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Protein

Uroplakin-3a

Gene

Upk3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Uroplakin-3a
Short name:
UP3a
Alternative name(s):
Uroplakin III
Short name:
UPIII
Gene namesi
Name:Upk3a
Synonyms:Upk3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:98914 Upk3a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 207LumenalSequence analysisAdd BLAST189
Transmembranei208 – 235HelicalSequence analysisAdd BLAST28
Topological domaini236 – 287CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000002263819 – 287Uroplakin-3aAdd BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JKX8
PRIDEiQ9JKX8

PTM databases

iPTMnetiQ9JKX8
PhosphoSitePlusiQ9JKX8

Expressioni

Gene expression databases

BgeeiENSMUSG00000022435 Expressed in 70 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_UPK3A
GenevisibleiQ9JKX8 MM

Interactioni

Subunit structurei

Heterodimer with uroplakin-1B (UPK1B).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Snx31Q6P8Y74EBI-7947322,EBI-10636102

Protein-protein interaction databases

IntActiQ9JKX8, 3 interactors
MINTiQ9JKX8
STRINGi10090.ENSMUSP00000023070

Structurei

3D structure databases

ProteinModelPortaliQ9JKX8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uroplakin-3 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE9T Eukaryota
ENOG41123W4 LUCA
GeneTreeiENSGT00510000048620
HOGENOMiHOG000143412
HOVERGENiHBG058769
InParanoidiQ9JKX8
KOiK19520
OMAiTEYRFKY
OrthoDBiEOG091G0F7J
PhylomeDBiQ9JKX8
TreeFamiTF336628

Family and domain databases

InterProiView protein in InterPro
IPR024831 Uroplakin-3
IPR024825 Uroplakin-3a
PANTHERiPTHR15446 PTHR15446, 1 hit
PTHR15446:SF17 PTHR15446:SF17, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JKX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLLWALLAL GCLRCGWTVN LQPQLASVTF ATNNPTLTTV ALEKPLCMFD
60 70 80 90 100
SSEPLSGSYE VYLYAMVDSA MSRNVSVQDS AGVPLSTTFR QTQGGRSGPY
110 120 130 140 150
KAAAFDLTPC GDLPSLDAVG DVTQASEILN AYLVRVGNNG TCFWDPNFQG
160 170 180 190 200
LCNPPLTAAT EYRFKYVLVN MSTGLVQDQT LWSDPIWTNR PIPYSAIDTW
210 220 230 240 250
PGRRSGGMIV ITSILGSLPF FLLVGFAGAI ILSFVDMGSS DGEMTHDSQI
260 270 280
TQEAVPKTLG TSEPSYSSVN RGPPLDRAEV FSSKLQD
Length:287
Mass (Da):30,990
Last modified:May 26, 2009 - v3
Checksum:i44CF39DA6CA30E88
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3LL → PP in AAF34681 (Ref. 1) Curated2
Sequence conflicti187W → R in AAF34681 (Ref. 1) Curated1
Sequence conflicti195S → L in AAF34681 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222750 mRNA Translation: AAF34681.2
DQ387454 mRNA Translation: ABD52002.1
CH466550 Genomic DNA Translation: EDL04442.1
BC125336 mRNA Translation: AAI25337.1
BC125338 mRNA Translation: AAI25339.1
CCDSiCCDS27716.1
RefSeqiNP_075967.2, NM_023478.2
UniGeneiMm.46214

Genome annotation databases

EnsembliENSMUST00000023070; ENSMUSP00000023070; ENSMUSG00000022435
GeneIDi22270
KEGGimmu:22270
UCSCiuc007xcs.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222750 mRNA Translation: AAF34681.2
DQ387454 mRNA Translation: ABD52002.1
CH466550 Genomic DNA Translation: EDL04442.1
BC125336 mRNA Translation: AAI25337.1
BC125338 mRNA Translation: AAI25339.1
CCDSiCCDS27716.1
RefSeqiNP_075967.2, NM_023478.2
UniGeneiMm.46214

3D structure databases

ProteinModelPortaliQ9JKX8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JKX8, 3 interactors
MINTiQ9JKX8
STRINGi10090.ENSMUSP00000023070

PTM databases

iPTMnetiQ9JKX8
PhosphoSitePlusiQ9JKX8

Proteomic databases

PaxDbiQ9JKX8
PRIDEiQ9JKX8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023070; ENSMUSP00000023070; ENSMUSG00000022435
GeneIDi22270
KEGGimmu:22270
UCSCiuc007xcs.2 mouse

Organism-specific databases

CTDi7380
MGIiMGI:98914 Upk3a

Phylogenomic databases

eggNOGiENOG410IE9T Eukaryota
ENOG41123W4 LUCA
GeneTreeiENSGT00510000048620
HOGENOMiHOG000143412
HOVERGENiHBG058769
InParanoidiQ9JKX8
KOiK19520
OMAiTEYRFKY
OrthoDBiEOG091G0F7J
PhylomeDBiQ9JKX8
TreeFamiTF336628

Miscellaneous databases

PROiPR:Q9JKX8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022435 Expressed in 70 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_UPK3A
GenevisibleiQ9JKX8 MM

Family and domain databases

InterProiView protein in InterPro
IPR024831 Uroplakin-3
IPR024825 Uroplakin-3a
PANTHERiPTHR15446 PTHR15446, 1 hit
PTHR15446:SF17 PTHR15446:SF17, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUPK3A_MOUSE
AccessioniPrimary (citable) accession number: Q9JKX8
Secondary accession number(s): Q27QV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 26, 2009
Last modified: September 12, 2018
This is version 107 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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