi474 ↔ 500By similarity
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi527 ↔ 549By similarity
Disulfide bondi590 ↔ 616By similarity
Disulfide bondi643 ↔ 665By similarity
Disulfide bondi708 ↔ 734By similarity
Glycosylationi711N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi749N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi761 ↔ 779By similarity
Glycosylationi781N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi817 ↔ 842By similarity
Glycosylationi857N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi869 ↔ 891By similarity
Disulfide bondi932 ↔ 958By similarity
Glycosylationi957N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi985 ↔ 1005By similarity
Glycosylationi1043N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1048 ↔ 1074By similarity
Disulfide bondi1165 ↔ 1191By similarity
Glycosylationi1168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1217N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1218 ↔ 1240By similarity
Disulfide bondi1278 ↔ 1306By similarity
Glycosylationi1285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1319N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1332N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1333 ↔ 1351By similarity
Disulfide bondi1391 ↔ 1417By similarity
Disulfide bondi1444 ↔ 1466By similarity
Glycosylationi1500N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1510 ↔ 1536By similarity
Glycosylationi1551N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1563 ↔ 1581By similarity
Disulfide bondi1620 ↔ 1647By similarity
Glycosylationi1646N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1675 ↔ 1697By similarity
Disulfide bondi1738 ↔ 1764By similarity
Disulfide bondi1791 ↔ 1812By similarity
Glycosylationi1802N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1819N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1905 ↔ 1927By similarity
Glycosylationi1967N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1978 ↔ 2006By similarity
Disulfide bondi2032 ↔ 2054By similarity
Glycosylationi2085N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi2092 ↔ 2118By similarity
Glycosylationi2117N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2217 ↔ 2247By similarity
Glycosylationi2274N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2275 ↔ 2297By similarity
Disulfide bondi2336 ↔ 2363By similarity
Disulfide bondi2390 ↔ 2411By similarity
Glycosylationi2400N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2452 ↔ 2478By similarity
Disulfide bondi2505 ↔ 2527By similarity
Glycosylationi2531N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2570 ↔ 2599By similarity
Glycosylationi2581N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2610N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2628 ↔ 2649By similarity
Disulfide bondi2689 ↔ 2715By similarity
Disulfide bondi2742 ↔ 2764By similarity
Disulfide bondi2805 ↔ 2831By similarity
Glycosylationi2813N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2860 ↔ 2883By similarity
Disulfide bondi2920 ↔ 2946By similarity
Glycosylationi2925N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi2977 ↔ 2999By similarity
Glycosylationi2989N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei3008PhosphothreonineBy similarity1
Disulfide bondi3037 ↔ 3064By similarity
Disulfide bondi3091 ↔ 3113By similarity
Glycosylationi3106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3125N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi3157 ↔ 3185By similarity
Disulfide bondi3215 ↔ 3237By similarity
Glycosylationi3268N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3278 ↔ 3306By similarity
Glycosylationi3283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3290N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3332 ↔ 3354By similarity
Glycosylationi3357N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3395 ↔ 3421By similarity
Disulfide bondi3448 ↔ 3470By similarity
Glycosylationi3457N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3511 ↔ 3537By similarity
Glycosylationi3533N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3564 ↔ 3586By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The precursor is cleaved by a trans-Golgi proteinase furin, removing a propeptide.By similarity
N-glycosylated.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei32 – 33Cleavage; by furinSequence analysis2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9JLB4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9JLB4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JLB4

PeptideAtlas

More...
PeptideAtlasi
Q9JLB4

PRoteomics IDEntifications database

More...
PRIDEi
Q9JLB4

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9JLB4, 39 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JLB4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JLB4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in kidney, thymus, ileum, placenta, small intestine and yolk sac. In kidney expressed on the apical brush border surface of proximal tubular cells, in particular in endosomes and recycling membranes vesicles, so-called dense apical tubules, which carry internalized receptors back to the cell surface. Expressed in fetal membranes of yolk sac, placenta of pregnant females.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in yolk sac endoderm as early as day 6 and is present at the apical surface of those cells throughout the remainder of pregnancy. Apical expression is pronounced in the extraembryonic visceral endoderm (VE) of 6-9.5 dpc. Expressed by a subpopulation of cells dispersed within the 7.5 dpc embryonic endoderm and having a migratory morphology. First detected at the eight-cell stage. At the 32-cell stage expressed in all outer cells which are at the origin of the trophectoderm (TE). During the blastocyst stage, expression is predominant at the apical membrane of the TE cells.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026726, Expressed in adult mammalian kidney and 146 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9JLB4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AMN.

Component of the cubam complex composed of one CUBN trimer and one AMN chain (By similarity). The cubam complex can dimerize (By similarity).

Interacts with LRP2 in a dual-receptor complex in a calcium-dependent manner.

Found in a complex with PID1/PCLI1, LRP1 and CUBNI.

Interacts with LRP1 and PID1/PCLI1 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
211163, 8 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9JLB4

Protein interaction database and analysis system

More...
IntActi
Q9JLB4, 3 interactors

Molecular INTeraction database

More...
MINTi
Q9JLB4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000089009

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9JLB4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JLB4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini129 – 165EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini167 – 208EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini260 – 301EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini302 – 345EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST44
Domaini346 – 385EGF-like 5PROSITE-ProRule annotationAdd BLAST40
Domaini395 – 430EGF-like 6PROSITE-ProRule annotationAdd BLAST36
Domaini432 – 468EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini474 – 586CUB 1PROSITE-ProRule annotationAdd BLAST113
Domaini590 – 702CUB 2PROSITE-ProRule annotationAdd BLAST113
Domaini708 – 816CUB 3PROSITE-ProRule annotationAdd BLAST109
Domaini817 – 928CUB 4PROSITE-ProRule annotationAdd BLAST112
Domaini932 – 1042CUB 5PROSITE-ProRule annotationAdd BLAST111
Domaini1048 – 1161CUB 6PROSITE-ProRule annotationAdd BLAST114
Domaini1165 – 1277CUB 7PROSITE-ProRule annotationAdd BLAST113
Domaini1278 – 1389CUB 8PROSITE-ProRule annotationAdd BLAST112
Domaini1391 – 1506CUB 9PROSITE-ProRule annotationAdd BLAST116
Domaini1510 – 1619CUB 10PROSITE-ProRule annotationAdd BLAST110
Domaini1620 – 1734CUB 11PROSITE-ProRule annotationAdd BLAST115
Domaini1738 – 1850CUB 12PROSITE-ProRule annotationAdd BLAST113
Domaini1852 – 1963CUB 13PROSITE-ProRule annotationAdd BLAST112
Domaini1978 – 2091CUB 14PROSITE-ProRule annotationAdd BLAST114
Domaini2092 – 2213CUB 15PROSITE-ProRule annotationAdd BLAST122
Domaini2217 – 2334CUB 16PROSITE-ProRule annotationAdd BLAST118
Domaini2336 – 2448CUB 17PROSITE-ProRule annotationAdd BLAST113
Domaini2452 – 2565CUB 18PROSITE-ProRule annotationAdd BLAST114
Domaini2570 – 2687CUB 19PROSITE-ProRule annotationAdd BLAST118
Domaini2689 – 2801CUB 20PROSITE-ProRule annotationAdd BLAST113
Domaini2805 – 2919CUB 21PROSITE-ProRule annotationAdd BLAST115
Domaini2920 – 3035CUB 22PROSITE-ProRule annotationAdd BLAST116
Domaini3037 – 3150CUB 23PROSITE-ProRule annotationAdd BLAST114
Domaini3157 – 3274CUB 24PROSITE-ProRule annotationAdd BLAST118
Domaini3278 – 3393CUB 25PROSITE-ProRule annotationAdd BLAST116
Domaini3395 – 3507CUB 26PROSITE-ProRule annotationAdd BLAST113
Domaini3511 – 3623CUB 27PROSITE-ProRule annotationAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni39 – 46Interaction with AMNBy similarity8

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CUB domains 5 to 8 mediate binding to CBLIF and ALB. CUB domains 1 and 2 mediate interaction with LRP2.By similarity
The cubam complex is composed of a 400 Angstrom long stem and a globular crown region. The stem region is probably formed by AMN and the CUBN N-terminal region, including the EGF-like domains. The crown is probably formed by the CUBN CUB domains.By similarity

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4292, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155299

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000172_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9JLB4

KEGG Orthology (KO)

More...
KOi
K14616

Identification of Orthologs from Complete Genome Data

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OMAi
FHLEYHP

Database of Orthologous Groups

More...
OrthoDBi
4105at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316224

Family and domain databases

Conserved Domains Database

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CDDi
cd00041, CUB, 27 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.120.290, 27 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR024731, EGF_dom
IPR035914, Sperma_CUB_dom_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00431, CUB, 27 hits
PF00008, EGF, 2 hits
PF12947, EGF_3, 1 hit
PF07645, EGF_CA, 3 hits
PF12661, hEGF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042, CUB, 27 hits
SM00181, EGF, 8 hits
SM00179, EGF_CA, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 27 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS01180, CUB, 27 hits
PS00022, EGF_1, 4 hits
PS01186, EGF_2, 2 hits
PS50026, EGF_3, 6 hits
PS01187, EGF_CA, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLB4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASHFLWGFV TLLMVPGLDG ETGTPEQKLQ KRIADLHQPR MTTEEGNLVF
60 70 80 90 100
LTSSAQNIEF RTGSLGKIKL NDDDLGECLH QIQRNKDDII DLKRNTTGLP
110 120 130 140 150
QNILSQVHQL NSKLVDLERD FQSLQQNVER KVCSSNPCHN GGTCVNLHDS
160 170 180 190 200
FICICPSQWK GLFCSEDVNE CVLYAGTPFG CQSGSTCVNT MGSFRCDCTP
210 220 230 240 250
DTYGPQCASK YNDCEQGSQQ LCKHGICEDL QRVYHGQLRF NCICDAGWTT
260 270 280 290 300
LPNGISCTED KDECSLQPSP CSEHAQCFNT QGSFYCGACP KGWQGNGYQC
310 320 330 340 350
QDINECEINN GGCSQAPLVP CLNTPGSFTC GNCPAGFSGD GRVCTPLDIC
360 370 380 390 400
SIHNGGCHPD ATCSSSSVLG SLLPVCTCPP GYTGNGYGSN GCVRLSNMCS
410 420 430 440 450
RHPCVNGQCI ETVSSYFCKC DSGWFGQNCT ENINECVSNP CLNGGTCIDG
460 470 480 490 500
VNGFTCDCTS SWTGYYCQTP QAACGGILSG TQGTFAYQSP NDTYVHNVNC
510 520 530 540 550
FWVVRTDEEK VLHITFTFFD LESASNCPRE YLQIHDGDSS ADFPLGRYCG
560 570 580 590 600
STPPQGVHSS ANSLYFHLYS EYIKRGRGFT ARWEAKLPEC GGILTGNYGS
610 620 630 640 650
ITSPGYPGNY PPGRDCVWNL LVSPGSLITF TFGTLSLESH NDCSKDYLEI
660 670 680 690 700
RDGPFHHDPI LGKFCTSLST PPLQTTGPAA RIHFHSDSET SDKGFHITYL
710 720 730 740 750
TTPSDLYCGG NYTDTEGELL LPPLTGPFSH SRQCVYLISQ PQGEQIVINF
760 770 780 790 800
THVELESQRG CSHTFIEVGD HESLLRKICG NETLFPIRSI SNNVWIRLRI
810 820 830 840 850
DALVQKASFR ADYQVACGGE LRGEGVIRSP FYPNAYAGRR TCRWTISQPP
860 870 880 890 900
REVVLLNFTD FQIGSSSSCD TDYIEIGPSS VLGSPGNEKF CGTNIPSFIT
910 920 930 940 950
SVYNVLYVTF VKSSSMENRG FMAMFSSEKL ECGKVLTEST GIIESPGHPN
960 970 980 990 1000
VYPSGVNCTW HIVVQRGQLI RLVFSSFYLE FHYNCANDYL EVYDTIAQTS
1010 1020 1030 1040 1050
LGRYCGKSIP PSLTSSSHSI KLIFVSDSAL AHEGFSINYE AINASSVCLY
1060 1070 1080 1090 1100
DYTDNFGRLS SPNFPNNYPH NWNCVYRITV GLNQQIALHF TDFALEDYFG
1110 1120 1130 1140 1150
PKCVDFVEIR DGGFETSPLI GIYCGSVFPP RIISHSNKLW LRFKSDTALT
1160 1170 1180 1190 1200
ARGFSAYWDA SSTGCGGNLT TPTGVLTSPN YPMPYYHSSE CYWRLEASRG
1210 1220 1230 1240 1250
SPFLLEFQDF HLEHHPNCSL DYLAVFDGPS TNSRLINKLC GDTPPAPIRS
1260 1270 1280 1290 1300
SKDIVLLKLR TDAGQQGRGF EINYRQTCDN VVIVNKTSGI LESINYPNPY
1310 1320 1330 1340 1350
DKDQRCNWTI QATTGNTVNY TFLEFDVENY VNCSTDYLEL YDGPQRIGRY
1360 1370 1380 1390 1400
CGENIPPPGA TTGSKLIVVF HTDGVDSGEK GFKMHWFIHG CGGEMSGTMG
1410 1420 1430 1440 1450
SFSSPGYPNS YPHNKECIWN IRVAPGNSIQ LTIHDFDVEY HASCKYDTLE
1460 1470 1480 1490 1500
IYTGLDFHSP RIAQLCSRSP SANPMQISST DNELAIRFKT DSSLNGRGFN
1510 1520 1530 1540 1550
ASWRAVPGGC GGIFQVSRGE IHSPNYPNNY RANTECSWII QVEKYHRVLL
1560 1570 1580 1590 1600
NITDFDLEAT DSCLMTYDGS SSANTRVATV CGRQQPPNSI TSSGNSLFVR
1610 1620 1630 1640 1650
FQSGSSSQSR GFRAQFRQEC GAHIITDSSD SISSPLYPAN YPNNQNCTWI
1660 1670 1680 1690 1700
IEAQPPFNHI ALSFTHFHLQ SSTDCTRDFV EILDGRDSDA PVQGRYCGTS
1710 1720 1730 1740 1750
LPHPIISFGN ALTVRFVSDS VYGFDGFHAI YSASTSACGG TFYTGDGIFN
1760 1770 1780 1790 1800
SPGYPEDYHS NTECVWNIAS SPGNHLQLSF LSFQLENSLN CNKDFVEIRE
1810 1820 1830 1840 1850
GNATGHLMGR YCGNSLPGNY SSIEGHNLWV RFVSDGSGTG MGFQARFKNI
1860 1870 1880 1890 1900
FGNDNIVGTH GKIATPFWPG NYPLNSNYRW TVNVDSSHII HGRILEMDIE
1910 1920 1930 1940 1950
LTTNCFYDSL KIYDGFDIHS RLIGTYCGTQ RESFSSSRNS LTFQFSSDSS
1960 1970 1980 1990 2000
KSGRGFLLEW FAVDVSNVTL PTIAPGACGG YMVTGDTPVF FFSPGWPGPY
2010 2020 2030 2040 2050
GNGADCIWII YAPDSTVELN ILSMDIEAQL SCSYDKLIIK DGDSRLSQQL
2060 2070 2080 2090 2100
AVLCGRSVPG PIRSTGEYMY IRFTSDGSVT GAGFNASFQK SCGGYLHADR
2110 2120 2130 2140 2150
GIITSPKYPD NYLPNLNCSW HVLVQSGLTI AVHFEQPFQI QNRDSSCSQG
2160 2170 2180 2190 2200
DYLVLRNGPD NHSPPLGPSG GNGRFCGIYT PSTLFTSDNE MFIQFISDNS
2210 2220 2230 2240 2250
NGGQGFKIRY EAKSLACGGT IYIHDANSDG YVTSPNYPAN YPQHAECIWI
2260 2270 2280 2290 2300
LEAPSGRSIQ LQFEDQFNIE ETPNCSASYL ELRDGANSNA PVLSKLCGHT
2310 2320 2330 2340 2350
LPRNWVSSRG LMYLKFHTEG GSGYMGFKAK YSIVSCGGTV SGDSGVIESV
2360 2370 2380 2390 2400
GYPTRLYANN VFCQWHIQGL PGHYLTIRFE DFNLQSSPGC AKDFVEIWEN
2410 2420 2430 2440 2450
HTSGILLGRY CGNSIPSSVD TSSNVASIRF VTDGSVTDSG FRLQFKSSRE
2460 2470 2480 2490 2500
VCGGDLHGPT GTFTSPNYPN PNPHPRICEW TINVHEGRQI ILTFTNLRLS
2510 2520 2530 2540 2550
TQQSCNTEHL IVFNGIRNNS PRLQKLCSRV NVTNEFKSSG NTMKVIFFTD
2560 2570 2580 2590 2600
GSRPYGGFTA SYTSSEDAVC GGTLPSVSGG NFSSPGYNGI RDYARNLDCE
2610 2620 2630 2640 2650
WTLSNPNREN SSISIHFLGL SLESHQDCTF DVLEFRVGNA DGPLIEKFCS
2660 2670 2680 2690 2700
LSAPRVPLVI PYPQVWIHFV SNERVEYTGF YVEYSFTNCG GIQTGENGVI
2710 2720 2730 2740 2750
SSPNYPNLYS RWTQCSWLLE APEGHTITLT FSDFSVENHP TCTSDSVTVR
2760 2770 2780 2790 2800
NGDSPGSPII GRYCGQSVPG PIQSGSNQLV VTFNTNNQGQ SRGFYATWNT
2810 2820 2830 2840 2850
NTLGCGGTLH SDNGTIKSPH WPQTFPENSR CSWTAVTHES KHWEISFDSN
2860 2870 2880 2890 2900
FRIPSSDSQC RNSFVKVWEG MLETNDALLA TSCGNVAPSP IVTLGNIFTA
2910 2920 2930 2940 2950
VFQSEEMPAQ GFSASFISRC GRTFNSSTGD IVSPNFPKHY DNNMNCNYYI
2960 2970 2980 2990 3000
DVAPQSLVIL TFVSFHLEDR SAVSGTCDYD GLHIIKGHNL SSTPLVTICG
3010 3020 3030 3040 3050
SETLRPLTID GPVMLNFYSD AYITDFGFKI SYRVANCGGI YSGTYGVLNS
3060 3070 3080 3090 3100
PSFSYTNYPN NVYCVYSLQV RNDRLILLRF NDFEIVPSNL CSHDYLEVFD
3110 3120 3130 3140 3150
GPSIGNRSIG KFCGSTLPQV IKSTNNSLTL LFKTDSSQTA RGWKVSFRET
3160 3170 3180 3190 3200
IGPQQGCGGY LTEDSKSFVS PDHDSDGLYD KGLNCIWYII APENKLVKLT
3210 3220 3230 3240 3250
FNAFTLEEPS SPGKCTFDYV QIADGASINS YLGGRFCGSS RPAPFISSGN
3260 3270 3280 3290 3300
FLTVQFVSDI SIQMRGFNAT YTFVDMPCGG TYNATSMPQN TSSPQLSNIR
3310 3320 3330 3340 3350
RPFSTCTWVI EAPPHQQVQI TVWKLQLPSQ DCSRSSLELQ DSEQTNGNQV
3360 3370 3380 3390 3400
TQFCGANYTT LPVFYSSGST AVVVFKSDFL NRNSRVHFTY EIADCNREYN
3410 3420 3430 3440 3450
QAFGNLKSPG WPQGYANNLD CSIILRAPQN HRISLFFYWF QLEDSRQCMN
3460 3470 3480 3490 3500
DFLEVRNGSS SSSPLLGKYC SNLLPNPIFS QSNELYLHFH SDDSDTHHGY
3510 3520 3530 3540 3550
EIIWASSPTG CGGTLLGNEG ILANPGFPDS YPNNTHCEWT IVAPSGRPLS
3560 3570 3580 3590 3600
VGFPFLSIDS PGGCDQNYLI LFNGPDANSP PFGPFCGIDT VVAPFHASSN
3610 3620
RVFIRFHAEY ATVSSGFEIM WSS
Length:3,623
Mass (Da):399,097
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC105089FE0E0F1ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti811 – 813ADY → NDL AA sequence (PubMed:11856751).Curated3
Sequence conflicti819G → S AA sequence (PubMed:11856751).Curated1
Sequence conflicti822 – 823RG → QD AA sequence (PubMed:11856751).Curated2
Sequence conflicti1859T → Q AA sequence (PubMed:11856751).Curated1
Sequence conflicti2105S → P AA sequence (PubMed:11856751).Curated1
Sequence conflicti2146 – 2148SCS → YGA AA sequence (PubMed:11856751).Curated3
Sequence conflicti2152Y → L AA sequence (PubMed:11856751).Curated1
Sequence conflicti2156R → S AA sequence (PubMed:11856751).Curated1
Sequence conflicti2531N → S AA sequence (PubMed:11856751).Curated1
Sequence conflicti2536 – 2538FKS → WTK AA sequence (PubMed:11856751).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL773538 Genomic DNA No translation available.
AL928807 Genomic DNA No translation available.
AF197159 mRNA Translation: AAF61487.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38048.1

NCBI Reference Sequences

More...
RefSeqi
NP_001074553.1, NM_001081084.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000091436; ENSMUSP00000089009; ENSMUSG00000026726

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
65969

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:65969

UCSC genome browser

More...
UCSCi
uc008ijz.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773538 Genomic DNA No translation available.
AL928807 Genomic DNA No translation available.
AF197159 mRNA Translation: AAF61487.1
CCDSiCCDS38048.1
RefSeqiNP_001074553.1, NM_001081084.2

3D structure databases

SMRiQ9JLB4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi211163, 8 interactors
CORUMiQ9JLB4
IntActiQ9JLB4, 3 interactors
MINTiQ9JLB4
STRINGi10090.ENSMUSP00000089009

PTM databases

GlyGeniQ9JLB4, 39 sites
iPTMnetiQ9JLB4
PhosphoSitePlusiQ9JLB4

Proteomic databases

jPOSTiQ9JLB4
MaxQBiQ9JLB4
PaxDbiQ9JLB4
PeptideAtlasiQ9JLB4
PRIDEiQ9JLB4

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
56802, 155 antibodies

Genome annotation databases

EnsembliENSMUST00000091436; ENSMUSP00000089009; ENSMUSG00000026726
GeneIDi65969
KEGGimmu:65969
UCSCiuc008ijz.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8029
MGIiMGI:1931256, Cubn

Phylogenomic databases

eggNOGiKOG4292, Eukaryota
GeneTreeiENSGT00940000155299
HOGENOMiCLU_000172_1_0_1
InParanoidiQ9JLB4
KOiK14616
OMAiFHLEYHP
OrthoDBi4105at2759
TreeFamiTF316224

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
65969, 2 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cubn, mouse

Protein Ontology

More...
PROi
PR:Q9JLB4
RNActiQ9JLB4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026726, Expressed in adult mammalian kidney and 146 other tissues
GenevisibleiQ9JLB4, MM

Family and domain databases

CDDicd00041, CUB, 27 hits
Gene3Di2.60.120.290, 27 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR024731, EGF_dom
IPR035914, Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431, CUB, 27 hits
PF00008, EGF, 2 hits
PF12947, EGF_3, 1 hit
PF07645, EGF_CA, 3 hits
PF12661, hEGF, 1 hit
SMARTiView protein in SMART
SM00042, CUB, 27 hits
SM00181, EGF, 8 hits
SM00179, EGF_CA, 7 hits
SUPFAMiSSF49854, SSF49854, 27 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS01180, CUB, 27 hits
PS00022, EGF_1, 4 hits
PS01186, EGF_2, 2 hits
PS50026, EGF_3, 6 hits
PS01187, EGF_CA, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUBN_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JLB4
Secondary accession number(s): B1AX10
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: July 27, 2011
Last modified: August 12, 2020
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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