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Protein

LIM homeobox transcription factor 1-alpha

Gene

Lmx1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi195 – 254HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM homeobox transcription factor 1-alpha
Alternative name(s):
LIM/homeobox protein 1.1
Short name:
LMX-1.1
LIM/homeobox protein LMX1A
Gene namesi
Name:Lmx1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1888519 Lmx1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Lmx1a are the cause of the spontaneous neurologic mutant mouse, called 'dreher' (dr) and results from a failure of the roof plate to develop.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758271 – 382LIM homeobox transcription factor 1-alphaAdd BLAST382

Proteomic databases

PaxDbiQ9JKU8
PRIDEiQ9JKU8

PTM databases

PhosphoSitePlusiQ9JKU8

Expressioni

Gene expression databases

BgeeiENSMUSG00000026686 Expressed in 60 organ(s), highest expression level in blood
CleanExiMM_LMX1A
ExpressionAtlasiQ9JKU8 baseline and differential
GenevisibleiQ9JKU8 MM

Interactioni

Protein-protein interaction databases

BioGridi225780, 5 interactors
STRINGi10090.ENSMUSP00000028003

Structurei

3D structure databases

ProteinModelPortaliQ9JKU8
SMRiQ9JKU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 92LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini92 – 154LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi240 – 274Gln-richAdd BLAST35
Compositional biasi257 – 265Poly-Gln9

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000231629
HOVERGENiHBG052335
InParanoidiQ9JKU8
KOiK09371
OMAiNDSLWHE
OrthoDBiEOG091G09Z3
PhylomeDBiQ9JKU8
TreeFamiTF315442

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00132 LIM, 2 hits
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q9JKU8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLDGLKMEEN FQSAIETSAS FSSLLGRAVS PKSVCEGCQR VISDRFLLRL
60 70 80 90 100
NDSFWHEQCV QCASCKEPLE TTCFYRDKKL YCKYHYEKLF AVKCGGCFEA
110 120 130 140 150
IAPNEFVMRA QKSVYHLSCF CCCVCERQLQ KGDEFVLKEG QLLCKGDYEK
160 170 180 190 200
ERELLSLVSP AASDSGKSDD EESLCKSAHG AGKGASEDGK DHKRPKRPRT
210 220 230 240 250
ILTTQQRRAF KASFEVSSKP CRKVRETLAA ETGLSVRVVQ VWFQNQRAKM
260 270 280 290 300
KKLARRQQQQ QQDQQNTQRL TSAQTNGSGN AGMEGIMNPY TTLPTPQQLL
310 320 330 340 350
AIEQSVYNSD PFRQGLTPPQ MPGDHMHPYG AEPLFHDLDS DDTSLSNLGD
360 370 380
CFLATSEAGP LQSRVGNPID HLYSMQNSYF TS
Length:382
Mass (Da):42,857
Last modified:October 1, 2000 - v1
Checksum:i6C856843FEAC6706
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226662 mRNA Translation: AAF43012.1
CCDSiCCDS15460.1
RefSeqiNP_387501.1, NM_033652.5
XP_006496674.1, XM_006496611.2
XP_017177173.1, XM_017321684.1
UniGeneiMm.330081

Genome annotation databases

EnsembliENSMUST00000028003; ENSMUSP00000028003; ENSMUSG00000026686
ENSMUST00000111377; ENSMUSP00000107008; ENSMUSG00000026686
GeneIDi110648
KEGGimmu:110648
UCSCiuc007dlc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226662 mRNA Translation: AAF43012.1
CCDSiCCDS15460.1
RefSeqiNP_387501.1, NM_033652.5
XP_006496674.1, XM_006496611.2
XP_017177173.1, XM_017321684.1
UniGeneiMm.330081

3D structure databases

ProteinModelPortaliQ9JKU8
SMRiQ9JKU8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi225780, 5 interactors
STRINGi10090.ENSMUSP00000028003

PTM databases

PhosphoSitePlusiQ9JKU8

Proteomic databases

PaxDbiQ9JKU8
PRIDEiQ9JKU8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028003; ENSMUSP00000028003; ENSMUSG00000026686
ENSMUST00000111377; ENSMUSP00000107008; ENSMUSG00000026686
GeneIDi110648
KEGGimmu:110648
UCSCiuc007dlc.1 mouse

Organism-specific databases

CTDi4009
MGIiMGI:1888519 Lmx1a

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000231629
HOVERGENiHBG052335
InParanoidiQ9JKU8
KOiK09371
OMAiNDSLWHE
OrthoDBiEOG091G09Z3
PhylomeDBiQ9JKU8
TreeFamiTF315442

Miscellaneous databases

PROiPR:Q9JKU8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026686 Expressed in 60 organ(s), highest expression level in blood
CleanExiMM_LMX1A
ExpressionAtlasiQ9JKU8 baseline and differential
GenevisibleiQ9JKU8 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00132 LIM, 2 hits
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLMX1A_MOUSE
AccessioniPrimary (citable) accession number: Q9JKU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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