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Protein

Intracellular hyaluronan-binding protein 4

Gene

Habp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation. Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress. Plays a role in pre-mRNA splicing regulation. Binds (via C-terminus) to poly(U) RNA. Involved in mRNA translation regulation, probably at the initiation step.By similarity

Miscellaneous

Able to bind hyaluronan. However, its intracellular localization suggests that this interaction may not be relevant in vivo.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing, Transcription, Transcription regulation, Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Intracellular hyaluronan-binding protein 41 Publication
Short name:
IHABP-41 Publication
Short name:
IHABP41 Publication
Alternative name(s):
Hyaluronic acid-binding protein 4Imported
Gene namesi
Name:Habp4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1891713 Habp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002579731 – 411Intracellular hyaluronan-binding protein 4Add BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei70Omega-N-methylarginineBy similarity1
Modified residuei74PhosphoserineBy similarity1
Modified residuei108PhosphoserineBy similarity1
Modified residuei352Phosphothreonine; by PKCBy similarity1
Modified residuei373Phosphothreonine; by PKCBy similarity1

Post-translational modificationi

Phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-352 and Thr-373.By similarity
Methylated. Methylation is decreased by phorbol 12-myristate 13-acetate (PMA)-activated PKC, in vitro.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9JKS5
PaxDbiQ9JKS5
PRIDEiQ9JKS5

PTM databases

iPTMnetiQ9JKS5
PhosphoSitePlusiQ9JKS5

Expressioni

Tissue specificityi

Expressed in adult heart, brain, liver, kidney, testis, and in various embryonic tissues, but not in adult spleen, lung or skeletal muscle.1 Publication

Gene expression databases

CleanExiMM_HABP4

Interactioni

Subunit structurei

Associates with polysomes. Interacts with FMR1. Interacts with FXR1 and FXR2. Interacts with CHD3 (via C-terminus). Interacts (via C-terminus) with RACK1. Interacts with p53/TP53 (By similarity). Interacts (via N-terminus) with SRSF9; this interaction is direct (PubMed:19523114). Interacts with SYNCRIP; this interaction is direct. Interacts with MEF2C (via N-terminus); this interaction decreases DNA-binding activity of MEF2C in myocardial cells in response to mechanical stress. Interacts with PRMT1 (via N-terminus) (By similarity). Interacts with SPIN1 (PubMed:23894536).By similarity2 Publications

Protein-protein interaction databases

IntActiQ9JKS5, 1 interactor
MINTiQ9JKS5
STRINGi10090.ENSMUSP00000021929

Structurei

3D structure databases

ProteinModelPortaliQ9JKS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili42 – 62Sequence analysisAdd BLAST21
Coiled coili279 – 301Sequence analysisAdd BLAST23

Domaini

The C-terminal region is necessary for nucleus and cytoplasmic localization. The N-terminal region is necessary for nucleus and nuclear bodies localization. Regions containing Arg-Gly-Gly repeats (RGG/RXR-box) may be preferentially methylated by PRMT1.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2945 Eukaryota
ENOG410YBHR LUCA
HOGENOMiHOG000220826
HOVERGENiHBG056357
InParanoidiQ9JKS5
KOiK19019
PhylomeDBiQ9JKS5

Family and domain databases

InterProiView protein in InterPro
IPR039764 HABP4/SERBP1
IPR006861 HABP4_PAIRBP1-bd
IPR032381 IHABP4_N
PANTHERiPTHR12299 PTHR12299, 1 hit
PfamiView protein in Pfam
PF04774 HABP4_PAI-RBP1, 1 hit
PF16174 IHABP4_N, 1 hit
SMARTiView protein in SMART
SM01233 HABP4_PAI-RBP1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9JKS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGALGSPVA AAGAAMQETF GCVVANRFHQ LLDDESDPFD ILREAEHRRQ
60 70 80 90 100
QQLQRKRRDE AAAASGAGHR GGRSPAVASG HRPGAGGRRE SQKERKSLAA
110 120 130 140 150
SGAQQPDSPG GPQPPGQKRT PRRGEQQGWN DNRGTDVVLE RAERRSYREY
160 170 180 190 200
RPYETERQAD LPVEKFTDEK PVDRFDRDRP LRGRGGPRGG LRSRGRGGPG
210 220 230 240 250
NRAFDSFDQR GKRDFERYSS NDKTNRMEDS MGGCGIRPWG SGKDTSDTEP
260 270 280 290 300
PAPMEETSMM EECQGTLDEE SAAKVPELEV EEENQVQEMT LDEWKNLQEQ
310 320 330 340 350
TRPKPEFNIR KPESTVPSKA VVIHKSRYRD DMVKEDYEDE SHVFRKAAND
360 370 380 390 400
ITSQLEINFG NLPRPGRGAR GSTRGGRGRM RRTENYGPRA EVVTQDVAPN
410
PDDPEDFPAL A
Length:411
Mass (Da):45,924
Last modified:October 31, 2006 - v2
Checksum:i234C0E38C98990F4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QKB2E9QKB2_MOUSE
Intracellular hyaluronan-binding pr...
Habp4
412Annotation score:
A0A1Y7VNT1A0A1Y7VNT1_MOUSE
Intracellular hyaluronan-binding pr...
Habp4
342Annotation score:

Sequence cautioni

The sequence BAB30437 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64A → AA in BAB30437 (PubMed:16141072).Curated1
Sequence conflicti187P → L in BAE25769 (PubMed:16141072).Curated1
Sequence conflicti194R → K in AAF36966 (PubMed:10887182).Curated1
Sequence conflicti266T → A in BAB30437 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227684 mRNA Translation: AAF36966.1
AK016800 mRNA Translation: BAB30437.1 Sequence problems.
AK144206 mRNA Translation: BAE25769.1
RefSeqiNP_064370.2, NM_019986.3
UniGeneiMm.40989

Genome annotation databases

GeneIDi56541
KEGGimmu:56541

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227684 mRNA Translation: AAF36966.1
AK016800 mRNA Translation: BAB30437.1 Sequence problems.
AK144206 mRNA Translation: BAE25769.1
RefSeqiNP_064370.2, NM_019986.3
UniGeneiMm.40989

3D structure databases

ProteinModelPortaliQ9JKS5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JKS5, 1 interactor
MINTiQ9JKS5
STRINGi10090.ENSMUSP00000021929

PTM databases

iPTMnetiQ9JKS5
PhosphoSitePlusiQ9JKS5

Proteomic databases

MaxQBiQ9JKS5
PaxDbiQ9JKS5
PRIDEiQ9JKS5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56541
KEGGimmu:56541

Organism-specific databases

CTDi22927
MGIiMGI:1891713 Habp4

Phylogenomic databases

eggNOGiKOG2945 Eukaryota
ENOG410YBHR LUCA
HOGENOMiHOG000220826
HOVERGENiHBG056357
InParanoidiQ9JKS5
KOiK19019
PhylomeDBiQ9JKS5

Miscellaneous databases

ChiTaRSiHabp4 mouse
PROiPR:Q9JKS5
SOURCEiSearch...

Gene expression databases

CleanExiMM_HABP4

Family and domain databases

InterProiView protein in InterPro
IPR039764 HABP4/SERBP1
IPR006861 HABP4_PAIRBP1-bd
IPR032381 IHABP4_N
PANTHERiPTHR12299 PTHR12299, 1 hit
PfamiView protein in Pfam
PF04774 HABP4_PAI-RBP1, 1 hit
PF16174 IHABP4_N, 1 hit
SMARTiView protein in SMART
SM01233 HABP4_PAI-RBP1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHABP4_MOUSE
AccessioniPrimary (citable) accession number: Q9JKS5
Secondary accession number(s): Q3UNH8, Q9D450
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 7, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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