Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-secretase 2

Gene

Bace2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 (By similarity).By similarity

Catalytic activityi

Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei106PROSITE-ProRule annotation1
Active sitei299PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.041

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-secretase 2 (EC:3.4.23.45)
Alternative name(s):
Aspartyl protease 1
Short name:
ASP1
Short name:
Asp 1
Beta-site amyloid precursor protein cleaving enzyme 2
Short name:
Beta-site APP cleaving enzyme 2
Memapsin-1
Membrane-associated aspartic protease 1
Theta-secretase
Gene namesi
Name:Bace2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1860440 Bace2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 469ExtracellularSequence analysisAdd BLAST450
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21
Topological domaini491 – 514CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3638357

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000038364620 – 62By similarityAdd BLAST43
ChainiPRO_000038364763 – 514Beta-secretase 2Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi229 ↔ 429By similarity
Disulfide bondi288 ↔ 453By similarity
Disulfide bondi340 ↔ 389By similarity
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Undergoes autoproteolytic cleavage.By similarity
Glycosylated.By similarity

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ9JL18
PaxDbiQ9JL18
PRIDEiQ9JL18

PTM databases

iPTMnetiQ9JL18
PhosphoSitePlusiQ9JL18

Interactioni

Subunit structurei

Monomer. Interacts ith RTN3 and RTN4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043918

Chemistry databases

BindingDBiQ9JL18

Structurei

3D structure databases

ProteinModelPortaliQ9JL18
SMRiQ9JL18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 425Peptidase A1PROSITE-ProRule annotationAdd BLAST338

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
HOGENOMiHOG000036572
InParanoidiQ9JL18
KOiK07747
PhylomeDBiQ9JL18
TreeFamiTF329595

Family and domain databases

CDDicd05473 beta_secretase_like, 1 hit
Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR009119 BACE
IPR009121 BACE2
IPR033874 Memapsin-like
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PTHR13683:SF262 PTHR13683:SF262, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR01817 BACE2
PR01815 BACEFAMILY
PR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9JL18-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGALLRALLL LVLAQWLLSA VPALAPAPFT LPLQVAGATN HRASAVPGLG
60 70 80 90 100
TPELPRADGL ALALEPVRAT ANFLAMVDNL QGDSGRGYYL EMLIGTPPQK
110 120 130 140 150
VQILVDTGSS NFAVAGAPHS YIDTYFDSES SSTYHSKGFD VTVKYTQGSW
160 170 180 190 200
TGFVGEDLVT IPKGFNSSFL VNIATIFESE NFFLPGIKWN GILGLAYAAL
210 220 230 240 250
AKPSSSLETF FDSLVAQAKI PDIFSMQMCG AGLPVAGSGT NGGSLVLGGI
260 270 280 290 300
EPSLYKGDIW YTPIKEEWYY QIEILKLEIG GQNLNLDCRE YNADKAIVDS
310 320 330 340 350
GTTLLRLPQK VFDAVVEAVA RTSLIPEFSD GFWTGAQLAC WTNSETPWAY
360 370 380 390 400
FPKISIYLRD ENASRSFRIT ILPQLYIQPM MGAGFNYECY RFGISSSTNA
410 420 430 440 450
LVIGATVMEG FYVVFDRAQR RVGFAVSPCA EIEGTTVSEI SGPFSTEDIA
460 470 480 490 500
SNCVPAQALN EPILWIVSYA LMSVCGAILL VLILLLLLPL HCRHAPRDPE
510
VVNDESSLVR HRWK
Length:514
Mass (Da):55,800
Last modified:October 1, 2000 - v1
Checksum:iA70725F2C1DF5B47
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0I8A0A0R4J0I8_MOUSE
Beta-secretase 2
Bace2
514Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11L → P in BAC34931 (PubMed:16141072).Curated1
Sequence conflicti11L → P in BAE38011 (PubMed:16141072).Curated1
Sequence conflicti11L → P in BAC37384 (PubMed:16141072).Curated1
Sequence conflicti37G → R in BAC34931 (PubMed:16141072).Curated1
Sequence conflicti37G → R in BAE38011 (PubMed:16141072).Curated1
Sequence conflicti37G → R in BAC37384 (PubMed:16141072).Curated1
Sequence conflicti53E → G in BAC37384 (PubMed:16141072).Curated1
Sequence conflicti369I → T in BAC34931 (PubMed:16141072).Curated1
Sequence conflicti488L → V in AAD45964 (PubMed:10683441).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216310 mRNA Translation: AAF36599.1
AK052309 mRNA Translation: BAC34931.1
AK078770 mRNA Translation: BAC37384.1
AK165036 mRNA Translation: BAE38011.1
CH466602 Genomic DNA Translation: EDL03663.1
BC120773 mRNA Translation: AAI20774.1
BC131947 mRNA Translation: AAI31948.1
AF051150 mRNA Translation: AAD45964.1
CCDSiCCDS28359.1
RefSeqiNP_062390.3, NM_019517.5
UniGeneiMm.102018
Mm.97885

Genome annotation databases

GeneIDi56175
KEGGimmu:56175
UCSCiuc008ade.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216310 mRNA Translation: AAF36599.1
AK052309 mRNA Translation: BAC34931.1
AK078770 mRNA Translation: BAC37384.1
AK165036 mRNA Translation: BAE38011.1
CH466602 Genomic DNA Translation: EDL03663.1
BC120773 mRNA Translation: AAI20774.1
BC131947 mRNA Translation: AAI31948.1
AF051150 mRNA Translation: AAD45964.1
CCDSiCCDS28359.1
RefSeqiNP_062390.3, NM_019517.5
UniGeneiMm.102018
Mm.97885

3D structure databases

ProteinModelPortaliQ9JL18
SMRiQ9JL18
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043918

Chemistry databases

BindingDBiQ9JL18
ChEMBLiCHEMBL3638357

Protein family/group databases

MEROPSiA01.041

PTM databases

iPTMnetiQ9JL18
PhosphoSitePlusiQ9JL18

Proteomic databases

MaxQBiQ9JL18
PaxDbiQ9JL18
PRIDEiQ9JL18

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56175
KEGGimmu:56175
UCSCiuc008ade.2 mouse

Organism-specific databases

CTDi25825
MGIiMGI:1860440 Bace2

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
HOGENOMiHOG000036572
InParanoidiQ9JL18
KOiK07747
PhylomeDBiQ9JL18
TreeFamiTF329595

Miscellaneous databases

ChiTaRSiBace2 mouse
PROiPR:Q9JL18
SOURCEiSearch...

Family and domain databases

CDDicd05473 beta_secretase_like, 1 hit
Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR009119 BACE
IPR009121 BACE2
IPR033874 Memapsin-like
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PTHR13683:SF262 PTHR13683:SF262, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR01817 BACE2
PR01815 BACEFAMILY
PR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBACE2_MOUSE
AccessioniPrimary (citable) accession number: Q9JL18
Secondary accession number(s): Q3TNS7
, Q8C5E9, Q8C793, Q9R1P7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again