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Protein

Lysophosphatidic acid receptor 2

Gene

Lpar2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation (By similarity).By similarity

GO - Molecular functioni

  • lysophosphatidic acid receptor activity Source: InterPro
  • PDZ domain binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 2
Short name:
LPA receptor 2
Short name:
LPA-2
Alternative name(s):
Lysophosphatidic acid receptor Edg-4
Gene namesi
Name:Lpar2
Synonyms:Edg4, Lpa2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1858422 Lpar2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 66CytoplasmicSequence analysisAdd BLAST15
Transmembranei67 – 87Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini88 – 104ExtracellularSequence analysisAdd BLAST17
Transmembranei105 – 124Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini125 – 144CytoplasmicSequence analysisAdd BLAST20
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 185ExtracellularSequence analysisAdd BLAST20
Transmembranei186 – 206Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini207 – 239CytoplasmicSequence analysisAdd BLAST33
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 270ExtracellularSequence analysis10
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 348CytoplasmicSequence analysisAdd BLAST57

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi273

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694261 – 348Lysophosphatidic acid receptor 2Add BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi308S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ9JL06

PTM databases

PhosphoSitePlusiQ9JL06

Expressioni

Tissue specificityi

Most abundantly expressed in testes, kidney, and embryonic brain. Other organs also express the transcript, including heart, lung, spleen, thymus, stomach, and adult brain. Several have little or no expression, including liver, small intestine, and skeletal muscle.

Interactioni

Subunit structurei

Interacts with SLC9A3R2/NHERF2, MAGI3 and PLCB3. Interacts with RALA and GRK2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9JL06, 2 interactors
MINTiQ9JL06

Structurei

3D structure databases

ProteinModelPortaliQ9JL06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi345 – 348PDZ-binding4

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000233501
HOVERGENiHBG103071
InParanoidiQ9JL06
PhylomeDBiQ9JL06

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004065 LPA_rcpt
IPR004066 LPA_rcpt_EDG4
PfamiView protein in Pfam
PF00001 7tm_1, 2 hits
PRINTSiPR01528 EDG4RECEPTOR
PR00237 GPCRRHODOPSN
PR01527 LPARECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9JL06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQCYYNETI GFFYNNSGKE LSLHWRPKDV VVVALGLTVS VLVLLTNLLV
60 70 80 90 100
IAAIASNRRF HQPIYYLLGN LAAADLFAGM AYLFLMFHTG PPHCQALHQR
110 120 130 140 150
LVPATGPAGH QPHGVSGHTA GIAVERHRSV MAVQLHSRLP RGRVVTLIVG
160 170 180 190 200
VWAAALGLGL LPAHFWHCLC DLDSCSRMVP LFSRSYLAAW ALSSLLVFLL
210 220 230 240 250
MVAVYTRIFF YVRRRVERMA EHVSCHPRYR ETTLSLVKTV VIILGAFVVC
260 270 280 290 300
WTPGQVVLLL DGLDCKTCNV LAVEKYFLLL AEANSLVNAV VYSCRDAEMR
310 320 330 340
RTFRRLLCCM CLRWSSHKSA RYSASAQTGA STRIMLPENG RPLMDSTL
Length:348
Mass (Da):38,777
Last modified:October 1, 2000 - v1
Checksum:iE3594382D616052C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P290Q6P290_MOUSE
Endothelial differentiation, lysoph...
Lpar2 Edg4, mCG_23088
348Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218844 Genomic DNA Translation: AAF65684.1
UniGeneiMm.23253

Similar proteinsi

Entry informationi

Entry nameiLPAR2_MOUSE
AccessioniPrimary (citable) accession number: Q9JL06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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