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Protein

Hypoxia up-regulated protein 1

Gene

Hyou1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxia up-regulated protein 1
Short name:
GRP-170
Alternative name(s):
140 kDa Ca(2+)-binding protein
Short name:
CBP-140
Gene namesi
Name:Hyou1
Synonyms:Grp170
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:108030 Hyou1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32By similarityAdd BLAST32
ChainiPRO_500005782733 – 999Hypoxia up-regulated protein 1Add BLAST967

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei567PhosphoserineBy similarity1
Glycosylationi596N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi830N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi862N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi869N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei883N6-acetyllysineCombined sources1
Glycosylationi922N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi931N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9JKR6
MaxQBiQ9JKR6
PaxDbiQ9JKR6
PeptideAtlasiQ9JKR6
PRIDEiQ9JKR6

2D gel databases

REPRODUCTION-2DPAGEiIPI00123342
Q3TZD0
Q64139
Q9JKR6

PTM databases

iPTMnetiQ9JKR6
PhosphoSitePlusiQ9JKR6
SwissPalmiQ9JKR6

Expressioni

Gene expression databases

BgeeiENSMUSG00000032115 Expressed in 271 organ(s), highest expression level in supraoptic nucleus
CleanExiMM_HYOU1
ExpressionAtlasiQ9JKR6 baseline and differential
GenevisibleiQ9JKR6 MM

Interactioni

Subunit structurei

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

Protein-protein interaction databases

BioGridi198427, 9 interactors
CORUMiQ9JKR6
IntActiQ9JKR6, 6 interactors
MINTiQ9JKR6
STRINGi10090.ENSMUSP00000068594

Structurei

3D structure databases

ProteinModelPortaliQ9JKR6
SMRiQ9JKR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi996 – 999Prevents secretion from ERSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi603 – 606Poly-Glu4

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0104 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00390000016919
HOGENOMiHOG000007865
HOVERGENiHBG106402
InParanoidiQ9JKR6
KOiK09486
OMAiYFNQAER
OrthoDBiEOG091G025X
PhylomeDBiQ9JKR6
TreeFamiTF105048

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 2 hits
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9JKR6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATVRRQRP RRLLCWALVA VLLADLLALS DTLAVMSVDL GSESMKVAIV
60 70 80 90 100
KPGVPMEIVL NKESRRKTPV TVTLKENERF LGDSAAGMAI KNPKATLRYF
110 120 130 140 150
QHLLGKQADN PHVALYRSRF PEHELIVDPQ RQTVRFQISP QLQFSPEEVL
160 170 180 190 200
GMVLNYSRSL AEDFAEQPIK DAVITVPAFF NQAERRAVLQ AARMAGLKVL
210 220 230 240 250
QLINDNTATA LSYGVFRRKD INSTAQNVMF YDMGSGSTVC TIVTYQTVKT
260 270 280 290 300
KEAGMQPQLQ IRGVGFDRTL GGLEMELRLR EHLAKLFNEQ RKGQKAKDVR
310 320 330 340 350
ENPRAMAKLL REANRLKTVL SANADHMAQI EGLMDDVDFK AKVTRVEFEE
360 370 380 390 400
LCADLFDRVP GPVQQALQSA EMSLDQIEQV ILVGGATRVP KVQEVLLKAV
410 420 430 440 450
GKEELGKNIN ADEAAAMGAV YQAAALSKAF KVKPFVVRDA VIYPILVEFT
460 470 480 490 500
REVEEEPGLR SLKHNKRVLF SRMGPYPQRK VITFNRYSHD FNFHINYGDL
510 520 530 540 550
GFLGPEDLRV FGSQNLTTVK LKGVGESFKK YPDYESKGIK AHFNLDESGV
560 570 580 590 600
LSLDRVESVF ETLVEDSPEE ESTLTKLGNT ISSLFGGGTS SDAKENGTDA
610 620 630 640 650
VQEEEESPAE GSKDEPAEQG ELKEEAEPPA EETSQPPPSE PKGDAAREGE
660 670 680 690 700
KPDEKESGDK PEAQKPNEKG QAGPEGAAPA PEEDKKPKPA RKQKMVEEIG
710 720 730 740 750
VELAVLDLPD LPEDELARSV QKLEELTLRD LEKQEREKAA NSLEAFIFET
760 770 780 790 800
QDKLYQPEYQ EVSTEEQREE ISGKLSATST WLEDEGFGAT TVMLKDKLAE
810 820 830 840 850
LRKLCQGLFF RVEERRKWPE RLSALDNLLN HSSIFLKGAR LIPEMDQVFT
860 870 880 890 900
EVEMTTLEKV INDTWAWKNA TLAEQAKLPA TEKPVLLSKD IEAKMMALDR
910 920 930 940 950
EVQYLLNKAK FTKPRPRPKD KNGTRAEPPL NASAGDQEEK VIPPAGQTEE
960 970 980 990
AKPILEPDKE ETGTEPADSE PLELGGPGAG PEQEEQSAGQ KRPSKNDEL
Length:999
Mass (Da):111,181
Last modified:October 1, 2000 - v1
Checksum:i2951482D1EE2EF36
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CYZ2E0CYZ2_MOUSE
Hypoxia up-regulated protein 1
Hyou1
172Annotation score:
F6TRP3F6TRP3_MOUSE
Hypoxia up-regulated protein 1
Hyou1
227Annotation score:
A0A1L1SQ34A0A1L1SQ34_MOUSE
Hypoxia up-regulated protein 1
Hyou1
153Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137Q → L in AAH50107 (PubMed:15489334).Curated1
Sequence conflicti227N → D in AAH50107 (PubMed:15489334).Curated1
Sequence conflicti247T → A in BAE34279 (PubMed:16141072).Curated1
Sequence conflicti290Q → R in BAE42657 (PubMed:16141072).Curated1
Sequence conflicti467R → G in AAB35051 (PubMed:7641295).Curated1
Sequence conflicti540K → R in AAH50107 (PubMed:15489334).Curated1
Sequence conflicti615E → K in AAH50107 (PubMed:15489334).Curated1
Sequence conflicti665Missing in AAB35051 (PubMed:7641295).Curated1
Sequence conflicti687P → L in AAB35051 (PubMed:7641295).Curated1
Sequence conflicti710D → N in AAB35051 (PubMed:7641295).Curated1
Sequence conflicti734Q → R in AAH50107 (PubMed:15489334).Curated1
Sequence conflicti744E → K in AAH50107 (PubMed:15489334).Curated1
Sequence conflicti772S → P in AAH50107 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228709 mRNA Translation: AAF65544.1
AK171769 mRNA Translation: BAE42657.1
AK145857 mRNA Translation: BAE26702.1
AK155721 mRNA Translation: BAE33401.1
AK157949 mRNA Translation: BAE34279.1
BC050107 mRNA Translation: AAH50107.1
S78797 mRNA Translation: AAB35051.1
CCDSiCCDS23107.1
RefSeqiNP_067370.3, NM_021395.4
XP_006510022.1, XM_006509959.2
XP_006510023.1, XM_006509960.2
XP_006510024.1, XM_006509961.2
UniGeneiMm.116721

Genome annotation databases

EnsembliENSMUST00000066601; ENSMUSP00000068594; ENSMUSG00000032115
ENSMUST00000160902; ENSMUSP00000125594; ENSMUSG00000032115
ENSMUST00000161318; ENSMUSP00000123700; ENSMUSG00000032115
GeneIDi12282
KEGGimmu:12282
UCSCiuc009pdf.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228709 mRNA Translation: AAF65544.1
AK171769 mRNA Translation: BAE42657.1
AK145857 mRNA Translation: BAE26702.1
AK155721 mRNA Translation: BAE33401.1
AK157949 mRNA Translation: BAE34279.1
BC050107 mRNA Translation: AAH50107.1
S78797 mRNA Translation: AAB35051.1
CCDSiCCDS23107.1
RefSeqiNP_067370.3, NM_021395.4
XP_006510022.1, XM_006509959.2
XP_006510023.1, XM_006509960.2
XP_006510024.1, XM_006509961.2
UniGeneiMm.116721

3D structure databases

ProteinModelPortaliQ9JKR6
SMRiQ9JKR6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198427, 9 interactors
CORUMiQ9JKR6
IntActiQ9JKR6, 6 interactors
MINTiQ9JKR6
STRINGi10090.ENSMUSP00000068594

PTM databases

iPTMnetiQ9JKR6
PhosphoSitePlusiQ9JKR6
SwissPalmiQ9JKR6

2D gel databases

REPRODUCTION-2DPAGEiIPI00123342
Q3TZD0
Q64139
Q9JKR6

Proteomic databases

EPDiQ9JKR6
MaxQBiQ9JKR6
PaxDbiQ9JKR6
PeptideAtlasiQ9JKR6
PRIDEiQ9JKR6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066601; ENSMUSP00000068594; ENSMUSG00000032115
ENSMUST00000160902; ENSMUSP00000125594; ENSMUSG00000032115
ENSMUST00000161318; ENSMUSP00000123700; ENSMUSG00000032115
GeneIDi12282
KEGGimmu:12282
UCSCiuc009pdf.2 mouse

Organism-specific databases

CTDi10525
MGIiMGI:108030 Hyou1

Phylogenomic databases

eggNOGiKOG0104 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00390000016919
HOGENOMiHOG000007865
HOVERGENiHBG106402
InParanoidiQ9JKR6
KOiK09486
OMAiYFNQAER
OrthoDBiEOG091G025X
PhylomeDBiQ9JKR6
TreeFamiTF105048

Miscellaneous databases

PROiPR:Q9JKR6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032115 Expressed in 271 organ(s), highest expression level in supraoptic nucleus
CleanExiMM_HYOU1
ExpressionAtlasiQ9JKR6 baseline and differential
GenevisibleiQ9JKR6 MM

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 2 hits
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHYOU1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKR6
Secondary accession number(s): Q3TAL1
, Q3TZD0, Q3U1U2, Q64139, Q80X75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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