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Protein

Glycolipid transfer protein

Gene

Gltp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140GlycolipidBy similarity1
Binding sitei207GlycolipidBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1660662 Glycosphingolipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Glycolipid transfer protein
Short name:
GLTP
Gene namesi
Name:Gltp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1929253 Gltp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001489162 – 209Glycolipid transfer proteinAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9JL62
MaxQBiQ9JL62
PaxDbiQ9JL62
PRIDEiQ9JL62

PTM databases

iPTMnetiQ9JL62
PhosphoSitePlusiQ9JL62

Expressioni

Gene expression databases

BgeeiENSMUSG00000011884 Expressed in 296 organ(s), highest expression level in skin epidermis
CleanExiMM_GLTP
ExpressionAtlasiQ9JL62 baseline and differential
GenevisibleiQ9JL62 MM

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207920, 1 interactor
IntActiQ9JL62, 2 interactors
MINTiQ9JL62
STRINGi10090.ENSMUSP00000012028

Structurei

3D structure databases

ProteinModelPortaliQ9JL62
SMRiQ9JL62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 551Add BLAST11
Repeati56 – 662Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 662 X 12 AA approximate tandem repeatsAdd BLAST22
Regioni48 – 55Glycolipid bindingBy similarity8

Sequence similaritiesi

Belongs to the GLTP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3221 Eukaryota
ENOG410YFEA LUCA
GeneTreeiENSGT00650000093230
HOGENOMiHOG000199421
HOVERGENiHBG019001
InParanoidiQ9JL62
OMAiACPYRKD
OrthoDBiEOG091G0IIT
PhylomeDBiQ9JL62
TreeFamiTF317467

Family and domain databases

Gene3Di1.10.3520.10, 1 hit
InterProiView protein in InterPro
IPR036497 GLTP_sf
IPR014830 Glycolipid_transfer_prot_dom
PfamiView protein in Pfam
PF08718 GLTP, 1 hit
SUPFAMiSSF110004 SSF110004, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9JL62-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLAEHLLK PLPADRQIET GPFLEAVAHL PPFFDCLGSP VFTPIKADIS
60 70 80 90 100
GNITKIKAVY DTDPAKFKTL QNILEVEKGM YGAEWPKVGA TLALLWLKRG
110 120 130 140 150
LRFIQVFLQS ICDGERDENH PNLIRVNANK AYEMALKKYH GWLVQKIFKA
160 170 180 190 200
ALYAAPYKSD FLKALSKGQN VTEEECLEKI RLFLVNYTAT IDAIYDMYTK

MNAELDYTV
Length:209
Mass (Da):23,690
Last modified:January 23, 2007 - v3
Checksum:iA7CBDD142C76BB1A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z1H8D3Z1H8_MOUSE
Glycolipid transfer protein
Gltp
179Annotation score:
D3Z1H9D3Z1H9_MOUSE
Glycolipid transfer protein
Gltp
190Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205 – 208LDYT → INYK in AAF33209 (Ref. 1) Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF209703 mRNA Translation: AAF33209.1
BC016584 mRNA Translation: AAH16584.1
AK003218 mRNA Translation: BAB22649.1
CCDSiCCDS19569.1
RefSeqiNP_062795.2, NM_019821.2
UniGeneiMm.275766

Genome annotation databases

EnsembliENSMUST00000012028; ENSMUSP00000012028; ENSMUSG00000011884
GeneIDi56356
KEGGimmu:56356
UCSCiuc008yzw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF209703 mRNA Translation: AAF33209.1
BC016584 mRNA Translation: AAH16584.1
AK003218 mRNA Translation: BAB22649.1
CCDSiCCDS19569.1
RefSeqiNP_062795.2, NM_019821.2
UniGeneiMm.275766

3D structure databases

ProteinModelPortaliQ9JL62
SMRiQ9JL62
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207920, 1 interactor
IntActiQ9JL62, 2 interactors
MINTiQ9JL62
STRINGi10090.ENSMUSP00000012028

PTM databases

iPTMnetiQ9JL62
PhosphoSitePlusiQ9JL62

Proteomic databases

EPDiQ9JL62
MaxQBiQ9JL62
PaxDbiQ9JL62
PRIDEiQ9JL62

Protocols and materials databases

DNASUi56356
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000012028; ENSMUSP00000012028; ENSMUSG00000011884
GeneIDi56356
KEGGimmu:56356
UCSCiuc008yzw.2 mouse

Organism-specific databases

CTDi51228
MGIiMGI:1929253 Gltp

Phylogenomic databases

eggNOGiKOG3221 Eukaryota
ENOG410YFEA LUCA
GeneTreeiENSGT00650000093230
HOGENOMiHOG000199421
HOVERGENiHBG019001
InParanoidiQ9JL62
OMAiACPYRKD
OrthoDBiEOG091G0IIT
PhylomeDBiQ9JL62
TreeFamiTF317467

Enzyme and pathway databases

ReactomeiR-MMU-1660662 Glycosphingolipid metabolism

Miscellaneous databases

PROiPR:Q9JL62
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000011884 Expressed in 296 organ(s), highest expression level in skin epidermis
CleanExiMM_GLTP
ExpressionAtlasiQ9JL62 baseline and differential
GenevisibleiQ9JL62 MM

Family and domain databases

Gene3Di1.10.3520.10, 1 hit
InterProiView protein in InterPro
IPR036497 GLTP_sf
IPR014830 Glycolipid_transfer_prot_dom
PfamiView protein in Pfam
PF08718 GLTP, 1 hit
SUPFAMiSSF110004 SSF110004, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLTP_MOUSE
AccessioniPrimary (citable) accession number: Q9JL62
Secondary accession number(s): Q91YJ7, Q9CTK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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