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Protein

Regulator of G-protein signaling 1

Gene

Rgs1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (PubMed:10779778). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor

Protein family/group databases

MoonDBiQ9JL25 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 1
Short name:
RGS1
Gene namesi
Name:Rgs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1354694 Rgs1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041761 – 209Regulator of G-protein signaling 1Add BLAST209

Proteomic databases

EPDiQ9JL25
PaxDbiQ9JL25
PRIDEiQ9JL25

PTM databases

iPTMnetiQ9JL25
PhosphoSitePlusiQ9JL25

Expressioni

Tissue specificityi

Detected in spleen, lymph node and intestine.1 Publication

Gene expression databases

BgeeiENSMUSG00000026358 Expressed in 62 organ(s), highest expression level in bone marrow
CleanExiMM_RGS1
ExpressionAtlasiQ9JL25 baseline and differential
GenevisibleiQ9JL25 MM

Interactioni

Subunit structurei

Interacts with GNAI1 and GNAQ.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9JL25, 3 interactors
STRINGi10090.ENSMUSP00000130339

Structurei

3D structure databases

ProteinModelPortaliQ9JL25
SMRiQ9JL25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 200RGSPROSITE-ProRule annotationAdd BLAST116

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiQ9JL25
KOiK16449
OMAiKIYKAFV
OrthoDBiEOG091G0BDG
PhylomeDBiQ9JL25
TreeFamiTF315837

Family and domain databases

Gene3Di1.10.196.10, 1 hit
InterProiView protein in InterPro
IPR016137 RGS
IPR030409 RGS1
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF34 PTHR10845:SF34, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JL25-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRAAAISMPR LNKMPGMFFS ASPKDSKEHS HSLLDDKKQK KRPKTFGMDV
60 70 80 90 100
KTYLRSMIPH LESGMKSAKS KDILSAEEVM QWSQSLEKLL ANQTGQNVFG
110 120 130 140 150
RFLKSEFSEE NIEFWLACED YKKTETDLLH NKAENIYKAF VHSDAVKQIN
160 170 180 190 200
IDFHTRESTA KKIKTPTPTS FDEAQKVIYS LMEKDSYPRF LKSNIYLNLL

NDLQANTLK
Length:209
Mass (Da):24,107
Last modified:March 24, 2009 - v2
Checksum:iF483A1690A3E2EB0
GO
Isoform 2 (identifier: Q9JL25-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Show »
Length:162
Mass (Da):18,792
Checksum:iA80EC6C3E35287DD
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WS51A0A087WS51_MOUSE
Regulator of G-protein-signaling 1
Rgs1
129Annotation score:
A0A0A0MQN0A0A0A0MQN0_MOUSE
Regulator of G-protein-signaling 1
Rgs1
110Annotation score:
A0A087WQQ4A0A087WQQ4_MOUSE
Regulator of G-protein-signaling 1
Rgs1
43Annotation score:
E9PZR4E9PZR4_MOUSE
Regulator of G-protein-signaling 1
Rgs1
46Annotation score:

Sequence cautioni

The sequence AAF34624 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH28634 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE23749 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE32557 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE41748 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE42139 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12N → D in BAE42139 (PubMed:16141072).Curated1
Sequence conflicti12N → D in BAE32557 (PubMed:16141072).Curated1
Sequence conflicti73I → M in BAE42139 (PubMed:16141072).Curated1
Sequence conflicti73I → M in BAE32557 (PubMed:16141072).Curated1
Sequence conflicti73I → M in BAE42382 (PubMed:16141072).Curated1
Sequence conflicti101R → K in BAE42139 (PubMed:16141072).Curated1
Sequence conflicti101R → K in BAE32557 (PubMed:16141072).Curated1
Sequence conflicti101R → K in BAE42382 (PubMed:16141072).Curated1
Sequence conflicti121Y → C in BAE32557 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0367321 – 47Missing in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK138688 mRNA Translation: BAE23749.1 Different initiation.
AK154394 mRNA Translation: BAE32557.1 Different initiation.
AK170366 mRNA Translation: BAE41748.1 Different initiation.
AK170957 mRNA Translation: BAE42139.1 Different initiation.
AK171306 mRNA Translation: BAE42382.1
AF215667 mRNA Translation: AAF34624.1 Different initiation.
BC028634 mRNA Translation: AAH28634.1 Different initiation.
CCDSiCCDS15349.2 [Q9JL25-1]
RefSeqiNP_056626.2, NM_015811.2 [Q9JL25-1]
UniGeneiMm.103701

Genome annotation databases

EnsembliENSMUST00000189061; ENSMUSP00000140624; ENSMUSG00000026358 [Q9JL25-1]
GeneIDi50778
KEGGimmu:50778
UCSCiuc007cxj.2 mouse [Q9JL25-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK138688 mRNA Translation: BAE23749.1 Different initiation.
AK154394 mRNA Translation: BAE32557.1 Different initiation.
AK170366 mRNA Translation: BAE41748.1 Different initiation.
AK170957 mRNA Translation: BAE42139.1 Different initiation.
AK171306 mRNA Translation: BAE42382.1
AF215667 mRNA Translation: AAF34624.1 Different initiation.
BC028634 mRNA Translation: AAH28634.1 Different initiation.
CCDSiCCDS15349.2 [Q9JL25-1]
RefSeqiNP_056626.2, NM_015811.2 [Q9JL25-1]
UniGeneiMm.103701

3D structure databases

ProteinModelPortaliQ9JL25
SMRiQ9JL25
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JL25, 3 interactors
STRINGi10090.ENSMUSP00000130339

Protein family/group databases

MoonDBiQ9JL25 Predicted

PTM databases

iPTMnetiQ9JL25
PhosphoSitePlusiQ9JL25

Proteomic databases

EPDiQ9JL25
PaxDbiQ9JL25
PRIDEiQ9JL25

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000189061; ENSMUSP00000140624; ENSMUSG00000026358 [Q9JL25-1]
GeneIDi50778
KEGGimmu:50778
UCSCiuc007cxj.2 mouse [Q9JL25-1]

Organism-specific databases

CTDi5996
MGIiMGI:1354694 Rgs1

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiQ9JL25
KOiK16449
OMAiKIYKAFV
OrthoDBiEOG091G0BDG
PhylomeDBiQ9JL25
TreeFamiTF315837

Miscellaneous databases

ChiTaRSiRgs1 mouse
PROiPR:Q9JL25
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026358 Expressed in 62 organ(s), highest expression level in bone marrow
CleanExiMM_RGS1
ExpressionAtlasiQ9JL25 baseline and differential
GenevisibleiQ9JL25 MM

Family and domain databases

Gene3Di1.10.196.10, 1 hit
InterProiView protein in InterPro
IPR016137 RGS
IPR030409 RGS1
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF34 PTHR10845:SF34, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS1_MOUSE
AccessioniPrimary (citable) accession number: Q9JL25
Secondary accession number(s): Q3TBD1
, Q3TC18, Q3TD56, Q3U477
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: March 24, 2009
Last modified: November 7, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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