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Protein

Interleukin-36 alpha

Gene

Il36a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4+ T-cells and splenocytes. May play a role in proinflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c+ alveolar macrophages. May be involved in T-cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c+ cells. May be involved in CD4+ T-cell proliferation. Induces NF-kappa B activation in macrophages.4 Publications

GO - Molecular functioni

  • cytokine activity Source: MGI
  • interleukin-1 receptor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-9014826 Interleukin-36 pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-36 alpha
Alternative name(s):
FIL1 epsilon
Interleukin-1 epsilon
Short name:
IL-1 epsilon
Interleukin-1 family member 6
Short name:
IL-1F6
Interleukin-1 homolog 1
Short name:
IL-1H1
Gene namesi
Name:Il36a
Synonyms:Fil1e, Il1e, Il1f6, Il1h1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1859324 Il1f6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00004305461 – 71 Publication7
ChainiPRO_00001536458 – 160Interleukin-36 alphaAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei98Nitrated tyrosineBy similarity1

Post-translational modificationi

N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).1 Publication

Keywords - PTMi

Nitration

Proteomic databases

PaxDbiQ9JLA2
PRIDEiQ9JLA2

PTM databases

PhosphoSitePlusiQ9JLA2

Expressioni

Tissue specificityi

Highly expressed in embryonic tissue and in tissues containing epithelial cells. Elevated expression levels are detected in chronic kidney disease; expressed inepithelia from the distal convoluted tubules (DCTs) to the cortical collecting ducts (CCDs) in single nephrons (at protein level).2 Publications

Inductioni

By IL-22 in normal and psoriasis-like skin.1 Publication

Gene expression databases

BgeeiENSMUSG00000026984 Expressed in 44 organ(s), highest expression level in uterine cervix
CleanExiMM_IL1F6
ExpressionAtlasiQ9JLA2 baseline and differential
GenevisibleiQ9JLA2 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028361

Structurei

3D structure databases

ProteinModelPortaliQ9JLA2
SMRiQ9JLA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410JBMR Eukaryota
ENOG41118FS LUCA
GeneTreeiENSGT00900000141014
HOVERGENiHBG052100
InParanoidiQ9JLA2
KOiK05484
OMAiPFLFYHN
OrthoDBiEOG091G0V8E
PhylomeDBiQ9JLA2
TreeFamiTF300203

Family and domain databases

InterProiView protein in InterPro
IPR000975 IL-1_fam
IPR003297 IL-1RA/IL-36
IPR027163 IL-36_alpha
IPR008996 IL1/FGF
PANTHERiPTHR10078:SF25 PTHR10078:SF25, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PRINTSiPR01360 INTRLEUKIN1X
SUPFAMiSSF50353 SSF50353, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKEKELRAA SPSLRHVQDL SSRVWILQNN ILTAVPRKEQ TVPVTITLLP
60 70 80 90 100
CQYLDTLETN RGDPTYMGVQ RPMSCLFCTK DGEQPVLQLG EGNIMEMYNK
110 120 130 140 150
KEPVKASLFY HKKSGTTSTF ESAAFPGWFI AVCSKGSCPL ILTQELGEIF
160
ITDFEMIVVH
Length:160
Mass (Da):18,015
Last modified:October 1, 2000 - v1
Checksum:iAA0434D68FF62F4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200493 mRNA Translation: AAF69249.1
AF206697 mRNA Translation: AAG35671.1
AK004061 mRNA Translation: BAB23147.1
CCDSiCCDS15734.1
RefSeqiNP_062323.1, NM_019450.3
UniGeneiMm.133095

Genome annotation databases

EnsembliENSMUST00000028361; ENSMUSP00000028361; ENSMUSG00000026984
GeneIDi54448
KEGGimmu:54448
UCSCiuc008ioq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200493 mRNA Translation: AAF69249.1
AF206697 mRNA Translation: AAG35671.1
AK004061 mRNA Translation: BAB23147.1
CCDSiCCDS15734.1
RefSeqiNP_062323.1, NM_019450.3
UniGeneiMm.133095

3D structure databases

ProteinModelPortaliQ9JLA2
SMRiQ9JLA2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028361

PTM databases

PhosphoSitePlusiQ9JLA2

Proteomic databases

PaxDbiQ9JLA2
PRIDEiQ9JLA2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028361; ENSMUSP00000028361; ENSMUSG00000026984
GeneIDi54448
KEGGimmu:54448
UCSCiuc008ioq.1 mouse

Organism-specific databases

CTDi54448
MGIiMGI:1859324 Il1f6

Phylogenomic databases

eggNOGiENOG410JBMR Eukaryota
ENOG41118FS LUCA
GeneTreeiENSGT00900000141014
HOVERGENiHBG052100
InParanoidiQ9JLA2
KOiK05484
OMAiPFLFYHN
OrthoDBiEOG091G0V8E
PhylomeDBiQ9JLA2
TreeFamiTF300203

Enzyme and pathway databases

ReactomeiR-MMU-9014826 Interleukin-36 pathway

Miscellaneous databases

PROiPR:Q9JLA2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026984 Expressed in 44 organ(s), highest expression level in uterine cervix
CleanExiMM_IL1F6
ExpressionAtlasiQ9JLA2 baseline and differential
GenevisibleiQ9JLA2 MM

Family and domain databases

InterProiView protein in InterPro
IPR000975 IL-1_fam
IPR003297 IL-1RA/IL-36
IPR027163 IL-36_alpha
IPR008996 IL1/FGF
PANTHERiPTHR10078:SF25 PTHR10078:SF25, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PRINTSiPR01360 INTRLEUKIN1X
SUPFAMiSSF50353 SSF50353, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL36A_MOUSE
AccessioniPrimary (citable) accession number: Q9JLA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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