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Protein

Taste receptor type 2 member 16

Gene

Tas2r16

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

GO - Molecular functioni

  • bitter taste receptor activity Source: GO_Central
  • G-protein coupled receptor activity Source: UniProtKB-KW
  • taste receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-RNO-418594 G alpha (i) signalling events
R-RNO-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 16
Short name:
T2R16
Alternative name(s):
T2R18
T2R3
Gene namesi
Name:Tas2r16
Synonyms:Tas2r18, Tas2r3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620735 Tas2r16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5ExtracellularSequence analysis5
Transmembranei6 – 26Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini27 – 44CytoplasmicSequence analysisAdd BLAST18
Transmembranei45 – 65Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini66 – 82ExtracellularSequence analysisAdd BLAST17
Transmembranei83 – 103Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini104 – 125CytoplasmicSequence analysisAdd BLAST22
Transmembranei126 – 146Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini147 – 183ExtracellularSequence analysisAdd BLAST37
Transmembranei184 – 204Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini205 – 233CytoplasmicSequence analysisAdd BLAST29
Transmembranei234 – 254Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini255 – 258ExtracellularSequence analysis4
Transmembranei259 – 279Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini280 – 299CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822681 – 299Taste receptor type 2 member 16Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JKU0
PRIDEiQ9JKU0

PTM databases

PhosphoSitePlusiQ9JKU0

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrine cells.1 Publication

Gene expression databases

GenevisibleiQ9JKU0 RN

Interactioni

Subunit structurei

Interacts with RTP3 and RTP4.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031530

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKNW Eukaryota
ENOG41119UD LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG098568
InParanoidiQ9JKU0
KOiK08474
OMAiCVTIIPS
OrthoDBiEOG091G0HIR
PhylomeDBiQ9JKU0
TreeFamiTF335891

Family and domain databases

InterProiView protein in InterPro
IPR007960 T2R
PANTHERiPTHR11394 PTHR11394, 1 hit
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JKU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPTQVTIFS IIMYVLESLV IIVQSCTTVA VLFREWMHFQ RLSPVEIILI
60 70 80 90 100
SLGISHFCLQ WTSMLYNFGT YSRPVLLFWK VSVVWEFMNV LTFWLTSLLA
110 120 130 140 150
VLYCVKVSSF SHPVFLWLRL KILKLVLWLL LGALIASCLS IIPSVVKYHI
160 170 180 190 200
QMELLTLDHL PKNSSLILRL QMFEWYFSNP FKMIGFGVPF LVFLISIILL
210 220 230 240 250
TVSLVQHWGQ MKHYSSSSSS LRAQCTVLKS LATFFIFFTS YFLTIVVSFI
260 270 280 290
GTVFDKKSWF WVCEAVIYGL VCIHFTSLMM SNPTLKKALR LQFWSPESS
Length:299
Mass (Da):34,642
Last modified:October 1, 2000 - v1
Checksum:iECDC2EBB29943B6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227141 mRNA Translation: AAF43914.1
RefSeqiNP_076484.1, NM_023994.1
UniGeneiRn.48783

Genome annotation databases

EnsembliENSRNOT00000034936; ENSRNOP00000031530; ENSRNOG00000021799
GeneIDi78980
KEGGirno:78980
UCSCiRGD:620735 rat

Similar proteinsi

Entry informationi

Entry nameiT2R16_RAT
AccessioniPrimary (citable) accession number: Q9JKU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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