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Protein

ADP-ribosylation factor-like protein 6-interacting protein 1

Gene

Arl6ip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (PubMed:18684713). Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 6-interacting protein 1
Short name:
ARL-6-interacting protein 1
Short name:
Aip-1
Alternative name(s):
Protein TBX2
Gene namesi
Name:Arl6ip1
Synonyms:Arl6ip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1858943 Arl6ip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 65LumenalSequence analysis3
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 133CytoplasmicSequence analysisAdd BLAST47
Transmembranei134 – 175HelicalSequence analysisAdd BLAST42
Topological domaini176 – 203LumenalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000646561 – 203ADP-ribosylation factor-like protein 6-interacting protein 1Add BLAST203

Proteomic databases

EPDiQ9JKW0
MaxQBiQ9JKW0
PaxDbiQ9JKW0
PRIDEiQ9JKW0

PTM databases

iPTMnetiQ9JKW0
PhosphoSitePlusiQ9JKW0
SwissPalmiQ9JKW0

Expressioni

Tissue specificityi

Expressed in the cerebral cortex, cerebellum, hippocampus, olfactory bulbs, medulla oblongate and limbic system (at protein level). Ubiquitous (PubMed:18684713). Expressed in all hematopoietic cell lineages, with highest levels in early myeloid progenitor cells.2 Publications

Gene expression databases

BgeeiENSMUSG00000030654 Expressed in 306 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiQ9JKW0 baseline and differential
GenevisibleiQ9JKW0 MM

Interactioni

Subunit structurei

Homooligomer (By similarity). Heterodimer with ARL6IP5 (PubMed:18684713). Interacts with ARL6 (PubMed:10508919). Interacts with TMEM33. Interacts with ATL1 (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207603, 1 interactor
IntActiQ9JKW0, 1 interactor
MINTiQ9JKW0
STRINGi10090.ENSMUSP00000032888

Family & Domainsi

Domaini

The transmembrane domains are required for its ability to shape the endoplasmic reticulum membrane into tubules.By similarity

Sequence similaritiesi

Belongs to the ARL6ip family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHBG Eukaryota
ENOG410Z6SH LUCA
GeneTreeiENSGT00390000005707
HOGENOMiHOG000034032
HOVERGENiHBG050558
InParanoidiQ9JKW0
OMAiQVDQKRA
OrthoDBiEOG091G0YIR
PhylomeDBiQ9JKW0
TreeFamiTF105477

Family and domain databases

InterProiView protein in InterPro
IPR033301 ARL6IP
PANTHERiPTHR20952:SF3 PTHR20952:SF3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9JKW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEGDNRSSN LLAVETASLE EQLQGWGEVM LMADKVLRWE RAWFPPAIMG
60 70 80 90 100
VVSLLFLIIY YLDPSVLSGV SCFVMFLCLA DYLVPILAPR IFGSNKWTTE
110 120 130 140 150
QQQRFHEICS NLVKTRRRAV GWWKRLFSLK EEKPKMYFMT MIISLAAVAW
160 170 180 190 200
VGQQVHNLLL TYLIVTFVLL LPGLNQHGII LKYIGMAKRE INKLLKQKEK

KNE
Length:203
Mass (Da):23,437
Last modified:October 1, 2000 - v1
Checksum:i34D10BE315F7B669
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SV01A0A0N4SV01_MOUSE
ADP-ribosylation factor-like protei...
Arl6ip1
35Annotation score:
A0A0N4SW86A0A0N4SW86_MOUSE
ADP-ribosylation factor-like protei...
Arl6ip1
62Annotation score:
A0A0U1RPY6A0A0U1RPY6_MOUSE
ADP-ribosylation factor-like protei...
Arl6ip1
111Annotation score:

Sequence cautioni

The sequence AAD33046 differs from that shown. Reason: Frameshift at position 116.Curated
The sequence AAF27313 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133669 mRNA Translation: AAD33046.1 Frameshift.
AF172088 mRNA Translation: AAF27313.1 Different initiation.
AF223953 mRNA Translation: AAF34706.1
BC010196 mRNA Translation: AAH10196.1
CCDSiCCDS21769.1
RefSeqiNP_062292.1, NM_019419.2
UniGeneiMm.29924

Genome annotation databases

EnsembliENSMUST00000032888; ENSMUSP00000032888; ENSMUSG00000030654
GeneIDi54208
KEGGimmu:54208
UCSCiuc009jjo.2 mouse

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133669 mRNA Translation: AAD33046.1 Frameshift.
AF172088 mRNA Translation: AAF27313.1 Different initiation.
AF223953 mRNA Translation: AAF34706.1
BC010196 mRNA Translation: AAH10196.1
CCDSiCCDS21769.1
RefSeqiNP_062292.1, NM_019419.2
UniGeneiMm.29924

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207603, 1 interactor
IntActiQ9JKW0, 1 interactor
MINTiQ9JKW0
STRINGi10090.ENSMUSP00000032888

PTM databases

iPTMnetiQ9JKW0
PhosphoSitePlusiQ9JKW0
SwissPalmiQ9JKW0

Proteomic databases

EPDiQ9JKW0
MaxQBiQ9JKW0
PaxDbiQ9JKW0
PRIDEiQ9JKW0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032888; ENSMUSP00000032888; ENSMUSG00000030654
GeneIDi54208
KEGGimmu:54208
UCSCiuc009jjo.2 mouse

Organism-specific databases

CTDi23204
MGIiMGI:1858943 Arl6ip1

Phylogenomic databases

eggNOGiENOG410IHBG Eukaryota
ENOG410Z6SH LUCA
GeneTreeiENSGT00390000005707
HOGENOMiHOG000034032
HOVERGENiHBG050558
InParanoidiQ9JKW0
OMAiQVDQKRA
OrthoDBiEOG091G0YIR
PhylomeDBiQ9JKW0
TreeFamiTF105477

Miscellaneous databases

ChiTaRSiArl6ip1 mouse
PROiPR:Q9JKW0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030654 Expressed in 306 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiQ9JKW0 baseline and differential
GenevisibleiQ9JKW0 MM

Family and domain databases

InterProiView protein in InterPro
IPR033301 ARL6IP
PANTHERiPTHR20952:SF3 PTHR20952:SF3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAR6P1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKW0
Secondary accession number(s): Q9JLI9, Q9WUG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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