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Protein

Interleukin-20

Gene

Il20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3.

GO - Molecular functioni

  • cytokine activity Source: MGI
  • interleukin-20 receptor binding Source: UniProtKB
  • interleukin-22 receptor binding Source: MGI

GO - Biological processi

  • hemopoiesis Source: UniProtKB
  • positive regulation of osteoclast differentiation Source: MGI

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-MMU-8854691 Interleukin-20 family signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-20
Short name:
IL-20
Alternative name(s):
Cytokine Zcyto10
Gene namesi
Name:Il20
Synonyms:Zcyto10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1890473 Il20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001538225 – 176Interleukin-20Add BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 126Sequence analysis
Disulfide bondi80 ↔ 132Sequence analysis
Disulfide bondi81 ↔ 134Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9JKV9
PRIDEiQ9JKV9

PTM databases

PhosphoSitePlusiQ9JKV9

Expressioni

Gene expression databases

BgeeiENSMUSG00000026416 Expressed in 67 organ(s), highest expression level in primary oocyte
CleanExiMM_IL20
ExpressionAtlasiQ9JKV9 baseline and differential
GenevisibleiQ9JKV9 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027673

Structurei

3D structure databases

ProteinModelPortaliQ9JKV9
SMRiQ9JKV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW76 Eukaryota
ENOG410YMTB LUCA
GeneTreeiENSGT00410000025637
HOGENOMiHOG000113033
HOVERGENiHBG108002
InParanoidiQ9JKV9
KOiK22667
OMAiHHTLRKI
OrthoDBiEOG091G0Q0Q
PhylomeDBiQ9JKV9
TreeFamiTF333253

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020443 IL-10/19/20/22/24/26_fam
IPR020423 IL-10_CS
IPR020442 IL-20
PfamiView protein in Pfam
PF00726 IL10, 1 hit
PRINTSiPR01935 INTRLEUKIN20
SMARTiView protein in SMART
SM00188 IL10, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00520 INTERLEUKIN_10, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9JKV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGFGLAFGL FSAVGFLLWT PLTGLKTLHL GSCVITANLQ AIQKEFSEIR
60 70 80 90 100
DSVQAEDTNI DIRILRTTES LKDIKSLDRC CFLRHLVRFY LDRVFKVYQT
110 120 130 140 150
PDHHTLRKIS SLANSFLIIK KDLSVCHSHM ACHCGEEAME KYNQILSHFI
160 170
ELELQAAVVK ALGELGILLR WMEEML
Length:176
Mass (Da):20,098
Last modified:October 1, 2000 - v1
Checksum:i08577AF656574771
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q2THG5Q2THG5_MOUSE
Interleukin 20 short form
Il20
154Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224267 mRNA Translation: AAF36680.1
CCDSiCCDS15263.1
RefSeqiNP_001298020.1, NM_001311091.1
NP_067355.1, NM_021380.2
UniGeneiMm.103794

Genome annotation databases

EnsembliENSMUST00000027673; ENSMUSP00000027673; ENSMUSG00000026416
GeneIDi58181
KEGGimmu:58181
UCSCiuc007cmr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIL20_MOUSE
AccessioniPrimary (citable) accession number: Q9JKV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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