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Protein

Exostosin-like 1

Gene

Extl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable glycosyltransferase.By similarity

Catalytic activityi

UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan = UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayi
UPA00378

Protein family/group databases

CAZyiGT47 Glycosyltransferase Family 47
GT64 Glycosyltransferase Family 64

Names & Taxonomyi

Protein namesi
Recommended name:
Exostosin-like 1 (EC:2.4.1.224)
Alternative name(s):
Exostosin-L
Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
Multiple exostosis-like protein
Gene namesi
Name:Extl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1888742 Extl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini30 – 669LumenalSequence analysisAdd BLAST640

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001496541 – 669Exostosin-like 1Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi263N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi577 ↔ 627By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JKV7
PRIDEiQ9JKV7

PTM databases

PhosphoSitePlusiQ9JKV7

Expressioni

Gene expression databases

BgeeiENSMUSG00000028838 Expressed in 172 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_EXTL1
GenevisibleiQ9JKV7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030643

Structurei

3D structure databases

ProteinModelPortaliQ9JKV7
SMRiQ9JKV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 47 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1021 Eukaryota
ENOG410XTFH LUCA
GeneTreeiENSGT00550000074496
HOGENOMiHOG000266990
HOVERGENiHBG003459
InParanoidiQ9JKV7
KOiK02368
OMAiWSHFWDE
OrthoDBiEOG091G0BDR
TreeFamiTF314231

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR004263 Exostosin
IPR027675 Exostosin-like_1
IPR015338 EXT_C
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR11062 PTHR11062, 1 hit
PTHR11062:SF8 PTHR11062:SF8, 1 hit
PfamiView protein in Pfam
PF03016 Exostosin, 1 hit
PF09258 Glyco_transf_64, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JKV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLWRRKSFWL ALSAFWLLLV LLGVFPLRLA VLPGPLPGRS QGWPRWLDAA
60 70 80 90 100
FLQSFSQSET NPEDVAQLPR VSRGSSCTWG ACFDTSKCRG KVLKIFVHSP
110 120 130 140 150
AGPTSEAQRR ILDSLEGSRY SALSPADACL LLFLPSQDRR GACGPLPPNW
160 170 180 190 200
NGGRNHLVLS LYPAPCTRLG QAMVAEASPS SDIFRPGFDL ALPYLPEAHP
210 220 230 240 250
LRGGAPGKLQ QHSPQPGATL LAVAEEKGRW RITSTHASAC LWDRHCEQDP
260 270 280 290 300
GPQQTYPGET LPNATFCLIP GHRSATSCFL QALQAGCIPV LLSPRWELPF
310 320 330 340 350
SEVIDWTKAA IIADERLPLQ VLAALREMLP SRVLALRQQT QFLWTAYFSS
360 370 380 390 400
VEKVIHTTLE IIQDRIWGAS GHPSLMWNSP PGALLALPTF STSLQDFPFY
410 420 430 440 450
HLQLGSGPGS SFSAVIWVGA SGESLLKLIQ EVAGSRHCAQ ILILWNSEKL
460 470 480 490 500
PPDRWPETAV PLTVIKGHRK VSNRFFPYSN ISTNVILSLD AQSTLSTSEV
510 520 530 540 550
DFAFVVWQSF PERMVGFLSG SHFWDEAQGG WGYRTGMTNE FSMVLTTAAF
560 570 580 590 600
YHRYYHTLFT HSLPKALRTI ADETPTCVDV LMNFLVATVT KLPPIKVPYG
610 620 630 640 650
RQHPEAVPMD SGDPRPVPEP QPLDQDCINR LAAGFGHMPL VSSQVRLDPV
660
LFKDPVSVQR KKYRSLEKP
Length:669
Mass (Da):74,079
Last modified:July 27, 2011 - v2
Checksum:i79629222B6CA3821
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32L → S in AAF61913 (PubMed:10878610).Curated1
Sequence conflicti190L → I in AAF61913 (PubMed:10878610).Curated1
Sequence conflicti361I → V in AAF61913 (PubMed:10878610).Curated1
Sequence conflicti450L → P in AAF61913 (PubMed:10878610).Curated1
Sequence conflicti540E → D in AAF61913 (PubMed:10878610).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224461 mRNA Translation: AAF61913.1
AL669982 Genomic DNA No translation available.
CCDSiCCDS18770.1
RefSeqiNP_062524.2, NM_019578.2
UniGeneiMm.30978

Genome annotation databases

EnsembliENSMUST00000030643; ENSMUSP00000030643; ENSMUSG00000028838
GeneIDi56219
KEGGimmu:56219
UCSCiuc012dmu.1 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

EXTL1 (putative HS transferase) [GAG Enzyme]

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224461 mRNA Translation: AAF61913.1
AL669982 Genomic DNA No translation available.
CCDSiCCDS18770.1
RefSeqiNP_062524.2, NM_019578.2
UniGeneiMm.30978

3D structure databases

ProteinModelPortaliQ9JKV7
SMRiQ9JKV7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030643

Protein family/group databases

CAZyiGT47 Glycosyltransferase Family 47
GT64 Glycosyltransferase Family 64

PTM databases

PhosphoSitePlusiQ9JKV7

Proteomic databases

PaxDbiQ9JKV7
PRIDEiQ9JKV7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030643; ENSMUSP00000030643; ENSMUSG00000028838
GeneIDi56219
KEGGimmu:56219
UCSCiuc012dmu.1 mouse

Organism-specific databases

CTDi2134
MGIiMGI:1888742 Extl1

Phylogenomic databases

eggNOGiKOG1021 Eukaryota
ENOG410XTFH LUCA
GeneTreeiENSGT00550000074496
HOGENOMiHOG000266990
HOVERGENiHBG003459
InParanoidiQ9JKV7
KOiK02368
OMAiWSHFWDE
OrthoDBiEOG091G0BDR
TreeFamiTF314231

Enzyme and pathway databases

UniPathwayi
UPA00378

Miscellaneous databases

PROiPR:Q9JKV7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028838 Expressed in 172 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_EXTL1
GenevisibleiQ9JKV7 MM

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR004263 Exostosin
IPR027675 Exostosin-like_1
IPR015338 EXT_C
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR11062 PTHR11062, 1 hit
PTHR11062:SF8 PTHR11062:SF8, 1 hit
PfamiView protein in Pfam
PF03016 Exostosin, 1 hit
PF09258 Glyco_transf_64, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEXTL1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKV7
Secondary accession number(s): E9QKA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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