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Protein

SERTA domain-containing protein 1

Gene

Sertad1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.1 Publication

GO - Biological processi

  • negative regulation of cell growth Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SERTA domain-containing protein 1
Alternative name(s):
CDK4-binding protein p34SEI1
Short name:
SEI-1
Transcriptional regulator interacting with the PHD-bromodomain 1
Short name:
TRIP-Br1
Gene namesi
Name:Sertad1
Synonyms:Sei1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913438 Sertad1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916121 – 236SERTA domain-containing protein 1Add BLAST236

Post-translational modificationi

Polyubiquitinated, which promotes proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9JL10
PRIDEiQ9JL10

Expressioni

Tissue specificityi

Detected at in testis, lung and, at lower levels, in muscle, liver, spleen, brain and heart.1 Publication

Developmental stagei

Detected as early as 7 dpc and persist until, at least, 17 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000008384 Expressed in 274 organ(s), highest expression level in blood
CleanExiMM_SERTAD1
ExpressionAtlasiQ9JL10 baseline and differential
GenevisibleiQ9JL10 MM

Interactioni

Subunit structurei

Interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Interacts with E2F1 and TFDP1; modulates transactivation activity of TFDP1/E2F complexes. Also interacts with CDK4.1 Publication

Protein-protein interaction databases

BioGridi207738, 12 interactors
CORUMiQ9JL10
STRINGi10090.ENSMUSP00000008528

Structurei

3D structure databases

ProteinModelPortaliQ9JL10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 85SERTAPROSITE-ProRule annotationAdd BLAST48

Phylogenomic databases

eggNOGiENOG410J0C8 Eukaryota
ENOG41114KT LUCA
GeneTreeiENSGT00730000111417
HOGENOMiHOG000133160
HOVERGENiHBG062592
InParanoidiQ9JL10
OMAiMYDSELW
OrthoDBiEOG091G0X9V
PhylomeDBiQ9JL10
TreeFamiTF101069

Family and domain databases

InterProiView protein in InterPro
IPR009263 SERTA_dom
PfamiView protein in Pfam
PF06031 SERTA, 1 hit
PROSITEiView protein in PROSITE
PS51053 SERTA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9JL10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSKGLKRKR EEEETMEALS VDSCWLDPSH PAVAQTPPTV ASSSLFDLSV
60 70 80 90 100
VKLHHSLRQS EPDLRHLVLV VNTLRRIQAS MEPAPVLPPE PIQPPAPSVA
110 120 130 140 150
DSLLASSDAG LSASMASLLE DLNHIEDLNQ APQPQADEGP PGRSIGGISP
160 170 180 190 200
NLGALDLLGP ATGCLLDDGL EGLFEDIDTS MYDSELWLPA SEGLKPGPEN
210 220 230
GPAKEEPPEL DEAELDYLMD VLVGTQALER PPGPGR
Length:236
Mass (Da):25,136
Last modified:October 1, 2000 - v1
Checksum:i989ADF8299DE84C5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z2X7D3Z2X7_MOUSE
SERTA domain-containing protein 1
Sertad1
84Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9 – 10KR → NG in BAB25588 (PubMed:16141072).Curated2
Sequence conflicti12E → K in AAK52829 (PubMed:11331592).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218291 mRNA Translation: AAF27653.1
AF366400 mRNA Translation: AAK52829.1
AF366401 mRNA Translation: AAK52830.1
AK004022 mRNA Translation: BAB23130.1
AK008303 mRNA Translation: BAB25588.1
BC016077 mRNA Translation: AAH16077.1
CCDSiCCDS21022.1
RefSeqiNP_061290.1, NM_018820.4
XP_006540280.1, XM_006540217.3
UniGeneiMm.153684

Genome annotation databases

EnsembliENSMUST00000008528; ENSMUSP00000008528; ENSMUSG00000008384
GeneIDi55942
KEGGimmu:55942
UCSCiuc009fwh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218291 mRNA Translation: AAF27653.1
AF366400 mRNA Translation: AAK52829.1
AF366401 mRNA Translation: AAK52830.1
AK004022 mRNA Translation: BAB23130.1
AK008303 mRNA Translation: BAB25588.1
BC016077 mRNA Translation: AAH16077.1
CCDSiCCDS21022.1
RefSeqiNP_061290.1, NM_018820.4
XP_006540280.1, XM_006540217.3
UniGeneiMm.153684

3D structure databases

ProteinModelPortaliQ9JL10
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207738, 12 interactors
CORUMiQ9JL10
STRINGi10090.ENSMUSP00000008528

Proteomic databases

PaxDbiQ9JL10
PRIDEiQ9JL10

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008528; ENSMUSP00000008528; ENSMUSG00000008384
GeneIDi55942
KEGGimmu:55942
UCSCiuc009fwh.1 mouse

Organism-specific databases

CTDi29950
MGIiMGI:1913438 Sertad1

Phylogenomic databases

eggNOGiENOG410J0C8 Eukaryota
ENOG41114KT LUCA
GeneTreeiENSGT00730000111417
HOGENOMiHOG000133160
HOVERGENiHBG062592
InParanoidiQ9JL10
OMAiMYDSELW
OrthoDBiEOG091G0X9V
PhylomeDBiQ9JL10
TreeFamiTF101069

Miscellaneous databases

PROiPR:Q9JL10
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008384 Expressed in 274 organ(s), highest expression level in blood
CleanExiMM_SERTAD1
ExpressionAtlasiQ9JL10 baseline and differential
GenevisibleiQ9JL10 MM

Family and domain databases

InterProiView protein in InterPro
IPR009263 SERTA_dom
PfamiView protein in Pfam
PF06031 SERTA, 1 hit
PROSITEiView protein in PROSITE
PS51053 SERTA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSRTD1_MOUSE
AccessioniPrimary (citable) accession number: Q9JL10
Secondary accession number(s): Q925E6, Q9D888
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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