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Entry version 174 (07 Oct 2020)
Sequence version 1 (01 Oct 2000)
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Protein

MAGUK p55 subfamily member 5

Gene

Mpp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (PubMed:17182851, PubMed:20237282). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (PubMed:22398208). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation and cerebellar layer organization (PubMed:26657772). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (PubMed:20237282). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (PubMed:15234345). May play a role in the T-cell receptor-mediated activation of NF-kappa-B (By similarity). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (PubMed:15677456). Required for the normal polarized localization of the vesicular marker STX4 (PubMed:20237282). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity).By similarity6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi486 – 493ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MAGUK p55 subfamily member 5
Alternative name(s):
Protein associated with Lin-7 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mpp5
Synonyms:Pals1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1927339, Mpp5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Golgi apparatus, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Conditional knockout in the retina results in mice which are viable, fertile, and morphologically normal apart from microphthalmia with severe defects in visual response (PubMed:22398208). From 13.5 days post-conception (dpc) retinas show variable morphology, including retinal folding, variable thickness and disorganization (PubMed:22398208). Postnatally the retinal lamina is thinner, and disorganized, with a shortening or absence of the inner and outer segments of photoreceptor cells (PubMed:22398208). By postnatal day 60 retinas are completely or partially devoid of the outer nuclear layers and photoreceptor layer, and feature a reduced number of photoreceptor cells, disrupted cell polarity and impaired distribution of retinal neurons (PubMed:22398208). Retinal distribution of Par3 and the Crb polarity complex proteins Crbs and Patj is disrupted (PubMed:22398208). Mature mice show aberrant proliferation and apoptosis of retinal epithelia with significantly reduced or undetectable a- and b-waves in electroretinogram-measured dark-adapted response (PubMed:22398208). Conditional knockout in cerebellum proliferating progenitors at 13.5 dpc results in mislocalization of apical polarity complex proteins such as Crb proteins, Pard3, and Prkci at 15.5 dpc (PubMed:26657772). Following cerebellum conditional knockout there is an increase in migration and premature differentiation of Pax2-positive ventricular zone cells at 17.5 dpc, resulting in a reduced number of glial cell progenitors (PubMed:26657772). Conditional knockout in cerebellum results in stunted cerebellum growth and indistinct vermis foliation at birth, there is also an evident reduction of Bergmann glia, oligodendrocyte, astrocyte and GABAergic interneuron progenitors (PubMed:26657772). Conditional knockout in cerebellum shows compromised Purkinje cell migration and formation failure of Purkinje cell plate to contain both Bergmann glia and Purkinje cells, possibly as a result of abnormal Reln-Dab1 signaling at P6 (PubMed:26657772). Conditional knockout in cerebellum results in poorly layered, smaller lobes, severe defects in fissure formation and a reduced number of cerebellar granule neurons and GABAergic interneurons from P8 to P21 (PubMed:26657772). RNAi-mediated knockdown in the sciatic nerve results in mislocalization of Exoc4/Sec8 and Stx4 in Schwann cells and thinning and shortening of Schwann cells as a result of a reduction in the myelinated fiber diameter caused by fewer myelin turns (PubMed:20237282). Conditional knockout of both MPP3 and MPP5 in the retina results in an increase in retinal degeneration that becomes evident at one month of age (PubMed:23893895).4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi32H → A: No effect on interaction with PARD6B. 1 Publication1
Mutagenesisi33R → A: No effect on interaction with PARD6B. 1 Publication1
Mutagenesisi34E → A: No effect on interaction with PARD6B. 1 Publication1
Mutagenesisi36A → G: No effect on interaction with PARD6B. 1 Publication1
Mutagenesisi37V → G: Prevents interaction with PARD6B. Does not affect localization to the tight junctions. 1 Publication1
Mutagenesisi37V → I: No effect on interaction with PARD6B. 1 Publication1
Mutagenesisi38D → A: Prevents interaction with PARD6B. 1 Publication1
Mutagenesisi38D → E: No effect on interaction with PARD6B. 1 Publication1
Mutagenesisi39C → A: No effect on interaction with PARD6B. 1 Publication1
Mutagenesisi40P → A: No effect on interaction with PARD6B. 1 Publication1
Mutagenesisi150L → G: No effect on PARD6B interaction. Prevents interaction with PATJ; when associated with G-154. 1 Publication1
Mutagenesisi154V → G: No effect on PARD6B interaction. Prevents interaction with PATJ; when associated with G-150. 1 Publication1
Mutagenesisi207E → Q: No effect on interaction with LIN7C. 1 Publication1
Mutagenesisi208L → G: Prevents interaction with LIN7C. 1 Publication1
Mutagenesisi212L → G: Prevents interaction with LIN7C. 1 Publication1
Mutagenesisi216H → N: No effect on interaction with LIN7C. 1 Publication1
Mutagenesisi221L → G: Partially prevents interaction with LIN7C. 1 Publication1
Mutagenesisi224H → N: Partially prevents interaction with LIN7C. 1 Publication1
Mutagenesisi225D → N: Prevents interaction with LIN7C. 1 Publication1
Mutagenesisi227V → G: Prevents interaction with LIN7C. 1 Publication1
Mutagenesisi379L → P: Failure to restore localization of MPP5 and PATJ to cell-cell contacts and to restore tight junction and adherens junction formation in cells where MPP5 has been knocked down. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000945811 – 675MAGUK p55 subfamily member 5Add BLAST675

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineBy similarity1
Modified residuei25PhosphoserineCombined sources1
Modified residuei83PhosphoserineBy similarity1
Modified residuei84PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9JLB2

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9JLB2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JLB2

PRoteomics IDEntifications database

More...
PRIDEi
Q9JLB2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JLB2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JLB2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in retina (at protein level) (PubMed:15558731, PubMed:23893895, PubMed:22398208). Expressed in the vascular plexus of the retina (at protein level) (PubMed:27466317). In the brain, expressed in the dentate gyrus of hippocampus, striatum and cerebellum (at protein level) (PubMed:15234345). Expressed in the sciatic nerve (at protein level) (PubMed:20237282). Expressed in the kidney nephron (at protein level) (PubMed:10753959, PubMed:15558731). Expressed in the lung, and heart (PubMed:10753959, PubMed:15558731). Expressed in placenta, brain, skeletal muscles, pancreas and liver (PubMed:10753959).7 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the developing sciatic nerve, with increasing expression from newborn to postnatal day 20, and decreasing expression at postnatal day 60 (P60) (at protein level) (PubMed:20237282). Expressed in the developing brain at 15.5 dpc in the upper rhombic lip, ventricular zone, and external granule layer (at protein level) (PubMed:26657772). At birth expressed in the ventricular apical lining cells, proliferating external granule layer (EGL) and Purkinje cell layer (PCL), with expression remaining abundant in the EGL and weakly evident in the PCL at P6 (at protein level) (PubMed:26657772). Expressed at P8 in the EGL, cerebellar granule neuron precursors, Bergmann glia, Pcna-positive progenitor cells in the white matter, and weakly in Pax6-positive postmitotic granule neurons (at protein level) (PubMed:26657772). Expressed weakly throughout the retina between 12.5 dpc and 14.5 dpc, becoming enriched in progenitors at the outer neuroblastic layer at 14.5 dpc (PubMed:22398208). Localized to the apical edge of the retina between 12.5 and 16.5 dpc (PubMed:22398208).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000021112, Expressed in dorsal pancreas and 284 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9JLB2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9JLB2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with MPP1 (By similarity).

Component of a complex composed of MPP5, CRB1 and MPP4 (By similarity).

Component of a complex composed of MPP5, MPP3 and CRB1; MPP5 acts as a bridging protein between MPP3 (via guanylate kinase-like domain) and CRB1 (PubMed:16519681).

Interacts (via PDZ domain) with CRB1 (via C-terminal ERLI motif) (By similarity). While the PDZ domain is sufficient for interaction with CRB1, the adjacent SH3 and guanylate kinase-like domains are likely to contribute to a high affinity interaction (By similarity).

Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, PATJ and PARD3/PAR3 (By similarity).

Forms a heterotrimeric complex composed of MMP5, LIN7B and PATJ; the N-terminal L27 domain of MPP5 interacts with the L27 domain of PATJ and the C-terminal L27 domain of MPP5 interacts with the L27 domain of LIN7B (By similarity).

Interacts with MPP7 (By similarity).

Interacts with CRB3 (PubMed:12527193).

Interacts with EZR (PubMed:15677456).

Interacts with PATJ (PubMed:11927608).

Interacts with LIN7C (PubMed:10753959).

Interacts with MPDZ (PubMed:15316081).

Interacts with PARD6B (PubMed:12545177, PubMed:15140881).

Interacts with SC6A1 (PubMed:15234345).

Interacts with CDH5; the interaction promotes MPP5 localization to cell junctions and is required for CDH5-mediated vascular lumen formation and endothelial cell (PubMed:27466317).

Interacts with NPHP1 (via coiled coil and SH3 domains) (By similarity).

Interacts with NPHP4 (By similarity).

By similarity10 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
207851, 9 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9JLB2

Protein interaction database and analysis system

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IntActi
Q9JLB2, 4 interactors

Molecular INTeraction database

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MINTi
Q9JLB2

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000080683

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q9JLB2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1675
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

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BMRBi
Q9JLB2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9JLB2

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9JLB2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini120 – 177L27 1PROSITE-ProRule annotationAdd BLAST58
Domaini179 – 235L27 2PROSITE-ProRule annotationAdd BLAST57
Domaini256 – 336PDZPROSITE-ProRule annotationAdd BLAST81
Domaini345 – 417SH3PROSITE-ProRule annotationAdd BLAST73
Domaini479 – 660Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 345Required for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions1 PublicationAdd BLAST345
Regioni21 – 140Interaction with PARD6B1 PublicationAdd BLAST120
Regioni181 – 243Interaction with LIN7C1 PublicationAdd BLAST63

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The L27 domain 1 functions in targeting to the tight junctions by binding to and stabilizing PATJ.2 Publications
The PDZ domain binds to the C-terminus of SC6A1.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0609, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000156087

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_001715_5_4_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9JLB2

KEGG Orthology (KO)

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KOi
K06091

Identification of Orthologs from Complete Genome Data

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OMAi
MMPMRRS

Database of Orthologous Groups

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OrthoDBi
531106at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9JLB2

TreeFam database of animal gene trees

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TreeFami
TF314263

Family and domain databases

Conserved Domains Database

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CDDi
cd12036, SH3_MPP5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR020590, Guanylate_kinase_CS
IPR014775, L27_C
IPR004172, L27_dom
IPR036892, L27_dom_sf
IPR015145, L27_N
IPR031185, MPP5
IPR035601, MPP5_SH3
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR036034, PDZ_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

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PANTHERi
PTHR23122:SF14, PTHR23122:SF14, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00625, Guanylate_kin, 1 hit
PF02828, L27, 1 hit
PF09060, L27_N, 1 hit
PF00595, PDZ, 1 hit
PF07653, SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00072, GuKc, 1 hit
SM00569, L27, 2 hits
SM00228, PDZ, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101288, SSF101288, 2 hits
SSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00856, GUANYLATE_KINASE_1, 1 hit
PS50052, GUANYLATE_KINASE_2, 1 hit
PS51022, L27, 2 hits
PS50106, PDZ, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9JLB2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTSYMNGHV TEESDSGIKN LDLASPEEYP KHREMAVDCP GDLGTRMMPV
60 70 80 90 100
RRSAQLERIR QQQEDMRRRR EEEGKKQELD LNSSMRLKKL AQIPPKTGID
110 120 130 140 150
NPIFDTEEGI VLESPHYAVN ILDVEDLFSS LKHIQHTLVD SQSQEDISLL
160 170 180 190 200
LQLVQNRDFQ NAFKIHNAVT VHMSKASPPF PLIANVQDLV QEVQTVLKPV
210 220 230 240 250
HQKEGQELTA LLNAPHIQAL LLAHDKVAEQ EMQLEPITDE RVYESIGHYG
260 270 280 290 300
GETVKIVRIE KARDIPLGAT VRNEMDSVII SRIVKGGAAE KSGLLHEGDE
310 320 330 340 350
VLEINGIEIR GKDVNEVFDL LSDMHGTLTF VLIPSQQIKP PPAKETVIHV
360 370 380 390 400
KAHFDYDPSD DPYVPCRELG LSFQKGDILH VISQEDPNWW QAYREGDEDN
410 420 430 440 450
QPLAGLVPGK SFQQQREAMK QTIEEDKEPE KSGKLWCAKK NKKKRKKVLY
460 470 480 490 500
NANKNDDYDN EEILTYEEMS LYHQPANRKR PIILIGPQNC GQNELRQRLM
510 520 530 540 550
NKEKDRFASA VPHTTRNRRD HEVAGRDYHF VSRQAFEADI AAGKFIEHGE
560 570 580 590 600
FEKNLYGTSI DSVRQVINSG KICLLSLRTQ SLKTLRNSDL KPYIIFIAPP
610 620 630 640 650
SQERLRALLA KEGKNPKPEE LREIIEKTRE MEQNNGHYFD TAIVNSDLDK
660 670
AYQELLRLIN KLDTEPQWVP STWLR
Length:675
Mass (Da):77,229
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i66670F919F18063B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P6P0A0A1W2P6P0_MOUSE
MAGUK p55 subfamily member 5
Mpp5
285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P7Z6A0A1W2P7Z6_MOUSE
MAGUK p55 subfamily member 5
Mpp5
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF199008 mRNA Translation: AAF63789.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS26001.1

NCBI Reference Sequences

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RefSeqi
NP_062525.1, NM_019579.3
XP_006516160.1, XM_006516097.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000082024; ENSMUSP00000080683; ENSMUSG00000021112

Database of genes from NCBI RefSeq genomes

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GeneIDi
56217

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:56217

UCSC genome browser

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UCSCi
uc007nzg.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199008 mRNA Translation: AAF63789.1
CCDSiCCDS26001.1
RefSeqiNP_062525.1, NM_019579.3
XP_006516160.1, XM_006516097.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VA8NMR-A236-335[»]
1VF6X-ray2.10C/D123-180[»]
BMRBiQ9JLB2
SMRiQ9JLB2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi207851, 9 interactors
CORUMiQ9JLB2
IntActiQ9JLB2, 4 interactors
MINTiQ9JLB2
STRINGi10090.ENSMUSP00000080683

PTM databases

iPTMnetiQ9JLB2
PhosphoSitePlusiQ9JLB2

Proteomic databases

jPOSTiQ9JLB2
MaxQBiQ9JLB2
PaxDbiQ9JLB2
PRIDEiQ9JLB2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
20, 328 antibodies

Genome annotation databases

EnsembliENSMUST00000082024; ENSMUSP00000080683; ENSMUSG00000021112
GeneIDi56217
KEGGimmu:56217
UCSCiuc007nzg.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64398
MGIiMGI:1927339, Mpp5

Phylogenomic databases

eggNOGiKOG0609, Eukaryota
GeneTreeiENSGT00940000156087
HOGENOMiCLU_001715_5_4_1
InParanoidiQ9JLB2
KOiK06091
OMAiMMPMRRS
OrthoDBi531106at2759
PhylomeDBiQ9JLB2
TreeFamiTF314263

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
56217, 1 hit in 20 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mpp5, mouse
EvolutionaryTraceiQ9JLB2

Protein Ontology

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PROi
PR:Q9JLB2
RNActiQ9JLB2, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000021112, Expressed in dorsal pancreas and 284 other tissues
ExpressionAtlasiQ9JLB2, baseline and differential
GenevisibleiQ9JLB2, MM

Family and domain databases

CDDicd12036, SH3_MPP5, 1 hit
Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR020590, Guanylate_kinase_CS
IPR014775, L27_C
IPR004172, L27_dom
IPR036892, L27_dom_sf
IPR015145, L27_N
IPR031185, MPP5
IPR035601, MPP5_SH3
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR036034, PDZ_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR23122:SF14, PTHR23122:SF14, 1 hit
PfamiView protein in Pfam
PF00625, Guanylate_kin, 1 hit
PF02828, L27, 1 hit
PF09060, L27_N, 1 hit
PF00595, PDZ, 1 hit
PF07653, SH3_2, 1 hit
SMARTiView protein in SMART
SM00072, GuKc, 1 hit
SM00569, L27, 2 hits
SM00228, PDZ, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF101288, SSF101288, 2 hits
SSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856, GUANYLATE_KINASE_1, 1 hit
PS50052, GUANYLATE_KINASE_2, 1 hit
PS51022, L27, 2 hits
PS50106, PDZ, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPP5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JLB2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: October 7, 2020
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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