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UniProtKB - Q9JKY2 (Q9JKY2_RAT)
Protein
Submitted name:
Zic family member 1
Gene
Zic1
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- adult walking behavior Source: RGD
- brain development Source: RGD
- central nervous system development Source: RGD
- pattern specification process Source: RGD
- positive regulation of protein import into nucleus Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of smoothened signaling pathway Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- spinal cord development Source: RGD
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Zic family member 1Submitted name: Zic proteinImportedSubmitted name: Zinc finger protein of the cerebellum 1, isoform CRA_aImported |
Gene namesi | ORF Names:rCG_25795Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620110, Zic1 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000014644, Expressed in cerebellum and 7 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 274 – 301 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 302 – 331 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 332 – 361 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 362 – 389 | C2H2-typeInterPro annotationAdd BLAST | 28 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 375 – 434 | DisorderedSequence analysisAdd BLAST | 60 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 386 – 434 | Polar residuesSequence analysisAdd BLAST | 49 |
Sequence similaritiesi
Belongs to the GLI C2H2-type zinc-finger protein family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160269 |
HOGENOMi | CLU_002678_37_1_1 |
OMAi | MKVHSKS |
OrthoDBi | 768287at2759 |
TreeFami | TF351425 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR041643, Znf_ZIC |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits PF18366, zf_ZIC, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
Q9JKY2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLDAGPQYP AIGVTTFGAS RHHSAGDVAE RDVGLGINPF ADGMGAFKLN
60 70 80 90 100
PSSHELASAG QTAFTSQAPG YAAAAALGHH HHPGHVGSYS SAAFNSTRDF
110 120 130 140 150
LFRNRGFGDA AAAASAQHSL FAASAGGFGG PHGHTDAAGH LLFSGLHEQA
160 170 180 190 200
AGHASPNVVN GQMRLGFSGD MYPRPEQYGQ VTSPRSEHYA APQLHGYGPM
210 220 230 240 250
NVNMAAHHGA GAFFRYMRQP IKQELICKWI EPEQLANPKK SCNKTFSTMH
260 270 280 290 300
ELVTHVTVEH VGGPEQSNHI CFWEECPREG KPFKAKYKLV NHIRVHTGEK
310 320 330 340 350
PFPCPFPGCG KVFARSENLK IHKRTHTGEK PFKCEFEGCD RRFANSSDRK
360 370 380 390 400
KHMHVHTSDK PYLCKMCDKS YTHPSSLRKH MKVHESSSQG SQPSPAASSG
410 420 430 440
YESSTPPTIV SPTTDNPTTS SMSPSSSAVH HTAGHSALSS NFNEWYV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF221839 mRNA Translation: AAF34656.1 CH473954 Genomic DNA Translation: EDL77550.1 |
RefSeqi | NP_073168.1, NM_022677.1 XP_008764676.1, XM_008766454.2 |
Genome annotation databases
Ensembli | ENSRNOT00000019860.6; ENSRNOP00000019860.3; ENSRNOG00000014644.6 |
GeneIDi | 64618 |
KEGGi | rno:64618 |
UCSCi | RGD:620110, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF221839 mRNA Translation: AAF34656.1 CH473954 Genomic DNA Translation: EDL77550.1 |
RefSeqi | NP_073168.1, NM_022677.1 XP_008764676.1, XM_008766454.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000019860 |
Genome annotation databases
Ensembli | ENSRNOT00000019860.6; ENSRNOP00000019860.3; ENSRNOG00000014644.6 |
GeneIDi | 64618 |
KEGGi | rno:64618 |
UCSCi | RGD:620110, rat |
Organism-specific databases
CTDi | 7545 |
RGDi | 620110, Zic1 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160269 |
HOGENOMi | CLU_002678_37_1_1 |
OMAi | MKVHSKS |
OrthoDBi | 768287at2759 |
TreeFami | TF351425 |
Gene expression databases
Bgeei | ENSRNOG00000014644, Expressed in cerebellum and 7 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR041643, Znf_ZIC |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits PF18366, zf_ZIC, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9JKY2_RAT | |
Accessioni | Q9JKY2Primary (citable) accession number: Q9JKY2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 1, 2000 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |